Practical tips to help stave off bankruptcy.

Do the math and find extra money.

 Many good contractors are struggling to survive America’s economic crisis and some have already lost their businesses. And far too many good employees are struggling at work as well as with finances at home.  

For over 300 years, scientists have primarily studied bacteria using liquid cultures or flat 2D plates in laboratory settings

The more things change…the harder it becomes to do your small business taxes. Between the Affordable Care Act coming into full effect, on-again off-again on-again tax credits gurgling out of Washington, and even a shakeup of the venerable TurboTax product line, this year—more than ever—small business owners need guidance and support as April 15 approaches.

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In 1938, Bill Hewlett and Dave Packard began working part-time in a Palo Alto garage. With $538 just in working capital, the pair developed an audio oscillator: it would become the first product for the fledgling Hewlett-Packard HPQ +0.00% partnership. Today, Hewlett-Packard sits at #35 on Forbes’ list of most valuable brands, with an estimated worth of $57.9 billion.

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Expert advice on handling panicked customers, interrupted supply chains, webinars, Zoom meetings, hyper kids, and a work environment that changes by the hour.

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[The New Humanitarian] Malakal, South Sudan -- 'There is no house, no food, and no place to sleep for the children.'

January 19, 2006 – There is a lot of talk in the media about natural disasters. In the past year the United States has faced hurricanes, flooding, tornados and fires. The first thing on the mind of anyone who goes through a disaster is physical survival. But what very few people consider is economic survival. Just because you lose all of your physical possessions doesn’t mean that you have to lose everything that you have worked for all of your life. But in order to survive economically, you need to do some pre-planning.

There is no fall too deep for Christ's love for us. Never lose hope, my brothers and my sisters.

Building on his homily from last week, Fr. Pat discusses an example of the authority of darkness, and encourages us with reminders of both Christ’s prayer for us, and of our fellowship with each other.

The fear of homeschooling or the fear that the virtual school stress we experienced this past spring is what we'd be sentencing ourselves to if we homeschool this fall. Let's talk about the difference between survival schooling and homeschooling. If schools remain closed this fall, is it possible to thrive and not just survive?

A key finding in the literature on industry evolution and strategy is that knowledge "inherited" from the founder's previous employer can be an important source of a new firm's capabilities. We analyze the conditions under which knowledge that is useful for carrying out a key value chain activity is inherited, and explore the mechanism through which such an inheritance shapes an entrant's strategies and, in the process, influences its performance. Evidence from the early U.S. auto industry indicates that employee spinoffs generated from incumbents that had integrated a key value chain activity were also more likely to integrate that activity than other entrants, which, we suggest, reflects the application of knowledge inheritance relative to that activity. Moreover, we find that the integration of this key activity, stimulated by knowledge inheritance, contributed to the establishment of defensible strategic positioning, thereby enhancing the survival duration of inheriting spinoffs. We thus link together the phenomena of knowledge inheritance, vertical integration, and strategic positioning to explain entrant performance. These three phenomena tend to be treated disparately in the literature, rather than in combination.

The law of requisite variety is widely employed in management theorizing, and is linked with core strategy themes such as contingency and fit. We reflect upon requisite variety as an archetypal borrowed concept. We contrast its premises with insights from institutional and commitment literatures, draw propositions that set boundaries to its applicability, and review the ramifications of what we term "complexity misalignment." In this way, we contradict foundational assumptions of the law, problematize adaptation- and survival-centric views of strategizing, and theorize the role of human agency in variously complex regimes.

Change is knocking on the door of Baltimore’s iconic Lexington Market. Ground has been broken on a new market building, and local vendors are wondering if they’ll have a place in the much-hyped new structure. In this episode, merchants, artisans, security officers, and custodians reflect on their lives and the uncertain future of the market they call home.

So here we are. Stuc- I mean, blessed being home with the fruit of our loins all the merry day.  Even the best, most patient of mothers find themselves feeling extra angst and exhaustion, not having anywhere to go, or to socialize with during quarantine. Here are some helpful tips to get us through. All to be exercised with a constant stream of prayer, and high end caffeine, of course. Create delusional time blocks for activities. It can be mind-numbingly boring sitting on the ground playing...

God promises to help us in our financial lives—even when we don’t know where our provision is going to come from. Jesus told the masses in His day (many of whom were unemployed), “Give your entire attention to what God is doing right now and don't get worked up about what may or may not happen tomorrow. God will help you deal with whatever hard things come up when the time comes” (Matt. 6:34 MSG). Comforting words…but how does it work when we are out of a job? And what are we to do with the...

The Brain Omega 3 Bar® features naturally occurring flavonoids and 8g of protein to offer better bioavailability of ingredients to nourish both the brain and body.

Volume 33, Issue 1, February 2024. Read the full article ›

The post A history of survival: preserving and working with an archive of single parent activism was curated by information for practice.

What if the August 23 earth tremors had been closer or stronger? Would you know what to do? Here are some tips from Catawba County Emergency Services.

Recent strides in biotechnology offer the promise of new and innovative applications -- from edible vaccines to protein-based electronics components.

Cardiac arrest strikes almost 600,000 people each year, killing the vast majority of those individuals, says a new report from the Institute of Medicine. Every year in the U.S., approximately 395,000 cases of cardiac arrest occur outside of a hospital setting, in which less than 6 percent survive.

Survivors of childhood cancer have an increased risk of experiencing disabling conditions, both from the cancer itself and from the effects of treatment, says a new report from the National Academies of Sciences, Engineering, and Medicine.

"We shouldn't need spy balloons from China or a Pentagon survival specialist to tell us."

Be fully prepared for all your adventures with the outdoor survival kit that includes everything you need & nothing you don't

This news release contains updated information and data not included in the abstract. Research Highlights: U.S. survival rates from out-of-hospital cardiac arrests fell significantly at the beginning of the COVID-19 pandemic in 2020 and only slightly ...

By Jon Queally Common Dreams “This is the stuff that worries me most. We don’t know what we’re doing, not trying to stop it, [and] with big consequences we don’t really understand.” The first global scientific review of its kind … Continue reading →

The author describes how her honeymoon was cut short when her plane crashed in the jungles of Peru, forcing her and her husband to try to survive aboard a makeshift raft as they made their way down the Amazon River to civilization.

We're back with more stories that listeners, like you, have shared on our voicemail. This week: The thin lines between life and death, and friendship and love. Leave your own voicemail at 702-706-TALK, or email us at podcast@storycorps.org.

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Manufacturers focus on reducing their operating costs, but cannot afford buying more productive machinery.

On Friday night, after I appeared on Alex Wagner’s MSNBC show to talk about my essay “Lessons on media policy at the slaughter-bench of history,” the number of subscribers to this newsletter exploded and nearly doubled overnight. via Pocket

Knowing how to fish is among the greatest assets anyone can possess when survival is on the line (pun intended)

The post Important to know! Survival Fishing: How to Catch Fish When SHTF appeared first on Powdered Wig Society.

Reactive oxygen species (ROS) are an unavoidable host environmental cue for intracellular pathogens such as Mycobacterium tuberculosis and Mycobacterium bovis; however, the signaling pathway in mycobacteria for sensing and responding to environmental stress remains largely unclear. Here, we characterize a novel CmtR-Zur-ESX3-Zn2+ regulatory pathway in M. bovis that aids mycobacterial survival under oxidative stress. We demonstrate that CmtR functions as a novel redox sensor and that its expression can be significantly induced under H2O2 stress. CmtR can physically interact with the negative regulator Zur and de-represses the expression of the esx-3 operon, which leads to Zn2+ accumulation and promotion of reactive oxygen species detoxication in mycobacterial cells. Zn2+ can also act as an effector molecule of the CmtR regulator, using which the latter can de-repress its own expression for further inducing bacterial antioxidant adaptation. Consistently, CmtR can induce the expression of EsxH, a component of esx-3 operon involved in Zn2+ transportation that has been reported earlier, and inhibit phagosome maturation in macrophages. Lastly, CmtR significantly contributes to bacterial survival in macrophages and in the lungs of infected mice. Our findings reveal the existence of an antioxidant regulatory pathway in mycobacteria and provide novel information on stress-triggered gene regulation and its association with host–pathogen interaction.

Visual Abstract

RAS genes are the most commonly mutated in human cancers and play critical roles in tumor initiation, progression, and drug resistance. Identification of targets that block RAS signaling is pivotal to develop therapies for RAS-related cancer. As RAS translocation to the plasma membrane (PM) is essential for its effective signal transduction, we devised a high-content screening assay to search for genes regulating KRAS membrane association. We found that the tyrosine phosphatase PTPN2 regulates the plasma membrane localization of KRAS. Knockdown of PTPN2 reduced the proliferation and promoted apoptosis in KRAS-dependent cancer cells, but not in KRAS-independent cells. Mechanistically, PTPN2 negatively regulates tyrosine phosphorylation of KRAS, which, in turn, affects the activation KRAS and its downstream signaling. Consistently, analysis of the TCGA database demonstrates that high expression of PTPN2 is significantly associated with poor prognosis of patients with KRAS-mutant pancreatic adenocarcinoma. These results indicate that PTPN2 is a key regulator of KRAS and may serve as a new target for therapy of KRAS-driven cancer.

Stephanie E. Hood
Dec 1, 2020; 61:1720-1732
Research Articles

Lipins are eukaryotic proteins with functions in lipid synthesis and the homeostatic control of energy balance. They execute these functions by acting as phosphatidate phosphatase enzymes in the cytoplasm and by changing gene expression after translocation into the cell nucleus, in particular under fasting conditions. Here, we asked whether nuclear translocation and the enzymatic activity of Drosophila Lipin serve essential functions and how gene expression changes, under both fed and fasting conditions, when nuclear translocation is impaired. To address these questions, we created a Lipin null mutant, a mutant expressing Lipin lacking a nuclear localization signal (Lipin^NLS), and a mutant expressing enzymatically dead Lipin. Our data support the conclusion that the enzymatic but not nuclear gene regulatory activity of Lipin is essential for survival. Notably, adult Lipin^NLS flies were not only viable but also exhibited improved life expectancy. In contrast, they were highly susceptible to starvation. Both the improved life expectancy in the fed state and the decreased survival in the fasting state correlated with changes in metabolic gene expression. Moreover, increased life expectancy of fed flies was associated with a decreased metabolic rate. Interestingly, in addition to metabolic genes, genes involved in feeding behavior and the immune response were misregulated in Lipin^NLS flies. Altogether, our data suggest that the nuclear activity of Lipin influences the genomic response to nutrient availability with effects on life expectancy and starvation resistance. Thus, nutritional or therapeutic approaches that aim at lowering nuclear translocation of lipins in humans may be worth exploring.

"Georgia is not heard or seen in the world, and many don't even know the location of the country," says TED Fellow and photographer Daro Sulakauri. Through her striking photographs of life in the shadows of Russian occupation, she uses her camera to create a living archive of her home country and defend against the erasure of its borders, culture and history.

The world’s slowest mammal is at risk of extinction by the end of the century due to their low metabolic rate and climate change

Feeding bees edible bits of hydrogel increases their odds of surviving pesticide exposure by 30 per cent

Tribalism can be toxic, yet we need more of it if we are to meet today’s global challenges, argues one anthropologist. His research reveals how to create a “teratribe”

Title: Survival Rates Better for Certain Heart Transplant Patients
Category: Health News
Created: 8/24/2010 6:10:00 PM
Last Editorial Review: 8/25/2010 12:00:00 AM

Title: Survival More Likely With Exercise-Related Cardiac Arrest: Study
Category: Health News
Created: 8/30/2012 6:05:00 PM
Last Editorial Review: 8/31/2012 12:00:00 AM

Title: Blood Pressure Drugs Linked to Longer Ovarian Cancer Survival
Category: Health News
Created: 8/24/2015 12:00:00 AM
Last Editorial Review: 8/25/2015 12:00:00 AM

Title: Oxygen Therapy Doesn't Boost Heart Attack Survival
Category: Health News
Created: 8/30/2017 12:00:00 AM
Last Editorial Review: 8/31/2017 12:00:00 AM

Title: Scientists Challenge Key Survival Stat Cited by U.S. Officials in Plasma Approval
Category: Health News
Created: 8/25/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM