Depuis que l'Europe a pu le tester lors de la gamescom en août dernier, inZOI est devenu l'un des jeux les plus attendus, notamment chez les amateurs de vie virtuelle....

(Telecompaper) New Ugandan operator Talkio Mobile has launched a festive campaign giving over 10,000 customers who book a Talkio SIM online automatic entry to a...

Plumbing & Mechanical recently had the chance to interview International Code Council CEO Dominic Sims about the current landscape for codes and standards and the plumbing industry overall. 

Nathan Todd Sims is recognized for his expert leadership of FusionFlix Entertainment

The 30-year-old has a huge following on Instagram.

When the SAS Global Forum 2020 conference was cancelled by the global COVID-19 pandemic, I felt sorry for the customers and colleagues who had spent months preparing their presentations. One presentation I especially wanted to attend was by Bucky Ransdell and Randy Tobias: "Introducing PROC SIMSYSTEM for Systematic Nonnormal Simulation". [...]

The post Introducing PROC SIMSYSTEM in SAS Viya appeared first on The DO Loop.

Life simulation game Inzoi will launch on PC via Steam early access on 28th March 2025, publishers Krafton have announced. Billed as a potential Sims 4 usurper, and equipped with syrupy Unreal Engine 5 visuals, it was originally slated for launch this year.

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But publisher leaves lucrative loophole for "early access" Patreon subscriptions.

Durham : Duke University Press, [2023]

THE next online concert from Turner Sims takes place tomorrow night.

RAAF veteran Frank Sims was disappointed to not be able to walk with remaining men in the Odd Bods Association but was grateful to have his family around him on Anzac Day in 2020. Brighton East, Melbourne.

Samvel K Gularyan
Apr 6, 2020; 0:RA120.001986v1-mcp.RA120.001986
Research

Glioblastoma (GBM) is one of the most aggressive human cancers with a median survival of less than two years. A distinguishing pathological feature of GBM is a high degree of inter- and intratumoral heterogeneity. Intertumoral heterogeneity of GBM has been extensively investigated on genomic, methylomic, transcriptomic, proteomic and metabolomics levels, however only a few studies describe intratumoral heterogeneity due to the lack of methods allowing to analyze GBM samples with high spatial resolution. Here, we applied TOF-SIMS (Time-of-flight secondary ion mass spectrometry) for the analysis of single cells and clinical samples such as paraffin and frozen tumor sections obtained from 57 patients. We developed a technique that allows us to simultaneously detect the distribution of proteins and metabolites in glioma tissue with 800 nm spatial resolution. Our results demonstrate that according to TOF-SIMS data glioma samples can be subdivided into clinically relevant groups and distinguished from the normal brain tissue. In addition, TOF-SIMS was able to elucidate differences between morphologically distinct regions of GBM within the same tumor. By staining GBM sections with gold-conjugated antibodies against Caveolin-1 we could visualize border between zones of necrotic and cellular tumor and subdivide glioma samples into groups characterized by different survival of the patients. Finally, we demonstrated that GBM contains cells that are characterized by high levels of Caveolin-1 protein and cholesterol. This population may partly represent a glioma stem cells. Collectively, our results show that the technique described here allows to analyze glioma tissues with a spatial resolution beyond reach of most of other omics approaches and the obtained data may be used to predict clinical behavior of the tumor.

"Although nearly a full century has passed since Cecil Sims graduated from this law school with top honors, across the academic campus he loved – and in the communities, courtrooms, and State House where he made his mark – his example still serves as a reminder that the actions of a single person can make a difference in countless lives," said Attorney General Holder.