According to the latest Canalys data, worldwide tablet shipments reached 33 million in Q3 2023, marking a 7% annual decline. But this represents an 8% sequential increase, reflecting a revival of the tablet market ahead of the crucial holiday season and the strong performance of new entrants in the space.

The Minister of Finance has approved amendments to Ontario Securities Commission (OSC) Rule 91-507 Trade Repositories and Derivatives Data Reporting and consequential amendments to OSC Rule 13-502 Fees (collectively, the Amendments) pursuant to

Fox and Friends – Fox News Channel – Broadcast November 11, 2024 Partial Transcript: Morano: “When Donald Trump won the first time in 2016, their attitude was: ‘We’re going to hold this off — this is an anomaly. We have a net zero climate agenda.’ Fast forward eight years later to 2024, and that entire […]

Mesoporous silicon nanoparticles co-deliver chemotherapeutic and genetic drugs with a time lag for more effectively countering cancer-cell protection mechanisms against drugs, as well as inhibiting cell growth and metastasis.

According to the latest Canalys data, worldwide tablet shipments reached 33 million in Q3 2023, marking a 7% annual decline. But this represents an 8% sequential increase, reflecting a revival of the tablet market ahead of the crucial holiday season and the strong performance of new entrants in the space.

Tricia Rowlison
Dec 1, 2020; 19:2090-2103
Research

Extracellular vesicles (EVs) secreted by the epididymal epithelium transfer to spermatozoa key proteins that are essential in promoting motility and subsequent fertilization success. Using the domestic cat model, the objectives were to (1) characterize and compare protein content of EVs between segments of the epididymis, and (2) compare EV protein compositions between normo- and teratospermic individuals (producing >60% of abnormal spermatozoa). Epididymal EVs from adult cats were isolated and assessed via liquid chromatography tandem MS. Both male types shared 3008 proteins in total, with 98 and 20 EV proteins unique to normospermic and teratospermic males, respectively. Expression levels of several proteins changed between epididymal segments in both male types. Several proteins in both groups were related to sperm motility (e.g. hexokinase 1, adenylate kinase isoenzyme) and zona pellucida or oolemma binding (e.g. disintegrin and metalloproteinase domain proteins, zona binding proteins 1 and 2). Interestingly, seven cauda-derived EV proteins trended downward in teratospermic compared with normospermic males, which may relate to poor sperm quality. Collective results revealed, for the first time, EV proteins related to sequential sperm maturation with differences observed between normospermic and teratospermic individuals.

This article has been withdrawn by the authors. This article did not comply with the editorial guidelines of MCP. Specifically, single peptide based protein identifications of 9-19% were included in the analysis and discussed in the results and conclusions. We wish to withdraw this article and resubmit a clarified, corrected manuscript for review.

Mahsa Altafi
Oct 23, 2024; 44:e0518242024-e0518242024
Systems/Circuits

Neural circuits supporting innate behaviors, such as feeding, exploration, and social interaction, intermingle in the lateral hypothalamus (LH). Although previous studies have shown that individual LH neurons change their firing relative to the baseline during one or more behaviors, the firing rate dynamics of LH populations within behavioral episodes and the coordination of behavior-related LH populations remain largely unknown. Here, using unsupervised graph-based clustering of LH neurons firing rate dynamics in freely behaving male mice, we identified distinct populations of cells whose activity corresponds to feeding, specific times during feeding bouts, or other innate behaviors—social interaction and novel object exploration. Feeding-related cells fired together with a higher probability during slow and fast gamma oscillations (30–60 and 60–90 Hz) than during nonrhythmic epochs. In contrast, the cofiring of neurons signaling other behaviors than feeding was overall similar between slow gamma and nonrhythmic epochs but increased during fast gamma oscillations. These results reveal a neural organization of ethological hierarchies in the LH and point to behavior-specific motivational systems, the dysfunction of which may contribute to mental disorders.

Republican Senators huddled for over two hours Tuesday night for a family meeting over who will take the reins from Sen. Mitch McConnell (R-KY).

The post Republican Senators Hold Leader Candidate Forum Hours Before Consequential Vote appeared first on Breitbart.

For January, the most recent month for which data is available, the TCI came in at -1.71, a significant improvement over December’s -6.1 and November’s -7.94. That was preceded by October’s -11.25, its lowest level since the April 2020 all-time low, at -28.66. The September TCI reading came in at -2.35.

Sequential uptick in October 2022 after facing declining trend in past five months; total investment flows however down 75 per cent y-o-y

Vice President Mike Pence owes Iowans more than a photo-op when he visits Des Moines today, according to Joe Biden’s campaign. “Iowans are seeing up close the most consequential failure...

Vice President Mike Pence owes Iowans more than a photo-op when he visits Des Moines today, according to Joe Biden’s campaign.

“Iowans are seeing up close the most consequential failure of government in modern American history,” said Kate Bedingfeld, spokeswoman for the former vice president and presumptive Democratic presidential nominee.

“With nearly 300,000 Iowans filing for unemployment, rural hospitals on life support, Latino communities disproportionately suffering and workers on the job without sufficient protection, Mike Pence owes Iowans more than a photo-op — he owes them answers,” she said.

Pence, head of the White House coronavirus task force, is scheduled to meet with Iowa Gov. Kim Reynolds and U.S. Sens. Chuck Grassley and Joni Ernst, all Republicans, as well as with faith, farm and food production leaders.

Pence will talk to faith leaders about how they are using federal and state guidelines to open their houses of worship in a safe and responsible manner.

Later, he will go to Hy-Vee’s headquarters in West Des Moines for a roundtable discussion with agriculture and food supply leaders to discuss steps being taken to ensure the food supply remains secure.

Pence has called Iowa a “success story” in its response to the COVID-19, but Bedingfeld said the Trump administration failed to protect Iowa families from the virus that has claimed the lives of 231 Iowans.

“From devastating losses across the state, at meatpacking plants to rural communities, one thing is clear — it’s Iowans and the American people who are paying the price for the Trump administration’s denials and delays in response to this pandemic,” she said.

“Instead of listening to our own intelligence agencies and public health experts, Donald Trump was fed dangerous propaganda from the Chinese Communist Party — and he bought it,” she said. “Iowans deserve better — they deserve Joe Biden.”

For his part, Grassley said he welcomes the discussion with Pence.

“There’s much work to be done, and the pandemic is disrupting all of our communities,” Grassley said. “It’s important to hear directly from those who help feed the nation and the world.”

Ernst also is looking forward to the discussion of how Iowa is working to protect the health and safety of Iowa’s families and communities while reopening the state’s economy.

“We continue to take an all-hands-on-deck approach to tackling this pandemic,” she said. “Together, we will get through this.”

Comments: (319) 398-8375; james.lynch@thegazette.com

A mixer system includes a mixing chamber with a drive panel, open top, discharge opening in a side of the mixing chamber, and door configured to open and close the discharge opening. A first mixing auger is disposed inside the mixing chamber, and a first auger drive is disposed on another side of the drive panel and connected to the first auger through the drive panel and connected to a driveline. A second mixing auger is disposed inside the mixing chamber on the first side of the drive panel, and another auger drive is connected to the second auger through the drive panel. A clutch is connected between the second auger drive and the driveline and configured to mechanically connect and disconnect the second auger drive from the driveline based on an input. A method of sequentially starting different augers within a mixing chamber is provided.

A surgical fastening instrument is provided. The surgical fastening instrument includes a handle portion and an elongate portion extending distally from the handle portion and defining a longitudinal axis along a length thereof. The surgical fastening instrument also includes an end effector assembly that includes an anvil and a cartridge supported adjacent a distal end of the elongate portion. Each of the anvil and the cartridge includes a tissue contacting surface oriented substantially perpendicular to the longitudinal axis. One or more independently movable pushers is configured to support one or more surgical fasteners. A thrust bar is operatively coupled to the elongate portion, wherein the thrust bar is movable over a predetermined stroke to effect sequential ejection of at least two surgical fasteners of the plurality of surgical fasteners from the cartridge.

A sequential punch press includes an upper die (10), a lower die (90), and an adjusting device (60) in the upper die. The upper die sequentially includes a punch set (20), a punch pad (30), a punch holder (40), and a stripper (50). A punch (70) is vertically and movably secured in the punch holder and received in the stripper. The adjusting device includes first and second sliding plates (64, 66) respectively having protrusions (65b, 67b), a piston cylinder (68) having a piston rod (682) fixedly connected with the first sliding plate, and a programmable controller for causing the piston rod to slidingly move the first sliding plate. When the first protrusions opposingly abut the second protrusions, the punch can extend beyond the stripper to punch a workpiece. When the first protrusions do not opposingly abut the second protrusions, the punch cannot extend beyond the stripper to punch the workpiece.

The disclosure relates generally to triple-redundant sequential state (TRSS) machines formed as integrated circuits on a semiconductor substrate, such as CMOS, and computerized methods and systems of designing the triple-redundant sequential state machines. Of particular focus in this disclosure are sequential state elements (SSEs) used to sample and hold bit states. The sampling and holding of bits states are synchronized by a clock signal thereby allowing for pipelining in the TRSS machines. In particular, the clock signal may oscillate between a first clock state and a second clock state to synchronize the operation of the SSE according to the timing provided by the clock states. The SSEs has a self-correcting mechanism to protect against radiation induced soft errors. The SSE may be provided in a pipeline circuit of a TRSS machine to receive and store a bit state of bit signal generated by combinational circuits within the pipeline circuit.

The disclosure relates generally to sequential state elements (SSEs), triple-mode redundant state machines (TMRSMs), and methods and systems for testing triple-mode redundant pipeline stages (TMRPSs) within the TMRSMs using triple-mode redundant SSEs (TMRSSEs). The SSEs, TMRSMs, TMRPSs, and TMRSSEs may be formed as integrated circuits on a semiconductor substrate. Of particular focus in this disclosure are SSEs used to sample and hold bit states. Embodiments of the SSEs have a self-correcting mechanism to protect against radiation-induced soft errors. The SSE may be provided in a pipeline circuit of a TMRSM to receive and store a bit state of a bit signal generated by combinational circuits within the pipeline circuit. More specifically, the SSEs may be provided in a TMRSSE configured to perform self-correction. Also disclosed are methods for using the TMRSSE to test redundant pipeline stages of the TMRSM.

An apparatus for anchoring at least two graft ligaments within a longitudinal bone tunnel includes a longitudinal sleeve having at least two ligament-contacting surfaces located in lateral opposition to a sleeve inner lumen. The sleeve is configured for at least partial insertion into the bone tunnel with each graft ligament positioned laterally adjacent a different ligament-contacting surface and at least partially located between the bone tunnel and the sleeve. An actuating member has proximal and distal actuating member ends. An asymmetrically offset profile is defined by the sleeve and/or the actuating member. The asymmetrically offset profile has engagement thresholds. The actuating member is inserted into the sleeve to cause frictional engagement of each graft ligament with both the bone tunnel and at least one ligament-contacting surface, the frictional engagement of each graft ligament being temporally spaced apart from the frictional engagement of at least one other graft ligament.

A sequential monitoring system is for an interlocking logic system and a track circuit system including a plurality of track circuits. The sequential monitoring system includes an interface between the interlocking logic system and the track circuit system; and a processor structured to monitor a state of each of the track circuits, validate a sequence of state changes of the track circuits, and interrupt and correct invalid track circuit state indications between the track circuit system and the interlocking logic system. The interface normally passes inputs from the track circuit system to outputs to the interlocking logic system. When an out of sequence event occurs, the processor applies a quarantine to a minimum of three of the track circuits in a quarantined area, thereby inhibiting use of an unoccupied track circuit in the quarantined area.

A field-sequential display panel, a field-sequential display apparatus and a driving method are provided. The field-sequential display apparatus includes a liquid crystal display panel and an OLED light source arranged at one side of the liquid crystal display panel where light is incident to provide trichromatic light for pixel cells of the liquid crystal display panel. The OLED light source includes multiple groups of trichromatic light sources, each of the groups of trichromatic light sources includes a first color sub-light source, a second color sub-light source and a third color sub-light source, and each sub-light source includes an anode, a cathode and a light emitting layer between the anode and the cathode.

Method and apparatus for lamination of substrates, e.g. rigid plastic layers, to manufacture laminated products. The methods include the sequential application of vacuum and mechanical force through a two-stroke process performed by a lamination apparatus having one or more force-producing stroke cylinders. Actuation of a cylinder to produce a first stroke creates a sealed chamber within the apparatus, enclosing a stack of substrates to be laminated. The sealed chamber may be evacuated of air by application of a vacuum. Subsequent actuation of a cylinder to produce a second stroke applies mechanical force to the sealed chamber, which compresses the substrates into a laminated product substantially free of air bubbles or voids.

Sequential this week ran a video this week showing us how the makers of the Pro 3, Prophets, and more are keeping productive during the pandemic. We wished Dave Smith a happy birthday recently; here's what everyone else is up to.

The post Synth maker Sequential checks in on how they’re running in the pandemic appeared first on CDM Create Digital Music.

This article has been withdrawn by the authors. This article did not comply with the editorial guidelines of MCP. Specifically, single peptide based protein identifications of 9-19% were included in the analysis and discussed in the results and conclusions. We wish to withdraw this article and resubmit a clarified, corrected manuscript for review.

Annalisa Fabretti, Samantha Leorato.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1611--1647.

Abstract:
We propose a method to generate random distributions with known quantile distribution, or, more generally, with known distribution for some form of generalized quantile. The method takes inspiration from the random Sequential Barycenter Array distributions (SBA) proposed by Hill and Monticino (1998) which generates a Random Probability Measure (RPM) with known expected value. We define the Sequential Quantile Array (SQA) and show how to generate a random SQA from which we can derive RPMs. The distribution of the generated SQA-RPM can have full support and the RPMs can be both discrete, continuous and differentiable. We face also the problem of the efficient implementation of the procedure that ensures that the approximation of the SQA-RPM by a finite number of steps stays close to the SQA-RPM obtained theoretically by the procedure. Finally, we compare SQA-RPMs with similar approaches as Polya Tree.

In the field of numerical weather prediction (NWP), the probabilistic distribution of the future state of the atmosphere is sampled with Monte-Carlo-like simulations, called ensembles. These ensembles have deficiencies (such as conditional biases) that can be corrected thanks to statistical post-processing methods. Several ensembles exist and may be corrected with different statistiscal methods. A further step is to combine these raw or post-processed ensembles. The theory of prediction with expert advice allows us to build combination algorithms with theoretical guarantees on the forecast performance. This article adapts this theory to the case of probabilistic forecasts issued as step-wise cumulative distribution functions (CDF). The theory is applied to wind speed forecasting, by combining several raw or post-processed ensembles, considered as CDFs. The second goal of this study is to explore the use of two forecast performance criteria: the Continous ranked probability score (CRPS) and the Jolliffe-Primo test. Comparing the results obtained with both criteria leads to reconsidering the usual way to build skillful probabilistic forecasts, based on the minimization of the CRPS. Minimizing the CRPS does not necessarily produce reliable forecasts according to the Jolliffe-Primo test. The Jolliffe-Primo test generally selects reliable forecasts, but could lead to issuing suboptimal forecasts in terms of CRPS. It is proposed to use both criterion to achieve reliable and skillful probabilistic forecasts.

Jere Koskela, Paul A. Jenkins, Adam M. Johansen, Dario Spanò.

Source: The Annals of Statistics, Volume 48, Number 1, 560--583.

Abstract:
We study weighted particle systems in which new generations are resampled from current particles with probabilities proportional to their weights. This covers a broad class of sequential Monte Carlo (SMC) methods, widely-used in applied statistics and cognate disciplines. We consider the genealogical tree embedded into such particle systems, and identify conditions, as well as an appropriate time-scaling, under which they converge to the Kingman $n$-coalescent in the infinite system size limit in the sense of finite-dimensional distributions. Thus, the tractable $n$-coalescent can be used to predict the shape and size of SMC genealogies, as we illustrate by characterising the limiting mean and variance of the tree height. SMC genealogies are known to be connected to algorithm performance, so that our results are likely to have applications in the design of new methods as well. Our conditions for convergence are strong, but we show by simulation that they do not appear to be necessary.

Xiaoqin Wang, Li Yin.

Source: The Annals of Statistics, Volume 48, Number 1, 138--160.

Abstract:
In sequential causal inference, two types of causal effects are of practical interest, namely, the causal effect of the treatment regime (called the sequential causal effect) and the blip effect of treatment on the potential outcome after the last treatment. The well-known $G$-formula expresses these causal effects in terms of the standard parameters. In this article, we obtain a new $G$-formula that expresses these causal effects in terms of the point observable effects of treatments similar to treatment in the framework of single-point causal inference. Based on the new $G$-formula, we estimate these causal effects by maximum likelihood via point observable effects with methods extended from single-point causal inference. We are able to increase precision of the estimation without introducing biases by an unsaturated model imposing constraints on the point observable effects. We are also able to reduce the number of point observable effects in the estimation by treatment assignment conditions.

Seong-Hwan Jun, Samuel W. K. Wong, James V. Zidek, Alexandre Bouchard-Côté.

Source: The Annals of Applied Statistics, Volume 13, Number 3, 1678--1707.

Abstract:
In this paper, we consider the knot-matching problem arising in computational forestry. The knot-matching problem is an important problem that needs to be solved to advance the state of the art in automatic strength prediction of lumber. We show that this problem can be formulated as a quadripartite matching problem and develop a sequential decision model that admits efficient parameter estimation along with a sequential Monte Carlo sampler on graph matching that can be utilized for rapid sampling of graph matching. We demonstrate the effectiveness of our methods on 30 manually annotated boards and present findings from various simulation studies to provide further evidence supporting the efficacy of our methods.

L. F. South, A. N. Pettitt, C. C. Drovandi.

Source: Bayesian Analysis, Volume 14, Number 3, 773--796.

Abstract:
Sequential Monte Carlo (SMC) methods for sampling from the posterior of static Bayesian models are flexible, parallelisable and capable of handling complex targets. However, it is common practice to adopt a Markov chain Monte Carlo (MCMC) kernel with a multivariate normal random walk (RW) proposal in the move step, which can be both inefficient and detrimental for exploring challenging posterior distributions. We develop new SMC methods with independent proposals which allow recycling of all candidates generated in the SMC process and are embarrassingly parallelisable. A novel evidence estimator that is easily computed from the output of our independent SMC is proposed. Our independent proposals are constructed via flexible copula-type models calibrated with the population of SMC particles. We demonstrate through several examples that more precise estimates of posterior expectations and the marginal likelihood can be obtained using fewer likelihood evaluations than the more standard RW approach.

Haolun Shi, Guosheng Yin.

Source: Bayesian Analysis, Volume 14, Number 2, 399--425.

Abstract:
Bayesian approaches to phase II clinical trial designs are usually based on the posterior distribution of the parameter of interest and calibration of certain threshold for decision making. If the posterior probability is computed and assessed in a sequential manner, the design may involve the problem of multiplicity, which, however, is often a neglected aspect in Bayesian trial designs. To effectively maintain the overall type I error rate, we propose solutions to the problem of multiplicity for Bayesian sequential designs and, in particular, the determination of the cutoff boundaries for the posterior probabilities. We present both theoretical and numerical methods for finding the optimal posterior probability boundaries with $alpha$ -spending functions that mimic those of the frequentist group sequential designs. The theoretical approach is based on the asymptotic properties of the posterior probability, which establishes a connection between the Bayesian trial design and the frequentist group sequential method. The numerical approach uses a sandwich-type searching algorithm, which immensely reduces the computational burden. We apply least-square fitting to find the $alpha$ -spending function closest to the target. We discuss the application of our method to single-arm and double-arm cases with binary and normal endpoints, respectively, and provide a real trial example for each case.

Chris Englund
Jan 5, 2005; 25:247-251
BRIEF COMMUNICATION

The standard initial management for infants and children with acute pyelonephritis is intravenous antibiotic treatment.

Our results support the use of an oral cefixime treatment of initial episodes of acute pyelonephritis involving a gram-negative bacteria strain in children aged 1 month to 3 years who are without urological abnormalities and without clinical hemodynamic impairment. (Read the full article)

Hi,

I am trying to characterize a D flip-flop for low voltage operation (0.6V) using Cadence Liberate (V16). This is a positive edge triggered D flip flop based on true-single-phase clocking scheme. After the characterization, the measurements reported for hold constraint arcs seem to deviate significantly from its (spectre) spice simulation.

The constraint and the power settings to the liberate are as follows : 

# -------------------------------------------- Timing Constraints --------------------------------------------------------------------------------
### Input waveform ###
set_var predriver_waveform 2;# 2=use pre-driver waveform
### Capacitance ###
set_var min_capacitance_for_outputs 1;# write min_capacitance attribute for output pins
### Timing ###
set_var force_condition 4
### Constraint ###
set_var constraint_info 2
#set_var constraint_search_time_abstol 1e-12 ;# 1ps resolution for bisection search
set_var nochange_mode 1 ;# enable nochange_* constraint characterization
### min_pulse_width ###
set_var conditional_mpw 0
set_var constraint_combinational 2

#---------------------------------------------- CCS Settings ----------------------------------------------------------------------------------------
set_var ccsn_include_passgate_attr 1
set_var ccsn_model_related_node_attr 1
set_var write_library_is_unbuffered 1

set_var ccsp_min_pts 15 ;# CCSP accuracy
set_var ccsp_rel_tol 0.01 ;# CCSP accuracy
set_var ccsp_table_reduction 0 ;# CCSP accuracy
set_var ccsp_tail_tol 0.02 ;# CCSP accuracy
set_var ccsp_related_pin_mode 2 ;# use 3 for multiple input switching scnarios and Voltus only libraries

#----------------------------------------------- Power ---------------------------------------------------------------------------------------------------
### Leakage ###
set_var max_leakage_vector [expr 2**10]
set_var leakage_float_internal_supply 0 ;# get worst case leakage for power switch cells when off
set_var reset_negative_leakage_power 1 ;# convert negative leakage current to 0

### Power ###
set_var voltage_map 1 ;# create pg_pin groups, related_power_pin / related_ground_pin
set_var pin_based_power 0 ;# 0=based on VDD only; 1=power based on VDD and VSS (default);
set_var power_combinational_include_output 0 ;# do not include output pins in when conditions for combinational cells

set_var force_default_group 1
set_default_group -criteria {power avg} ;# use average for default power group

#set_var power_subtract_leakage 4 ;# use 4 for cells with exhaustive leakage states.
set_var subtract_hidden_power 2 ;# 1=subtract hidden power for all cells
set_var subtract_hidden_power_use_default 3 ;# 3=subtract hidden power from matched when condition then default group
set_var power_multi_output_binning_mode 1 ;# binning for multi-output cell considered for both timing and power arcs
set_var power_minimize_switching 1
set_var max_hidden_vector [expr 2**10]
#--------------------------------------------------------------------------------------------------------------------------------------------------------------

I specifically used set_var constraint_combinational 2 in the settings, in case the Bisection pass/fail mode fails to capture the constraints. In my spice simulation, the hold_rise (D=1, CLK=R, Q=R) arc at-least requires ~250 ps for minimum CLK/D slew combination (for the  by default smallest capacitive load as per Liberate)  while Liberate reports only ~30 ps. The define_cell template to this flip flop is pretty generic, which does not have any user specified arcs. So which settings most likely affecting the constraint measurements in Liberate and how can I debug this issue ?

Thanks

Anuradha