R.N. Ravi, the Tamil Nadu Governor, presided over the International Yoga Day celebrations held on the Rajbhavan premises. The Governor participated in various Yoga activities.

Livelihood College is the new address for youth of Dantewada who, disoriented by years of Naxal violence, see it as a new beginning

Kristina Drizyte-Miller, Jing Chen, Hong Cao, Micah B. Schott, and Mark A. McNiven

Epithelial cells such as liver-resident hepatocytes rely heavily on the Rab family of small GTPases to perform membrane trafficking events that dictate cell physiology and metabolism. Not surprisingly, disruption of several Rabs can manifest in metabolic diseases or cancer. Rab32 is expressed in many secretory epithelial cells but its role in cellular metabolism is virtually unknown. In this study, we find that Rab32 associates with lysosomes and regulates proliferation and cell size of Hep3B hepatoma and HeLa cells. Specifically, we identify that Rab32 supports mTORC1 signaling under basal and amino acid stimulated conditions. Consistent with inhibited mTORC1, an increase in nuclear TFEB localization and lysosome biogenesis is also observed in Rab32-depleted cells. Finally, we find that Rab32 interacts with mTOR kinase and that loss of Rab32 reduces the association of mTOR and mTORC1 pathway proteins with lysosomes, suggesting that Rab32 regulates lysosomal mTOR trafficking. In summary, these findings suggest that Rab32 functions as a novel regulator of cellular metabolism through supporting mTORC1 signaling.

Kristina Drizyte-Miller
Apr 15, 2020; 0:jcs.236661v1-jcs.236661
Articles

Russia marked 75 years since the Soviet victory over Nazi Germany in the Second World War on Saturday, but the coronavirus outbreak forced it to scale back celebrations seen as boosting support for President Vladimir Putin.

Russia marked 75 years since the Soviet victory over Nazi Germany in World War Two on Saturday, but the coronavirus outbreak forced it to scale back celebrations seen as boosting support for President Vladimir Putin. With coronavirus infections rising, Putin last month postponed the highlight of annual Victory Day celebrations,...

The post Putin presides over slimmed down Victory Day as virus cases rise appeared first on Cyprus Mail.

President Vladimir Putin told Russians on Saturday they are invincible when they stand together as he presided over celebrations of victory in World War Two that were slimmed down because of the coronavirus outbreak.

President Vladimir Putin told Russians on Saturday they are invincible when they stand together as he presided over celebrations of victory in World War Two that were slimmed down because of the coronavirus outbreak.

By Gabrielle Tétrault-Farber and Andrew OsbornMOSCOW, May 9 (Reuters) - President Vladimir Putin told Russians on Saturday they are invincible when they...

President Vladimir Putin told Russians on Saturday they are invincible when they stand together as he presided over celebrations of victory in World War Two that were slimmed down because of the coronavirus outbreak.

'I truly believe that Durga resides in us, women,' says Rani Mukerji. 'If a woman believes that and she chanalises that energy, she will be able to ward off a lot of things.'