rbm Strain-affected ferroelastic domain walls in RbMnFe charge-transfer materials undergoing collective Jahn–Teller distortion By pubs.rsc.org Published On :: RSC Adv., 2024, 14,35081-35089DOI: 10.1039/D4RA06397J, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marius Hervé, Shintaro Akagi, Laurent Guérin, Leland B. Gee, Ryan D. Ribson, Matthieu Chollet, Marco Cammarata, Shuntaro Nagashima, Shin-ichi Ohkoshi, Hiroko Tokoro, Eric ColletThis X-ray diffraction study of RbMnFe materials reveals the ferroelastic domains walls resulting from collective Jahn–Teller distortion coupled to intermetallic charge-transfer and the spatial extension of the strain around the walls.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
rbm Relax FRBM target for states to fight COVID-19 By www.financialexpress.com Published On :: 2020-05-08T05:30:00+05:30 States should be allowed to issue ‘pandemic relief’ bonds, with the central bank being allowed to buy these bonds by printing money and monetising their debt. Full Article Opinion
rbm Punjab Cabinet amends FRBM Act for Rs 928 crore additional borrowing By www.newkerala.com Published On :: Tue, 03 Mar 2020 05:42:01 +0530 Full Article
rbm States should avail 0.5% fiscal deficit deviation through FRBM Act: Finance Commission chairman NK Singh By www.financialexpress.com Published On :: 2020-04-25T03:45:00+05:30 In view of the massive disruption to economic activity due to Covid-19 impact and likely huge shortfall in revenues, the council felt that fiscal response to the crisis should be much more nuanced. Full Article Economy
rbm RNA Binding Motif Protein RBM45 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19 through Binding to Novel Intron Splicing Enhancers By mbio.asm.org Published On :: 2020-03-10T01:30:41-07:00 ABSTRACT During infection of human parvovirus B19 (B19V), one viral precursor mRNA (pre-mRNA) is transcribed by a single promoter and is alternatively spliced and alternatively polyadenylated. Here, we identified a novel cis-acting sequence (5'-GUA AAG CUA CGG GAC GGU-3'), intronic splicing enhancer 3 (ISE3), which lies 72 nucleotides upstream of the second splice acceptor (A2-2) site of the second intron that defines the exon of the mRNA encoding the 11-kDa viral nonstructural protein. RNA binding motif protein 45 (RBM45) specifically binds to ISE3 with high affinity (equilibrium dissociation constant [KD] = 33 nM) mediated by its RNA recognition domain and 2-homo-oligomer assembly domain (RRM2-HOA). Knockdown of RBM45 expression or ectopic overexpression of RRM2-HOA in human erythroid progenitor cells (EPCs) expanded ex vivo significantly decreased the level of viral mRNA spliced at the A2-2 acceptor but not that of the mRNA spliced at A2-1 that encodes VP2. Moreover, silent mutations of ISE3 in an infectious DNA of B19V significantly reduced 11-kDa expression. Notably, RBM45 also specifically interacts in vitro with ISE2, which shares the octanucleotide (GGGACGGU) with ISE3. Taken together, our results suggest that RBM45, through binding to both ISE2 and ISE3, is an essential host factor for maturation of 11-kDa-encoding mRNA. IMPORTANCE Human parvovirus B19 (B19V) is a human pathogen that causes severe hematological disorders in immunocompromised individuals. B19V infection has a remarkable tropism with respect to human erythroid progenitor cells (EPCs) in human bone marrow and fetal liver. During B19V infection, only one viral precursor mRNA (pre-mRNA) is transcribed by a single promoter of the viral genome and is alternatively spliced and alternatively polyadenylated, a process which plays a key role in expression of viral proteins. Our studies revealed that a cellular RNA binding protein, RBM45, binds to two intron splicing enhancers and is essential for the maturation of the small nonstructural protein 11-kDa-encoding mRNA. The 11-kDa protein plays an important role not only in B19V infection-induced apoptosis but also in viral DNA replication. Thus, the identification of the RBM45 protein and its cognate binding site in B19V pre-mRNA provides a novel target for antiviral development to combat B19V infection-caused severe hematological disorders. Full Article
rbm ACRO offers unique insights on risk-based monitoring of clinical trials, calls for adoption of RBM as a best practice By www.acrohealth.org Published On :: Thu, 16 May 2019 19:01:42 +0000 Following meetings with then-Commissioner Scott Gottlieb and senior leadership from the Center for Drug Evaluation and Research on the role of CROs and technology companies in designing and implementing risk-based monitoring (RBM) of clinical trials, ACRO this week submitted extensive comments on recent FDA Guidance.Increasing the use of innovative RBM technologies helps make clinical trials safer, more efficient and higher quality. ACRO’s comments offer unique insights into the recent expansion of RBM implementation and call for further increasing the use of these oversight technologies. Full Article News Press Releases digital FDA oversight RBM Risk Based Montoring
rbm New ACRO Report Quantifies Benefits of RBM for Quality Reviews By www.acrohealth.org Published On :: Thu, 17 Oct 2019 20:39:48 +0000 A new report based on a survey of ACRO members reveals that Risk-Based Monitoring (RBM) makes clinical trial quality review more efficient... Full Article News Reports FDA RBM Risk Based Montoring
rbm The Oxford handbook of new audiovisual aesthetics / edited by John Richardson, Claudia Gorbman, Carol Vernallis By prospero.murdoch.edu.au Published On :: Full Article