Yisrael Hasson also condemned the decision to prioritize safeguarding the Prime Minister's son's reputation over national security.

Fr. Christopher sets the record straight on the celebration of Christmas.

Artificial intelligence has more in common with ants than humans, says Neil Lawrence. Only by taking a more nuanced view of intelligence can we see how machines will truly transform society

Artificial intelligence has more in common with ants than humans, says Neil Lawrence. Only by taking a more nuanced view of intelligence can we see how machines will truly transform society

Kelly Lee Owens “Dreamstate” There’s not a lot of lyrics to “Dreamstate” beyond variations on the phrases “feel the dreamstate” and “dream to live,” but Kelly Lee Owens gets a lot out of those words. It’s in the repetition, the re-arranging of the words, and how she seems to surf the waves of her synth […]

Fernando Alonso has revealed that Michael Schumacher suspected he deliberately held up the German during qualifying in Melbourne

Nothing exposes the hollowness of the claims corporations now make to intellectual property as much as their own histories, says George Monbiot.

Sushma Swaraj used the most backward face of religion - its treatment of widows - to register her protest at the prospect of Sonia as PM, notes Kalpana Sharma.

A self-declared "free spirit man" who contested a parking fine in court loses his year-long battle, with a judge saying the case involved "legal nonsense" and was "an unnecessary waste" of resources.

Also drawn for the tour show. And also animated, though that was done by the excellent Chris Lincé, not by me.

And indeed not in Salford. Because in Salford, the computer that we run the show on froze at the start of the Kirates sketch, and Simon and I had to stick our heads round the back cloth and do it live. Whilst in the middle of changing into our red trousers...

In the "pedo guy" trial, Musk's lawyers dismissed Twitter as a "not a source of facts."

Library administration.

GUTTING news for great swathes of the Great British public - eating chips is not exercise.

The pandemic has boosted appreciation for public schools; the next step is greater funding, argues education historian and activist Diane Ravitch.

ABSTRACT

The nonsense-mediated decay (NMD) pathway presents a challenge for RNA viruses with termination codons that precede extended 3' untranslated regions (UTRs). The umbravirus Pea enation mosaic virus 2 (PEMV2) is a nonsegmented, positive-sense RNA virus with an unusually long 3' UTR that is susceptible to NMD. To establish a systemic infection, the PEMV2 long-distance movement protein p26 was previously shown to both stabilize viral RNAs and bind them for transport through the plant’s vascular system. The current study demonstrated that p26 protects both viral and nonviral messenger RNAs from NMD. Although p26 localizes to both the cytoplasm and nucleolus, p26 exerts its anti-NMD effects exclusively in the cytoplasm independently of long-distance movement. Using a transcriptome-wide approach in the model plant Nicotiana benthamiana, p26 protected a subset of cellular NMD target transcripts, particularly those containing long, structured, GC-rich 3' UTRs. Furthermore, transcriptome sequencing (RNA-seq) revealed that the NMD pathway is highly dysfunctional during PEMV2 infection, with 1,820 (48%) of NMD targets increasing in abundance. Widespread changes in the host transcriptome are common during plant RNA virus infections, and these results suggest that, in at least some instances, virus-mediated NMD inhibition may be a major contributing factor.

IMPORTANCE Nonsense-mediated decay (NMD) represents an RNA regulatory pathway that degrades both natural and faulty messenger RNAs with long 3' untranslated regions. NMD targets diverse families of RNA viruses, requiring that viruses counteract the NMD pathway for successful amplification in host cells. A protein required for long-distance movement of Pea enation mosaic virus 2 (PEMV2) is shown to also protect both viral and host mRNAs from NMD. RNA-seq analyses of the Nicotiana benthamiana transcriptome revealed that PEMV2 infection significantly impairs the host NMD pathway. RNA viruses routinely induce large-scale changes in host gene expression, and, like PEMV2, may use NMD inhibition to alter the host transcriptome in an effort to increase virus amplification.

MARTIN SAMUEL - CHIEF SPORTS WRITER: The idea McIlroy needs to show greater loyalty to the game on this side of the Atlantic, or risk forfeiting his place in the Ryder Cup team, is just nonsense.

IAN LADYMAN: Already we owe them, Brendan Rodgers and Frank Lampard. Even if they do not manage to keep it up we should thank them all the same.

This week not one but two new series from Julian Alexander Kitchener-Fellowes, Baron Fellowes of West Stafford, and you do wonder if he can be stopped

Priti Patel blasted rapper Dave's incendiary claims that Boris Johnson is a 'real racist' this morning on Sky News and BBC Breakfast, calling them 'utter nonsense' and 'highly inappropriate'.

'Total nonsense - this story was out almost a year ago, it was debunked, we rejected it completely,' minister of foreign affairs Adel al-Jubeir said in Davos on Thursday.

A conservative news magazine's claim Kushner told Saudi's de facto ruler Mohammed bin Salman it was OK to arrest Jamal Khashoggi and Democrats are aware was dismissed by the White House.

Trump tweeted early on Wednesday morning that he wished former National Security Adviser John Bolton would have came forward with his complaints when he was getting fired.

This week not one but two new series from Julian Alexander Kitchener-Fellowes, Baron Fellowes of West Stafford, and you do wonder if he can be stopped

ADRIAN KAJUMBA: Frank Lampard's career was record-breaking and by the end of it his CV was glittering. When it comes to knowing what it takes to reach the top, Lampard is as well-placed as anyone.

London : Facet Publishing, 2020.

Schwichtenberg, Jakob, author

Hayden Library - PR4879.L2 Z94 2018