This week Zorba and Karl discuss how melatonin gummies may have a higher dose than what’s on the label, and they examine new research showing sedentary time may significantly enlarge […]

Nutraland USA, Inc., will use its SupplySide West booth, #6951, to introduce Somato™, a whole-food derived melatonin sourced exclusively from tomatoes. This innovative ingredient is poised to revolutionize the natural products industry, offering an eco-friendly, natural alternative to synthetic melatonin for use in functional foods and dietary supplements.

Title: How Does Melatonin Make You Feel, and Are There Side Effects?
Category: Health and Living
Created: 7/15/2022 12:00:00 AM
Last Editorial Review: 7/15/2022 12:00:00 AM

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The supplement melatonin, which has been shown to help ease jet lag, is generally safe for short-term use, but long-term use hasn't been studied enough.

Atlanta natural health clinic Southern Environmental Medicine Center notes taking melatonin supplements is effective for treating frequent insomnia. This is a naturally occurring hormone in the body that regulates the sleep cycle.

The invention concerns a new process for the preparation of crystalline form of agomelatine from a solution of agomelatine in a solvent, characterized in that the agomelatine is crystallized by instantaneous precipitation from said solution, at a temperature equal to or below −10° C.

Solid state light emitting devices include multiple LED components providing adjustable melatonin suppression effects. Multiple LED components may be operated simultaneously according to different operating modes according to which their combined output provides the same or similar chromaticity, but provides melatonin suppressing effects that differ by at least a predetermined threshold amount between the different operating modes. Switching between operating modes may be triggered by user input elements, timers/clocks, or sensors (e.g., photosensors). Chromaticity of combined output of multiple LED components may also be adjusted, together with providing adjustable melatonin suppression effects at each selected combined output chromaticity.

Sleep disturbance affects 47% to 60% of children with atopic dermatitis and is a leading cause of impaired quality of life for the patients and their family.

Sleep disturbance in children with atopic dermatitis can be predicted by a Scoring Atopic Dermatitis index of ≥48.7, and lower nocturnal melatonin secretion might play a role in the pathophysiology. (Read the full article)

BACKGROUND:

Approximately 25% of children with concussion have persistent postconcussive symptoms (PPCS) with resultant significant impacts on quality of life. Melatonin has significant neuroprotective properties, and promising preclinical data suggest its potential to improve outcomes after traumatic brain injury. We hypothesized that treatment with melatonin would result in a greater decrease in PPCS symptoms when compared with a placebo.

Researchers find that even just sleeping with a shirt that one's romantic partner has worn leads to improved slumber.

Melatonin is a hormone known to promote sleep. But, have you ever wondered how melatonin helps to promote sleep? Researchers from the University of Missouri School of Medicine have discovered how melatonin suppresses the neurons in the brain that keeps you awake and alert. The findings of the study, which is published in the Journal of Pineal Research, could lead to new therapies for those who suffer from insomnia.

"We as a society are losing sleep because we are working too hard, and it's causing a variety of health concerns," said Mahesh Thakkar, lead author of the study. "We often don't even think about sleep or consider it important. However, there is nothing more important than sleep. We need to focus on therapies that can help you have quality sleep, not just sleep."

Using a mouse model, Thakkar's research found that melatonin infused in the brain at dark -- when the mice are awake and active -- increased sleep and reduced wakefulness by suppressing specific neurons that stimulate the brain to wake up.

Thakkar also discovered that blocking melatonin receptors in the brain at bedtime significantly increased wakefulness. The experiments singled out one receptor, MT1, as the mechanism via which melatonin acts to inhibit the specific orexin neurons that wake you up. This discovery could help lead to medications that target only the MT1 receptor instead of multiple receptors, which could lead to fewer side effects for those who take sleep-promoting drugs.

"Melatonin has been used as a sleep drug for many years, but people didn't know how it worked," Thakkar said. "Our research suggests that if you target the melatonin MT1 receptor, you will get the most sleep with minimal side effects."

(Edited by mid-day online desk, with inputs from PTI)

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In humans and vertebrates light pollution was found to suppress melatonin production, said researchers from Leibniz-Institute of Freshwater Ecology and Inland Fisheries (IGB).

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Interview with Ciaran J. McMullan, MD, author of Melatonin Secretion and the Incidence of Type 2 Diabetes