Douglas Hamp is a specialist in ancient languages including Biblical Hebrew and Koine Greek. Doug says something ominous is coming upon the world: it is Satan's final effort in the battle to destroy the image that man was created in, which has been raging since the beginning of time. If Satan can destroy the image, then he can avert his own destruction. The prophecy of Genesis 3:15 states the serpent will one day mix his seed with humanity as a counterfeit of the Messiah. Jesus told us that the last days will be like the days of Noah when fallen angels mixed their seed with humanity. In the Book of Daniel we read that "they" will again mingle with the seed of men. How so? Satan will use man's desire to be his own god to deceive him into believing the ultimate lie - that his fallen messengers are both the creators and saviors of man. He will not do this openly but will deceive mankind through demons which are masquerading as "aliens" who are spreading the message that the inhabitants of the earth can evolve to be like them and obtain transcendent powers. Finally, the seed of the Serpent will come; he will be a man who will be greater than his fellows, who will understand sinister schemes and shall rise up and become the Antichrist. That day of fulfillment is nearly upon us!

Silicon Valley Sleuth reported this morning how several stories about Google buying Sun suspiciously made it to the front page of Digg.com. These "baseless rumours" were all submitted and promoted by a small group of Digg members that seemed to be working together. I found this story through Digg itself, where it was posted on the front page. It later... (381 words)

Aim/Purpose: In this paper, we address the theoretical challenges today’s scientific community faces to precisely draw lines between true and false pictures. In particular, we focus on problems related to the hidden wonders of science and the shiny images produced for scientific papers or to appeal to wider audiences. Background: As rumors (hoaxes) and false news (fake news) explode across society and the current network, several initiatives using current technology have been launched to study this phenomena and limit the social impact. Over the last two decades, inappropriate scientific behavior has raised more questions about whether some scientific images are valid. Methodology: This work is not about analyzing whether today’s images are objective. Instead, we advocate for a general approach that makes it easier to truly believe in all kinds of knowledge, scientific or otherwise (Goldman, 1967; Goldman, & Olson, 2009). This need to believe is closely related to social order (Shapin, 1994). Contribution: We conclude that we must ultimately move away from older ideas about truth and objectivity in research to broadly approach how science and knowledge are represented and move forward with this theoretical approach when communicating science to the public. Findings: Contemporary visual culture suggests that our world is expressed through images, which are all around us. Therefore, we need to promote the reliability of scientific pictures, which visually represent knowledge, to add meaning in a world of complex high-tech science (Allamel-Raffin, 2011; Greenberg, 2004; Rosenberger, 2009). Since the time of Galileo, and today more than ever, scientific activity should be understood as knowledge produced to reveal, and therefore inform us of, (Wise, 2006) all that remains unexplained in our world, as well as everything beyond our senses. Recommendation for Researchers: In journalism, published scientific images must be properly explained. Journalists should tell people the truth, not fake objectivity. Today we must understand that scientific knowledge is mapped, simulated, and accessed through interfaces, and is uncertain. The scientific community needs to approach and explain how knowledge is represented, while paying attention to detail. Future Research: In today’s expanding world, scientific research takes a more visual approach. It is important for both the scientific community and the public to understand how the technologies used to visually represent knowledge can account for why, for example, we know more about electrons than we did a century ago (Arabatzis, 1996), or why we are beginning to carefully understand the complexities and ethical problems related to images used to promote knowledge through the media (see, i.e., López-Cantos, 2017).

Drama continued to encompass NASCAR ahead of its championship-deciding season finale as the sanctioning body issued $600,000 in fines and suspended nine team members from three different teams on Tuesday for alleged race manipulation at Martinsville Speedway.

Group Processes &Intergroup Relations, Ahead of Print. Researchers often ask participants to affirm positive aspects or shared values for a group important to them (a group affirmation manipulation) in order to encourage healthy behavior, acknowledge historical harm, accept group-based criticism, or diffuse the impact of social exclusion. An exploratory meta-analysis of 92 experiments that included […]

The post How to improve group affirmation manipulations: A systematic review and meta-analysis was curated by information for practice.

Liquid crystals are strange substances, both fish and fowl. They can flow like a liquid, but have the orderly molecular structure of a crystalline solid. And that internal structure can be changed by small cues from outside.

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Today's tutorial will walk you through some essential manipulation, blending and colour matching techniques. In this lesson I'll show you how you can convert a forest into a dark, foggy, ominous scene. You'll learn how to work with shadows, lighting, adjustment layers, layer masks, dodge & burning and much more.

In this tutorial, I'll show how you can combine different stock images to create this cohesive and unified scene of an aquatic Giant tortoise. You'll also learn how to manipulate trees, stones, waterfalls and textures to create an island on the tortoise. Finally, we'll add lighting effects and adjust the colour of our entire scene.

BethDunn just wrote a great post about mail fundraisng appeals and two schools of thought that are applied to them throughout the industry.

On the one hand there is the practical appeal to a donor's sense of logic and decency. On the other hand, there are the emotional appeals dripping with manipulation sent out to shock or shame a donor into action.

While On Fundraising's primary focus is telephone fundraising, this subject matter is relevant to On Fundraising for two reasons.

Mail appeals and phone appeals are generally part of the same campaign. Sometimes a donor is called first, other times they'll get a mailer and then a follow up call.

Increasingly donors are savvy enough and self-aware enough to take strong offense at the manipulative tone of fundraising letters. We live in an age where almost any information is available to those who want to find it. Todays activist donors do just that.

Donor's often know more about a subject than the front line people raising money for it. As well they should. So sending out these mail broadsides is certainly no good way to show respect for a donor's intellect or for their prior support.

The second reason this issue applies to On Fundraising, is that many telefundraisers mirror or amplify the sentiments expressed by these letters in a misguided attempt to manipulate donors into reactionary giving based solely on emotion. This works for now, however donors are self-aware and savvy enough to know when they're being manipulated. Surprisingly enough, they don't like it.

Todays donors aren't simply tithing blindly in the hopes that some good will come of it. More and more, donors support organizations as active participants in an effort to improve our world. How does a person like this feel when they receive a dunning letter dripping with sensationalized woe? Like a patsy.

All in all, these medieval scare tactics don't belong in modern fundraising. Yes psychology has its place in fundraising, but too often psychology is a euphemism for manipulation. Fundraisers who are good at their jobs are masters of speech, language, and persuasion. Its better to convince someone to give than to trick them into it .

http://smalldots.wordpress.com/2008/05/12/the-model-of-a-modern-major-fundraising-letter/

Persuasion or manipulation? Limiting campaigning online Expert comment NCapeling 15 February 2021

To tackle online disinformation and manipulation effectively, regulators must clarify the dividing line between legitimate and illegitimate campaign practices.

Democracy is at risk, not only from disinformation but from systemic manipulation of public debate online. Evidence shows social media drives control of narratives, polarization, and division on issues of politics and identity. We are now seeing regulators turn their attention to protecting democracy from disinformation and manipulation. But how should they distinguish between legitimate and illegitimate online information practices, between persuasive and manipulative campaigning?

Unregulated, the tactics of disinformation and manipulation have spread far and wide. They are no longer the preserve merely of disaffected individuals, hostile international actors, and authoritarian regimes. Facebook’s periodic reporting on coordinated inauthentic behaviour and Twitter’s on foreign information operations reveal that militaries, governments, and political campaigners in a wide range of countries, including parts of Europe and America, have engaged in manipulative or deceptive information campaigns.

For example, in September 2019, Twitter removed 259 accounts it says were ‘falsely boosting’ public sentiment online that it found to be operated by Spain’s conservative and Christian-democratic political party Partido Popular. In October 2020, Facebook removed accounts with around 400,000 followers linked to Rally Forge, a US marketing firm which Facebook claims was working on behalf of right-wing organisations Turning Point USA and Inclusive Conservation Group. And in December 2020, Facebook took down a network of accounts with more than 6,000 followers, targeting audiences in Francophone Africa and focusing on France’s policies there, finding it linked with individuals associated with the French military.

Public influence on a global scale

Even more revealingly, in its 2020 Global Inventory of Organized Social Media Manipulation, the Oxford Internet Institute (OII) found that in 81 countries, government agencies and/or political parties are using ‘computational propaganda’ in social media to shape public attitudes.

These 81 countries span the world and include not only authoritarian and less democratic regimes but also developed democracies such as many EU member states. OII found that countries with the largest capacity for computational propaganda – which include the UK, US, and Australia – have permanent teams devoted to shaping the online space overseas and at home.

OII categorizes computational propaganda as four types of communication strategy – the creation of disinformation or manipulated content such as doctored images and videos; the use of personal data to target specific segments of the population with disinformation or other false narratives; trolling, doxing or online harassment of political opponents, activists or journalists; and mass-reporting of content or accounts posted or run by opponents as part of gaming the platforms’ automated flagging, demotion, and take-down systems.

Doubtless some of the governments included within OII’s statistics argue their behaviour is legitimate and appropriate, either to disseminate information important to the public interest or to wrestle control of the narrative away from hostile actors. Similarly, no doubt some political campaigners removed by the platforms for alleged engagement in ‘inauthentic behaviour’ or ‘manipulation’ would defend the legitimacy of their conduct.

The fact is that clear limits of acceptable propaganda and information influence operations online do not exist. Platforms still share little information overall about what information operations they see being conducted online. Applicable legal principles such as international human rights law have not yet crystallised into clear rules. As information operations are rarely exposed to public view – with notable exceptions such as the Cambridge Analytica scandal – there is relatively little constraint in media and public scrutiny or censure.

OII’s annual reports and the platforms’ periodic reports demonstrate a continual expansion of deceptive and manipulative practices since 2016, and increasing involvement of private commercial companies in their deployment. Given the power of political influence as a driver, this absence of clear limits may result in ever more sophisticated techniques being deployed in the search for maximal influence.

Ambiguity over reasonable limits on manipulation plays into the hands of governments which regulate ostensibly in the name of combating disinformation, but actually in the interests of maintaining their own control of the narrative and in disregard of the human right to freedom of expression. Following Singapore’s 2019 prohibition of online untruths, 17 governments ranging from Bolivia to Vietnam to Hungary passed regulations during 2020 criminalising ‘fake news’ on COVID-19 while many other governments are alleged to censor opposition arguments or criticisms of official state narratives.

Clear limits are needed. Facebook itself has been calling for societal discussion about the limits of acceptable online behaviour for some time and has issued recommendations of its own.

The European Democracy Action Plan: Aiming to protect pluralism and vigour in democracy

The European Democracy Action Plan (EDAP), which complements the European Commission’s Digital Services Act and Digital Markets Act proposals, is a welcome step. It is ground-breaking in its efforts to protect the pluralism and vigour of European democracies by tackling all forms of online manipulation, while respecting human rights.

While the EDAP tackles disinformation, it also condemns two categories of online manipulation – information influence operations which EDAP describes as ‘coordinated efforts by either domestic or foreign actors to influence a target audience using a range of deceptive means’ and foreign interference, described as ‘coercive and deceptive efforts to disrupt the free formation and expression of individuals’ political will by a foreign state actor or its agents’. These categories include influence operations such as harnessing fake accounts or gaming algorithms, and the suppression of independent information sources through censorship or mass reporting.

But the categories are so broad they risk capturing disinformation practices not only of rogue actors, but also of governments and political campaigners both outside and within the EU. The European Commission plans to work towards refined definitions. Its discussions with member states and other stakeholders should start to determine which practices ought to be tackled as manipulative, and which ought to be tolerated as legitimate campaigning or public information practices.

The extent of the EDAP proposals on disinformation demonstrates the EU’s determination to tackle online manipulation. The EDAP calls for improved practical measures building on the Commission’s 2020 acceleration of effort in the face of COVID-19 disinformation. The Commission is considering how best to impose costs on perpetrators of disinformation, such as by disrupting financial incentives or even imposing sanctions for repeated offences.

Beyond the regulatory and risk management framework proposed by the Digital Services Act (DSA), the Commission says it will issue guidance for platforms and other stakeholders to strengthen their measures against disinformation, building on the existing EU Code of Practice on Disinformation and eventually leading to a strengthened Code with more robust monitoring requirements. These are elements of a broader package of measures in the EDAP to preserve democracy in Europe.

Until there are clear limits, manipulative practices will continue to develop and to spread. More actors will resort to them in order not to be outgunned by opponents. It is hoped forthcoming European discussions – involving EU member state governments, the European Parliament, civil society, academia and the online platforms – will begin to shape at least a European and maybe a global consensus on the limits of information influence, publicly condemning unacceptable practices while safeguarding freedom of expression.

Most importantly, following the example of the EDAP, the preservation of democracy and human rights – rather than the promotion of political or commercial interest – should be the lodestar for those discussions.

to change minds the art of influence without manipulation

Researchers at the University of Toronto have created an RNA-targeting technology that uses the CRISPR system to precisely manipulate human gene parts

Manchester, UK : Manchester University Press, Date of production or publication2017.

That comes after Twitter had announced that it will require users to have an account on the social media platform to view tweets.

While warning aircraft and vessels near western border areas, South Korea's military did not specify how North Korea was interfering with GPS signals or detail the extent of disruptions

Tune into our new show Fox League Live on Channel 502 Monday to Friday at 6.30pm and on Saturday at 3pm and Sunday at 5pm.

Many of the social media network's users were outraged to learn they could've been unwitting participants in the study.

Using CSS3 to animate a set of thumbnail images.

We are pleased to announce a new Audio Inserts feature in the Auphonic API: audio inserts are separate audio files (like intros/outros), which will be inserted into your production at a defined offset.
This blog post shows how one can use this feature for Dynamic Ad Insertion and discusses other Audio Manipulation Methods of the Auphonic API.

API-only Feature

For the general podcasting hobbyist, or even for someone producing a regular podcast, the features that are accessible via our web interface are more than sufficient.

However, some of our users, like podcasting companies who integrate our services as part of their products, asked us for dynamic ad insertions. We teamed up with them to develop a way of making this work within the Auphonic API.

We are pleased therefore to announce audio inserts - a new feature that has been made part of our API. This feature is not available through the web interface though, it requires the use of our API.

Before we talk about audio inserts, let's talk about what you need to know about dynamic ad insertion!

Dynamic Ad Insertion

There are two ways of dealing with adverts within podcasts. In the first, adverts are recorded or edited into the podcast and are fixed, or baked in. The second method is to use dynamic insertion, whereby the adverts are not part of the podcast recording/file but can be inserted into the podcast afterwards, at any time.

This second approach would allow you to run new ad campaigns across your entire catalog of shows. As a podcaster this allows you to potentially generate new revenue from your old content.

As a hosting company, dynamic ad insertion allows you to choose up to date and relevant adverts across all the podcasts you host. You can make these adverts relevant by subject or location, for instance.

Your users can define the time for the ads and their podcast episode, you are then in control of the adverts you insert.

Audio Inserts in Auphonic

Whichever approach to adverts you are taking, using audio inserts can help you.

Audio inserts are separate audio files which will be inserted into your main single or multitrack production at your defined offset (in seconds).

When a separate audio file is inserted as part of your production, it creates a gap in the podcast audio file, shifting the audio back by the length of the insert. Helpfully, chapters and other time-based information like transcriptions are also shifted back when an insert is used.

The biggest advantage of this is that Auphonic will apply loudness normalization to the audio insert so, from an audio point of view, it matches the rest of the podcast.

Although created with dynamic ad insertion in mind, this feature can be used for any type of audio inserts: adverts, music songs, individual parts of a recording, etc. In the case of baked-in adverts, you could upload your already processed advert audio as an insert, without having to edit it into your podcast recording using a separate audio editing application.

Please note that audio inserts should already be edited and processed before using them in production. (This is usually the case with pre-recorded adverts anyway). The only algorithm that Auphonic applies to an audio insert is loudness normalization in order to match the loudness of the entire production. Auphonic does not add any other processing (i.e. no leveling, noise reduction etc).

Audio Inserts Coding Example

Here is a brief overview of how to use our API for audio inserts. Be warned, this section is coding heavy, so if this isn't your thing, feel free to move along to the next section!

You can add audio insert files with a call to https://auphonic.com/api/production/{uuid}/multi_input_files.json, where uuid is the UUID of your production.
Here is an example with two audio inserts from an https URL. The offset/position in the main audio file must be given in seconds:

curl -X POST -H "Content-Type: application/json" 
    https://auphonic.com/api/production/{uuid}/multi_input_files.json 
    -u username:password 
    -d '[
            {
                "input_file": "https://mydomain.com/my_audio_insert_1.wav",
                "type": "insert",
                "offset": 20.5
            },
            {
                "input_file": "https://mydomain.com/my_audio_insert_2.wav",
                "type": "insert",
                "offset": 120.3
            }
        ]'

More details showing how to use audio inserts in our API can be seen here.

Additional API Audio Manipulations

In addition to audio inserts, using the Auphonic API offers a number of other audio manipulation options, which are not available via the web interface:

Cut start/end of audio files: See Docs

In Single-track productions, this feature allows the user to cut the start and/or the end of the uploaded audio file. Crucially, time-based information such as chapters etc. will be shifted accordingly.

Fade In/Out time of audio files: See Docs

This allows you to set the fade in/out time (in ms) at the start/end of output files. The default fade time is 100ms, but values can be set between 0ms and 5000ms.
This feature is also available in our Auphonic Leveler Desktop App.

Adding intro and outro: See Docs

Automatically add intros and outros to your main audio input file, as it is also available in our web interface.

Add multiple intros or outros: See Docs

Using our API, you can also add multiple intros or outros to a production. These intros or outros are played in series.

Overlapping intros/outros: See Docs

This feature allows intros/outros to overlap either the main audio or the following/previous intros/outros.

Conclusion

If you haven't explored our API already, the new audio inserts feature allows for greater flexibility and also dynamic ad insertion.
If you offer online services to podcasters, the Auphonic API would also then allow you to pass on Auphonic's audio processing algorithms to your customers.

If this is of interest to you or you have any new feature suggestions that you feel could benefit your company, please get in touch. We are always happy to extend the functionality of our products!

In this work, we consider a group of robots working together to manipulate a rigid object to track a desired trajectory in $SE(3)$. The robots have no explicit communication network among them, and they do no know the mass or friction properties of the object, or where they are attached to the object. However, we assume they share data from a common IMU placed arbitrarily on the object. To solve this problem, we propose a decentralized adaptive control scheme wherein each agent maintains and adapts its own estimate of the object parameters in order to track a reference trajectory. We present an analysis of the controller's behavior, and show that all closed-loop signals remain bounded, and that the system trajectory will almost always (except for initial conditions on a set of measure zero) converge to the desired trajectory. We study the proposed controller's performance using numerical simulations of a manipulation task in 3D, and with hardware experiments which demonstrate our algorithm on a planar manipulation task. These studies, taken together, demonstrate the effectiveness of the proposed controller even in the presence of numerous unmodelled effects, such as discretization errors and complex frictional interactions.

A remote manipulation apparatus includes a main body and a manipulating handle manipulated by a user to move to cover all the orientations from a manipulation basis position defined on a basis of the main body. Movement of the manipulating handle relative to the manipulation basis position corresponds to movement of a pointer image relative to a screen basis position on a screen of a display apparatus. An auxiliary navigational display window includes a specified button image assigned with pointer-pulling information. When the auxiliary navigational display window appears on the screen, the manipulating handle is automatically driven to a position that corresponds to a position of the specified button image on the screen so that the pointer image is moved onto the specified button image that is assigned with the pointer-pulling information.

A suction gripper for transferring ophthalmic lenses from a storage cup into a centering cup has a suction head with several suction openings and several suction cups, wherein the suction cups are positioned on a convexly rounded surface. At least some of the suction openings are arranged in the suction cups and at least one suction opening is arranged remote from the suction cups on the suction head. The suction gripper is used in a manipulation system for ophthalmic lenses that encompasses ophthalmic lenses, a storage cup, a centering cup and the suction gripper.

A book having a page construction for improved page manipulation. The book includes a plurality of pages bound together at an edge margin, wherein each page includes a bound edge and a plurality of free edges. At least one of the free edges of at least one of the pages includes an edge relief. The pages may comprise cardboard or other stiff material having a thickness. The free edges include opposed top and bottom edges and a side edge. The edge relief may extend along the entire side edge or only a portion thereof. The edge relief may be in the form of, for example, a chamfer, a bevel, a radius, a notch, a step, or the like.

California on Monday sued two gasoline trading firms, alleging they took advantage of a 2015 refinery explosion in Torrance to improperly drive up the price at the pump.

London : Macmillan, 1874-1876.

Lebanese authorities detained the head of the exchange dealers syndicate Mahmoud Mrad in a bid to end the manipulation of the dollar in the parallel market, Financial Prosecutor Judge Ali Ibrahim said Friday.

Scapy is a powerful interactive packet manipulation tool, packet generator, network scanner, network discovery tool, and packet sniffer. It provides classes to interactively create packets or sets of packets, manipulate them, send them over the wire, sniff other packets from the wire, match answers and replies, and more. Interaction is provided by the Python interpreter, so Python programming structures can be used (such as variables, loops, and functions). Report modules are possible and easy to make. It is intended to do the same things as ttlscan, nmap, hping, queso, p0f, xprobe, arping, arp-sk, arpspoof, firewalk, irpas, tethereal, tcpdump, etc.

Scapy is a powerful interactive packet manipulation tool, packet generator, network scanner, network discovery tool, and packet sniffer. It provides classes to interactively create packets or sets of packets, manipulate them, send them over the wire, sniff other packets from the wire, match answers and replies, and more. Interaction is provided by the Python interpreter, so Python programming structures can be used (such as variables, loops, and functions). Report modules are possible and easy to make. It is intended to do the same things as ttlscan, nmap, hping, queso, p0f, xprobe, arping, arp-sk, arpspoof, firewalk, irpas, tethereal, tcpdump, etc.

Scapy is a powerful interactive packet manipulation tool, packet generator, network scanner, network discovery tool, and packet sniffer. It provides classes to interactively create packets or sets of packets, manipulate them, send them over the wire, sniff other packets from the wire, match answers and replies, and more. Interaction is provided by the Python interpreter, so Python programming structures can be used (such as variables, loops, and functions). Report modules are possible and easy to make. It is intended to do the same things as ttlscan, nmap, hping, queso, p0f, xprobe, arping, arp-sk, arpspoof, firewalk, irpas, tethereal, tcpdump, etc.

Scapy is a powerful interactive packet manipulation tool, packet generator, network scanner, network discovery tool, and packet sniffer. It provides classes to interactively create packets or sets of packets, manipulate them, send them over the wire, sniff other packets from the wire, match answers and replies, and more. Interaction is provided by the Python interpreter, so Python programming structures can be used (such as variables, loops, and functions). Report modules are possible and easy to make. It is intended to do the same things as ttlscan, nmap, hping, queso, p0f, xprobe, arping, arp-sk, arpspoof, firewalk, irpas, tethereal, tcpdump, etc.

AV Arcade Pro version 5.4.3 suffers from an insecure cookie vulnerability that allows for access bypass.

ABSTRACT

Human noroviruses (HuNoVs) are the leading cause of nonbacterial gastroenteritis worldwide. Histo-blood group antigen (HBGA) expression is an important susceptibility factor for HuNoV infection based on controlled human infection models and epidemiologic studies that show an association of secretor status with infection caused by several genotypes. The fucosyltransferase 2 gene (FUT2) affects HBGA expression in intestinal epithelial cells; secretors express a functional FUT2 enzyme, while nonsecretors lack this enzyme and are highly resistant to infection and gastroenteritis caused by many HuNoV strains. These epidemiologic associations are confirmed by infections in stem cell-derived human intestinal enteroid (HIE) cultures. GII.4 HuNoV does not replicate in HIE cultures derived from nonsecretor individuals, while HIEs from secretors are permissive to infection. However, whether FUT2 expression alone is critical for infection remains unproven, since routinely used secretor-positive transformed cell lines are resistant to HuNoV replication. To evaluate the role of FUT2 in HuNoV replication, we used CRISPR or overexpression to genetically manipulate FUT2 gene function to produce isogenic HIE lines with or without FUT2 expression. We show that FUT2 expression alone affects both HuNoV binding to the HIE cell surface and susceptibility to HuNoV infection. These findings indicate that initial binding to a molecule(s) glycosylated by FUT2 is critical for HuNoV infection and that the HuNoV receptor is present in nonsecretor HIEs. In addition to HuNoV studies, these isogenic HIE lines will be useful tools to study other enteric microbes where infection and/or disease outcome is associated with secretor status.

IMPORTANCE Several studies have demonstrated that secretor status is associated with susceptibility to human norovirus (HuNoV) infection; however, previous reports found that FUT2 expression is not sufficient to allow infection with HuNoV in a variety of continuous laboratory cell lines. Which cellular factor(s) regulates susceptibility to HuNoV infection remains unknown. We used genetic manipulation of HIE cultures to show that secretor status determined by FUT2 gene expression is necessary and sufficient to support HuNoV replication based on analyses of isogenic lines that lack or express FUT2. Fucosylation of HBGAs is critical for initial binding and for modification of another putative receptor(s) in HIEs needed for virus uptake or uncoating and necessary for successful infection by GI.1 and several GII HuNoV strains.

Zhi-Jun Zhao, Davina Derous, Abby Gerrard, Jing Wen, Xue Liu, Song Tan, Catherine Hambly, and John R. Speakman

Lactating mice increase food intake 4- to 5-fold, reaching an asymptote in late lactation. A key question is whether this asymptote reflects a physiological constraint, or a maternal investment strategy (a ‘restraint’). We exposed lactating mice to periods of food restriction, hypothesizing that if the limit reflected restraint, they would compensate by breaching the asymptote when refeeding. In contrast, if it was a constraint, they would by definition be unable to increase their intake on refeeding days. Using isotope methods, we found that during food restriction, the females shut down milk production, impacting offspring growth. During refeeding, food intake and milk production rose again, but not significantly above unrestricted controls. These data provide strong evidence that asymptotic intake in lactation reflects a physiological/physical constraint, rather than restraint. Because hypothalamic neuropeptide Y (Npy) was upregulated under both states of restriction, this suggests the constraint is not imposed by limits in the capacity to upregulate hunger signalling (the saturated neural capacity hypothesis). Understanding the genetic basis of the constraint will be a key future goal and will provide us additional information on the nature of the constraining factors on reproductive output, and their potential links to life history strategies.

Twitter said it would suspend 70 accounts posting content supporting the Michael Bloomberg campaign in a pattern that violates company rules.

The former vice president of reinsurance of American International Group Inc. (AIG), was sentenced today to four years in prison for his role in a fraudulent scheme to manipulate AIG’s financial statements.

A 24-count indictment charging five individuals with various crimes arising from an alleged scheme to defraud investors through the manipulation of the publicly traded stocks of three companies was unsealed today in Tulsa, Okla.

A securities attorney was charged in an indictment unsealed today with participating in a stock registration evasion scheme involving nine different publicly traded companies and with defrauding investors in a manipulation scheme related to three of the companies.

A stock trader from Jupiter, Fla., pleaded guilty today to engaging in a market manipulation scheme involving several publicly traded companies. Earlier today, Paul M. Gozzo, 33, pleaded guilty before U.S. District Judge Donald L. Graham in Miami to one count of conspiracy to commit securities fraud and one count of securities fraud.

Phillip Windom Offill Jr., 51, of Dallas, was indicted on March 12, 2009, and today was found guilty of one count of conspiracy to commit registration violations, securities fraud and nine counts of wire fraud.