Proteins are well known `shapeshifters' which change conformation to function. In crystallography, multiple conformational states are often present within the crystal and the resulting electron-density map. Yet, explicitly incorporating alternative states into models to disentangle multi-conformer ensembles is challenging. We previously reported the tool FLEXR, which, within a few minutes, automatically separates conformational signal from noise and builds the corresponding, often missing, structural features into a multi-conformer model. To make the method widely accessible for routine multi-conformer building as part of the computational toolkit for macromolecular crystallography, we present a graphical user interface (GUI) for FLEXR, designed as a plugin for Coot 1. The GUI implementation seamlessly connects FLEXR models with the existing suite of validation and modeling tools available in Coot. We envision that FLEXR will aid crystallographers by increasing access to a multi-conformer modeling method that will ultimately lead to a better representation of protein conformational heterogeneity in the Protein Data Bank. In turn, deeper insights into the protein conformational landscape may inform biology or provide new opportunities for ligand design. The code is open source and freely available on GitHub at https://github.com/TheFischerLab/FLEXR-GUI.

Company's Linear Motion and Assembly Technologies Group increases sales by 40 percent, leads by 25 percent, with redesigned Web site featuring downloadable 3D models

Systems and methods for implementing FlexRay communications between FlexRay nodes using Ethernet are provided. An Ethernet switch includes ports, each of which receives an Ethernet data packet (EDP) from a respective FlexRay node. Each EDP includes a FlexRay message, which includes at least one of a data frame and a frame identification (ID). A first EDP is received at a first port no later than a second EDP is received at a second port. The Ethernet switch also includes a controller module that determines whether the second EDP has higher priority than the first EDP based on the frame IDs associated with the first and second EDPs. The controller module is configured to route the second EDP to a second destination no later than routing the first EDP to a first destination and meet FlexRay transmission cycle times when it has been determined that the second EDP has higher priority.

macOS and iOS have a vulnerability with ImageIO where memory safety issues occur when processing OpenEXR images.

ExRobotics B.V., a Netherlands-based developer of robotics technology for hazardous environments, and Yokogawa Electric Corporation (TOKYO: 6841), a global provider of industrial automation, control, and measurement technology, announce the signing of a licensing agreement that will enable Yokogawa to sell and deploy ExRobotics' inspection robot hardware and software platforms worldwide.

The Duke and Duchess of Sussex have hit 11.3 million followers on Instagram, catching up with the Duke and Duchess of Cambridge.