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Three-component Friedel–Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(III) electrophile

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00489B, Research Article
Open Access
Jun Kikuchi, Toya Nagata, Shingo Ito, Naohiko Yoshikai
A three-component Friedel–Crafts type difunctionalization of ynamides with an iodine(III) electrophile and electron-rich (hetero)arenes has been developed, enabling regio- and stereoselective synthesis of densely functionalized enamides.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Catalytic Atroposelective Friedel-Crafts Alkylation to Access Axially Chiral C2-Arylindoles via Dynamic Kinetic Resolutions

Org. Chem. Front., 2025, Accepted Manuscript
DOI: 10.1039/D4QO01611D, Research Article
Xiao-Long He, Jiang Deng, Wei Li, Chenhao Zhou, Zhiming Li, Haibo Zhou, Junyuan Yan, Zhouyu Wang, Shan Qian
Indole-based atropisomers have emerged as an important backbone in drug discovery and novel catalyst/ligand design. However, the development of asymmetric synthesis of axially chiral 2-arylindoles is sluggish due to the...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Edelmannswort

Wenn jemand nicht aus, sondern gerade nach Afghanistan flieht, muss es ihm schon äußerst schlecht gehen. Verteidigungsminister zu Guttenberg hat also offenbar gerade ein Problem im heimischen politisch-akademischen Zweifrontenkrieg.




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Vijesti :: Lovro Nedeljković osmi na Balkanu

Autor: Redakcija 031 Naslov: Lovro Nedeljković osmi na Balkanu
Postano: 13.11.2024. 11:05 (GMT 1) U rumunjskom gradu Campulung Moldovenescu održano je prvenstvo Balkana u krosu.

Konkurencija je bila vrlo jaka, a u sastavu hrvatske reprezentacije našao se i član AK Slavonija-Žito Lovro Nedeljković. U utrci seniora na 10.000 metara naš je dugoprugaš zauzeo vrlo dobro, osmo mjesto s rezultatom 31:59,33.

Zlato je osvojio Albanac David Nikolli s vremenom 30:24,61, srebro je zaslužio Turčin Ayetullah Aslanhan (30:32,31), dok je bronca pripala Ukrajincu Ihoru Porozovu (30:44,86).

Nedeljković je, inače, ostvario najbolji plasman od hrvatskih reprezentativaca koji su nastupili u ovoj konkurenciji.


Tekst i foto: AK Slavonija-Žito




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CA6493 GENTRI - Edelweiss

Catégorie - GROUPES » Genre - Vocale








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Community in times of COVID: building resilience in a self-help neighborhood in Medellin.

Children's Geographies; 06/21/2024
(AN 178113385); ISSN: 14733285
Academic Search Premier




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Nationalize Psychedelics

Psychedelic-assisted therapy is still awaiting official approval, but private firms are already using patents to corner the market. Government-funded research shouldn’t yield big profits for Big Pharma. Above: A laboratory technician displays hallucinogenic psilocybin mushrooms at Rose City Laboratories in Portland, Oregon

The post Nationalize Psychedelics was curated by information for practice.





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Dusen Dusen + Jen Stark’s Psychedelic Collab Of Summer-Ready Accessories

Designed for Waves Wine, the new terry-cloth beach towel + tote bag is a fusion of Ellen Van Dusen, of Dusen Dusen, and Jen Stark’s signature creative styles.




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Exploiting Friedel pairs to interpret scanning 3DXRD data from complex geological materials

A new processing technique for synchrotron scanning 3D X-ray diffraction data is introduced, utilizing symmetric Bragg reflections hkl and hkl, known as Friedel pairs. This technique is designed to tackle the difficulties associated with large, highly deformed, polyphase materials, especially geological samples.




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Exploiting Friedel pairs to interpret scanning 3DXRD data from complex geological materials

The present study introduces a processing strategy for synchrotron scanning 3D X-ray diffraction (s3DXRD) data, aimed at addressing the challenges posed by large, highly deformed, polyphase materials such as crystalline rocks. Leveraging symmetric Bragg reflections known as Friedel pairs, our method enables diffraction events to be precisely located within the sample volume. This method allows for fitting the phase, crystal structure and unit-cell parameters at the intra-grain scale on a voxel grid. The processing workflow incorporates several new modules, designed to (i) efficiently match Friedel pairs in large s3DXRD datasets containing up to 108 diffraction peaks; (ii) assign phases to each pixel or voxel, resolving potential ambiguities arising from overlap in scattering angles between different crystallographic phases; and (iii) fit the crystal orientation and unit cell locally on a point-by-point basis. We demonstrate the effectiveness of our technique on fractured granite samples, highlighting the ability of the method to characterize complex geological materials and show their internal structure and mineral composition. Additionally, we include the characterization of a metal gasket made of a commercial aluminium alloy, which surrounded the granite sample during experiments. The results show the effectiveness of the technique in recovering information about the internal texture and residual strain of materials that have undergone high levels of plastic deformation.




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Could California Be The Next State To Legalize Psychedelics?

Don't fear the 'shrooms.; Credit: /iStockphoto.com

AirTalk

California on Tuesday moved another step closer to decriminalizing psychedelics — amid a debate over whether their prohibition is an outdated remnant of the War on Drugs — after the author removed a substance (ketamine) from the bill that opponents said can be used as a date-rape drug.

The bill would allow those 21 and older to possess for personal use and “social sharing” psilocybin, the hallucinogenic component of so-called magic mushrooms. It also covers psilocybin, dimethyltryptamine (DMT), ibogaine, mescaline excluding peyote, lysergic acid diethylamide (LSD) and 3,4-methylenedioxymethamphetamine (MDMA, often called ecstasy).

The bill bars sharing with those under age 21 or possessing the substances on school grounds. It would remove the state’s ban on cultivating or transferring mushroom spores or other material containing psilocybin or psilocybin.

Even if California makes the bill law, the drugs would still be illegal under federal law.

With files from the Associated Press.

Guests:

Scott Wiener, author of SB 519; California State Senator representing Senate District 11, which includes all of the city and county of San Francisco, Broadmoor, Colma, Daly City, and part of South San Francisco; he tweets @Scott_Wiener

John Lovell, legislative director of the California Narcotics Officers Association

This content is from Southern California Public Radio. View the original story at SCPR.org.




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The PR Week: 7.3.2024 - Richard Edelman, Edelman

The global CEO of Edelman talks about PR’s strong performance in Cannes, his agency’s financial year, areas of interest for acquisitions and much more.




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Marquis Who's Who Honors Julie A. Russell, PsyD, for Expertise in Psychedelic Research Psychology

Julie A. Russell, PsyD, is lauded for pioneering psychedelic treatments in mental health care




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The 3rd Annual Psychedelic Therapeutics & Drug Development Conference Brings Together Leading Experts to Discuss Latest Findings and Future Directions

Experts gather to explore the latest breakthroughs in psychedelic research at international conference




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Take a Simulated Psychedelic Trip with Daisies on Acid

Los Angeles based producer collective, Beats Freaks Geeks harness the power of AI for a mind-bending visual and auditory odyssey




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Renée S. Edelman Featured in the June/July 2023 Issue of Fortune Magazine

Renée S. Edelman shared her professional achievements and industry expertise in Fortune magazine




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The VA is undeterred on psychedelics

The Department of Veterans Affairs remains convinced that psychedelic therapy can help treat veterans with post-traumatic stress disorder — and it’s going to try to prove it. That commitment comes despite the FDA’s August rejection of a drug company’s plan to offer a psychedelic regimen for PTSD.




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Psychedelics and Marijuana on the Ballot: How Should Employers Prepare for Potential Legalization?

Voters in several states will decide whether marijuana or, in one case, psychedelic substances should be legal in the upcoming November 5, 2024 general election. Employers should keep their eyes on these ballot measures and prepare for questions regarding changes to workplace policies if some or all of them pass. A rundown of the ballot measures in these jurisdictions follows.




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15 Best Psychedelic Rock Songs of All Time

Psychedelic rock is more than just a genre; it’s an experience—a kaleidoscopic journey that pushes the boundaries of sound, perception, and imagination. Born in the 1960s, this mind-bending fusion of rock, surrealism, and experimentation became the soundtrack to a cultural revolution, forever altering the landscape of modern music. With its swirling guitars, hypnotic rhythms, and […]

The post 15 Best Psychedelic Rock Songs of All Time first appeared on Singersroom.com.



  • Best Songs Guide

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¿Qué está pasando con la gobernabilidad en Medellín?

Panelistas analizaron el panorama político de la ciudad; creen que hay una mezcla de falta de experiencia y de diálogo entre la ciudad y la administración.




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Psychedelic Drugs and Near-Death Experiences: New Research Supports Bible Truth

A new study involving a special group of people shows significant overlap between psychedelic trips and near-death experiences. What does the Bible say about the latter?




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Revocatoria del alcalde de Medellín: ¿a qué conduce?, ¿qué falta y qué viene?




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Trabajo sí hay: Más de 1.000 vacantes en la Feria del Empleo en Medellín




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Vicerrector académico Universidad de Medellín: “Estamos haciéndonos fuertes en nuevas tecnologías”

La Luciérnaga transmitió el programa de este miércoles desde la Universidad de Medellín como parte de su apuesta por el diálogo desde las regiones “Ruta Regiones”




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La luciérnaga desde la Universidad de Medellin


La Luciérnaga se enciende para hablar del mal manejo de las comuniaciones en el Gobierno. También, ¿qué ha pasado con las obras de Bogotá? Además, como será la supuesta llegada de los extraterrestres .La Luciérnaga, un espacio de humor, análisis y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.l




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Encuesta polimétrica, explosión Medellín y aumenta narcotráfico

La Luciérnaga se enciende para analizar los resultados de la encuesta polimétrica de este mes. Se encontró que, por primera vez, la desfavorabilidad del presidente es superior a su favorabilidad asimismo la de Francia Marquez. Además, se presentó una fuerte explosión en Medellín la cual se presentó en una edificación. Hubo personas heridas y varios vehículos como edificios sufrieron daños producto del estallido. También, según la (ONU) se conoció que Colombia es el mayor productor de coca en el mundo, con un aumento de 43% frente al año inmediatamente anterior. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.




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Así venderían ilegalmente vacunas de COVID-19 en Medellín




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Teléfono De La Esperanza, línea de atención para crisis en Medellín




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No podemos hablar el lenguaje de la Alcaldía: Muñoz de TeleMedellín




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El emprendimiento en Medellín que consigue arqueros para partidos de fútbol




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Padre del sacerdote encontrado murto en Medellín: “Mi hijo me dijo que volvía a las 10”

Esta fue la última conversación de José González, padre del sacerdote hallado muerto en un bar de la capital antioqueña,  Javier Eduardo González Pertuz




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Histórico hallazgo: encuentran bebé de hace 1.600 años en medio de obras en Medellín




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Mocedades se presentará en Medellín con su ‘infinito tour’

La agrupación española tendrá a Colombia y realizará un nuevo lanzamiento junto a Plácido Domingo.




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Mocedades se presentará en Medellín con su ‘infinito tour’

La agrupación española vendrá a Colombia y realizará un nuevo lanzamiento junto a Plácido Domingo.




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Natalia Jiménez en Colombia: se presentará el 23 y 24 de marzo en Bogotá y Medellín

En 10AM Hoy por Hoy de Caracol Radio habló la reconocida cantante española, Natalia Jiménez, de cara a sus dos presentaciones en Colombia.




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Falso duque español les sacó 1.500 millones a 18 personas en Medellín: hablan las víctimas




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La Orquesta Filarmónica de Medellín celebra sus 40 años con Mozart y Beethoven

Desde su formación en un pequeño garage hasta el Latin Grammy a Mejor Álbum de Música Latina para Niños, la Filarmónica conmemora su larga trayectoria




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¿Por qué está tan caro arrendar y comprar casa en Medellín?

En Caracol Radio habló Andrés González, director de la Cámara Nacional Inmobiliaria, sobre las causas de los incrementos en el arriendo.




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Presidenta Ejecutiva de Proantioquia: “La cultura nos ha salvado en Medellín”




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¿El fútbol se quedará sin estadio en Medellín por conciertos en el Atanasio Girardot?

Cristian Sánchez, Director del Instituto de Deportes y recreación de Medellín, aseguró en 10AM que no todos los conciertos están confirmados




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“Hice quedar en alto a la institución”: patrullero que cantó con Romeo Santos en Medellín




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Museo de Pablo Escobar era un activo del Cartel de Medellín y ahora tendría otro fin: SAE

En Caracol Radio estuvo Mauricio Urquijo, director territorial occidente de la SAE




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“Para mí no hay paz total, eso fracasó”: alcalde de Medellín, Federico Gutiérrez

En 10AM Hoy por Hoy de Caracol Radio estuvo el alcalde de Medellín, Federico Gutiérrez, para hablar sobre la seguridad y los retos que enfrenta la ciudad.




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Medellín tendrá interrupción de acueducto




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Medellín es la primera ciudad de Latinoamérica en estar en el Metaverso

Medellín es la primera ciudad de Latinoamérica en estar en el Metaverso