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Fr. Anthony talks with Fr. Gregory Jensen about motivated reason and the consequences of mixing micro and macro domains. They suggest that our increasing tribalism is exacerbated of confusing pastoral and public communications - something that is all but impossible to avoid on social media. Enjoy the show!

Aim/Purpose: While existing literature has extensively explored factors influencing the success of big data projects and proposed big data maturity models, no study has harnessed machine learning to predict project success and identify the critical features contributing significantly to that success. The purpose of this paper is to offer fresh insights into the realm of big data projects by leveraging machine-learning algorithms. Background: Previously, we introduced the Global Big Data Maturity Model (GBDMM), which encompassed various domains inspired by the success factors of big data projects. In this paper, we transformed these maturity domains into a survey and collected feedback from 90 big data experts across the Middle East, Gulf, Africa, and Turkey regions regarding their own projects. This approach aims to gather firsthand insights from practitioners and experts in the field. Methodology: To analyze the feedback obtained from the survey, we applied several algorithms suitable for small datasets and categorical features. Our approach included cross-validation and feature selection techniques to mitigate overfitting and enhance model performance. Notably, the best-performing algorithms in our study were the Decision Tree (achieving an F1 score of 67%) and the Cat Boost classifier (also achieving an F1 score of 67%). Contribution: This research makes a significant contribution to the field of big data projects. By utilizing machine-learning techniques, we predict the success or failure of such projects and identify the key features that significantly contribute to their success. This provides companies with a valuable model for predicting their own big data project outcomes. Findings: Our analysis revealed that the domains of strategy and data have the most influential impact on the success of big data projects. Therefore, companies should prioritize these domains when undertaking such projects. Furthermore, we now have an initial model capable of predicting project success or failure, which can be invaluable for companies. Recommendations for Practitioners: Based on our findings, we recommend that practitioners concentrate on developing robust strategies and prioritize data management to enhance the outcomes of their big data projects. Additionally, practitioners can leverage machine-learning techniques to predict the success rate of these projects. Recommendation for Researchers: For further research in this field, we suggest exploring additional algorithms and techniques and refining existing models to enhance the accuracy and reliability of predicting the success of big data projects. Researchers may also investigate further into the interplay between strategy, data, and the success of such projects. Impact on Society: By improving the success rate of big data projects, our findings enable organizations to create more efficient and impactful data-driven solutions across various sectors. This, in turn, facilitates informed decision-making, effective resource allocation, improved operational efficiency, and overall performance enhancement. Future Research: In the future, gathering additional feedback from a broader range of big data experts will be valuable and help refine the prediction algorithm. Conducting longitudinal studies to analyze the long-term success and outcomes of Big Data projects would be beneficial. Furthermore, exploring the applicability of our model across different regions and industries will provide further insights into the field.

Evaluation &the Health Professions, Ahead of Print. This systematic review provides an overview of the unique challenges allied health professions face in the translation and implementation of evidence into practice, which remain relatively under reported and uninformed by a theoretical basis of behaviour change. MEDLINE, EMBASE, CINAHL and Scopus databases from 2010 to 2022 were […]

The post Factors Influencing the Translation of Evidence Into Clinical Practice for Hospital Allied Health Professionals in Terms of the Domains of Behaviour Change Theory: A Systematic Review was curated by information for practice.

Nanoscale structural and electronic heterogeneities are prevalent in condensed matter physics. Investigating these heterogeneities in 3D has become an important task for understanding material properties. To provide a tool to unravel the connection between nanoscale heterogeneity and macroscopic emergent properties in magnetic materials, scanning transmission X-ray microscopy (STXM) is combined with X-ray magnetic circular dichroism. A vector tomography algorithm has been developed to reconstruct the full 3D magnetic vector field without any prior noise assumptions or knowledge about the sample. Two tomographic scans around the vertical axis are acquired on single-crystalline Nd2Fe14B pillars tilted at two different angles, with 2D STXM projections recorded using a focused 120 nm X-ray beam with left and right circular polarization. Image alignment and iterative registration have been implemented based on the 2D STXM projections for the two tilts. Dichroic projections obtained from difference images are used for the tomographic reconstruction to obtain the 3D magnetization distribution at the nanoscale.

MltG, a membrane-bound lytic transglycosyl­ase, has roles in terminating glycan polymerization in peptidoglycan and incorporating glycan chains into the cell wall, making it significant in bacterial cell-wall biosynthesis and remodeling. This study provides the first reported MltG structure from Mycobacterium abscessus (maMltG), a superbug that has high antibiotic resistance. Our structural and biochemical analyses revealed that MltG has a flexible peptidoglycan-binding domain and exists as a monomer in solution. Further, the putative active site of maMltG was disclosed using structural analysis and sequence comparison. Overall, this study contributes to our understanding of the transglycosyl­ation reaction of the MltG family, aiding the design of next-generation antibiotics targeting M. abscessus.

We enumerate the 55083357 iso-edge subdivisions of six-dimensional translational lattices. We report on the use of the method of canonical forms that allows us to apply hashing techniques used in modern databases.

A Comprehensive Survey of ChatGPT and Its Applications Across Domains

One-Click Threat Intelligence and Real-Time Verdicts Empower Security Researchers and Analysts of All Skill Levels

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This is to let those who read, and hopefully enjoy, my blog know about an upcoming change. When I originally assembled my current website I placed my blog in a subdomain (it turns out this was not my wisest move).  That is why the URL for my website is www.howardgrill.com, while the URL for my […]

As with any high-stakes event, elections have become a prime target for cybercriminals seeking to exploit public trust through impersonation, misinformation, and scams. CSC's comprehensive research about the 2024 U.S. Election reveals the alarming role of dormant domains, which have the potential to be exploited for launching cyber attacks against political campaigns, organizations, and constituents.

In CSC's recent insight paper, we address the trend that many business leaders today don't realize the extent to which their modern enterprise -- and its millions of digital assets -- rely on. It's a vast domain ecosystem that needs to be protected from online threats. Often, to better understand this need for domain security, we need to understand how critical and interconnected domains are within a business.

Public Interest Registry (PIR), the nonprofit managing the .ORG domain, recently announced it now oversees 11 million registrations. Jon Nevett, PIR's CEO, attributes this growth to what he describes as a "responsible" expansion, emphasizing a focus on security and community support.

Location: Electronic Resource- 

Location: Engineering Library- TK5105.888.E87 2016

Paul Kafasis returns to the show to talk about the iPhone 14 Pro, Apple Watch Ultra, AirPods Pro, and Rogue Amoeba’s 20th anniversary.

M. Wang
Aug 1, 2012; 11:492-500
Technological Innovation and Resources

Human genetic studies recently identified an association of SNPs in the 17-β hydroxysteroid dehydrogenase 13 (HSD17B13) gene with alcoholic and nonalcoholic fatty liver disease development. Mutant HSD17B13 variants devoid of enzymatic function have been demonstrated to be protective from cirrhosis and liver cancer, supporting the development of HSD17B13 as a promising therapeutic target. Previous studies have demonstrated that HSD17B13 is a lipid droplet (LD)-associated protein. However, the critical domains that drive LD targeting or determine the enzymatic activity have yet to be defined. Here we used mutagenesis to generate multiple truncated and point-mutated proteins and were able to demonstrate in vitro that the N-terminal hydrophobic domain, PAT-like domain, and a putative α-helix/β-sheet/α-helix domain in HSD17B13 are all critical for LD targeting. Similarly, we characterized the predicted catalytic, substrate-binding, and homodimer interaction sites and found them to be essential for the enzymatic activity of HSD17B13, in addition to our previous identification of amino acid P260 and cofactor binding site. In conclusion, we identified critical domains and amino acid sites that are essential for the LD localization and protein function of HSD17B13, which may facilitate understanding of its function and targeting of this protein to treat chronic liver diseases.

MICAL is an oxidoreductase that participates in cytoskeleton reorganization via actin disassembly in the presence of NADPH. Although three MICALs (MICAL1, MICAL2 and MICAL3) have been identified in mammals, only the structure of mouse MICAL1 has been reported. Here, the first crystal structure of human MICAL3, which contains the flavin-containing monooxygenase (FMO) and calponin-homology (CH) domains, is reported. MICAL3 has an FAD/NADP-binding Rossmann-fold domain for mono­oxygenase activity like MICAL1. The FMO and CH domains of both MICAL3 and MICAL1 are highly similar in structure, but superimposition of the two structures shows a different relative position of the CH domain in the asymmetric unit. Based on kinetic analyses, the catalytic efficiency of MICAL3 dramatically increased on adding F-actin only when the CH domain was available. However, this did not occur when two residues, Glu213 and Arg530, were mutated in the FMO and CH domains, respectively. Overall, MICAL3 is structurally highly similar to MICAL1, which suggests that they may adopt the same catalytic mechanism, but the difference in the relative position of the CH domain produces a difference in F-actin substrate specificity.

Kelly L. Dunlevy, Valentina Medvedeva, Jade E. Wilson, Mohammed Hoque, Trinity Pellegrin, Adam Maynard, Madison M. Kremp, Jason S. Wasserman, Andrey Poleshko, and Richard A. Katz

A large fraction of epigenetically silent heterochromatin is anchored to the nuclear periphery via "tethering proteins" that function to bridge heterochromatin and the nuclear membrane or nuclear lamina. We identified previously a human tethering protein, PRR14, that binds heterochromatin through an N-terminal domain, but the mechanism and regulation of nuclear lamina association remained to be investigated. Here we identify an evolutionarily conserved PRR14 nuclear lamina binding domain (LBD) that is both necessary and sufficient for positioning of PRR14 at the nuclear lamina. We also show that PRR14 associates dynamically with the nuclear lamina, and provide evidence that such dynamics are regulated through phosphorylation-dephosphorylation of the LBD. Furthermore, we identified a PP2A phosphatase recognition motif within the evolutionarily conserved PRR14 C-terminal Tantalus domain. Disruption of this motif affected PRR14 localization to the nuclear lamina. The overall findings demonstrate a heterochromatin anchoring mechanism whereby the PRR14 tether simultaneously binds heterochromatin and the nuclear lamina through two separable, modular domains. The findings also describe an optimal PRR14 LBD fragment that could be used for efficient targeting of fusion proteins to the nuclear lamina.

Automattic announced that it has secured to rights the the .blog top-level domain. It will soon start offering them to customers.

Read more on howtoweb.com

It is well-known that a celebrated J"{o}rgens-Calabi-Pogorelov theorem for Monge-Amp`ere equations states that any classical (viscosity) convex solution of $det(D^2u)=1$ in $mathbb{R}^n$ must be a quadratic polynomial. Therefore, it is an interesting topic to study the existence and uniqueness theorem of such fully nonlinear partial differential equations' Dirichlet problems on exterior domains with suitable asymptotic conditions at infinity. As a continuation of the works of Caffarelli-Li for Monge-Amp`ere equation and of Bao-Li-Li for $k$-Hessian equations, this paper is devoted to the solvability of the exterior Dirichlet problem of Hessian quotient equations $sigma_k(lambda(D^2u))/sigma_l(lambda(D^2u))=1$ for any $1leq l<kleq n$ in all dimensions $ngeq 2$. By introducing the concept of generalized symmetric subsolutions and then using the Perron's method, we establish the existence theorem for viscosity solutions, with prescribed asymptotic behavior which is close to some quadratic polynomial at infinity.

We relate the $L^p$-mapping properties of the Bergman projections on two domains in $mathbb{C}^n$, one of which is the quotient of the other under the action of a finite group of biholomorphic automorphisms. We use this relation to deduce the sharp ranges of $L^p$-boundedness of the Bergman projection on certain $n$-dimensional model domains generalizing the Hartogs triangle.

We study the dependence of the first eigenvalue of the Finsler $p$-Laplacian and the corresponding eigenfunctions upon perturbation of the domain and we generalize a few results known for the standard $p$-Laplacian. In particular, we prove a Frech'{e}t differentiability result for the eigenvalues, we compute the corresponding Hadamard formulas and we prove a continuity result for the eigenfunctions. Finally, we briefly discuss a well-known overdetermined problem and we show how to deduce the Rellich-Pohozaev identity for the Finsler $p$-Laplacian from the Hadamard formula.

We first give a sufficient condition, issued from pluripotential theory, for an unbounded domain in the complex Euclidean space $mathbb C^n$ to be Kobayashi hyperbolic. Then, we construct an example of a rigid pseudoconvex domain in $mathbb C^3$ that is Kobayashi hyperbolic and has a nonempty core. In particular, this domain is not biholomorphic to a bounded domain in $mathbb C^3$ and the mentioned above sufficient condition for Kobayashi hyperbolicity is not necessary.

The central aim of this paper is to study (regional) fractional Poincar'e type inequalities on unbounded domains satisfying the finite ball condition. Both existence and non existence type results are established depending on various conditions on domains and on the range of $s in (0,1)$. The best constant in both regional fractional and fractional Poincar'e inequality is characterized for strip like domains $(omega imes mathbb{R}^{n-1})$, and the results obtained in this direction are analogous to those of the local case. This settles one of the natural questions raised by K. Yeressian in [ extit{Asymptotic behavior of elliptic nonlocal equations set in cylinders, Asymptot. Anal. 89, (2014), no 1-2}].

In this paper we study removable singularities for regular $(1,1/2)$-Lipschitz solutions of the heat equation in time varying domains. We introduce an associated Lipschitz caloric capacity and we study its metric and geometric properties and the connection with the $L^2$ boundedness of the singular integral whose kernel is given by the gradient of the fundamental solution of the heat equation.

We investigate the Boundary Harnack Principle in H"older domains of exponent $alpha>0$ by the analytical method developed in our previous work "A short proof of Boundary Harnack Principle".

We present a LiDAR-based and real-time capable 3D perception system for automated driving in urban domains. The hierarchical system design is able to model stationary and movable parts of the environment simultaneously and under real-time conditions. Our approach extends the state of the art by innovative in-detail enhancements for perceiving road users and drivable corridors even in case of non-flat ground surfaces and overhanging or protruding elements. We describe a runtime-efficient pointcloud processing pipeline, consisting of adaptive ground surface estimation, 3D clustering and motion classification stages. Based on the pipeline's output, the stationary environment is represented in a multi-feature mapping and fusion approach. Movable elements are represented in an object tracking system capable of using multiple reference points to account for viewpoint changes. We further enhance the tracking system by explicit consideration of occlusion and ambiguity cases. Our system is evaluated using a subset of the TUBS Road User Dataset. We enhance common performance metrics by considering application-driven aspects of real-world traffic scenarios. The perception system shows impressive results and is able to cope with the addressed scenarios while still preserving real-time capability.

Embodiments provide various techniques for dynamic adjustment of a number of threads for execution in any domain based on domain utilizations. In a multiprocessor system, the utilization for each domain is monitored. If a utilization of any of these domains changes, then the number of threads for each of the domains determined for execution may also be adjusted to adapt to the change.

The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.

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M. Wang
Aug 1, 2012; 11:492-500
Technological Innovation and Resources

The ribosome biogenesis factor Las1 is an essential endoribonuclease that is well-conserved across eukaryotes and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domain-containing nuclease family. HEPN nucleases participate in diverse RNA cleavage pathways and share a short HEPN nuclease motif (RφXXXH) important for RNA cleavage. Most HEPN nucleases participate in stress-activated RNA cleavage pathways; Las1 plays a fundamental role in processing pre-rRNA. Underscoring the significance of Las1 function in the cell, mutations in the human LAS1L (LAS1-like) gene have been associated with neurological dysfunction. Two juxtaposed HEPN nuclease motifs create Las1's composite nuclease active site, but the roles of the individual HEPN motif residues are poorly defined. Here using a combination of in vivo experiments in Saccharomyces cerevisiae and in vitro assays, we show that both HEPN nuclease motifs are required for Las1 nuclease activity and fidelity. Through in-depth sequence analysis and systematic mutagenesis, we determined the consensus HEPN motif in the Las1 subfamily and uncovered its canonical and specialized elements. Using reconstituted Las1 HEPN-HEPN' chimeras, we defined the molecular requirements for RNA cleavage. Intriguingly, both copies of the Las1 HEPN motif were important for nuclease function, revealing that both HEPN motifs participate in coordinating the RNA within the Las1 active site. We also established that conformational flexibility of the two HEPN domains is important for proper nuclease function. The results of our work reveal critical information about how dual HEPN domains come together to drive Las1-mediated RNA cleavage.

The formation and properties of liquid-ordered (Lo) lipid domains (rafts) in the plasma membrane are still poorly understood. This limits our ability to manipulate ordered lipid domain-dependent biological functions. Giant plasma membrane vesicles (GPMVs) undergo large-scale phase separations into coexisting Lo and liquid-disordered lipid domains. However, large-scale phase separation in GPMVs detected by light microscopy is observed only at low temperatures. Comparing Förster resonance energy transfer-detected versus light microscopy-detected domain formation, we found that nanodomains, domains of nanometer size, persist at temperatures up to 20°C higher than large-scale phases, up to physiologic temperature. The persistence of nanodomains at higher temperatures is consistent with previously reported theoretical calculations. To investigate the sensitivity of nanodomains to lipid composition, GPMVs were prepared from mammalian cells in which sterol, phospholipid, or sphingolipid composition in the plasma membrane outer leaflet had been altered by cyclodextrin-catalyzed lipid exchange. Lipid substitutions that stabilize or destabilize ordered domain formation in artificial lipid vesicles had a similar effect on the thermal stability of nanodomains and large-scale phase separation in GPMVs, with nanodomains persisting at higher temperatures than large-scale phases for a wide range of lipid compositions. This indicates that it is likely that plasma membrane nanodomains can form under physiologic conditions more readily than large-scale phase separation. We also conclude that membrane lipid substitutions carried out in intact cells are able to modulate the propensity of plasma membranes to form ordered domains. This implies lipid substitutions can be used to alter biological processes dependent upon ordered domains.

The ribosome biogenesis factor Las1 is an essential endoribonuclease that is well-conserved across eukaryotes and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domain-containing nuclease family. HEPN nucleases participate in diverse RNA cleavage pathways and share a short HEPN nuclease motif (RφXXXH) important for RNA cleavage. Most HEPN nucleases participate in stress-activated RNA cleavage pathways; Las1 plays a fundamental role in processing pre-rRNA. Underscoring the significance of Las1 function in the cell, mutations in the human LAS1L (LAS1-like) gene have been associated with neurological dysfunction. Two juxtaposed HEPN nuclease motifs create Las1's composite nuclease active site, but the roles of the individual HEPN motif residues are poorly defined. Here using a combination of in vivo experiments in Saccharomyces cerevisiae and in vitro assays, we show that both HEPN nuclease motifs are required for Las1 nuclease activity and fidelity. Through in-depth sequence analysis and systematic mutagenesis, we determined the consensus HEPN motif in the Las1 subfamily and uncovered its canonical and specialized elements. Using reconstituted Las1 HEPN-HEPN' chimeras, we defined the molecular requirements for RNA cleavage. Intriguingly, both copies of the Las1 HEPN motif were important for nuclease function, revealing that both HEPN motifs participate in coordinating the RNA within the Las1 active site. We also established that conformational flexibility of the two HEPN domains is important for proper nuclease function. The results of our work reveal critical information about how dual HEPN domains come together to drive Las1-mediated RNA cleavage.

S. A. Nazarov
Trans. Moscow Math. Soc. 80 (2020), 1-51.
Abstract, references and article information

Takahito Kashiwabara and Tomoya Kemmochi
Math. Comp. 89 (2020), 1647-1679.
Abstract, references and article information

D. Pauly and S. Repin
St. Petersburg Math. J. 31 (2020), 533-555.
Abstract, references and article information

The ribosome biogenesis factor Las1 is an essential endoribonuclease that is well-conserved across eukaryotes and a newly established member of the higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domain-containing nuclease family. HEPN nucleases participate in diverse RNA cleavage pathways and share a short HEPN nuclease motif (RφXXXH) important for RNA cleavage. Most HEPN nucleases participate in stress-activated RNA cleavage pathways; Las1 plays a fundamental role in processing pre-rRNA. Underscoring the significance of Las1 function in the cell, mutations in the human LAS1L (LAS1-like) gene have been associated with neurological dysfunction. Two juxtaposed HEPN nuclease motifs create Las1's composite nuclease active site, but the roles of the individual HEPN motif residues are poorly defined. Here using a combination of in vivo experiments in Saccharomyces cerevisiae and in vitro assays, we show that both HEPN nuclease motifs are required for Las1 nuclease activity and fidelity. Through in-depth sequence analysis and systematic mutagenesis, we determined the consensus HEPN motif in the Las1 subfamily and uncovered its canonical and specialized elements. Using reconstituted Las1 HEPN-HEPN' chimeras, we defined the molecular requirements for RNA cleavage. Intriguingly, both copies of the Las1 HEPN motif were important for nuclease function, revealing that both HEPN motifs participate in coordinating the RNA within the Las1 active site. We also established that conformational flexibility of the two HEPN domains is important for proper nuclease function. The results of our work reveal critical information about how dual HEPN domains come together to drive Las1-mediated RNA cleavage.

Ilya Levental
May 1, 2020; 61:592-594
Commentary

The formation and properties of liquid-ordered (Lo) lipid domains (rafts) in the plasma membrane are still poorly understood. This limits our ability to manipulate ordered lipid domain-dependent biological functions. Giant plasma membrane vesicles (GPMVs) undergo large-scale phase separations into coexisting Lo and liquid-disordered lipid domains. However, large-scale phase separation in GPMVs detected by light microscopy is observed only at low temperatures. Comparing Förster resonance energy transfer-detected versus light microscopy-detected domain formation, we found that nanodomains, domains of nanometer size, persist at temperatures up to 20°C higher than large-scale phases, up to physiologic temperature. The persistence of nanodomains at higher temperatures is consistent with previously reported theoretical calculations. To investigate the sensitivity of nanodomains to lipid composition, GPMVs were prepared from mammalian cells in which sterol, phospholipid, or sphingolipid composition in the plasma membrane outer leaflet had been altered by cyclodextrin-catalyzed lipid exchange. Lipid substitutions that stabilize or destabilize ordered domain formation in artificial lipid vesicles had a similar effect on the thermal stability of nanodomains and large-scale phase separation in GPMVs, with nanodomains persisting at higher temperatures than large-scale phases for a wide range of lipid compositions. This indicates that it is likely that plasma membrane nanodomains can form under physiologic conditions more readily than large-scale phase separation. We also conclude that membrane lipid substitutions carried out in intact cells are able to modulate the propensity of plasma membranes to form ordered domains. This implies lipid substitutions can be used to alter biological processes dependent upon ordered domains.