Dior ha lanzado, junto a la casa de porcelana Bernardaud, tres portavelas elaborados a mano. Leer

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It's not too late to decorate your porch for Halloween...this quick and easy Halloween pumpkin diorama will make a great weekend project!

Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks  Nature.com

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Having a facial in a department store might not sound the most relaxing experience. However, once the door slides shut on Dior’s private spa room in Debenhams’ flagship store in intu Watford, it only takes a moment to tune out the voices from outside and tap into your inner zen.

Dr. Ifediora has been endorsed by Marquis Who's Who as a leader in the nephrology field

A diorganomagnesium-containing synthesis means, a method for its preparation and its use.

Plugin Boutique has launched an exclusive sale on the TS-1 plugin Audiority, offering 77% off on the multimode frequency dependent transient shaper designed to manage the attack and sustain of an incoming audio signal. TS-1 features a “Compression by Saturation” concept to add warmth and punch to your drum tracks without losing dynamics. TS-1 features […]

The post TS-1 multi-mode transient shaper by Audiority on sale for $9.99 USD appeared first on rekkerd.org.

Plugin Boutique has launched a sale on the Scattered Grains sound library by Audiority, offering 50% off on the collection of 100 Omnisphere presets for ambient, film, soundtrack and underscore music. Scattered Grains explores exotic techniques to create ambiences, soundscapes and textures combining high speed arpeggios, reverbs and the new InnerSpace effect. All presets can […]

The post Scattered Grains for Omnisphere by Audiority on sale for $15 USD appeared first on rekkerd.org.

Hermes India had recorded a net profit of Rs 12.1 crore the year before. Revenue from operations rose 11% from the previous year’s Rs 98.8 crore on a standalone basis, according to its filings with the Registrar of Companies (RoC).

In the end Mines Rovers were too good for Railways, securing their 42nd Goldfields Football League flag with a thumping 64-point win.

Ordior Has Signed Patrick Mathias Aka Password For A World Wide Exclusive Publishing And Administration Agreement!

Ordior Has Signed BlackFaceNaija For A World Wide Exclusive Publishing And Administration Agreement!

Ordior Has Signed African China For A World Wide Exclusive Publishing And Administration Agreement!

You Read That Right, The Classic Hits From DJ Central Season 1 Are Now Available On Amazon Prime For Your Viewing Pleasure, And Season 6 Is In Production!

Ordior Has Signed Patrick Mathias Aka Password For A World Wide Exclusive Publishing And Administration Agreement!

Ordior Has Signed BlackFaceNaija For A World Wide Exclusive Publishing And Administration Agreement!

Edmund Cotter Has Been Working With The DJ Central, Ordior, And Blue Pie Teams For Over A Year Now, And It’s Time To Give Him An Official Warm Welcome!

, As Of 1st July 2019, The Ordior Royalty Vault Administration And Rights Management System Has Now Completed Processing And Management Of Over 600,000,000 Streams And Downloads!

VOLUME 292 (2017) PAGES 3531–3540This article has been withdrawn by Shuofeng Hu, Xiaomin Ying, Xiangming Zhang, and Ya Wang. Baocheng Hu, Xiang Wang, Ping Wang, Jian Wang, and Hongyan Wang could not be reached. In Fig. 1C, the DAPI and merged images for the no IR control were switched. The DNA-PKcs and actin immunoblots on the left appear to have been spliced. In Fig. 4C, the DNA-PKcs immunoblot appears to have been spliced. In Fig. 4D, lanes 1 and 5; lanes 2, 6, and 8; and lanes 3 and 7 of the DNA-PKcs immunoblot are the same. In the p-DNA-PKcs immunoblot, lanes 1 and 8, lanes 2 and 6, and lanes 3 and 7 are the same. In the CRY2 immunoblot, lanes 5 and 7 are the same. In the CDC25A immunoblot, lanes 3 and 8 are the same. In the GSK3B immunoblot, lanes 1 and 5 and lanes 3 and 7 are the same. Also in the GSK3B immunoblot, the upper GSK3B bands in lanes 6 and 8 are the same. Lanes 4 and 8 of the cyclin D1 immunoblot are the same. In Fig. 5A, the CDC25A immunoblot appears to have been spliced. Also in Fig. 5A, lanes 2–4 and lanes 6–8 of the CDC25A immunoblot are the same. Lanes 4–6 and 7–9 of the actin immunoblot are the same. In Fig. 5C, lane 1 of the CDC25A immunoblot was reused in lane 5, and lanes 3 and 4 were reused in lanes 7 and 8. In the...

The molecular mechanisms underlying exceptional radioresistance in pancreatic cancer remain elusive. In the present study, we established a stable radioresistant pancreatic cancer cell line MIA PaCa-2-R by exposing the parental MIA PaCa-2 cells to fractionated ionizing radiation (IR). Systematic proteomics and bioinformatics analysis of protein expression in MIA PaCa-2 and MIA PaCa-2-R cells revealed that several growth factor-/cytokine-mediated pathways, including the OSM/STAT3, PI3K/AKT, and MAPK/ERK pathways, were activated in the radioresistant cells, leading to inhibition of apoptosis and increased epithelial-mesenchymal plasticity. In addition, the radioresistant cells exhibited enhanced capabilities of DNA repair and antioxidant defense compared with the parental cells. We focused functional analysis on one of the most up-regulated proteins in the radioresistant cells, ecto-5'-nucleotidase (CD73), which is a cell surface protein that is overexpressed in different types of cancer. Ectopic overexpression of CD73 in the parental cells resulted in radioresistance and conferred resistance to IR-induced apoptosis. Knockdown of CD73 re-sensitized the radioresistant cells to IR and IR-induced apoptosis. The effect of CD73 on radioresistance and apoptosis is independent of the enzymatic activity of CD73. Further studies demonstrate that CD73 up-regulation promotes Ser-136 phosphorylation of the proapoptotic protein BAD and is required for maintaining the radioresistant cells in a mesenchymal state. Our findings suggest that expression alterations in the IR-selected pancreatic cancer cells result in hyperactivation of the growth factor/cytokine signaling that promotes epithelial-mesenchymal plasticity and enhancement of DNA repair. Our results also suggest that CD73, potentially a novel downstream factor of the enhanced growth factor/cytokine signaling, confers acquired radioresistance by inactivating proapoptotic protein BAD via phosphorylation of BAD at Ser-136 and by maintaining the radioresistant pancreatic cancer cells in a mesenchymal state.

Sunder Mudaliar
Jul 1, 2016; 39:1115-1122
Diabetes Care Symposium

OBJECTIVE

We examined detailed renal and cardiovascular (CV) outcomes after gastric bypass (GBP) surgery in people with obesity and type 2 diabetes mellitus (T2DM), across several renal function categories, in a nationwide cohort study.

Obesity is associated with cardiometabolic risk factors and chronic conditions, such as type 2 diabetes. However, a proportion of overweight and obese youth remain free from cardiometabolic risk factors and are considered metabolically healthy.

This study provides insight into the determinants of cardiometabolic risk factors and the concept in health promotion of "fitness versus fatness." Hepatic lipid accumulation and not fitness level appears to drive cardiometabolic risk factor clustering among overweight and obese youth. (Read the full article)

Online beauty retailer Escentual has analysed sales figures to reveal the top ten male scents for Christmas 2019, and retro fragrances released in the '90s and noughties dominate the list.

The Oscar-winning actress, 28, displayed her huge ring as she arrived at the Dior autumn-winter Paris Fashion Week presentation at Musée Rodin in the French capital on Tuesday afternoon.

The fashionista, 45, arrived in style at the Dior Homme Menswear Fall/Winter 2020-2021 show, which was held as part of Paris Fashion Week in the French capital on Friday.

The wife of Justin Bieber, 23, joined supermodels Gigi Hadid and Cara Delevingne at the star-studded runway event.

The Anti-artist, 31, looked lovely wearing a complete look from the French fashion house for dinner at Giorgio Baldi in Santa Monica. Rihanna slipped into a Dior monogram-patterned dress.

Lady Gaga attended the Screen Actors Guild Awards this Sunday in a cleavage-baring Dior gown fresh off the catwalk. The haute couture dress debuted at the brand's Paris show Monday.

The actress, 29, was joined by American supermodel Karlie Kloss as she arrived to sit front row at the fashion show in France on Tuesday.

Julianne Moore and Jennifer Lawrence enjoyed a sweet reunion on the front row of the Dior Paris Fashion Week show on Tuesday.

I arrive at the V&A for the Dior exhibition with news ringing in my ears that the Duchesses of Cambridge and Sussex employ staff to regulate the abuse aimed at them on social media.

The actress, who won the Best Actress in a Drama Series prize for The Morning Show, revealed the gorgeous white silk dress she wore was actually from her own closet.

Jennifer Aniston looked like a knockout on the red carpet of the SAG Awards.

The 28-year-old rocked a pair of Dior x Air Jordan 1s, which don't become available until next year. Scott has the hookup with Nike, having released several of his own collabs, including his AJ1s.

The Morning Show star, 50, looked radiant in a black Dior gown as her team helped put the finishing touches to her stylish custom couture look on Monday.

Man who died of cardiorespiratory arrest tests +ve