Liquid biopsies have emerged as a powerful tool in modern medicine, enabling non-invasive detection and monitoring of diseases such as cancer. At the foref

RUTHERFORD, N.J., Dec. 5, 2023 — Intelligent Light has announced it has been selected by AFWERX for a Direct-to-Phase II contract in the amount of $1.15 Million focused on IntelliTwin […]

The post AFWERX Selects IntelliTwin as the Realizable Digital Thread for HPC-scale CFD appeared first on HPCwire.

In this edition of the Women in CFD series, we feature Vassiliki Moschou, aka Vicky, senior supervisor at BETA CAE, now part of Cadence. Her career journey serves as an inspiration for anyone who believes that studying in one field and working in another is less desirable. Vicky demonstrates how knowledge gained in one discipline can be effectively applied in another, often providing fresh and intriguing insights. Join us in this conversation to learn more about Vicky, her career path, and her advice for those considering a career in a field different from their studies. Tell us something about yourself. I've lived all my 41 years in the vibrant city of Thessaloniki, Greece. I’m married to my high school sweetheart, and together we're raising two incredible daughters who are 11 and almost 8 years old. These girls are absolutely the center of my world, and every day with them feels like a gift. My entire life, including where I have built my career and family, is deeply rooted in Thessaloniki. It's not just where I am from; it's a big part of who I am. Could you share your educational background and how you first became interested in computational fluid dynamics (CFD)? In 2001, I started my academic journey at the Computer Science Department of Aristotle University of Thessaloniki , where I focused on studying signal processing and artificial intelligence. This field fascinated me, and I pursued a master’s degree in the same area to further my expertise. Concurrently, I was involved in European research programs on signal/audio processing and machine learning methodologies. It became evident early on that my career would revolve around software engineering, a path I was fully prepared to pursue. However, everything took a turn when I joined BETA CAE in 2008. It was there that I was introduced to the field of CFD, which was completely unfamiliar to me at the time. This presented a new challenge that I eagerly accepted. I received support from all my colleagues, but I was primarily mentored by two brilliant and dedicated engineers, Michael Giannakidis and Vangelis Skaperdas , who introduced me to the world of CFD. Over time, what was once an unknown territory for me has become my passion. My journey through CFD has been a significant part of my professional growth. In my 30s, I pursued and completed a PhD in systems physiology in collaboration with the Medical and Computer Science Departments of Aristotle University of Thessaloniki. Our research focused on examining the EGF-activated MAPK pathway (often associated with cancer) from the perspective of complex self-organizing systems. Using graph theory, signal processing, and machine learning, we extracted information from the signals observed in this dynamic, distributed biological system to target novel drug development. What are the different positions you have held within the company, and what responsibilities do you currently hold? I started my career as a junior engineer at BETA CAE (now Cadence). It was a role that plunged me deep into the fascinating worlds of software and CFD, a crucial time of my career filled with learning and growth. My hard work and dedication didn't go unnoticed, and after a few years, I was promoted. That promotion was the first step on a career ladder that I've been ascending ever since. Now, I'm in the position of a senior supervisor. Though my job now involves a wide range of managerial tasks, I'm still deeply passionate about the technical side of things. I love writing code and working through the complexities of our projects, merging my leadership responsibilities with my enthusiasm for the technical facets of our work. What would you be doing if not working in CFD? Had my career taken a different trajectory, I envision myself in a role deeply embedded in human connections—perhaps as the owner of a quaint bakery or a cozy hotel, a teacher, or even venturing into human resources. There's a certain allure in careers that foster direct engagement with people, creating experiences and memories. In fact, I have an inherent desire to connect and communicate with people, aspects that are fundamentally different yet equally fulfilling as my current career. What are some of your favorite pastimes and hobbies? Family is at the center of my leisure time. We love taking short trips to the village, hanging out with our friends, and connecting. Our activities range from solving puzzles in escape rooms to passionately cheering at basketball games, especially since my older daughter has taken up the sport. But beyond these activities, being a mother is my most cherished pastime. The moments I share with my daughters, the lessons we learn together, and the joy we find in everyday adventures are what I hold dear. What are your thoughts on women in technical fields? The landscape for women in technical fields is gradually transforming, a change I observe with optimism and hope. In Greece, the increasing presence of women in engineering is a positive sign. In Cadence specifically, the representation of women is high compared to other tech companies. As a mother to two daughters, I am acutely aware of the importance of being a role model to them. It's crucial to demonstrate that aspirations should not be limited by gender and that the technical field is as much a place for women as it is for men. Encouraging this mindset is vital for the progress of our society and for the empowerment of the next generation of women in technology. Advice from Vicky for those considering a career in a field different from their studies: Learning is a lifelong journey. Embrace every challenge as an opportunity to grow and learn something new. Stay curious and adaptable to navigate the ever-evolving landscape of technology. Being labeled an 'expert' is less important than the willingness to learn and adapt. Finding happiness in your work can lead to natural success. In the epoch of artificial intelligence, train the most powerful neural network: your brain. At Cadence, our commitment is towards establishing an inclusive workspace where women feel empowered to achieve their professional best. Anchored by our One Cadence—One Team ethos, we take pride in fostering a community where our driven, devoted, and skilled women employees excel, making exceptional contributions to our customers, communities, and one another. Are you just like Vicky, venturing beyond your academic background, and considering a career in a different domain while being surrounded by an encouraging and uplifting atmosphere? Then, you won't want to miss exploring career opportunities at Cadence—celebrated as 'A Great Place for Women to Work'! Click the button below to discover your next adventure! Learn more about Cadence Fem.AI Alliance, which aims to lead the gender equity revolution in the AI workforce.

2. The Informant in the present case had floated a Tender No. A/59919/Shirt Khakhi/DGOS/OS-PII/Proc Sec, dated 19.06.2017 for procurement of 1,38,251 Shirt Man's Cellular Cotton 1973 Pattern (Modified) Khaki ("Item"). The Informant has stated that out of 14 firms which participated, only 09 qualified for the opening of their commercial bids.

3. The Informant has averred that Commercial Negotiation Committee ('CNC') observed that the rates may have been quoted after collusion by the said four firms (Opposite Parties). As submitted by the Informant, details of the bid are reproduced in the table below:

Table 1: Details of Bidders S. No Firm Name Rate (in Rs) Status

The transmembrane intracellular lectin ER–Golgi intermediate compartment protein 53 (ERGIC-53) and the soluble EF-hand multiple coagulation factor deficiency protein 2 (MCFD2) form a complex that functions as a cargo receptor, trafficking various glycoproteins between the endoplasmic reticulum (ER) and the Golgi apparatus. It has been demonstrated that the carbohydrate-recognition domain (CRD) of ERGIC-53 (ERGIC-53CRD) interacts with N-linked glycans on cargo glycoproteins, whereas MCFD2 recognizes polypeptide segments of cargo glycoproteins. Crystal structures of ERGIC-53CRD complexed with MCFD2 and mannosyl oligosaccharides have revealed protein–protein and protein–sugar binding modes. In contrast, the polypeptide-recognition mechanism of MCFD2 remains largely unknown. Here, a 1.60 Å resolution crystal structure of the ERGIC-53CRD–MCFD2 complex is reported, along with three other crystal forms. Comparison of these structures with those previously reported reveal that MCFD2, but not ERGIC-53–CRD, exhibits significant conformational plasticity that may be relevant to its accommodation of various polypeptide ligands.

This article reports conformational polymorphisms of the EF-hand protein MCFD2 which is involved in glycoprotein transport..

UK GOVERNMENT RECOGNISES ROUTE TO MARKET CHALLENGES AND SHOWS SIGNIFICANT SHIFT IN APPROACH FOR UK RENEWABLES On 2 March 2020, the UK Department for Business, Energy and Industrial Strategy (BEIS) published a consultation on the Contracts for Differ...

Anthony served body last week in a sexy Maleficent costume at her annual Halloween party. She wore the classic horns and wings with a black lace catsuit, revealing her sexy lingerie underneath.

Gigi and Bella Hadid led the fashion stars at the 2019 CFDA/Vogue Fashion Fund Awards. Gigi was clad in a sheer olive dress while Bella wore a black velvet suits with faux piercings.

Barker Library - TA357.B273 2014

Barker Library - TA357.J384 2015

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