Mevalonate kinase is central to the isoprenoid biosynthesis pathway. Here, high-resolution X-ray crystal structures of two mevalonate kinases are presented: a eukaryotic protein from Ramazzottius varieornatus and an archaeal protein from Methanococcoides burtonii. Both enzymes possess the highly conserved motifs of the GHMP enzyme superfamily, with notable differences between the two enzymes in the N-terminal part of the structures. Biochemical characterization of the two enzymes revealed major differences in their sensitivity to geranyl pyrophosphate and farnesyl pyrophosphate, and in their thermal stabilities. This work adds to the understanding of the structural basis of enzyme inhibition and thermostability in mevalonate kinases.

Joe Marler discussed his recent comments about the Haka, which sparked backlash.

Rangers have been criticised by Celtic fan Sir Rod Stewart but Gers great Ally McCoist has hit back at the music legend.

RANGERS legend Ally McCoist has hailed sub Kyle Lafferty after the stunning win over St Johnstone.

Argyll McCoist, 20, (pictured) was uninsured when he ran a red light and hit 21-year-old Stephen Murdoch in his £20,000 Audi in Bishopton, Renfrewshire, before driving off.