autos

Auto setup remote branch with push.autoSetupRemote | by Anjusha Khandavalli | Medium




autos

HolidayAutos

Holiday Autos Cheap Holiday Car Rental




autos

Gibson Agency Group of Huntsville, Alabama is an Independent Insurance Group Providing Property and Casuality Insurance for Autos, Homes, Life and Business in the Greater Huntsville Area

Local independent insurance group has expanded coverage all over the State of Alabama and Tennessee




autos

Jordan Anderson Racing Bommarito Autosport Partners with Alsco Uniforms

Utah-based company signs multi-race agreement with Jeb Burton and the #27 team




autos

AutoSpares – Free WP Theme for Autos/Cars related Blogs

A perfect WP theme with  Unique and modern style, having the classic combination of white, silver, navy blue and orange. XHTML 1.0 Transitional Adsense Ready A lot of advertising spots 125×125 Admin CMS Options   DOWNLOAD | PREVIEW    





autos

MEXICÁNICOS llega a Discovery en Español con los diseños más sorprendentes de hot rods y limusinas - Conoce al legendario restaurador y mecánico Martín Vaca quien construye autos [..]

Conoce al legendario restaurador y mecánico Martín Vaca quien construye autos fuera de serie desde hace más de 50 años. MEXICÁNICOS, estreno el 2 de marzo a las 10PM




autos

AutoSave with VSCode

Visual Studio Code has taken the crown of most used text editor, at least in JavaScript spheres. VSCode is fast, feature-filled, and supports thousands of plugins to boost productivity. Developers can also tweak hundreds of settings to enrich functionality. One such feature is the autoSave feature. To autoSave files with VS Code, you can add […]

The post AutoSave with VSCode appeared first on David Walsh Blog.




autos

Autoshock

The transition to electric vehicles cannot be rushed into without a master plan involving all stakeholders




autos

Of autos, meters and fare play




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Market LIVE: Sensex ends 232 pts up, Nifty Bank rises over 750 pts from day’s low; autos, financial stocks gain

Share Market News Today | Sensex, Nifty, Share Prices LIVE: As many as 21 stocks out 30 Sensex scrips finished trade in positive territory with M&M as the top gainer, up 5.27 per cent, followed by Bajaj Finance, HDFC Bank and ICICI Bank.





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Customized Reminders Help Drive Additional Business, AutoShop Express Says

Auto repair shop owners need to find ways to keep customers coming back in the face of potential economic uncertainty, according to distributor.




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Shift Up Now and HQ Autosport Combine To Field A CoEd Team for 2019 25 Hours of Thunderhill

Teams to field a CoEd team of three female drivers and males.




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AutoSOS: Towards Multi-UAV Systems Supporting Maritime Search and Rescue with Lightweight AI and Edge Computing. (arXiv:2005.03409v1 [cs.RO])

Rescue vessels are the main actors in maritime safety and rescue operations. At the same time, aerial drones bring a significant advantage into this scenario. This paper presents the research directions of the AutoSOS project, where we work in the development of an autonomous multi-robot search and rescue assistance platform capable of sensor fusion and object detection in embedded devices using novel lightweight AI models. The platform is meant to perform reconnaissance missions for initial assessment of the environment using novel adaptive deep learning algorithms that efficiently use the available sensors and computational resources on drones and rescue vessel. When drones find potential objects, they will send their sensor data to the vessel to verity the findings with increased accuracy. The actual rescue and treatment operation are left as the responsibility of the rescue personnel. The drones will autonomously reconfigure their spatial distribution to enable multi-hop communication, when a direct connection between a drone transmitting information and the vessel is unavailable.




autos

BACKLIGHT UNIT AND AUTOSTEREOSCOPIC 3D DISPLAY DEVICE INCLUDING THE SAME

Discussed are a backlight unit and an autostereoscopic 3D (three-dimensional) display device including the same, in which a 3D image can be displayed without using a 3D light controller that includes a liquid crystal layer. The backlight unit may include a 3D light guide plate having first light output patterns, first light sources irradiating light to at least one side of the 3D light guide plate, a 2D (two-dimensional) light guide plate arranged below the 3D light guide plate, and second light sources irradiating light to at least one side of the 2D light guide plate. The first light output patterns are a plurality of line prism patterns spaced apart from each other.




autos

Verschenkt die Autos und gebt noch 1000 Euro dazu!

Abwrackprämien und Rabattaktionen haben der Wirtschaft nie geholfen, mitunter sogar geschadet, meint unser Autor. Er hat eine bessere Idee, wie wir die Hunderttausenden unverkauften Neuwagen loswerden – sozial gerecht und ökonomisch vernünftig.




autos

Haaveiletko matkailuautosta? – Kiinnitä huomiota näihin 8 asiaan | Paikalliset | Helsingin Uutiset




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Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease

Background

The inactivation of the ciliary proteins polycystin 1 or polycystin 2 leads to autosomal dominant polycystic kidney disease (ADPKD). Although signaling by primary cilia and interstitial inflammation both play a critical role in the disease, the reciprocal interactions between immune and tubular cells are not well characterized. The transcription factor STAT3, a component of the cilia proteome that is involved in crosstalk between immune and nonimmune cells in various tissues, has been suggested as a factor fueling ADPKD progression.

Method

To explore how STAT3 intersects with cilia signaling, renal inflammation, and cyst growth, we used conditional murine models involving postdevelopmental ablation of Pkd1, Stat3, and cilia, as well as cultures of cilia-deficient or STAT3-deficient tubular cell lines.

Results

Our findings indicate that, although primary cilia directly modulate STAT3 activation in vitro, the bulk of STAT3 activation in polycystic kidneys occurs through an indirect mechanism in which primary cilia trigger macrophage recruitment to the kidney, which in turn promotes Stat3 activation. Surprisingly, although inactivating Stat3 in Pkd1-deficient tubules slightly reduced cyst burden, it resulted in a massive infiltration of the cystic kidneys by macrophages and T cells, precluding any improvement of kidney function. We also found that Stat3 inactivation led to increased expression of the inflammatory chemokines CCL5 and CXCL10 in polycystic kidneys and cultured tubular cells.

Conclusions

STAT3 appears to repress the expression of proinflammatory cytokines and restrict immune cell infiltration in ADPKD. Our findings suggest that STAT3 is not a critical driver of cyst growth in ADPKD but rather plays a major role in the crosstalk between immune and tubular cells that shapes disease expression.




autos

A Post Hoc Analysis of Statin Use in Tolvaptan Autosomal Dominant Polycystic Kidney Disease Pivotal Trials

Background and objectives

Tolvaptan is approved to slow kidney function decline in adults with autosomal dominant polycystic kidney disease (ADPKD) at risk of rapid progression. Because in vitro studies indicated that the tolvaptan oxobutyric acid metabolite inhibits organic anion–transporting polypeptide (OATP)1B1 and OATP1B3, United States prescribing information advises avoiding concurrent use with OATP1B1/1B3 substrates, including hepatic hydroxymethyl glutaryl–CoA reductase inhibitors (statins). This post hoc analysis of the pivotal phase 3 tolvaptan trials (Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes [TEMPO] 3:4 trial [NCT00428948] and Replicating Evidence of Preserved Renal Function: an Investigation of Tolvaptan Safety and Efficacy in ADPKD [REPRISE] trial [NCT02160145]) examined the safety of concurrent tolvaptan/statin use.

Design, setting, participants, & measurements

The trials randomized a combined total of 2815 subjects with early- to late-stage ADPKD to tolvaptan (n=1644) or placebo (n=1171) for 3 years (TEMPO 3:4) and 1 year (REPRISE). Statin use was unrestricted, and 597 subjects (21.2% overall; 332 [20.2%] tolvaptan, 265 [22.6%] placebo) received statins. Statin use (duration, dose change, statin change, permanent discontinuation), incidences of statin-related adverse events, and hepatic transaminase elevations were determined for subjects who received tolvaptan+statin, placebo+statin, tolvaptan alone, and placebo alone.

Results

No differences in statin use parameters between tolvaptan- and placebo-treated subjects were observed. No statistically significant increases in commonly reported statin-related adverse events (e.g., musculoskeletal disorders, gastrointestinal symptoms) were seen between subjects receiving tolvaptan+statin and placebo+statin. For example, in TEMPO 3:4, frequencies were 5.4% and 7.8%, respectively, for myalgia (difference –2.4%; 95% confidence interval, –11.2% to 6.4%) and 9.3% and 7.8%, respectively, for abdominal pain (difference 1.5%; –7.9% to 10.9%). In an analysis that excluded participants concurrently using allopurinol, the frequency of alanine transaminase or aspartate transaminase >3x upper limit of normal in the pooled study populations was 3.6% for the tolvaptan+statin group and 2.3% for the placebo+statin group (difference 1.4%; –2.0% to 4.7%).

Conclusions

Tolvaptan has been used safely in combination with statins in clinical trials.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2020_04_06_CJN.08170719.mp3




autos

MEXICÁNICOS llega a Discovery en Español con los diseños más sorprendentes de hot rods y limusinas - Conoce al legendario restaurador y mecánico Martín Vaca quien construye autos [..]

Conoce al legendario restaurador y mecánico Martín Vaca quien construye autos fuera de serie desde hace más de 50 años. MEXICÁNICOS, estreno el 2 de marzo a las 10PM




autos

Second quarter will be 'worst point in time' for European autos, analyst says

Jurgen Pieper, senior advisor for automobiles at Metzler, discusses the impact of the coronavirus pandemic on the autos sector.




autos

United States Retail Sales Ex Autos MoM

Retail Sales Ex Autos in the United States decreased to -4.20 percent in March from -0.40 percent in February of 2020. Retail Sales Ex Autos in the United States averaged 0.34 percent from 1992 until 2020, reaching an all time high of 2.60 percent in December of 1999 and a record low of -4.20 percent in March of 2020. Retail Sales Ex Autos report in the US provides aggregated measure of sales of retail goods and services excluding the automobile sector over a period of a month. This page provides the latest reported value for - United States Retail Sales Ex Autos MoM - plus previous releases, historical high and low, short-term forecast and long-term prediction, economic calendar, survey consensus and news.




autos

e-autos for Kochi: union leaders, drivers meet experts online

Many of them created their first email ids to take part in event




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Field performance evaluation of Autosense II at Leesburg mainline toll plaza




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Field performance evaluation of autosense AXLE Counter at Leesburg mainline plaza




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Chd turns down demand to ply private cabs, autos

The UT administration has rejected requests of private taxi operators to allow them to operate in the city at a time when coronavirus has hit the business of web-based taxis and private tours and travellers. Following the guidelines of the ministry of home affairs (MHA), the administration has the representation made by private taxi operators, as cabs and private taxis are not allowed in the “red zone” — a label, according to the government, for a place having a high number of Covid-19 cases.