science and technology

Artificial intelligence performance in testing microfluidics for point-of-care

Lab Chip, 2024, 24,4998-5008
DOI: 10.1039/D4LC00671B, Paper
Open Access
Mert Tunca Doganay, Purbali Chakraborty, Sri Moukthika Bommakanti, Soujanya Jammalamadaka, Dheerendranath Battalapalli, Anant Madabhushi, Mohamed S. Draz
AI is revolutionizing medicine by enhancing diagnostics and patient care. Our study showed ML and DL AI models excel in microchip testing, underscoring AI's potential to improve precision medicine and POC diagnostics.
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science and technology

Dynamic sampling from ex vivo adipose tissue using droplet-based microfluidics supports separate mechanisms for glycerol and fatty acid secretion

Lab Chip, 2024, 24,5020-5031
DOI: 10.1039/D4LC00664J, Paper
Md Moniruzzaman, Andresa B. Bezerra, Md Mohibullah, Robert L. Judd, James G. Granneman, Christopher J. Easley
Droplet-based microfluidic sampling of adipose tissue reveals unique information on lipolytic dynamics.
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science and technology

Inertial co-focusing of heterogeneous particles in hybrid microfluidic channels with constantly variable cross-sections

Lab Chip, 2024, 24,5032-5042
DOI: 10.1039/D4LC00479E, Paper
Tianwei Zhao, Peng Zeng, Yuanting Zhang, Jinxia Li, Hui Sun, Imrich Gablech, Honglong Chang, Xichen Yuan, Pavel Neužil, Jianguo Feng
Inertial focusing chips based on hybrid microfluidic channels were presented for high-efficiency heterogeneous particle co-focusing, offering significant applications in microfluidic flow cytometry and single-cell analysis.
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science and technology

Microfluidic antisolvent crystallization for chiral symmetry breaking

Lab Chip, 2024, 24,5055-5064
DOI: 10.1039/D4LC00658E, Paper
Jiye Jang, Gerard Coquerel, Tae Seok Seo, Woo-Sik Kim, Bum Jun Park
Microfluidic antisolvent crystallization was used to study the effect of solution volume on chiral symmetry breaking (CSB) in NaClO3 crystals. 100% CSB occurs below a critical emulsion volume due to rapid molecule depletion and suppressed nucleation.
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science and technology

Surface modification of paper-based microfluidic devices via initiated chemical vapor deposition

Lab Chip, 2024, 24,4940-4947
DOI: 10.1039/D4LC00414K, Tutorial Review
Stacey Bacheller, Malancha Gupta
Paper-based microfluidic devices offer a low-cost platform for biological and environmental detection. This tutorial review shows that initiated chemical vapor deposition can be used to modify these devices with functional polymers.
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science and technology

Exploring cancer-associated fibroblast-induced resistance to tyrosine kinase inhibitors in hepatoma cells using a liver-on-a-chip model

Lab Chip, 2024, 24,5043-5054
DOI: 10.1039/D4LC00624K, Paper
Madhu Shree Poddar, Yu-De Chu, Gaurav Pendharkar, Cheng-Hsien Liu, Chau-Ting Yeh
3D liver-on-a-chip reveals AHSG and CLEC3B to mediate cancer-associated fibroblast-induced resistance to TKIs in hepatoma cells.
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science and technology

Rapid low-cost assembly of modular microvessel-on-a-chip with benchtop xurography

Lab Chip, 2024, 24,5065-5076
DOI: 10.1039/D4LC00565A, Paper
Open Access
Shashwat S. Agarwal, Marcos Cortes-Medina, Jacob C. Holter, Alex Avendano, Joseph W. Tinapple, Joseph M. Barlage, Miles M. Menyhert, Lotanna M. Onua, Jonathan W. Song
Our study is a novel implementation of xurography for multi-layer microfluidic device fabrication. We demonstrate the versatility of this approach by presenting several modular 3D vessel-matrix arrangements.
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science and technology

Compact lens-free imager using a thin-film transistor for long-term quantitative monitoring of stem cell culture and cardiomyocyte production

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00528G, Paper
Open Access
Taishi Kakizuka, Tohru Natsume, Takeharu Nagai
A novel compact lens-free imager achieved high-throughput long-term monitoring within an incubator, demonstrating the quantification of the confluency of human iPS cells, epithelial-to-mesenchymal transition, and cardiomyocyte beating dynamics.
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science and technology

Applying Low Levels of Strain to Model Nascent Phenomenon of Retinal Pathologies

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00205A, Paper
Chase Paterson, Elizabeth Vargis
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly. A better understanding of the mechanisms of the disease, especially at early stages, could elucidate new...
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science and technology

A nanofluidic exchanger for harvesting saline gradient energy

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00544A, Paper
Saranath Sripriya, Cyril Picard, Vincent Larrey, Frank Fournel, Elisabeth Charlaix
Optimising, by tailored flows, the coupled ion transport in the proximity of selective nanopores multiplies by 300 the recovered osmotic power.
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science and technology

A microfluidic hanging droplet as a programmable platform for mammalian egg vitrification

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00428K, Paper
Open Access
Haidong Feng, Georgios Katsikis, India D. Napier, Gong Du, Josh Lim, Joseph O. Doyle, Scott R. Manalis, Linda G. Griffith
Programmable microfluidic hanging drop system for motorized, contactless cryoprotectant loading and egg vitrification.
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science and technology

Zonal patterning of extracellular matrix and stromal cell populations along a perfusable cellular microchannel

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00579A, Paper
Open Access
Brea Chernokal, Bryan J. Ferrick, Jason P. Gleghorn
Developed a system to regionally pattern stromal cell populations and hydrogel properties along the length of a perfused epithelial tube. This enables the dissection of specific microenvironmental factors that govern developmental tissue patterning.
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science and technology

Self-actuated microfluidic chiplet for two-stage multiplex nucleic acid amplification assay

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00752B, Paper
Open Access
Felix Ansah, Marziyeh Hajialyani, Fatemeh Ahmadi, Yuming Gu, Ergün Alperay Tarım, Michael G. Mauk, Gordon A. Awandare, Haim H. Bau
Self-actuated chiplet for Penn-RAMP assay.
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science and technology

Correction: Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90093F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Madhu Shree Poddar, Yu-De Chu, Chau-Ting Yeh, Cheng-Hsien Liu
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science and technology

A gravity-driven tissue chip to study the efficacy and toxicity of cancer therapeutics

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00404C, Paper
Open Access
Pouria Rafsanjani Nejad, Astha Lamichhane, Prasiddha Guragain, Gary Luker, Hossein Tavana
A 96-well plate format, fully-automated multi-organ tissue chip array with gravity-driven flow for cancer research.
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science and technology

5-axis CNC micro-milling machine for three-dimensional microfluidics

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00496E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mitchell Modarelli, Devin Kot-Thompson, Kazunori Hoshino
The gold standard of microfluidic fabrication techniques, SU-8 patterning, requires photolithography equipment and facilities and is not suitable for 3D microfluidics. A 3D printer is more convenient and may achieve...
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science and technology

3D-printed microfluidic–microwave device for droplet network formation and characterisation

Lab Chip, 2024, 24,5101-5112
DOI: 10.1039/D4LC00387J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kai Silver, Jin Li, Adrian Porch, William David Jamieson, Oliver Castell, Pantelitsa Dimitriou, Colin Kallnik, David Barrow
A 3D-printed microwave–microfluidic device using a liquid metal resonator for droplet network formation and characterisation.
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science and technology

Effect of base methylation on binding and mobility of bacterial protein Hfq on double-stranded DNA

Lab Chip, 2024, 24,5137-5144
DOI: 10.1039/D4LC00628C, Paper
Jijo Easo George, Rajib Basak, Indresh Yadav, Chuan Jie Tan, Jeroen A. van Kan, Frank Wien, Véronique Arluison, Johan R. C. van der Maarel
Using nanofluidics to probe protein mobility on DNA reveals how DNA base methylation impacts protein–DNA interactions.
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science and technology

Real-time monitoring of a 3D blood–brain barrier model maturation and integrity with a sensorized microfluidic device

Lab Chip, 2024, 24,5085-5100
DOI: 10.1039/D4LC00633J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Ceccarelli, Marie Celine Lefevre, Attilio Marino, Francesca Pignatelli, Katarzyna Krukiewicz, Matteo Battaglini, Gianni Ciofani
A new in vitro sensorized model of the blood–brain barrier has been developed and characterized.
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science and technology

Acoustic enrichment of sperm for in vitro fertilization

Lab Chip, 2024, 24,5113-5123
DOI: 10.1039/D4LC00604F, Paper
Open Access
Chunqiu Zhang, Ning Rong, Ziyi Lin, Peng-Qi Li, Jingyao Shi, Wei Zhou, Lili Niu, Fei Li, Rongxin Tang, Lei Li, Long Meng
This study introduces an acoustofluidic device that leverages acoustic streaming to efficiently accumulate sperm. Importantly, ultrasound significantly improves sperm motility, increases fertilization rates and accelerates multicellular development.
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science and technology

Real-time impedance-activated dielectrophoretic actuation for reconfigurable manipulation of single flowing particles

Lab Chip, 2024, 24,5145-5154
DOI: 10.1039/D4LC00622D, Paper
Alexis Lefevre, Cristian Brandi, Adele De Ninno, Filippo Ruggiero, Enrico Verona, Michaël Gauthier, Paolo Bisegna, Aude Bolopion, Federica Caselli
We present an original all-electrical platform that combines MIC-sensing and DEP-actuation for precise and selective trajectory control of single flowing particles.
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science and technology

Integrated device for plasma separation and nucleic acid extraction from whole blood toward point-of-care detection of bloodborne pathogens

Lab Chip, 2024, 24,5124-5136
DOI: 10.1039/D4LC00571F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Abigail G. Ayers, Christia M. Victoriano, Samuel K. Sia
This work presents PRECISE, a device that integrates plasma separation and nucleic acid extraction, enabling streamlined sample preparation of whole blood for point-of-care diagnostics without external equipment or electricity.
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science and technology

Impact of microchannel width on axons for brain-on-chip applications

Lab Chip, 2024, 24,5155-5166
DOI: 10.1039/D4LC00440J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katarina Vulić, Giulia Amos, Tobias Ruff, Revan Kasm, Stephan J. Ihle, Joël Küchler, János Vörös, Sean Weaver
Axon growth is influenced by the width and number of microchannels, with growth cone adaptability reaching its limit for constraints smaller than 350 nm. Tradeoffs between axon growth and control need to be made for neurofluidic devices.
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science and technology

Optical tweezer-assisted cell pairing and fusion for somatic cell nuclear transfer within an open microchannel

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00561A, Paper
Yidi Zhang, Han Zhao, Zhenlin Chen, Zhen Liu, Hanjin Huang, Yun Qu, Yaowei Liu, Mingzhu Sun, Dong Sun, Xin Zhao
We developed a somatic cell nuclear transfer-electrofusion system for pairing and fusing oocytes and somatic cells with a thousand-fold volume difference. The system showed a 90.56% pairing efficiency, potentially boosting batch cloning efficiency.
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science and technology

Dual-drive acoustic micromixer for rapid nucleation and ultrafast growth of perovskite nanoparticles

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00721B, Paper
Zhifang Liu, Yuwen Lu, Wei Tan, Guorui Zhu
An acoustic micromixer driven by bubbles and sharp edges, controlling the nucleation and growth of perovskite nanoparticles.
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science and technology

Observing root growth and signalling responses to stress gradients and pathogens using the bi-directional dual-flow RootChip

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00659C, Paper
Open Access
Claudia Allan, Yiling Sun, Stephen C. Whisson, Michael Porter, Petra C. Boevink, Volker Nock, Claudia-Nicole Meisrimler
Using a bi-directional dual-flow RootChip with integrated force sensing micropillars, root growth and signalling responses to stress gradients and pathogens were studied in Arabidopsis thaliana, Nicotiana benthamiana and Solanum lycopersicum.
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science and technology

Discretised microfluidics for noninvasive health monitoring using sweat sensing

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00763H, Paper
Open Access
Emma J. M. Moonen, Walther Verberne, Eduard Pelssers, Jason Heikenfeld, Jaap M. J. den Toonder
We present the first wearable device with integrated electrowetting, which collects and transports sweat from single glands and measures sweat rate for extremely low sweat rate. This enables non-invasive biomarker monitoring of hospitalized patients.
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science and technology

An imaging scheme to study the flow dynamics of co-flow regimes in microfluidics: implications for nanoprecipitation

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00652F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wali Inam, Anton Vladyka, Joanna W. Pylvänäinen, Junel Solis, Dado Tokic, Pasi Kankaanpää, Hongbo Zhang
Herein, by presenting a novel imaging-based scheme for analyzing fluid interactions in co-flow regimes, we identify oscillatory and chaotic flow behaviors to optimize nanoprecipitation through controlled fluid manipulation.
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science and technology

Microstring-engineered tension tissues: a novel platform for replicating tissue mechanics and advancing mechanobiology

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00753K, Paper
Zixing Zhou, Tingting Li, Wei Cai, Xiaobin Zhu, Zuoqi Zhang, Guoyou Huang
A simple, cost-effective approach for fabricating soft microstring chips that enables precise engineering of tension tissues (METTs), advancing research in mechanobiology and biomedical applications.
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science and technology

SERS-based pump-free microfluidic chip sensor for highly sensitive competitive immunoassay of cortisol in human sweat

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00858H, Paper
Siyue Xiong, Chushu Zhu, Chengxuan Wang, Peitao Dong, Xuezhong Wu
Cortisol, known as the "stress hormone," is secreted by the adrenal cortex. Measuring cortisol levels in body fluids is essential for evaluating stress levels, adrenal function, hormone imbalances, and psychological...
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science and technology

How to identify hidden signs of your child's depression and how to go about it

This article will highlight common signs of depression in children and offer practical steps for parents to ensure their child gets the support needed to overcome these challenges.




science and technology

Monkeypox in India: 6 dos and don'ts that you must follow

By following these do's and don'ts, you can protect yourself and others from Mpox while maintaining your health and well-being.




science and technology

Navratri 2024: 5 fasting rules for diabetics to ensure stable blood sugar levels

Here are five essential fasting rules to help maintain stable blood sugar levels during Navratri 2024.




science and technology

PCOS and PCOD: What's the difference? Symptoms, causes, treatment, prevention

While you can't fully prevent PCOD or PCOS, early detection and healthy lifestyle choices can help manage symptoms.




science and technology

Ceiling prices of 8 common drugs raised by 50%, these medicines treat asthma, tuberculosis, others...

The National Pharmaceutical Pricing Authority (NPPA) has sanctioned the ceiling price hike for 11 formulations by 50 per cent in response to representations from drug makers.




science and technology

ModaXL 200 mg Review - Dosage, Interactions, Side Effects (Full Guide)

Want to order ModaXL 200 mg in 2024? Read this guide and learn more about the smart drug ModaXL. Safety, correct dosages, possible side effects, best places to buy the nootropic and much more in this helpful review.




science and technology

Karwa Chauth 2024: 5 fasting tips for women with diabetes

Here are five fasting tips to help them manage diabetes effectively during Karwa Chauth 2024.




science and technology

Delhi pollution: Tips to protect your lungs as AQI levels rise

Here are some essential tips to help protect your lungs during this pollution surge.




science and technology

Fake or real paneer: How to check its purity at home?

While officials are trying to stop fake paneer from reaching consumers, you can also check for purity at home with these easy tests.




science and technology

Diwali 2024: 5 must try sugar-free recipes for diabetics this Diwali

This Diwali, try these five delectable sugar-free recipes tailored for diabetics that allow you to enjoy the festival guilt-free!




science and technology

'I have not worked out': This is how Vidya Balan achieved drastic weight loss without exercising

Despite numerous diets and rigorous workouts, she frequently found that the weight would return.




science and technology

What is Seasonal Affective Disorder? Why it happens in winter?

Common SAD symptoms include hopelessness, loss of interest in daily activities, fatigue, trouble focusing, and changes in sleep and appetite.




science and technology

Diwali 2024: How to get rid of acidity, bloating, constipation post Diwali binge?

Here are some natural ways to help ease digestive discomfort post-Diwali.




science and technology

Can air pollution make you fat? Know how high AQI impact your health

Studies indicate that extended exposure to pollutants like particulate matter (PM2.5), nitrogen dioxide, and carbon monoxide can lead to systemic inflammation and metabolic disruptions, both of which play a significant role in weight gain.




science and technology

Shah Rukh Khan feels breathless after quitting smoking: Know withdrawal symptoms, how to manage them

Quitting smoking is a major accomplishment, but it can come with withdrawal symptoms that vary in intensity and duration based on the individual and how long they smoked.




science and technology

What is elimination inflammation diet that helped Vidya Balan lose weight?

Chronic inflammation can cause weight gain, fatigue, and pain. It is linked to serious conditions like diabetes and heart disease.




science and technology

'I gain weight as body...' Arjun Kapoor reveals being diagnosed with Hashimoto's disease

Hashimoto's disease can lead to hypothyroidism, or an underactive thyroid, causing symptoms like fatigue, weight gain, dry skin, and slowed heart rate.




science and technology

Is kala namak really a detox? Shalini Passi swears by this simple health hack

Kala namak is believed to aid in digestion by helping regulate pH levels and providing essential electrolytes.




science and technology

What is saree, petticoat cancer? From causes, symptoms to prevention, all you need to know

Research shows that tight petticoats worn with sarees may increase the risk of skin cancer in women due to constant....




science and technology

New health directive in Tamil Nadu, Government declares THIS as notifiable disease

Tamil Nadu has declared THIS as a notifiable disease requiring hospitals to report cases and deaths to improve monitoring and treatment.