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Author Correction: Proteomic and interactomic insights into the molecular basis of cell functional diversity




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The regulation and functions of DNA and RNA G-quadruplexes




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Lipid rafts come of age




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The expanding regulatory mechanisms and cellular functions of circular RNAs




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How plants silence stress




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Mechanisms governing autophagosome biogenesis




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Nature Reviews Molecular Cell Biology




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Regulatory DCs




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Complement swings the balance




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Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal




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CD300f in depression




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Novel specialized cell state and spatial compartments within the germinal center




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Author Correction: Climate change: an enduring challenge for vector-borne disease prevention and control




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Autoimmunity and organ damage in systemic lupus erythematosus




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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation




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Nature Immunology




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Defense Playbook for Campaigns

The 2018 National Defense Strategy (NDS) is predicated on a single organizing principle: America’s military pre-eminence is rapidly eroding. This is not a new concept. For years, experts have warned that the economic and technological advancements of U.S. adversaries, coupled with the 2008 financial crisis and America’s focus on peripheral conflicts, have caused a decline in America’s military dominance. 

In this context, the advances of near-peer competitors such as China and Russia have created plausible “theories of victory” in potential conflicts across Eastern Europe and East Asia. Competitors’ unaddressed improvements in strategic innovation, economic investment, and dual-use technology increases the risk of conflict and strains the U.S. alliance system. It is urgent that the United States reestablish and maintain credible deterrents against these near-peer competitors. After decades of focusing on post-Cold War ‘shaping’ operations, the American military needs to reinvigorate for full spectrum great power competition.

This report is intended as a blueprint on how to begin that process from graduate students at the Belfer Center for Science and International Affairs at Harvard University. Contained inside are 12 memorandums. Each provides a high-level overview and specific recommendations on a key issue of American defense policy. 




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Joseph S. Nye: U.S. and China Need a More Cooperative Security Stance

Joseph S. Nye: U.S. and China Need a More Cooperative Security Stance




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Breaking Down the Huawei v. Pentagon Dispute

If nothing else, the long-running Huawei situation shows the importance of considering the supply chain when it comes to cybersecurity. Huawei being the Chinese telecommunications equipment maker basically banned by the federal government. Bruce Schneier joins Host Tom Temin on Federal Drive.




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COVID-19's Painful Lesson About Strategy and Power

Joseph Nye writes that while trade wars have set back economic globalization,  the environmental globalization represented by pandemics and climate change is unstoppable. Borders are becoming more porous to everything from drugs to infectious diseases to cyber terrorism, and the United States must use its soft power of attraction to develop networks and institutions that address these new threats.




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An Interview with Bruce Schneier, Renowned Security Technologist

Bruce Schneier discusses current security technology concerns with The Politic's Eric Wallach.




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Spies Are Fighting a Shadow War Against the Coronavirus

Calder Walton describes four ways how intelligence services are certain to contribute to defeating COVID-19 and why pandemic intelligence will become a central part of future U.S. national security.




science and technology

No, the Coronavirus Will Not Change the Global Order

Joseph Nye advises skepticism toward claims that the pandemic changes everything. China won't benefit, and the United States will remain preeminent.




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Getting Smart on Pandemics: Intelligence in the Wake of COVID-19

This episode of Horns of a Dilemma touches on whether the failure to properly anticipate and warn about the novel coronavirus constitutes an intelligence failure, what changes might be required in the intelligence community in the wake of the pandemic, and what type of investigation or inquiry might be appropriate in order to learn lessons and incorporate changes for both the intelligence community and the whole of government moving forward.




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There's No Such Thing as Good Liberal Hegemony

Stephen Walt argues that as democracies falter, it's worth considering whether the United States made the right call in attempting to create a liberal world order.




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So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




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This Virus Is Tough, but History Provides Perspective: The 1968 Pandemic and the Vietnam War

Nathaniel L. Moir recounts the events of 1968: The war in Vietnam and extensive civil unrest in the United States — and yet another big problem that made life harder. In 1968, the H3N2 pandemic killed more individuals in the United States than the combined total number of American fatalities during both the Vietnam and Korean Wars.




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To Pressure Iran, Pompeo Turns to the Deal Trump Renounced

The secretary of state is preparing an argument that the U.S. remains a participant in the Obama-era nuclear deal, with the goal of extending an arms embargo or destroying the accord.




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Poll: What the American Public Likes and Hates about Trump's Nuclear Policies

The authors conducted a study which highlights how the U.S. public as a whole and various demographic groups view President Donald Trump's positions on nuclear weapons.




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How the Pentagon Is Struggling to Stay out of Politics

 Gen. Mark. A. Milley’s job is to provide sound military advice to the president. But at a deeper level, his responsibility is to safeguard the independence and integrity of the armed forces. The last thing the country needs is a military leadership that’s trying to curry favor with any commander in chief, particularly one who’s hungry for affirmation.




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Why Bernie Sanders Will Win in 2020, No Matter Who Gets Elected

Stephen Walt writes that even though Bernie Sanders is out of the presidential race, the time has come for many of the policies that he promoted: Universal Healthcare; Democratic Socialism; Income Redistribution; and Foreign Policy.




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Oil's Collapse Is a Geopolitical Reset In Disguise

The world is on the cusp of a geopolitical reset. The global pandemic could well undermine international institutions, reinforce nationalism and spur de-globalization. But far-sighted leadership could also rekindle cooperation, glimmers of which appeared in the G-20’s offer of debt relief for some of the world’s poorest countries, a joint plea from more than 200 former national leaders for a more coordinated pandemic response and an unprecedented multinational pact to arrest the crash in oil markets.  




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Romney's Reckless China Rhetoric Risks New Cold War

Rachel Esplin Odell argues for a wiser and more conservative strategy that resists the temptation to exaggerate the challenge posed by China.




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The United States Forgot Its Strategy for Winning Cold Wars

Stephen Walt writes that arguments against U.S. offshore balancing misunderstand history. The strategy that worked against the Soviet Union can work against China.




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Maxwell Taylor's Cold War: From Berlin to Vietnam

Nathaniel Moir reviews Maxwell Taylor's Cold War: From Berlin to Vietnam by Ingo Trauschweizer.




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Breaking the Ice: How France and the UK Could Reshape a Credible European Defense and Renew the Transatlantic Partnership

History is replete with irony, but rarely more poignantly than in the summer of 2016 when, on 23 June, the UK voted to leave the European Union and the next day, 24 June, the EU published its Global Strategy document asserting its ambition of “strategic autonomy.” Whither Franco-British defense cooperation in such chaotic circumstances? This paper attempts to provide the outline of an answer to that question.




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Clinical and Translational Gastroenterology




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Defense Playbook for Campaigns

The 2018 National Defense Strategy (NDS) is predicated on a single organizing principle: America’s military pre-eminence is rapidly eroding. This is not a new concept. For years, experts have warned that the economic and technological advancements of U.S. adversaries, coupled with the 2008 financial crisis and America’s focus on peripheral conflicts, have caused a decline in America’s military dominance. 

In this context, the advances of near-peer competitors such as China and Russia have created plausible “theories of victory” in potential conflicts across Eastern Europe and East Asia. Competitors’ unaddressed improvements in strategic innovation, economic investment, and dual-use technology increases the risk of conflict and strains the U.S. alliance system. It is urgent that the United States reestablish and maintain credible deterrents against these near-peer competitors. After decades of focusing on post-Cold War ‘shaping’ operations, the American military needs to reinvigorate for full spectrum great power competition.

This report is intended as a blueprint on how to begin that process from graduate students at the Belfer Center for Science and International Affairs at Harvard University. Contained inside are 12 memorandums. Each provides a high-level overview and specific recommendations on a key issue of American defense policy. 




science and technology

Joseph S. Nye: U.S. and China Need a More Cooperative Security Stance

Joseph S. Nye: U.S. and China Need a More Cooperative Security Stance




science and technology

Breaking Down the Huawei v. Pentagon Dispute

If nothing else, the long-running Huawei situation shows the importance of considering the supply chain when it comes to cybersecurity. Huawei being the Chinese telecommunications equipment maker basically banned by the federal government. Bruce Schneier joins Host Tom Temin on Federal Drive.




science and technology

COVID-19's Painful Lesson About Strategy and Power

Joseph Nye writes that while trade wars have set back economic globalization,  the environmental globalization represented by pandemics and climate change is unstoppable. Borders are becoming more porous to everything from drugs to infectious diseases to cyber terrorism, and the United States must use its soft power of attraction to develop networks and institutions that address these new threats.




science and technology

An Interview with Bruce Schneier, Renowned Security Technologist

Bruce Schneier discusses current security technology concerns with The Politic's Eric Wallach.




science and technology

Spies Are Fighting a Shadow War Against the Coronavirus

Calder Walton describes four ways how intelligence services are certain to contribute to defeating COVID-19 and why pandemic intelligence will become a central part of future U.S. national security.




science and technology

No, the Coronavirus Will Not Change the Global Order

Joseph Nye advises skepticism toward claims that the pandemic changes everything. China won't benefit, and the United States will remain preeminent.




science and technology

Getting Smart on Pandemics: Intelligence in the Wake of COVID-19

This episode of Horns of a Dilemma touches on whether the failure to properly anticipate and warn about the novel coronavirus constitutes an intelligence failure, what changes might be required in the intelligence community in the wake of the pandemic, and what type of investigation or inquiry might be appropriate in order to learn lessons and incorporate changes for both the intelligence community and the whole of government moving forward.




science and technology

There's No Such Thing as Good Liberal Hegemony

Stephen Walt argues that as democracies falter, it's worth considering whether the United States made the right call in attempting to create a liberal world order.




science and technology

So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




science and technology

This Virus Is Tough, but History Provides Perspective: The 1968 Pandemic and the Vietnam War

Nathaniel L. Moir recounts the events of 1968: The war in Vietnam and extensive civil unrest in the United States — and yet another big problem that made life harder. In 1968, the H3N2 pandemic killed more individuals in the United States than the combined total number of American fatalities during both the Vietnam and Korean Wars.




science and technology

To Pressure Iran, Pompeo Turns to the Deal Trump Renounced

The secretary of state is preparing an argument that the U.S. remains a participant in the Obama-era nuclear deal, with the goal of extending an arms embargo or destroying the accord.




science and technology

Poll: What the American Public Likes and Hates about Trump's Nuclear Policies

The authors conducted a study which highlights how the U.S. public as a whole and various demographic groups view President Donald Trump's positions on nuclear weapons.