A superintendent outlines the importance of various groups coming together to address teacher recruitment and retention challenges in Idaho.

Representatives from school districts, state education agencies, and institutions of higher education in Idaho convene to discuss teacher recruitment and retention.

After photos surfaced of staff at dressed in Halloween costumes as Mexicans and a border wall bearing the slogan "Make America Great Again," the employees responsible won't be returning to their classrooms on Monday.

Schools in Idaho are moving towards competency-based education in order to provide more personalized learning for all students. Read more from Tom's recent visit.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

When Idaho education leaders pitched social-emotional learning training for teachers, some state lawmakers compared the plan to dystopian behavior control. Some walked out of the meeting.

A private pre-K-12 school in Idaho welcomes students back after its coronavirus shutdown, but with shortened days, a closed cafeteria, no bus service, and other signs that things aren't back to normal.

In a small region of Vermont, a fierce debate raged over consolidating five tiny school districts into one.

A state law aimed at encouraging—or prodding—small, rural districts to merge has hit some speed bumps on the road to implementation.

State Education Secretary Rebecca Holcombe has been officiating over the state's politically thorny district consolidation process, and many are asking for it to be placed on hold until the state board replaces her.

[Rome] : [Chez Bouchard et Gravier], [1785]

[Paris] : [de l'Imprimerie de Clousier], [between 1780 and 1789]

[United States] : National Technical Information Service, United States Department of Commerce, 1984.

François Bachoc, José Betancourt, Reinhard Furrer, Thierry Klein.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1962--2008.

Abstract:
The asymptotic analysis of covariance parameter estimation of Gaussian processes has been subject to intensive investigation. However, this asymptotic analysis is very scarce for non-Gaussian processes. In this paper, we study a class of non-Gaussian processes obtained by regular non-linear transformations of Gaussian processes. We provide the increasing-domain asymptotic properties of the (Gaussian) maximum likelihood and cross validation estimators of the covariance parameters of a non-Gaussian process of this class. We show that these estimators are consistent and asymptotically normal, although they are defined as if the process was Gaussian. They do not need to model or estimate the non-linear transformation. Our results can thus be interpreted as a robustness of (Gaussian) maximum likelihood and cross validation towards non-Gaussianity. Our proofs rely on two technical results that are of independent interest for the increasing-domain asymptotic literature of spatial processes. First, we show that, under mild assumptions, coefficients of inverses of large covariance matrices decay at an inverse polynomial rate as a function of the corresponding observation location distances. Second, we provide a general central limit theorem for quadratic forms obtained from transformed Gaussian processes. Finally, our asymptotic results are illustrated by numerical simulations.

Sylvain Arlot, Alain Celisse

Source: Statist. Surv., Volume 4, 40--79.

Abstract:
Used to estimate the risk of an estimator or to perform model selection, cross-validation is a widespread strategy because of its simplicity and its (apparent) universality. Many results exist on model selection performances of cross-validation procedures. This survey intends to relate these results to the most recent advances of model selection theory, with a particular emphasis on distinguishing empirical statements from rigorous theoretical results. As a conclusion, guidelines are provided for choosing the best cross-validation procedure according to the particular features of the problem in hand.

Stefan Richter, Rainer Dahlhaus.

Source: The Annals of Statistics, Volume 47, Number 4, 2145--2173.

Abstract:
We propose an adaptive bandwidth selector via cross validation for local M-estimators in locally stationary processes. We prove asymptotic optimality of the procedure under mild conditions on the underlying parameter curves. The results are applicable to a wide range of locally stationary processes such linear and nonlinear processes. A simulation study shows that the method works fairly well also in misspecified situations.

Adam R. Brentnall, Jack Cuzick.

Source: Statistical Science, Volume 35, Number 1, 14--30.

Abstract:
Strategies to prevent cancer and diagnose it early when it is most treatable are needed to reduce the public health burden from rising disease incidence. Risk assessment is playing an increasingly important role in targeting individuals in need of such interventions. For breast cancer many individual risk factors have been well understood for a long time, but the development of a fully comprehensive risk model has not been straightforward, in part because there have been limited data where joint effects of an extensive set of risk factors may be estimated with precision. In this article we first review the approach taken to develop the IBIS (Tyrer–Cuzick) model, and describe recent updates. We then review and develop methods to assess calibration of models such as this one, where the risk of disease allowing for competing mortality over a long follow-up time or lifetime is estimated. The breast cancer risk model model and calibration assessment methods are demonstrated using a cohort of 132,139 women attending mammography screening in the State of Washington, USA.

Treat the babe in your life to one (or two or three) of these indulgent gifts.

Here’s where you can snag their Alo Yoga Moto leggings for less.

The rainbow sports bra and leggings set from Splits59 is a must-have for anyone craving a pop of color in their workout wardrobe.

This is not a drill: You can get up to 50% off at Nordstrom right now.

WD Knowles
Nov 1, 1981; 1:1236-1241
Articles

Jozsef Csicsvari
Jan 1, 1999; 19:274-287
Articles

KM Harris
Aug 1, 1989; 9:2982-2997
Articles

Peter Klivenyi
Jan 1, 2000; 20:1-7
Cellular

Spanish translation of the BIS press release about the BIS Quarterly Review, March 2018

Spanish version of executive summary of report on Central bank digital currencies published by the Committee on Payments and Market Infrastructures (CPMI) and the Markets Committee, March 2018.

Spanish version of Press release about CPMI and the Markets Committee issuing a report on "Central bank digital currencies" (12 March 2018)

Spanish version of BIS Press Release - Big tech in finance: opportunities and risks, 23 June 2019

Giving birth triggers a wide repertoire of physiological and behavioral changes in the mother to enable her to feed and care for her offspring. These changes require coordination and are often orchestrated from the CNS, through as of yet poorly understood mechanisms. A neuronal population with a central role in puerperal changes is the tuberoinfundibular dopamine (TIDA) neurons that control release of the pituitary hormone, prolactin, which triggers key maternal adaptations, including lactation and maternal care. Here, we used Ca²⁺ imaging on mice from both sexes and whole-cell recordings on female mouse TIDA neurons in vitro to examine whether they adapt their cellular and network activity according to reproductive state. In the high-prolactin state of lactation, TIDA neurons shift to faster membrane potential oscillations, a reconfiguration that reverses upon weaning. During the estrous cycle, however, which includes a brief, but pronounced, prolactin peak, oscillation frequency remains stable. An increase in the hyperpolarization-activated mixed cation current, I_h, possibly through unmasking as dopamine release drops during nursing, may partially explain the reconfiguration of TIDA rhythms. These findings identify a reversible plasticity in hypothalamic network activity that can serve to adapt the dam for motherhood.

SIGNIFICANCE STATEMENT Motherhood requires profound behavioral and physiological adaptations to enable caring for offspring, but the underlying CNS changes are poorly understood. Here, we show that, during lactation, neuroendocrine dopamine neurons, the "TIDA" cells that control prolactin secretion, reorganize their trademark oscillations to discharge in faster frequencies. Unlike previous studies, which typically have focused on structural and transcriptional changes during pregnancy and lactation, we demonstrate a functional switch in activity and one that, distinct from previously described puerperal modifications, reverses fully on weaning. We further provide evidence that a specific conductance (I_h) contributes to the altered network rhythm. These findings identify a new facet of maternal brain plasticity at the level of membrane properties and consequent ensemble activity.

Functional recovery after cortical injury, such as stroke, is associated with neural circuit reorganization, but the underlying mechanisms and efficacy of therapeutic interventions promoting neural plasticity in primates are not well understood. Bone marrow mesenchymal stem cell-derived extracellular vesicles (MSC-EVs), which mediate cell-to-cell inflammatory and trophic signaling, are thought be viable therapeutic targets. We recently showed, in aged female rhesus monkeys, that systemic administration of MSC-EVs enhances recovery of function after injury of the primary motor cortex, likely through enhancing plasticity in perilesional motor and premotor cortices. Here, using in vitro whole-cell patch-clamp recording and intracellular filling in acute slices of ventral premotor cortex (vPMC) from rhesus monkeys (Macaca mulatta) of either sex, we demonstrate that MSC-EVs reduce injury-related physiological and morphologic changes in perilesional layer 3 pyramidal neurons. At 14-16 weeks after injury, vPMC neurons from both vehicle- and EV-treated lesioned monkeys exhibited significant hyperexcitability and predominance of inhibitory synaptic currents, compared with neurons from nonlesioned control brains. However, compared with vehicle-treated monkeys, neurons from EV-treated monkeys showed lower firing rates, greater spike frequency adaptation, and excitatory:inhibitory ratio. Further, EV treatment was associated with greater apical dendritic branching complexity, spine density, and inhibition, indicative of enhanced dendritic plasticity and filtering of signals integrated at the soma. Importantly, the degree of EV-mediated reduction of injury-related pathology in vPMC was significantly correlated with measures of behavioral recovery. These data show that EV treatment dampens injury-related hyperexcitability and restores excitatory:inhibitory balance in vPMC, thereby normalizing activity within cortical networks for motor function.

SIGNIFICANCE STATEMENT Neuronal plasticity can facilitate recovery of function after cortical injury, but the underlying mechanisms and efficacy of therapeutic interventions promoting this plasticity in primates are not well understood. Our recent work has shown that intravenous infusions of mesenchymal-derived extracellular vesicles (EVs) that are involved in cell-to-cell inflammatory and trophic signaling can enhance recovery of motor function after injury in monkey primary motor cortex. This study shows that this EV-mediated enhancement of recovery is associated with amelioration of injury-related hyperexcitability and restoration of excitatory-inhibitory balance in perilesional ventral premotor cortex. These findings demonstrate the efficacy of mesenchymal EVs as a therapeutic to reduce injury-related pathologic changes in the physiology and structure of premotor pyramidal neurons and support recovery of function.

The Farmers’ Market has been postponed for Friday 6 March and until further notice.

New research suggests the civilization used huge enclosures to trap and stockpile live fish to support its complex society

Select Andrew Lloyd Webber productions will stream on YouTube for 48 hours at a time

An unfortunate diet of pizza grease and sand clogged her innards, amassing a giant and unpassable lump of feces in her gut

With Washington, D.C. COVID-19 state of emergency, Smithsonian officials say museums to close Saturday, March 14; events canceled through May 3

Highway 8, otherwise known as the Dempster Highway, will be closed to all traffic at 5 p.m. on Friday, according to the government of the Northwest Territories.

Buenos Aires, Argentina :: Miembros de la comunidad japonesa encuentran amigos en un barco de visita y escuchan el evangelio en su lengua materna.