pti Effects of Coffee Consumption on Fasting Blood Glucose and Insulin Concentrations: Randomized controlled trials in healthy volunteers By care.diabetesjournals.org Published On :: 2004-12-01 Rob M. van DamDec 1, 2004; 27:2990-2992Brief Reports Full Article
pti Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Obesity is associated with microvascular insulin resistance, which is characterized by impaired insulin-mediated microvascular recruitment. Glucagon-like peptide 1 (GLP-1) recruits skeletal and cardiac muscle microvasculature, and this action is preserved in insulin-resistant rodents. We aimed to examine whether GLP-1 recruits microvasculature and improves the action of insulin in obese humans. RESEARCH DESIGN AND METHODS Fifteen obese adults received intravenous infusion of either saline or GLP-1 (1.2 pmol/kg/min) for 150 min with or without a euglycemic insulin clamp (1 mU/kg/min) superimposed over the last 120 min. Skeletal and cardiac muscle microvascular blood volume (MBV), flow velocity and blood flow, brachial artery diameter and blood flow, and pulse wave velocity (PWV) were determined. RESULTS Insulin failed to change MBV or flow in either skeletal or cardiac muscle, confirming the presence of microvascular insulin resistance. GLP-1 infusion alone increased MBV by ~30% and ~40% in skeletal and cardiac muscle, respectively, with no change in flow velocity, leading to a significant increase in microvascular blood flow in both skeletal and cardiac muscle. Superimposition of insulin to GLP-1 infusion did not further increase MBV or flow in either skeletal or cardiac muscle but raised the steady-state glucose infusion rate by ~20%. Insulin, GLP-1, and GLP-1 + insulin infusion did not alter brachial artery diameter and blood flow or PWV. The vasodilatory actions of GLP-1 are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. CONCLUSIONS In obese humans with microvascular insulin resistance, GLP-1’s vasodilatory actions are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. Full Article
pti Policy Options for Responding to Changing Migration Flows at the Southwest Border By www.migrationpolicy.org Published On :: Wed, 03 Apr 2019 13:27:37 -0400 Testimony of Andrew Selee, President of MPI, before Senate Committee on Homeland Security and Governmental Affairs on April 4, 2019 regarding response to changing migration flows at the Southwest border. Full Article
pti National Children’s Dental Health Month highlights optimally fluoridated water By www.ada.org Published On :: Wed, 29 Jan 2020 09:30:00 -0600 This year the February observance of National Children’s Dental Health Month honors the 75th anniversary of community water fluoridation with its theme, “Fluoride in water prevents cavities! Get it from the tap!” Full Article
pti SBA will resume accepting Paycheck Protection Program applications April 27 By www.ada.org Published On :: Sun, 26 Apr 2020 08:29:00 -0500 The Small Business Administration will resume accepting Paycheck Protection Program loan applications at 10:30 a.m. EST on April 27 from “approved lenders on behalf of any eligible borrower,” the agency said. Full Article
pti Patient portals need proxy options for better privacy protection, study finds By www.upi.com Published On :: Mon, 04 May 2020 15:27:49 -0400 More patient portals and electronic health records should enable users to create "proxy" accounts for nurses and home aids to prevent unintentional sharing of personal health details, researchers said Monday. Full Article
pti Use of Glucagon-Like Peptide 1 Receptor Agonists and Risk of Serious Renal Events: Scandinavian Cohort Study By care.diabetesjournals.org Published On :: 2020-04-28T10:59:59-07:00 OBJECTIVETo assess the association between use of glucagon-like peptide 1 (GLP-1) receptor agonists and risk of serious renal events in routine clinical practice.RESEARCH DESIGN AND METHODSThis was a cohort study using an active-comparator, new-user design and nationwide register data from Sweden, Denmark, and Norway during 2010–2016. The cohort included 38,731 new users of GLP-1 receptor agonists (liraglutide 92.5%, exenatide 6.2%, lixisenatide 0.7%, and dulaglutide 0.6%), matched 1:1 on age, sex, and propensity score to a new user of the active comparator, dipeptidyl peptidase 4 (DPP-4) inhibitors. The main outcome was serious renal events, a composite including renal replacement therapy, death from renal causes, and hospitalization for renal events. Secondary outcomes were the individual components of the main outcome. Hazard ratios (HRs) were estimated using Cox models and an intention-to-treat exposure definition. Mean (SD) follow-up time was 3.0 (1.7) years.RESULTSMean (SD) age of the study population was 59 (10) years, and 18% had cardiovascular disease. A serious renal event occurred in 570 users of GLP-1 receptor agonists (incidence rate 4.8 events per 1,000 person-years) and in 722 users of DPP-4 inhibitors (6.3 events per 1,000 person-years, HR 0.76 [95% CI 0.68–0.85], absolute difference –1.5 events per 1,000 person-years [–2.1 to –0.9]). Use of GLP-1 receptor agonists was associated with a significantly lower risk of renal replacement therapy (HR 0.73 [0.62–0.87]) and hospitalization for renal events (HR 0.73 [0.65–0.83]) but not death from renal causes (HR 0.72 [0.48–1.10]). When we used an as treated exposure definition in which patients were censored at treatment cessation or switch to the other study drug, the HR for the primary outcome was 0.60 (0.49–0.74).CONCLUSIONSIn this large cohort of patients seen in routine clinical practice in three countries, use of GLP-1 receptor agonists, as compared with DPP-4 inhibitors, was associated with a reduced risk of serious renal events. Full Article
pti Global warming fuels algal bloom disrupting fisheries in Arabian Sea By www.upi.com Published On :: Mon, 04 May 2020 14:47:01 -0400 A new scientific study published Monday found that global warming is fueling a destructive algal bloom that is disrupting fisheries in the Arabian sea. Full Article
pti Early marine reptiles used pebble-like teeth to crush shellfish By www.upi.com Published On :: Fri, 08 May 2020 11:43:37 -0400 Some early ichthyosaurs used rounded, pebble-like teeth to crush the shells of snails and clam-like bivalves, according to new research. Full Article
pti Ask Ariely: On Overwhelming Options, Better Budgets, and Expensive Emotions By danariely.com Published On :: Sat, 15 Feb 2020 12:30:34 +0000 Here’s my Q&A column from the WSJ this week — and if you have any questions for me, you can tweet them to @danariely with the hashtag #askariely, post a comment on my Ask Ariely Facebook page, or email them to AskAriely@wsj.com. ___________________________________________________ Hi, Dan. I offered to purchase a computer... Full Article Ask Ariely Behavioral Economics advice column ask ariely Behavioral Economics & Psychology dear dan wall street journal wsj
pti [ Yahoo Answers ] Open Question : Nowadays many of legit questions are getting removed without notice. There's no appeal options also. How can I report about these mistakes? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:15:35 +0000 *my legit questions Full Article
pti Why Women May Be More Susceptible to Mood Disorders By rss.sciam.com Published On :: Tue, 14 Apr 2020 10:45:00 GMT New research in mice suggests that a pregnancy hormone contributes to brain and behavioral changes caused by childhood adversity -- Read more on ScientificAmerican.com Full Article Mind Behavior & Society Mental Health
pti Good Options Can Mask Bad Choices By www.washingtonpost.com Published On :: Mon, 14 Jan 2008 00:00:00 EST Take a step back from the Republican and Democratic presidential primary races and you will see a sharp difference between the two. Full Article Opinions Good Options Can Mask Bad Choices
pti Legal Migration for Work and Training: Mobility Options to Europe for Those Not in Need of Protection By www.migrationpolicy.org Published On :: Fri, 18 Oct 2019 10:55:17 -0400 As EU Member States struggle to deliver on the European Union's call to expand channels for foreign workers, they should focus more on attracting the middle- and low-skilled third-country nationals needed by the labor market yet for whom few opportunities for admission exist. They also would do well to consider their migration policies in light of labor market, foreign policy, and development objectives, rather than as a means to reduce irregular migration, this report cautions. Full Article
pti Genetic Susceptibility Determines {beta}-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76) By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Previous studies suggested that childhood prediabetes may develop prior to obesity and be associated with relative insulin deficiency. We proposed that the insulin-deficient phenotype is genetically determined and tested this hypothesis by longitudinal modeling of insulin and glucose traits with diabetes risk genotypes in the EarlyBird cohort. RESEARCH DESIGN AND METHODS EarlyBird is a nonintervention prospective cohort study that recruited 307 healthy U.K. children at 5 years of age and followed them throughout childhood. We genotyped 121 single nucleotide polymorphisms (SNPs) previously associated with diabetes risk, identified in the adult population. Association of SNPs with fasting insulin and glucose and HOMA indices of insulin resistance and β-cell function, available from 5 to 16 years of age, were tested. Association analysis with hormones was performed on selected SNPs. RESULTS Several candidate loci influenced the course of glycemic and insulin traits, including rs780094 (GCKR), rs4457053 (ZBED3), rs11257655 (CDC123), rs12779790 (CDC123 and CAMK1D), rs1111875 (HHEX), rs7178572 (HMG20A), rs9787485 (NRG3), and rs1535500 (KCNK16). Some of these SNPs interacted with age, the growth hormone–IGF-1 axis, and adrenal and sex steroid activity. CONCLUSIONS The findings that genetic markers influence both elevated and average courses of glycemic traits and β-cell function in children during puberty independently of BMI are a significant step toward early identification of children at risk for diabetes. These findings build on our previous observations that pancreatic β-cell defects predate insulin resistance in the onset of prediabetes. Understanding the mechanisms of interactions among genetic factors, puberty, and weight gain would allow the development of new and earlier disease-management strategies in children. Full Article
pti Keep Your YouTube Subscriptions in Sync With Inoreader By blog.inoreader.com Published On :: Thu, 16 Apr 2020 09:05:12 +0000 Did you know you can subscribe to YouTube channels and playlist in Inoreader? Simply paste the URL of the channel… Full Article Uncategorized
pti Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide By care.diabetesjournals.org Published On :: 2011-11-21T22:32:39-08:00 OBJECTIVE We conducted an open-label, phase I study using autologous umbilical cord blood (UCB) infusion to ameliorate type 1 diabetes (T1D). Having previously reported on the first 15 patients reaching 1 year of follow-up, herein we report on the complete cohort after 2 years of follow-up. RESEARCH DESIGN AND METHODS A total of 24 T1D patients (median age 5.1 years) received a single intravenous infusion of autologous UCB cells and underwent metabolic and immunologic assessments. RESULTS No infusion-related adverse events were observed. β-Cell function declined after UCB infusion. Area under the curve C-peptide was 24.3% of baseline 1 year postinfusion (P < 0.001) and 2% of baseline 2 years after infusion (P < 0.001). Flow cytometry revealed increased regulatory T cells (Tregs) (P = 0.04) and naive Tregs (P = 0.001) 6 and 9 months after infusion, respectively. CONCLUSIONS Autologous UCB infusion in children with T1D is safe and induces changes in Treg frequency but fails to preserve C-peptide. Full Article
pti Forthcoming HOPOS Special Issue on Descriptive Psychology and Völkerpsychologie By ahp.apps01.yorku.ca Published On :: Fri, 01 May 2020 18:20:00 +0000 Two pieces forthcoming in a special issue of HOPOS, the official journal of the International Society for the History of Philosophy of Science, will be of interest to AHP readers. The special issue, “Descriptive Psychology and Völkerpsychologie—in the Contexts of Historicism, Relativism, and Naturalism,” is guest-edited by Christian Damböck, Uljana Feest, and Martin Kusch. Full details … Continue reading Forthcoming HOPOS Special Issue on Descriptive Psychology and Völkerpsychologie → Full Article General
pti The Paradox of Online Dating: Too Many Options Makes It Harder to Invest in a Relationship By feedproxy.google.com Published On :: Fri, 27 Mar 2020 14:00:00 +0000 In any relationship, you’re bound to discover that your partner has one or two (or maybe ten or twenty) quirks that eventually come to annoy you. In these situations, it's tempting to think that you might be happier with someone else—someone who doesn’t have the same set of peccadillos. However, according to behavioral economist Dr. Dan Ariely, this kind of thinking can set you up for a lifetime of disappointment. Full Article Videos
pti How to make pandemics optional, not inevitable | Sonia Shah By feedproxy.google.com Published On :: Wed, 01 Apr 2020 16:10:01 +0000 What can past pandemics teach us how to tackle the current one? Tracing the history of contagions from cholera to Ebola and beyond, science journalist Sonia Shah explains why we're more vulnerable to outbreaks now than ever before, what we can do to minimize the spread of coronavirus and how to prevent future pandemics. (This virtual conversation is part of the TED Connects series, hosted by science curator David Biello and current affairs curator Whitney Pennington Rodgers. Recorded March 31, 2020) Full Article Higher Education
pti Given the option, Montana schools choose to remain closed By feedproxy.google.com Published On :: 2020-04-29T19:30:41-04:00 Full Article Education
pti Measuring the Impact of Common-Core Test Disruptions in Three States By feedproxy.google.com Published On :: Fri, 19 Jun 2015 00:00:00 +0000 A Smarter Balanced testing vendor has released completion rates in three states that had serious challenges giving the common-core aligned exam. Full Article North_Dakota
pti Given the option, Montana schools choose to remain closed By feedproxy.google.com Published On :: 2020-04-30T08:46:34-04:00 Full Article Education
pti Given the option, Montana schools choose to remain closed By feedproxy.google.com Published On :: Thu, 30 Apr 2020 00:00:00 +0000 Full Article Montana
pti Trust Local School Leaders, a State Chief Says as Optional Reopening Date Nears By feedproxy.google.com Published On :: Tue, 05 May 2020 00:00:00 +0000 Montana Superintendent Elsie Arntzen offers practical advice to schools that could open as early as May 7, even as she says "how they open schools and how learning takes place is up to them." Full Article Montana
pti Adoption of New Science Standards May Start With Rhode Island By feedproxy.google.com Published On :: Thu, 16 May 2013 00:00:00 +0000 Rhode Island may become the first state to adopt the Next Generation Science Standards. Full Article Rhode_Island
pti To make terms of compromise a rule of Court or not? That is the question : an analysis of the options available to settle estate matters / presended by Christina Flourentzou, Supreme Court of South Australia.. By www.catalog.slsa.sa.gov.au Published On :: Full Article
pti Troubling ambiguity : governance in SA Health / a report by The Hon. Bruce Lander QC, Independent Commissioner Against Corruption. By www.catalog.slsa.sa.gov.au Published On :: "... The report has been prepared for the purpose of highlighting several areas of concern I have about governance arrangements in SA Health that contribute to risks of corruption, misconduct and maladministration...." -- page 4. Full Article
pti Synergistic genetic biocontrol options for common carp (Cyprinus carpio) / Claus Wedekind. By www.catalog.slsa.sa.gov.au Published On :: Full Article
pti Vulnerable private renters : evidence and options / Australian Government Productivity Commission. By www.catalog.slsa.sa.gov.au Published On :: Full Article
pti Rewording the brain : how cryptic crosswords can improve your memory and boost the power and agility of your brain / David Astle. By www.catalog.slsa.sa.gov.au Published On :: Memory. Full Article
pti The gospel of climate skepticism : why evangelical Christians oppose action on climate change / Robin Globus Veldman. By www.catalog.slsa.sa.gov.au Published On :: Climatic changes -- Effect of human beings on -- Religious aspects -- Christianity. Full Article
pti Proprioceptive receptor potentials of oscillatory form. By search.wellcomelibrary.org Published On :: 195? Full Article
pti Description des causes et des effets de la maladie connue sous le nom de diabetes / par M. Pharamond. By feedproxy.google.com Published On :: Paris : Gabon, 1829. Full Article
pti Description of an apparatus intended to facilitate the treatment of fractures of the lower extremity / by T.M. Greenhow. By feedproxy.google.com Published On :: London : S. Highley, 1833. Full Article
pti Description of an element board and combined handle electrode for the medical application of electricity / by A. Hughes Bennett. By feedproxy.google.com Published On :: London : H.K. Lewis, 1882. Full Article
pti Description of an improved apparatus for inhalation of vapour in the cure of diseases / by John Gairdner. By feedproxy.google.com Published On :: [Edinburgh] : [publisher not identified], [1823] Full Article
pti A description of the arteries of the human body / by John Barclay. By feedproxy.google.com Published On :: Edinburgh : T. Bryce, 1812. Full Article
pti A description of the arteries of the human body. Reduced to tables / by Adolphus Murray ; Translated from the original by Archd. Scott. By feedproxy.google.com Published On :: Edinburgh : And Bell and Bradfute, and E. Balfour, 1801. Full Article
pti A description of the diseased conditions of the knee-joint which require amputation of the limb, and those conditions which are favourable to excision of the joint : with an explanation of the relative advantages of both operations as far as can be ascert By feedproxy.google.com Published On :: London : J. Churchill, 1865. Full Article
pti A description of the genus Cinchona, comprehending the various species of vegetables from which the Peruvian and other barks of a similar quality are taken. Illustrated by figures of all the species hitherto discovered. To which is prefixed Professor Vahl By feedproxy.google.com Published On :: London : printed for B. and J. White, 1797. Full Article
pti Descriptive anatomy of the horse and domestic animals / chiefly compiled from the manuscripts of Thomas Strangeways and Professor Goodsir by J. Wilson Johnston and T.J. Call. By feedproxy.google.com Published On :: Edinburgh : MacLachlan and Stewart, 1870. Full Article
pti Descriptive Biochemie : mit besonderer Berücksichtigung der chemischen Arbeitsmethoden / von Sigmund Fränkel. By feedproxy.google.com Published On :: Wiesbaden : J.F. Bergmann, 1907. Full Article
pti Descriptive catalogue of the anatomical and pathological museum of the School of Medicine, Park Street, Dublin / by John Houston. By feedproxy.google.com Published On :: London : Dublin, 1843. Full Article
pti Descriptive catalogue of the anatomical museum of the Boston society for medical improvement / by J.B.S. Jackson. By feedproxy.google.com Published On :: Boston : W.D. Ticknor, 1847. Full Article
pti Descriptive catalogue of the Anatomical Museum of the University of Edinburgh. By feedproxy.google.com Published On :: Edinburgh : William Whyte, 1829. Full Article
pti Descriptive catalogue of the museum illustrative of Dr Evory Kennedy's lectures on midwifery, and the diseases of women and children. By feedproxy.google.com Published On :: [Edinburgh?] : [publisher not identified], 1840. Full Article
pti Descriptive catalogue of the preparations in the Museum of the Royal College of Surgeons in Ireland / by John Houston. By feedproxy.google.com Published On :: Edinburgh : Hodges and Smith, 1834-1840. Full Article
pti A descriptive catalogue of the Warren Anatomical Museum / by J. B. S. Jackson. By feedproxy.google.com Published On :: Boston : A. Williams, 1870. Full Article
