Germans -- Victoria -- History.

Domestic fiction.

Architecture, Domestic -- Australia -- History -- 20th century.

Coronavirus is disrupting every facet of American life, including millions of students who will be out of school for several weeks.

As Oklahoma teachers prepare for day four of their statewide walkout, here's a guide to the larger picture of teacher protests.

[Rome?] : [publisher not identified], [1807?]

London (5 Haymarket) : Published ... by J. Hogarth, June 1 1849.

The Boston Bruins didn't take long to put the painful memory of the 2010 Stanley Cup Playoffs behind them.

Rockville, Maryland : The National Institute on Drug Abuse, 1976.

[London] : [publisher not identified], [2019]

Sabrina Ionescu wins the Wooden Award for the second year in a row, becoming the fifth in the trophy's history to win in back-to-back seasons. With the honor, she completes a complete sweep of the national postseason player of the year awards. As a senior, Ionescu matched her own single-season mark with eight triple-doubles in 2019-20, and she was incredibly efficient from the field with a career-best 51.8 field goal percentage.

Zhonghua Liu, Ian Barnett, Xihong Lin.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 433--451.

Abstract:
Principal component analysis (PCA) is a popular method for dimension reduction in unsupervised multivariate analysis. However, existing ad hoc uses of PCA in both multivariate regression (multiple outcomes) and multiple regression (multiple predictors) lack theoretical justification. The differences in the statistical properties of PCAs in these two regression settings are not well understood. In this paper we provide theoretical results on the power of PCA in genetic association testings in both multiple phenotype and SNP-set settings. The multiple phenotype setting refers to the case when one is interested in studying the association between a single SNP and multiple phenotypes as outcomes. The SNP-set setting refers to the case when one is interested in studying the association between multiple SNPs in a SNP set and a single phenotype as the outcome. We demonstrate analytically that the properties of the PC-based analysis in these two regression settings are substantially different. We show that the lower order PCs, that is, PCs with large eigenvalues, are generally preferred and lead to a higher power in the SNP-set setting, while the higher-order PCs, that is, PCs with small eigenvalues, are generally preferred in the multiple phenotype setting. We also investigate the power of three other popular statistical methods, the Wald test, the variance component test and the minimum $p$-value test, in both multiple phenotype and SNP-set settings. We use theoretical power, simulation studies, and two real data analyses to validate our findings.

Our Lady of Grace School (Glengowrie, S.A.)

Christian Gaser
Oct 8, 2003; 23:9240-9245
BehavioralSystemsCognitive

MN Shadlen
Feb 15, 1996; 16:1486-1510
Articles

M Niethammer
Apr 1, 1996; 16:2157-2163
Articles

Investment of cognitive effort is required in everyday life and has received ample attention in recent neurocognitive frameworks. The neural mechanism of effort investment is thought to be structured hierarchically, with dorsal anterior cingulate cortex (dACC) at the highest level, recruiting task-specific upstream areas. In the current fMRI study, we tested whether dACC is generally active when effort demand is high across tasks with different stimuli, and whether connectivity between dACC and task-specific areas is increased depending on the task requirements and effort level at hand. For that purpose, a perceptual detection task was administered that required male and female human participants to detect either a face or a house in a noisy image. Effort demand was manipulated by adding little (low effort) or much (high effort) noise to the images. Results showed a network of dACC, anterior insula (AI), and intraparietal sulcus (IPS) to be more active when effort demand was high, independent of the performed task (face or house detection). Importantly, effort demand modulated functional connectivity between dACC and face-responsive or house-responsive perceptual areas, depending on the task at hand. This shows that dACC, AI, and IPS constitute a general effort-responsive network and suggests that the neural implementation of cognitive effort involves dACC-initiated sensitization of task-relevant areas.

SIGNIFICANCE STATEMENT Although cognitive effort is generally perceived as aversive, its investment is inevitable when navigating an increasingly complex society. In this study, we demonstrate how the human brain tailors the implementation of effort to the requirements of the task at hand. We show increased effort-related activity in a network of brain areas consisting of dorsal anterior cingulate cortex (dACC), anterior insula, and intraparietal sulcus, independent of task specifics. Crucially, we also show that effort-induced functional connectivity between dACC and task-relevant areas tracks specific task demands. These results demonstrate how brain regions specialized to solve a task may be energized by dACC when effort demand is high.

Lead decontamination policies enacted in August are now in conflict with measures to prevent spread of COVID-19

This eruption is the longest since 2018 when the volcano caused a deadly tsunami

From doodle sessions to zoo tours, here's a week of online activities to keep your kids learning during the school shutdown

Authors, scientists and others are offering fun livestream lessons and performances to keep kids engaged during isolation

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Test your mettle with this puzzle created exclusively for our readers

Find the capital cities, working from a list of state names

RCMP say they were first called about the fires at 10 p.m. CST on May 7.

A virus that spreads fear and stigma, as well as disease. It’s the story of HIV/AIDS as well as COVID-19. The former executive director of AIDS Thunder Bay reflects on the similarities he sees between HIV 35 years ago, and the coronavirus now.

There are 14 active cases of COVID-19 remaining in the province.

Service Team members share why they enjoy being onsite during Setup Week, when the vision of TeenStreet becomes a reality for them, and what part of the upcoming conference they are most excited for.

A longstanding battle between an Alberta entrepreneur and a $50-million lottery winner is still raging after a new legal judgment, a securities investigation, allegations of harassment and even duelling ebooks.

Major League Baseball owners will discuss a length for the amateur draft next week and are likely to start the selections on the original date of June 10, a person familiar with the deliberations told The Associated Press.

Tampa Bay Rays' Blake Snell claimed champion status after defeating Lucas Giolito of the Chicago White Sox in the inaugural MLB The Show player league on Sunday.

OK, you’re gonna hear a lot about Joementum.

At the onset of the coronavirus crisis, the Federal Reserve relied on repurchase agreements, or repos, as a large part...

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The volatility experienced this spring in the 7 trillion-dollar foreign exchange market was unprecedented. The JP Morgan G7 FX Volatility...

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Award-winning children's book explores big questions about colonization and identity.