Current guidelines recommend renal ultrasound as a screening test after febrile urinary tract infection, with voiding cystourethrogram (VCUG) only if the ultrasound is abnormal. Few studies have evaluated the accuracy of ultrasound as a screening test for VCUG-identified abnormalities.

This study shows that ultrasound is a poor screening test for genitourinary abnormalities identified on VCUG, such as vesicoureteral reflux. Neither positive nor negative ultrasounds reliably identify or rule out such abnormalities. Ultrasound and VCUG provide different, but complementary, information. (Read the full article)

Herpes encephalitis outside the neonatal period is typically severe and recognizable to clinicians. Excessive testing for herpes encephalitis is associated with increased medical costs and hospital length of stay, and risks patient harm.

Herpes testing and empirical acyclovir treatment in older and less unwell patients has been increasing in US pediatric hospitals over the past decade, which may reflect a more fundamental problem in current approaches to clinical decision-making. (Read the full article)

Prophylactic indomethacin in extremely low birth weight infants decreases severe intraventricular hemorrhage and patent ductus arteriosus but it is unknown whether concurrent enteral feeding and prophylactic indomethacin is associated with increased risk of spontaneous intestinal perforation.

The combination of prophylactic indomethacin and enteral feeding during the first 3 days after birth does not increase the risk of spontaneous intestinal perforation. (Read the full article)

Several injuries have been suggested to be disproportionately associated with abuse in young children, but rates of abuse among children with these injuries are not currently known.

Abuse is diagnosed commonly in children with sentinel injuries, including the majority of children <24 months with rib fractures. (Read the full article)

National guidelines recommend testing and prophylaxis for chlamydia, gonorrhea, and pregnancy for adolescent sexual assault victims. Little is known about rates of testing and prophylaxis in adolescent victims of sexual assault evaluated in pediatric emergency departments.

There is significant variation in testing and prophylaxis practices in the pediatric emergency department evaluation of adolescent victims of sexual assault. Adolescents cared for in emergency departments with clinical pathways are more likely to receive recommended prophylaxis. (Read the full article)

I regularly receive invitations to participate in essay contests devoted to rethinking American education. These competitions, I fear, are the worst way to spur real change.

If I've learned anything after hanging out at a think tank for close to two decades, it's that dreaming up education innovations is easy. Number 12 in our countdown is my take on the goofy contests that talkers seem to be so fond of.

David Figlio and Eduwonkette discuss if today's testing and accountability policies accurately depict student performance and the size of the achievement

What should be included in a measure of school quality? If not by standardized test scores, how should we measure student achievement? Julian Vasquez Heilig and I each have some thoughts.

Federal law requires states to report student test scores in achievement levels, but leaders in the Golden State want to take a different approach.

A 10-year study by a blue-ribbon panel of scientists concludes that high-stakes testing and other accountability measures have largely failed to translate to real improvements in student achievement.

Brain infections with Cryptococcus neoformans are associated with significant morbidity and mortality. Cryptococcosis typically presents as meningoencephalitis or fungal mass lesions called cryptococcomas. Despite frequent in vitro discoveries of promising novel antifungals, the clinical need for drugs that can more efficiently treat these brain infections remains. A crucial step in drug development is the evaluation of in vivo drug efficacy in animal models. This mainly relies on survival studies or post-mortem analyses in large groups of animals, but these techniques only provide information on specific organs of interest at predefined time points. In this proof-of-concept study, we validated the use of non-invasive preclinical imaging to obtain longitudinal information on the therapeutic efficacy of amphotericin B or fluconazole monotherapy in meningoencephalitis and cryptococcoma mouse models. Bioluminescence imaging (BLI) enabled the rapid in vitro and in vivo evaluation of drug efficacy while complementary high-resolution anatomical information obtained by magnetic resonance imaging (MRI) of the brain allowed a precise assessment of the extent of infection and lesion growth rates. We demonstrated a good correlation between both imaging readouts and the fungal burden in various organs. Moreover, we identified potential pitfalls associated with the interpretation of therapeutic efficacy based solely on post-mortem studies, demonstrating the added value of this non-invasive dual imaging approach compared to standard mortality curves or fungal load endpoints. This novel preclinical imaging platform provides insights in the dynamic aspects of the therapeutic response and facilitates a more efficient and accurate translation of promising antifungal compounds from bench to bedside.

Aspergillus niger, the third species responsible for invasive aspergillosis has been considered as a homogeneous species until DNA-based identification uncovered many cryptic species. These species have been recently reclassified into the Aspergillus section Nigri. However little is yet known among the section Nigri about the species distribution and the antifungal susceptibility pattern of each cryptic species. A total of 112 clinical isolates collected from 5 teaching hospitals in France and phenotypically identified as A. niger were analyzed. Identification to the species level was carried out by nucleotide sequence analysis. The Minimum Inhibitory Concentrations (MICs) of itraconazole, voriconazole, posaconazole, isavuconazole and amphotericin B were determined by both the EUCAST and gradient concentration strips methods. Aspergillus tubingensis (n=51, 45.5%) and A. welwitschiae (n=50, 44.6%) were the most common species while A. niger accounted for only 6.3% (n=7). The MICs of azoles drugs were higher for A. tubingensis than for A. welwitschiae. The MIC of amphotericin B was 2 mg/L or less for all isolates. Importantly, MICs determined by EUCAST showed no correlation with those determined by gradient concentration strips methods, these latter being lower than the former (Spearman's rank correlation tests ranging - depending on the antifungal agent - from 0.01 to 0.25; p>0.4). In conclusion, A. niger should be considered as a minority species in the section Nigri. The differences in MICs between species for different azoles underline the importance of accurate identification. Significant divergences in the determination of MIC between EUCAST and gradient concentration strips methods require further investigation.

BACKGROUND AND OBJECTIVES:

Rates of sexually transmitted infections (STIs) have increased over the decade. Guidelines recommend HIV testing with incident STIs. Prevalence and factors associated with HIV testing in acute STIs are unknown in adolescents. Our objective was to determine the prevalence of completed HIV testing among adolescents with incident STIs and identify patient and health care factors associated with HIV testing.

If you want to get healthy, a fitness tracker can help. Here at PCMag, we put them through vigorous testing to see which ones are up to the challenge.

Happy Valley LaunchBox powered by PNC Bank is accepting applications through May 15 for its Idea TestLab that will now be hosted virtually in June. Open to the community, the four-week Idea TestLab program is designed to help teams evaluate the viability of their business ideas by coaching them through a proven method of customer discovery and problem analysis.

While we wait for Apple Arcade to launch for iOS devices, Google is preparing its own app/game subscription service for Android called Play Pass.

Your router is the at the heart of your home network, so it's important to get the right one. Here's how we test every Wi-Fi router we review.

Staff from NHS England have been asked to travel hundreds of miles to Scotland to be tested for coronavirus, according to reports.

A sixth resident has died from coronavirus in a care home on Skye.

John Penders
Aug 1, 2006; 118:511-521
ARTICLES

See who is through after October's mini-tournaments; the remaining groups run from 13 to 19 November.

The Los Angeles school district wants to pay teachers based on how much they improve their students' scores on standardized tests, an idea that has provoked a negative reaction from the teachers' union.

The winning writers of Penn State University Libraries Short Stories’ “April Showers” spring 2020 contest have been announced. Representing six Penn State campuses, the latest writing contest challenged Penn State students, faculty and staff across the commonwealth to unleash their best original short stories or poetry on the theme of weather.

Penn State alumnus and author Paul Levine's latest novel, "Cheater's Game," focuses on the college admissions scandal.

Elementary school teachers in the Peach State are using "game-based" formative assessments to take a pulse on their students' learning.

As the two big groups of states craft common-assessment systems, experts warn that the smallest details could undermine their work.

Since learning is so nuanced, so too should be the means in which we assess it. Let's offer students the opportunity to be seen as whole people who can demonstrate different skills and knowledge in a plethora of ways over a period of time.

Most states have raised their expectations for what constitutes proficiency on state math and reading tests in the last decade, according to a new study.

Education Week asked three 8th grade teachers to evaluate real student responses to an open-ended question on the National Assessment of Educational Progress in social studies. Here's what they said.

The PARCC and Smarter Balanced assessments have evolved since they were launched in 2015. Here's a guide to understanding them now.

As civic education undergoes a renaissance in schools, educators are looking beyond standardized tests to determine whether the lessons empower students to embrace civic behaviors, like voting or volunteering.

The collection and use of data about just how prepared individual children are to enter kindergarten can be a ticklish proposition.

Within three weeks, a pandemic has completely changed the national landscape on testing. The U.S. Department of Education has now excused all 50 states and the District of Columbia from the requirement that they test all their students in math and English/language arts.

Following a March 19 announcement by Pennsylvania Gov. Tom Wolf to end physical operations at many businesses statewide, Penn State Executive Vice President and Provost Nicholas P. Jones shared the following message with the University community.

Source: www.extremetech.com - Friday, May 08, 2020
Public health officials universally agree that the world needs much more coronavirus testing before we can safely ease current lock-down restrictions. Even at the low end, experts say we’ll need to do hundreds of thousands more daily tests, but the equipment and resources to make that happen are in short supply. An MIT spin-off company called Sherlock Biosciences has gotten FDA approval to begin using its CRISPR-based COVID-19 test , which promises to be faster and easy to perform without access to a full lab. Current coronavirus testing is based on PCR (polymerase chain reaction), the same technology used in DNA tests. This involves repeatedly heating the sample to amplify the genetic material so technicians can detect viral RNA. Sequencing those samples to hunt for viral genes requires expensive machines that many facilities don’t have, but the Sherlock method relies on a device similar to a pregnancy test. MIT’s Broad Institute developed Sherlock as a way to identify diseases with the clever addition of a reporter molecule with a DNA segment. Sherlock Biosciences now develops tests with this technology for specific diseases like COVID-19. CRISPR/Cas9 has gained fame as a powerful tool for genetic engineering, but that’s slightly different than the system devised by Sherlock. CRISPR is the sequence that guides Cas9 to the specific genetic code where you want to make a cut (known as cleaving), but scientists can also pair CRISP

The Scottish Government’s testing strategy during the coronavirus pandemic is to be investigated by the Health and Sport Committee.

In a sprawling but nuanced examination, comedian John Oliver explained why the U.S. standardized testing system exists and the harms it creates.

Both the House and Senate ESEA bills keep annual tests, but they go very different ways on a lot of other assessment issues.

The Assessment for Learning Project, a partnership between Center for Innovation in Education and Next Generation Learning Challenges, granted twelve grants totaling $2 million for rethinking assessment.

The Democratic presidential candidate likes to highlight his vote against the No Child Left Behind Act in 2001, although his record on the issue of high-stakes standardized testing isn't black and white.

(As of 29 April 2020) Information on travel restrictions and advice on quarantine measures.

Vatican City, Mar 31, 2020 / 10:28 am (CNA).- Cardinal Philippe Ouédraogo of Burkina Faso has tested positive for the coronavirus, his archdiocese announced Tuesday. He is the second cardinal known to have tested positive for the virus, which is now a global pandemic.

Ouédraogo, 75, has been admitted to a medical clinic in Burkina Faso’s capital Ouagadougou.  He is “in good condition and his close collaborators are reported to be self-isolating,” a spokesman for Burkina Faso’s bishops’ conference, Fr. Paul Dah, told ACI Africa on March 31.

The cardinal is president of the African continental bishops’ conference, the Symposium of Episcopal Conferences of Africa and Madagascar (SECAM). He was elected to the post in July 2019. He has been Archbishop of Ouagadougou in Burkina Faso for ten years, and was made a cardinal by Pope Francis in 2014.

Ouédraogo is the second bishop from Burkina Faso known to have contracted COVID-19, as countries across Africa implement lockdowns and restrictions to slow the spread of the virus across the continent.

Another Burkina Faso bishop, Archbishop Emeritus Séraphin François Rouamba of Koupela, tested positive for COVID-19 after being admitted to Our Lady of Peace clinic for urgent treatment on March 19.

The 78-year-old archbishop has since been transferred to another hospital and is reportedly in stable condition, according to a March 25 statement from Bishop Laurent Birfuore Dabire of Dori, Burkina Faso.

Burkina Faso has the largest documented coronavirus outbreak in West Africa, with 249 documented cases as of March 31, according to Johns Hopkins University Coronavirus Resource Center.

The coronavirus has spread throughout the African continent to 47 countries, according to the Africa Center for Disease Control. In North Africa, Egypt, Algeria, and Morocco each have more than 500 documented cases, and the South African government has reported more than 1,300.

Three Nigerian states began two-week mandatory lockdown this week to combat the spread of the virus, including Lagos, Africa’s most populous city with more than 20 million people.

Zimbabwe and Mauritius have also implemented national shut-downs, and the bishops in South Sudan and Zimbabwe have suspended public Masses.

Cardinal Angelo De Donatis, vicar general of the Diocese of Rome, tested positive for coronavirus on March 30.

Other bishops in Italy, France, China, and the United States have also tested positive for COVID-19, and Bishop Angelo Moreschi, 67, died in the Italian city of Brescia on March 25 after contracting the coronavirus.

 

 

A 64-core/128-thread CPU. A new challenger in laptop processors. A feisty new fighter in midrange graphics. These three things have three letters in common. Plus: SSDs take on stunning new capacities, speeds, and looks.

What's CES without a little desktop-PC excess? These dozen products were the ones that mesmerized the PC modder and builder in us.

Massive distribution efforts by OM teams in Bangladesh over more than 10 years sowed gospel seeds and made the Bengali New Testament a #1 best seller.

Somerset West stands out as one of the fastest growing property areas – commercial, residential and industrial - in the Western Cape, according to a new report on the state of the property sector in the Western Cape.

Single women dominated property sales in 2017, 2018 and 2019, compared to single men and even married couples, according to data analytics firm Lightstone.