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Four Theories and a Philosophy: Self-Management Education for Individuals Newly Diagnosed With Type 2 Diabetes

T. Chas Skinner
Apr 1, 2003; 16:
Lifestyle and Behavior




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Kohl & Frisch: A Prescription for Competition

How can Canadian pharmaceutical wholesaler Kohl & Frisch deploy its new market clout after acquiring a key competitor?




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People just wah hear sumpn different - Govana finds captive audience as ‘Convo Pt 2’ hits a million views

Back in January when dancehall artiste Govana released the track HAMANTS Convo, the storyline captivated listeners across the globe. For weeks, the song, which highlights infidelity in relationships, trended at number one on the local YouTube...




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Gospel Spotlight: Gospel Song winner explores ‘Excess Love’

E xcess Love, a song by Nigerian gospel artiste Mercy Chinwo, has found favour with both Christians and non-Christians alike and has been flooding the airwaves since last year. Joanna Walker, the Jamaica Cultural Development Commission's (JCDC)...




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Bars may have to remove stools and tables - Holness hints at measures that could accompany reopening of pubs

It is possible that the next time you walk into a bar you may find that there is only standing room, and you are among a handful of persons allowed inside. Prime Minister Andrew Holness said that in addition to having a specific gathering rule,...




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Dry pipes worry Love Street

Residents of Love Street, a section of Jones Town in Kington, say the area has been suffering from a chronic water shortage for more than two months. Daniesha Taylor, who has lived in the community for 30 years, is fearful that the lack of water...




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Starscope

GLEANER HOROSCOPE MAY 8 2020 WHAT TO DO AND WHEN TO DO IT Entertainment and romance...................14th Domestic and family matters.................13th Bargain hunting and shopping................10th Selling...




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Chic on Sticks going the extra mile for persons with disabilities

Her voice cracked as she related the story of a man with disabilities who lost his wife and whose child has had to drop out of school because he has no money. All he has is Bridgette Johnson, a fellow disabled person who has dedicated her life...




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Fitness freak promotes sperm smoothie

Eyes popped and mouths dropped wide open this week when it was reported in this newspaper that a British woman is using sperm smoothies to build her immune system. Tracy Kiss, 32, said she takes the sperm straight from the source - her boyfriend...




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New Research Reveals Dramatic Shifts in US Household Spending

Data from March shows similarities in spending across various demographics.




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Alumni and Students From Greater China Donate PPE to NY Healthcare Workers Desperate for Gear

As the pandemic ebbed in China, alumni from the region raised more than $2.1 million to send crucial protective gear to New York healthcare workers.




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Competition Policy

Conference

Need for a paradigm shift?

23 May 2019 - 9:30am to 5:30pm

Chatham House, London

Overview

Agenda

Speakers

Pricing and booking information

Sponsors

Media partners and supporting organizations

Venue and accommodation

Press registration

Contact us

Models for antitrust policy and competition regulation have traditionally been guided by principles that have prioritized consumer welfare standards, albeit according to varied interpretations, and antitrust has often been seen as disconnected from mainstream public interest and political debate. But what can lawmakers and regulators do to meet the challenges of the political trend of populism that is prevailing in many developed economies? What should competition regulators do in response to the idea that the consumer welfare standard should be replaced – or supplemented – with another standard, or more broadly interpreted to allow consideration of consumer welfare effects that go beyond price, including the surrender by consumers of their personal data?  

In this context the annual Chatham House Competition Policy conference will assess how a range of public interest considerations — such as unemployment, discrimination or protection of small businesses — and rapidly evolving marketplaces, are reshaping thinking on antitrust policy and the regulation of markets to the extent that changes to the scope and nature of the consumer welfare standard are being advocated.

Discussion themes include:

  • A consumer welfare approach versus market regulation
  • Potential changes to the consumer welfare approach to encompass concerns other than price-related effects
  • Advances in technology and the rise of new and unseen competition concerns 
  • The realities of AI and big data for competition and market regulation
  • What do these potential changes and new market realities mean for the consistency and predictability of antitrust decisions and business certainty
  • To what extent do public interest considerations and wider trade issues impact on international cooperation between antitrust regulators

Continuing Professional Development 
6 CPD hours are available for delegates attending this event, as per the Bar Standards Board’s CPD Provider Accreditation Scheme. For professionals regulated by the Solicitors Regulation Authority, 6 CPD hours are available for delegates that remain opted into the 16 hours annual CPD requirement.

The Chatham House Rule 
To enable as open a debate as possible, this conference will be held under the Chatham House Rule.

Twitter 
@CH_Events
#CHCompetition

Thursday 23 May
0930

Welcome and Chair's opening remarks
Howard Shelanski, Professor of Law, Georgetown University; Partner, Davis Polk & Wardwell   

Session One | Competition Policy and Regulation: Pressures in a Globalised Economy
1000-1110

This opening session will assess the current political and economic dynamics that are shaping the decision-making environment for competition policy and regulation, and how in the context of the ongoing globalisation of the world economy, the pressures and expectations of populist movements along with rising trade tensions may influence the principles of competition policy and regulation across developed and developing countries.

Chair
Howard Shelanski, Professor of Law, Georgetown University; Partner, Davis Polk & Wardwell   

Speakers
Andreas Mundt, President, Bundeskartellamt
Rebecca Slaughter, Commissioner, Federal Trade Commission
Sarah Cardell, General Counsel, Competition and Markets Authority
Liyuan Wang, State Administration for Market Regulation, China

Questions and discussion

1110 – 1130 Refreshments

Session Two | Merger Control in an Environment of Trade Tensions and Populist Challenges
1130–1300

  • How should competition authorities react to growing calls for them to take a tougher stance in relation to mergers and acquisitions in the face of increasing market concentration and the rise of common ownership?
  • Do big businesses cause problems beyond their effects on competition?  If so, are antitrust laws the cure?
  • To what extent should competition authorities have greater ability to intervene to protect smaller companies, or prevent their acquisition, where competition is not (yet) threatened?
  • Where competition authorities do intervene, how should they ensure that they do not stifle investment or discourage innovation?
  • Should competition authorities assess mergers on public interest grounds, including how mergers impact on labour markets or national security?  Should they be asking whether mergers will reduce competition for employees?
  • How should competition authorities respond to calls for the promotion of national champions or other protectionist tendencies?

Chair
Jorge Padilla, Senior Managing Director and Head, Compass Lexecon Europe

Speakers
Cecilio Madero Villarejo, Deputy Director-General, DG Competition, European Commission
Amelia Fletcher, Professor of Competition Policy, Centre for Competition Policy, University of East Anglia
Aaron Hoag, Chief, Technology and Financial Services Section, Antitrust Division, U.S. Department of Justice
Wolfgang Heckenberger, Chief Counsel Competition, Siemens
Alex Nourry, Partner, Clifford Chance

Questions and discussion

1300 – 1400 Lunch

Session Three | Antitrust Tools and the Challenges of the Digital Economy
1400–1540

  • Does the current antitrust framework need to be supplemented by regulation, inter alia to ensure common standards on transparency and fairness of online platforms?
  • Is there a risk that undue intervention by competition authorities or regulation will hurt innovation and destroy incentives for new entrants to emerge capable of challenging incumbents?
  • Does the possession of so-called Big Data give rise to barriers to entry or more efficient and innovative markets?
  • Whilst the use of pricing algorithms can benefit consumers, how concerned should competition authorities be about the possibility that algorithms might facilitate collusive outcomes and lead to higher prices for consumers?
  • Is there any reason to be concerned about the ability of firms to innovate without fear of undue enforcement, particularly given the special duty ascribed to dominant companies as regards their competitors and consumers?

Chair
Thomas Vinje, Partner, Chairman, Global Antitrust Group, Clifford Chance

Speakers
Jason Furman, Professor of the Practice of Economic Policy, Harvard Kennedy School
Tommaso Valletti, Chief Competition Economist, European Commission
Heike Schweitzer, Professor, Humboldt University
David Sevy, Executive Vice President, Compass Lexecon
Horacio Gutierrez, General Counsel, VP Business & Legal Affairs, Spotify

Questions and discussion

1540 – 1610 Afternoon refreshments

Session Four | International Co-operation Between Competition Authorities: Ensuring Consistent and Effective Enforcement in Interconnected Economy
1600–1730

  • How can the compatibility of procedural and substantive competition rules be maintained, along with legal certainty and predictability, in the face of the growing divergence in trade and industrial policies and conflicting public interest goals?
  • To what extent, if any, could the promotion of best practices and substantive convergence in competition enforcement through multi-lateral organisations such as the OECD and the ICN be enhanced?
  • What other steps could be taken to increase co-operation and coordination in the enforcement of the competition rules such as, for example, the development of international standards for comity, systems of mutual recognition of decisions of other authorities or deference to a lead authority?
  • Is bi-lateral and multi-lateral cooperation sufficient to ensure effective and consistent enforcement or is there a greater need for supra-national authorities, at least, regionally, if not internationally?
  • Can or should WTO rules play a greater role in ensuring a level playing field and thereby removing the incentives for divergence in the scope and enforcement of the competition rules?

Chair
Sean Ennis, Director, Centre for Competition Policy and Professor of Competition Policy, University of East Anglia

Speakers
Isolde Goggin, Chairperson of the Competition and Consumer Protection Commission, Ireland
João Paulo Resende, Commissioner, Administrative Council for Economic Defense, Brazil 
Gabriel Harnier, Head of Law, Patents & Compliance, Bayer
Avaantika Kakkar, Partner, Head of Competition Practice, Cyril Amarchand Mangaldas

Questions and discussion

1730 Close of conference and drinks reception

© The Royal Institute of International Affairs 2019

Speakers

Sarah Cardell

General Counsel, CMA

Sean Ennis

Director, Centre for Competition Policy and Professor of Competition Policy, University of East Anglia

Amelia Fletcher

Professor of Competition Policy at the Centre for Competition Policy, University of East Anglia

Jason Furman

Professor of the Practice of Economic Policy, Harvard Kennedy School

Isolde Goggin

Chairperson, Competition and Consumer Protection Commission, Ireland

Horacio Gutierrez

General Counsel and VP Business & Legal Affairs, Spotify

Gabriel Harnier

General Counsel, Bayer

Wolfgang Heckenberger

Senior Competition Advisor, Siemens

Aaron Hoag

Chief, Technology and Financial Services Section, Antitrust Division, U.S. Department of Justice

Avaantika Kakkar

Partner, Head of Competition Practice, Cyril Amarchand Mangaldas

Andreas Mundt

President, Bundeskartellamt

Alex Nourry

Partner, Clifford Chance

Dr Jorge Padilla

Senior Managing Director and Head, Compass Lexecon Europe

João Paulo Resende

Commissioner, Administrative Council for Economic Defense, Brazil

Heike Schweitzer

Professor of Competition, Humboldt University

David Sevy

Executive Vice President, Compass Lexecon

Howard Shelanski

Professor of Law, Georgetown University; Partner, Davis Polk & Wardwell LLP

Rebecca Slaughter

Commissioner, Federal Trade Commission

Tommaso Valletti

Chief Competition Economist, European Commission

Cecilio Madero Villarejo

Deputy Director-General, DG Competition, European Commission

Thomas Vinje

Partner and Chairman, Global Antitrust Group, Clifford Chance

Liyuan Wang

Deputy Director, State Administration for Market Regulation, China

General Counsel of major companies may register at the standard government department rate.

Ways to book:

  1. Online: Click here to complete the online registration form
  2. Phone: Call Boudicca Georgii Hellberg on +44 (0)20 7314 2785
  3. Email/Post: Download a PDF registration form, complete and return to Boudicca Georgii Hellberg via email or post: Chatham House, 10 St. James's Square, London, SW1Y 4LE

Check if your organization is a member of Chatham House here.

 RATE (+VAT):
Partners and major corporate members 
All organizations£595
Standard corporate members 
Commercial organizations£1,180
Government departments/agencies/intergovernmental organizations£700
NGOs/academic institutions/associations (including not for profits and registered charities)£460
Non-members 
Commercial organizations£1,295
Government departments/agencies/intergovernmental organizations£750
NGOs/academic insitutions/associations (including not for profits and registered charities)£510

Your delegate pass includes:

  • Conference attendance
  • Documentation
  • Lunch and refreshments

Travel and accommodation are not included.

If you are interested in becoming a sponsor for this event, please contact Kamil Hussain on +44 (0)20 7957 5783

If you are interested in becoming a media partner or supporting organization for this event, please contact Ayesha Arif on +44 (0)20 7957 5753

Chatham House
10 St James's Square
London
SW1Y 4LE
UK
conferences@chathamhouse.org

Telephone: +44 (0)20 7957 5643
Fax: +44 (0)20 7957 5710

If you wish to book the venue for your own event please phone +44 (0)20 7314 2764

Directions
The nearest tube station is Piccadilly Circus which is on the Piccadilly and the Bakerloo Underground lines. From Piccadilly follow Regent Street southwards towards Pall Mall and take the first road on the right called Jermyn Street. Duke of York Street is the second road on the left and leads to St James's Square. Chatham House is immediately on your right.

Map

Accommodation
Although we cannot book accommodation for delegates, we have arranged a reduced rate at some nearby hotels, where you can book your own accommodation. Please inform the hotel that you will be attending a conference at Chatham House (The Royal Institute of International Affairs) to qualify for the Institute's reduced rate.

Please note all rates are subject to availability.

Flemings Mayfair
13 Half Moon Street
Mayfair
London - W1J 7BH

Tel: + 44 (0)20 7499 2964
Fax: + 44 (0)20 7499 1817
reservations@flemings.co.uk

Classic Double without breakfast: £195 +VAT

The Cavendish London
81 Jermyn Street
London - SW1U 6JF

Tel: + 44 (0)20 7930 2111
Fax: + 44 (0)20 7839 2125
enquiry.cavendish@the-ascott.com 

Classic Room without breakfast: £195 +VAT

Book The Cavendish online

The Stafford London 
St James's Place
London - SW1A 1NJ

Tel: 020 7493 0111
Fax: 020 7493 7121
​reservations@thestaffordlondon.com

Classic Queen without breakfast: £247 +VAT
Quote Chatham House

This conference will be held under the Chatham House Rule. Information for journalists.

Press can request a press pass.

For enquiries relating to the conference agenda or sponsorship please call Kamil Hussain on +44 (0) 20 7957 5783

For registration enquiries please call Boudicca Georgii Hellberg on +44 (0)20 7314 2785

For general enquiries please email conferences@chathamhouse.org 

Department/project




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Security and Prosperity in the Asia-Pacific: The Role of International Law

Research Event

27 March 2019 - 10:00am to 5:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Koji Tsuruoka, Ambassador of Japan to the United Kingdom
Ben Saul, Associate Fellow, International Law Programme, Chatham House; Challis Chair of International Law, Australian National University
Lee Chen Chen, Director, Singapore Institute of International Affairs
Aniruddha​ Rajput, Member, UN International Law Commission; Consultant, Withersworldwide

 

The rapid growth in the Asia-Pacific’s economic and political power has significant implications for global governance. Asia-Pacific countries such as Japan, India and China – and regional bodies such as ASEAN – are increasingly informing, influencing and seeking to shape international standards and norms.

This conference will bring together international law and policy experts to explore the political and legal dynamics affecting economic relations, security challenges and maritime governance in the region.

Given security and prosperity challenges within the region as well as the increasingly complex environment for global governance, to what extent is international law operating as a tool of cooperation in the Asia-Pacific? In which areas is it a source of friction?

And what are the broader implications for global governance including the development of international law?

Chanu Peiris

Programme Manager, International Law
+44 (0)20 7314 3686




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Security and Prosperity in Asia: The Role of International Law

1 November 2019

The 'Security and Prosperity in Asia' conference looked at the impact of international law in the Asia-Pacific with a focus on regional economic and security issues such as the South China Sea disputes.

Security and Prosperity in Asia Cover Image.jpg

Singapore skyline at sunset, 2016. Photo: Getty Images.

About the Conference

At a time of geopolitical uncertainty and with multilateralism under pressure, this conference brought together diverse actors to explore the evolving role of international law on critical security and economic issues in the Asia-Pacific. From trade agreements to deep-sea mining, cyberwarfare to territorial disputes, the breadth of the discussion illustrated the growing reach of international law in the region.

Hosted by the International Law Programme and the Asia-Pacific Programme at Chatham House on 27 March 2019, the conference focused on three themes: trade and investment, maritime security and governance, and emerging security challenges. What trends are emerging in terms of engagement with international law in the region, and how can international standards play a greater role in encouraging collaboration and reducing tensions? And, with the eastward shift in geopolitical power, how will Asia-Pacific states shape the future of international law?




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Power Politics Could Impede Progress on Responsible Regulation of Cyberspace

3 December 2019

Harriet Moynihan

Senior Research Fellow, International Law Programme
A new Chatham House paper examines the prospects of countries reaching agreement on issues of sovereignty and non-intervention in cyberspace in the face of persistent, low-level, state-to-state cyber attacks.

2019-11-29-Intl-Law-Cyberattacks.jpg

A computer hacked by a virus known as Petya. The Petya ransomware cyberattack hit computers of Russian and Ukrainian companies on 27 June 2017. Photo: Getty Images.

In discussions to date about how international law applies in cyberspace, commentators have tended to focus their attention on how the rules on the use of force, or the law of armed conflict, apply to cyber activities conducted by states that give rise to physical damage, injury or death.

But in practice, the vast majority of state cyberattacks fall below this threshold. Far more common are persistent, low-level attacks that may leave no physical trace but that are capable of doing significant damage to a state’s ability to control its systems, often at serious economic cost.

Such cyber incursions might include network disruptions in the operation of another government’s websites; tampering with electoral infrastructure to change or undermine the result; or using cyber means to destabilize another state’s financial sector.

For these kinds of cyber operation, the principle of sovereignty, and the principle of non-intervention in another state’s internal affairs, are the starting point.

A UN Group of Government Experts (GGE) agreed in 2013 and 2015 that the principles in the UN Charter, including sovereignty and the prohibition on intervention in another state’s affairs, apply to states’ activities in cyberspace. The 2015 GGE also recommended eleven (non-binding) norms of responsible state behaviour in cyberspace.

However, states have not yet reached agreement on how to apply these principles. Until recently, there has also been very little knowledge of what states actually do in cyberspace, as they usually conduct cyber operations covertly and have been reluctant to put their views on record.

A new Chatham House research paper analyses the application of the principles of sovereignty and non-intervention to state cyberattacks that fall below the principle of use of force. As well as analysing the application of the law in this area, the paper also makes recommendations to governments on how they might best make progress in reaching agreement in this area.

Existing rules or new rules?

As the research paper makes clear, there is currently some debate, principally between countries in the West, about the extent to which sovereignty is a legally binding rule in the context of cyberspace and, if so, how it and the principle of non-intervention might apply in practice.

In the last few years, certain states have put on record how they consider international law to apply to states’ activities in cyberspace, namely the UK, Australia, France and the Netherlands. While there may be some differences in their approaches, which are discussed in the paper, there also remains important common ground: namely, that existing international law already provides a solid framework for regulating states’ cyber activities, as it regulates every other domain of state-to-state activity.

There is also an emerging trend for states to work together when attributing cyberattacks to hostile states, enabling them to call out malign cyber activity when it violates international law. (See, for example, the joint statements made in relation to the NotPetya cyber attack and malicious cyber activity attributed to the Russian government).

However, other countries have questioned whether existing international law as it stands is capable of regulating states’ cyber interactions and have called for ‘new legal instruments’ in this area.

This includes a proposal by the Shanghai Cooperation Organization (led by Russia and China) for an International Code of Conduct on Information Security, a draft of which was submitted to the UN in 2011 and 2015, without success. The UN has also formed a new Open-Ended Working Group (OEWG) under a resolution proposed by Russia to consider how international law applies to states’ activities in cyberspace.

The resolution establishing the OEWG, which began work earlier this year, includes the possibility of the group ‘introducing changes to the rules, norms and principles of responsible behaviour of States’ agreed in the 2013 and 2015 GGE reports. In the OEWG discussions at the UN in September, several countries claimed that a new legal instrument was needed to fill the ‘legal vacuum’ (Cuba) or ‘the gap of ungoverned areas’ (Indonesia).

It would be concerning if the hard-won consensus on the application of international law to cyberspace that has been reached at past GGEs started to unravel. In contrast to 2013 and 2015, the 2017 meeting failed to reach an agreement.

On 9 December, a renewed GGE will meet in New York, but the existence of the OEWG exploring the same issues in a separate process reflects the fact that cyber norms have become an area of geopolitical rivalry.

Aside from the application of international law, states are also adopting divergent approaches to the domestic regulation of cyberspace within their own territory. The emerging trend towards a ‘splinternet’ – i.e. between states that believe the internet should be global and open on the hand, and those that favour a ‘sovereignty and control’ model on the other  – is also likely to make discussions at the GGE more challenging.

Distinct from the international law concept of sovereignty is the notion of ‘cybersovereignty’, a term coined by China to describe the wide-ranging powers it assumes under domestic law to regulate its citizens’ access to the internet and personal data within its territory. This approach is catching on (as reflected in Russia’s recently enacted ‘Sovereign Internet Law’), with other authoritarian states likely to follow suit.

The importance of non-state actors

In parallel with regional and UN discussions on how international law applies, a number of initiatives by non-state actors have also sought to establish voluntary principles about responsible state behaviour in cyberspace.

The Global Commission on the Stability of Cyberspace, a multi-stakeholder body that has proposed principles, norms and recommendations to guide responsible behaviour by all parties in cyberspace, recently published its final report. The Cybersecurity Tech Accord  aims to promote collaboration between tech companies on stability and resilience in cyberspace. President Macron’s ‘Paris Call for Trust and Security in Cyberspace’ has to date received the backing of 67 states, 139 international and civil society organizations, and 358 private-sector organizations.

It remains to be seen in the long term whether the parallel processes at the UN will work constructively together or be competitive. But notwithstanding the challenging geopolitical backdrop, the UN GGE meeting next week at the least offers states the opportunity to consolidate and build on the results of past meetings; to increase knowledge and discussion about how international law might apply; and to encourage more states to put their own views of these issues on the record.




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Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPAR{alpha}-regulated genes [Lipids]

Fatty acid transport protein 2 (FATP2) is highly expressed in the liver, small intestine, and kidney, where it functions in both the transport of exogenous long-chain fatty acids and the activation of very-long-chain fatty acids. Here, using a murine model, we investigated the phenotypic impacts of deleting FATP2, followed by a transcriptomic analysis using unbiased RNA-Seq to identify concomitant changes in the liver transcriptome. WT and FATP2-null (Fatp2−/−) mice (5 weeks) were maintained on a standard chow diet for 6 weeks. The Fatp2−/− mice had reduced weight gain, lowered serum triglyceride, and increased serum cholesterol levels and attenuated dietary fatty acid absorption. Transcriptomic analysis of the liver revealed 258 differentially expressed genes in male Fatp2−/− mice and a total of 91 in female Fatp2−/− mice. These genes mapped to the following gene ontology categories: fatty acid degradation, peroxisome biogenesis, fatty acid synthesis, and retinol and arachidonic acid metabolism. Targeted RT-quantitative PCR verified the altered expression of selected genes. Of note, most of the genes with increased expression were known to be regulated by peroxisome proliferator–activated receptor α (PPARα), suggesting that FATP2 activity is linked to a PPARα-specific proximal ligand. Targeted metabolomic experiments in the Fatp2−/− liver revealed increases of total C16:0, C16:1, and C18:1 fatty acids; increases in lipoxin A4 and prostaglandin J2; and a decrease in 20-hydroxyeicosatetraenoic acid. We conclude that the expression of FATP2 in the liver broadly affects the metabolic landscape through PPARα, indicating that FATP2 provides an important role in liver lipid metabolism through its transport or activation activities.




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COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10 [Lipids]

Coenzyme Q (Qn) is a vital lipid component of the electron transport chain that functions in cellular energy metabolism and as a membrane antioxidant. In the yeast Saccharomyces cerevisiae, coq1–coq9 deletion mutants are respiratory-incompetent, sensitive to lipid peroxidation stress, and unable to synthesize Q6. The yeast coq10 deletion mutant is also respiratory-deficient and sensitive to lipid peroxidation, yet it continues to produce Q6 at an impaired rate. Thus, Coq10 is required for the function of Q6 in respiration and as an antioxidant and is believed to chaperone Q6 from its site of synthesis to the respiratory complexes. In several fungi, Coq10 is encoded as a fusion polypeptide with Coq11, a recently identified protein of unknown function required for efficient Q6 biosynthesis. Because “fused” proteins are often involved in similar biochemical pathways, here we examined the putative functional relationship between Coq10 and Coq11 in yeast. We used plate growth and Seahorse assays and LC-MS/MS analysis to show that COQ11 deletion rescues respiratory deficiency, sensitivity to lipid peroxidation, and decreased Q6 biosynthesis of the coq10Δ mutant. Additionally, immunoblotting indicated that yeast coq11Δ mutants accumulate increased amounts of certain Coq polypeptides and display a stabilized CoQ synthome. These effects suggest that Coq11 modulates Q6 biosynthesis and that its absence increases mitochondrial Q6 content in the coq10Δcoq11Δ double mutant. This augmented mitochondrial Q6 content counteracts the respiratory deficiency and lipid peroxidation sensitivity phenotypes of the coq10Δ mutant. This study further clarifies the intricate connection between Q6 biosynthesis, trafficking, and function in mitochondrial metabolism.




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The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis [Cell Biology]

Sperm head shaping is a key event in spermiogenesis and is tightly controlled via the acrosome–manchette network. Linker of nucleoskeleton and cytoskeleton (LINC) complexes consist of Sad1 and UNC84 domain–containing (SUN) and Klarsicht/ANC-1/Syne-1 homology (KASH) domain proteins and form conserved nuclear envelope bridges implicated in transducing mechanical forces from the manchette to sculpt sperm nuclei into a hook-like shape. However, the role of LINC complexes in sperm head shaping is still poorly understood. Here we assessed the role of SUN3, a testis-specific LINC component harboring a conserved SUN domain, in spermiogenesis. We show that CRISPR/Cas9-generated Sun3 knockout male mice are infertile, displaying drastically reduced sperm counts and a globozoospermia-like phenotype, including a missing, mislocalized, or fragmented acrosome, as well as multiple defects in sperm flagella. Further examination revealed that the sperm head abnormalities are apparent at step 9 and that the sperm nuclei fail to elongate because of the absence of manchette microtubules and perinuclear rings. These observations indicate that Sun3 deletion likely impairs the ability of the LINC complex to transduce the cytoskeletal force to the nuclear envelope, required for sperm head elongation. We also found that SUN3 interacts with SUN4 in mouse testes and that the level of SUN4 proteins is drastically reduced in Sun3-null mice. Altogether, our results indicate that SUN3 is essential for sperm head shaping and male fertility, providing molecular clues regarding the underlying pathology of the globozoospermia-like phenotype.




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Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome

Xien Yu Chua
Apr 1, 2020; 19:730-743
Technological Innovation and Resources




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Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis

Beatriz Rocha
Apr 1, 2020; 19:574-588
Research




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Peptide-based interaction proteomics

Katrina Meyer
Apr 28, 2020; 0:R120.002034v1-mcp.R120.002034
Review




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Modulation of natural HLA-B*27:05 ligandome by ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 2 (ERAP2)

Elena Lorente
Apr 7, 2020; 0:RA120.002014v1-mcp.RA120.002014
Research




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Characterization of Prenylated C-terminal Peptides Using a Thiopropyl-based Capture Technique and LC-MS/MS

James A. Wilkins
Apr 13, 2020; 0:RA120.001944v1-mcp.RA120.001944
Research




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Seminal Plasma Proteome as an Indicator of Sperm Dysfunction and Low Sperm Motility

Yunlei Li
Apr 20, 2020; 0:RA120.002017v1-mcp.RA120.002017
Research




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Proteaphagy in mammalian cells can function independent of ATG5/ATG7

Tatjana Goebel
Apr 16, 2020; 0:RA120.001983v1-mcp.RA120.001983
Research




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Identification of an Unconventional Subpeptidome Bound to the Behcet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1)

Liye Chen
May 1, 2020; 19:871-883
Research




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Quantitative proteomics of human heart samples collected in vivo reveal the remodeled protein landscape of dilated left atrium without atrial fibrillation

Nora Linscheid
Apr 14, 2020; 0:RA119.001878v1-mcp.RA119.001878
Research




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Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity

Mona Radwan
Apr 1, 2020; 19:640-654
Research




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A cross-linking mass spectrometry approach defines protein interactions in yeast mitochondria

Andreas Linden
Apr 24, 2020; 0:RA120.002028v1-mcp.RA120.002028
Research




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Characterization of signaling pathways associated with pancreatic {beta}-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice

Taewook Kang
Apr 7, 2020; 0:RA119.001882v1-mcp.RA119.001882
Research




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Proteome and phosphoproteome analysis of brown adipocytes reveals that RICTOR loss dampens global insulin/AKT signaling

Samuel W Entwisle
Apr 6, 2020; 0:RA120.001946v2-mcp.RA120.001946
Research




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Large-scale Identification of N-linked Intact Glycopeptides in Human Serum using HILIC Enrichment and Spectral Library Search

Qingbo Shu
Apr 1, 2020; 19:672-689
Research




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Selection of features with consistent profiles improves relative protein quantification in mass spectrometry experiments

Tsung-Heng Tsai
Mar 31, 2020; 0:RA119.001792v1-mcp.RA119.001792
Research




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Quantitative Profiling of the Human Substantia Nigra Proteome from Laser-capture Microdissected FFPE Tissue

Eva Griesser
May 1, 2020; 19:839-851
Research




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Improving Identification of In-organello Protein-Protein Interactions Using an Affinity-enrichable, Isotopically Coded, and Mass Spectrometry-cleavable Chemical Crosslinker

Karl A. T. Makepeace
Apr 1, 2020; 19:624-639
Research




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Acquiring and Analyzing Data Independent Acquisition Proteomics Experiments without Spectrum Libraries

Lindsay K Pino
Apr 20, 2020; 0:P119.001913v1-mcp.P119.001913
Perspective




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A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients

Dorte B. Bekker-Jensen
Apr 1, 2020; 19:716-729
Technological Innovation and Resources




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Proximity Dependent Biotinylation: Key Enzymes and Adaptation to Proteomics Approaches

Payman Samavarchi-Tehrani
May 1, 2020; 19:757-773
Review




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A New Type of Learning Community

Setting high standards is expected from all educators. Yet, I think I may have taken this to an extreme in my 2019 spring senior seminar course in algebraic combinatorics. Students walked in to class, got a copy of the syllabus … Continue reading




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Transparency and Accountability for Drone Use: European Approaches

Invitation Only Research Event

11 March 2019 - 9:30am to 12 March 2019 - 12:30pm

Chatham House

With increased use of military drones in recent years there have also been many calls for greater transparency and accountability with regards to drone operations.

This would allow for greater public understanding, particularly as the complex nature of military operations today intensifies difficulties in sustaining perceptions of the legitimate use of force.

For example, in Europe, leading states rely on the US for drone platforms and for the infrastructure - such as military communication networks - that enable those operations, while the US also relies on airbases in European states to operate its drone programme.

In addition, with reports that the US is loosening the rules on the use of drones, it is important to understand how European approaches to transparency and accountability may be affected by these developments.

This workshop focuses on how European states can facilitate transparency to ensure accountability for drone use, as well as what the limits might be, considering both the complexity of military operations today and the need for achieving operational goals.

With the US easing restrictions on export controls, the discussion also considers the role of regulation in ensuring accountability and prospects for developing common standards.

Attendance at this event is by invitation only.

Nilza Amaral

Project Manager, International Security Programme




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European Approaches to Remote Warfare

Research Event

15 May 2019 - 9:00am to 6:00pm

Brussels, Belgium

With continuing instability at Europe's borders, along with uncertainty on future US support for NATO, many European countries are increasing their allocations to defence budgets and to collective European strategic defence. In addition, with non-state armed groups creating instability and threatening civilian lives and livelihoods in proximity to the EU’s borders, various operations have been carried out in conflict theatres in the Middle East, North Africa and the Sahel under the auspices of NATO, the UN, the EU or by single EU member states.

Although European military personnel have been deployed in many regions, with countries becoming more reluctant to deploy ‘boots on the ground’, warfare has been increasingly conducted through remote means. This has led to criticism on the limited transparency and accountability mechanisms at work in these operations, while some have questioned the military effectiveness of such tactics or the capacity and willingness of states to ensure that targets are struck accurately and without impact on civilian populations.

Against this background, the EU has started allocating resources to military research and development projects with a focus on unmanned systems and related technologies. Under the auspices of the European Defence Fund such funding is set to increase, while potential bilateral programmes between some states have also been explored. Despite concerns raised by the European Parliament, the development of these policies and technologies has taken place without significant consideration of what the legal, ethical and military-strategic impact of these instruments might be.    

This event will bring together a range of experts, policymakers and civil society organizations to discuss the technology horizon of European defence investments and policy developments around remote warfare. Participants will discuss the implications of the new EU defence fund, legal, ethical, and transparency issues in military research and development and the position of the EU as a global actor. 

This event is being organized in partnership with PAX Netherlands.

THIS EVENT IS NOW FULL AND REGISTRATION HAS CLOSED.

Nilza Amaral

Project Manager, International Security Programme




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The Implications of Drone Proliferation in Europe

Invitation Only Research Event

20 May 2019 - 9:30am to 21 May 2019 - 12:30pm

Chatham House, London

Several countries in Europe are currently developing, increasing or arming their drone capabilities. This increase in drone capability is taking place through procurement by individual states, bilateral projects – such as the French-German Future Combat Air Systems – and multinational efforts that include the development of the Eurodrone – a project by Germany, France, Italy and Spain – and the nEUROn which involves France, Greece, Italy, Spain, Sweden and Switzerland. In addition, the EU has recently approved the European Defence Fund which, along with funds for joint development of defence equipment and technology and for defence research, also includes direct funding to support the development of the Eurodrone.
  
Other recent developments include the UK obtaining the MQ−9B SkyGuardian – an updated variant of the MQ-9 Reaper – and Germany signing a leasing agreement for the Israeli-made Heron TP. Also, in March 2019, the US State Department approved the sale of the MQ-9B SkyGuardian to Belgium and announced the provision of MQ-9 Reaper drones to the Netherlands. While the UK and France are the only countries in Europe so far to possess armed drones, Italy is on track to acquire armed drones in the near future. However, out of the European countries currently seeking to obtain unarmed drones – including Spain, Poland and Greece – only Switzerland has so far ruled out weaponizing its drones in the future.
 
This Chatham House workshop will examine key issues pertaining to drone proliferation in Europe including: 
  • The risks and challenges of the increasing number and arming of drones. 
  • The risks for countries of not doing so in terms of geostrategic interests and the future battlefield.
  • Opportunities for developing common standards on drone transfers and deployment across EU member states.
  • Sharing and cooperation on drone use.
  • What legal and policy implications might arise for European states as a result.

With Brexit on the horizon, participants will also consider what impact this may have on future drone developments in Europe.

Attendance at this event is by invitation only.

Nilza Amaral

Project Manager, International Security Programme




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Peter Watkins

Associate Fellow, International Security Programme

Biography

Peter Watkins became an associate fellow for Chatham House in June 2019. Before that, from 2014 to 2018, he was Director General (DG) in the UK Ministry of Defence (MoD) responsible for strategic defence policy, including key multilateral and bilateral relationships (such as NATO), nuclear, cyber, space and prosperity (latterly this post was known as the DG Strategy and International).

Previously he served as DG of the Defence Academy, Director of Operational Policy, Director responsible for the UK share of the multinational Typhoon combat aircraft programme and as Defence Counsellor in the UK Embassy in Berlin.

He is a frequent participant in conferences on defence and security in the UK and overseas.

He was awarded the CB (2019) and CBE (2004) for services to defence. He has an MA from Cambridge University.

Areas of expertise

  • European security
  • Deterrence policy
  • Nuclear policy
  • Stabilisation and peacekeeping
  • International armaments cooperation

Past experience

2006-07Fellow, Weatherhead Center for International Affairs, Harvard University
1993-94Senior course member, NATO Defense College

 




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The Future of EU–US Cooperation in Space Traffic Management and Space Situational Awareness

29 August 2019

As more space activities develop, there is an increasing requirement for comprehensive space situational awareness (SSA). This paper provides an overview of the current landscape in SSA and space traffic management as well as possible scenarios for EU–US cooperation in this area. 

Alexandra Stickings

Research Fellow for Space Policy and Security, RUSI

2019-08-19-SpaceTrafficManagement.jpg

Deployment of the NanoRacks-Remove Debris Satellite from the International Space Station. Photo: Getty Images.

Summary

  • Space situational awareness (SSA) and space traffic management (STM) are essential for sustainable near-Earth orbit. International cooperation in SSA and STM is vital with the growing number of satellite operators and the increasingly complex space environment.
  • The various definitions of SSA and STM are ambiguous. Understanding the activities that fall under each term can better assist in finding areas for cooperation and collaboration.
  • SSA has historically been a military activity, leading to an incomplete public catalogue of its use and barriers to sharing information with other states and the commercial sector. The rise in private space actors has increased the number of commercial STM providers and, with plans in the US to move responsibility for STM to civilian control, there will likely be more opportunities for international collaboration, particularly through the EU Space Surveillance and Tracking (SST) programme.
  • Individual EU member states possess developed STM capabilities, but overall these are still some way behind those of allies such as the US. Further investment in STM infrastructure and programmes is required for the EU and individual European states to be an essential partner to the US and add value to the global effort.
  • There are worldwide challenges, both political and technical, to providing STM coverage, which may lead to a lack of collaboration and gaps in understanding of activities in orbit. Existing sensors have limitations in terms of the size of objects that can be detected and the precision with which their movements can be predicted. These capability gaps represent opportunities for the EU to contribute.
  • The EU can build on its tradition of support for openness and civil society by creating a system that fosters an environment of cooperation and collaboration involving industry, commercial STM providers and the wider international community.
  • Although collaboration in STM is vital, the EU should also aim to tackle issues within the wider definition of SSA including space weather, intelligence and the security of ground stations.
  • The EU is well placed to become a global leader in SSA and STM. However, it needs to take into consideration the current political and technical landscape when making decisions regarding investment in capabilities and the pursuit of international partnerships.




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Smart Peace

With the number of violent conflicts increasing, there is a worldwide need to respond more effectively. Dialogue and mediation are proven to be effective in preventing and resolving conflicts, which are often complex, political and frequently-changing.

But there is more to be done to understand how these approaches can adapt – responding quickly to changing politics and overcoming obstacles that block progress.

Smart Peace is a global initiative led by Conciliation Resources, which combines the varied expertise of different consortium partners to address the challenges of building peace – focusing on the Central African Republic, Nigeria and Myanmar.

This work combines peacebuilding techniques, conflict analysis, rigorous evaluation and behavioural insights. The resulting lessons will help communities, international organisations and governments to implement peace strategies with greater confidence.

This project is funded with UK aid from the UK government.

Smart Peace Partners

Department contact

Nilza Amaral

Project Manager, International Security Programme




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EU–US Cooperation on Tackling Disinformation

3 October 2019

Disinformation, as the latest iteration of propaganda suitable for a digitally interconnected world, shows no signs of abating. This paper provides a holistic overview of the current state of play and outlines how EU and US cooperation can mitigate disinformation in the future.

Sophia Ignatidou

Academy Associate, International Security Programme

2019-09-19-FakeNews.jpg

A congressional staff member displays print outs of social media posts during a hearing before the House Select Intelligence Committee 1 November 2017 in Washington, DC. Photo: Getty Images.
  • EU and US cooperation on tackling disinformation needs to be grounded in an international human rights framework in order to bridge the differences of both parties and include other countries facing this challenge.
  • The disinformation debate needs to be reformulated to cover systemic issues rather than merely technical or security concerns. A lag in regulatory development has led to systemic vulnerabilities. In this context, policymakers need to push for more evidence-based analysis, which is only attainable if technology companies engage in honest debate and allow meaningful access to data – as determined by government appointed researchers rather than the companies themselves – taking into account and respecting users’ privacy.
  • Data governance needs to be the focus of attempts to tackle disinformation. Data’s implications for information, market and power asymmetries, feed into and exacerbate the problem.
  • Policymakers should focus on regulating the distribution of online content rather than the subject matter itself, which may have implications for freedom of speech.
  • Disinformation is mainly the result of inefficient gatekeeping of highly extractive digital companies. The old gatekeepers, journalists and their respective regulators, need to be actively engaged in devising the new regulatory framework.
  • Legacy media need to urgently consider the issue of ‘strategic silence’ and avoid being co-opted by political actors aiming to manipulate the accelerated, reactive news cycle by engaging in divisive ‘clickbait’ rhetoric verging on disinformation and propaganda. When strategic silence is not an option, contextual analysis is fundamental.
  •  The EU delegation should assist the coordination of EU–US efforts to tackle disinformation by drawing on the work and expertise at the G7 Rapid Response Mechanism (RRM), the Transatlantic Commission on Election Integrity (TCEI), the European Centre of Excellence for Countering Hybrid Threats (Hybrid CoE), the High-level Panel on Digital Cooperation, and work with the International Telecommunication Union (ITU) to foster a long-term interdisciplinary forum to harness technological innovation to protect and support democracy from threats such as disinformation.
  • The EU and US must avoid rushed regulation that may condone enhanced surveillance or vilify journalism that scrutinizes those in power in the name of security.




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AI-driven Personalization in Digital Media: Political and Societal Implications

2 December 2019

The fallout from disinformation and online manipulation strategies have alerted Western democracies to the novel, nuanced vulnerabilities of our information society. This paper outlines the implications of the adoption of AI by the the legacy media, as well as by the new media, focusing on personalization.

Sophia Ignatidou

Academy Associate, International Security Programme

2019-12-02-AI-Driven-Personalization-small.jpg

The Reuters and other news apps seen on an iPhone, 29 January 2019. Photo: Getty Images.

Summary

  • Machine learning (ML)-driven personalization is fast expanding from social media to the wider information space, encompassing legacy media, multinational conglomerates and digital-native publishers: however, this is happening within a regulatory and oversight vacuum that needs to be addressed as a matter of urgency.
  • Mass-scale adoption of personalization in communication has serious implications for human rights, societal resilience and political security. Data protection, privacy and wrongful discrimination, as well as freedom of opinion and of expression, are some of the areas impacted by this technological transformation.
  • Artificial intelligence (AI) and its ML subset are novel technologies that demand novel ways of approaching oversight, monitoring and analysis. Policymakers, regulators, media professionals and engineers need to be able to conceptualize issues in an interdisciplinary way that is appropriate for sociotechnical systems.
  • Funding needs to be allocated to research into human–computer interaction in information environments, data infrastructure, technology market trends, and the broader impact of ML systems within the communication sector.
  • Although global, high-level ethical frameworks for AI are welcome, they are no substitute for domain- and context-specific codes of ethics. Legacy media and digital-native publishers need to overhaul their editorial codes to make them fit for purpose in a digital ecosystem transformed by ML. Journalistic principles need to be reformulated and refined in the current informational context in order to efficiently inform the ML models built for personalized communication.
  • Codes of ethics will not by themselves be enough, so current regulatory and legislative frameworks as they relate to media need to be reassessed. Media regulators need to develop their in-house capacity for thorough research and monitoring into ML systems, and – when appropriate –proportionate sanctions for actors found to be employing such systems towards malign ends. Collaboration with data protection authorities, competition authorities and national electoral commissions is paramount for preserving the integrity of elections and of a political discourse grounded on democratic principles.
  • Upskilling senior managers and editorial teams is fundamental if media professionals are to be able to engage meaningfully and effectively with data scientists and AI engineers.




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The Smart Peace Initiative: An Integrated and Adaptive Approach to Building Peace

Invitation Only Research Event

12 May 2020 - 10:00am to 11:30am
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Smart Peace brings together global expertise in conflict analysis and research, peacebuilding and mediation programming, and behavioural science and evaluation. Together, Smart Peace partners are developing integrated and adaptive peace initiatives, working with local partners to prevent and resolve complex and intractable conflicts in Central African Republic, Myanmar and northern Nigeria.
 
This roundtable is an opportunity for Smart Peace partners to share the Smart Peace concept, approach and objectives, and experiences of the first phases of programme implementation. Roundtable discussions among participants from policy, practice and research communities will inform future priorities and planning for Smart Peace learning, advocacy and communication.
 
Smart Peace partners include Conciliation Resources, Behavioural Insights Team, The Centre for Humanitarian Dialogue, Chatham House, ETH Zurich, International Crisis Group and The Asia Foundation.

Nilza Amaral

Project Manager, International Security Programme




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Deterrence Perspectives in the 21st Century

The aim of this project is to provide a space to explore creative/disruptive ideas in order to make headway on perspectives concerning deterrence. This will encourage ‘responsible disruption’ in the nuclear field.

Concerns about transatlantic security are high following the US 2018 Nuclear Posture Review and its interpretation of the Russian doctrine, the demise of the Intermediate Range Nuclear Forces Treaty (INF), the uncertainty surrounding the potential extension of the New Strategic Arms Reduction Treaty (New START), and Russian deployment of Avangard hypersonic, nuclear-capable missile systems.

Emerging technologies, especially quantum technologies, jeopardize the reliability of existing encryption measures. Some of the most sophisticated cyber attacks are already assisted by artificial intelligence. The possibility that nuclear weapons systems can be interfered with both during conflict and peacetime by these technologies, without the knowledge of the possessor state, raises questions on the reliability and integrity of these systems, with implications for military decision-making, particularly to deterrence policy.

These issues and more indicate the changes in the security landscape that have a bearing on the future of nuclear deterrence.

This project is supported by the Hiroshima Prefecture and Government of Ireland.




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Perspectives on Nuclear Deterrence in the 21st Century

20 April 2020

Nuclear deterrence theory, with its roots in the Cold War era, may not account for all eventualities in the 21st century. Researchers at Chatham House have worked with eight experts to produce this collection of essays examining four contested themes in contemporary policymaking on deterrence.

Dr Beyza Unal

Senior Research Fellow, International Security Programme

Yasmin Afina

Research Assistant, International Security Programme

Dr Patricia Lewis

Research Director, Conflict, Science & Transformation; Director, International Security Programme

Dr John Borrie

Associate Fellow, International Security Programme

Dr Jamie Shea

Associate Fellow, International Security Programme

Peter Watkins

Associate Fellow, International Security Programme

Dr Maria Rost Rublee

Associate Professor of International Relations, Monash University

Cristina Varriale

Research Fellow in Proliferation and Nuclear Policy, RUSI

Dr Tanya Ogilvie-White

Adjunct Senior Fellow, Griffith Asia Institute, Griffith University

Dr Andrew Futter

Associate Professor of International Politics, University of Leicester

Christine Parthemore

Chief Executive Officer, Council on Strategic Risks (CSR)

2020-04-20-NuclearDeterrence.jpeg

Royal Navy Vanguard Class submarine HMS Vigilant returning to HMNB Clyde after extended deployment. The four Vanguard-class submarines form the UK's strategic nuclear deterrent force. Photo: Ministry of Defence.

Summary

  • This collection of essays explores, from the perspectives of eight experts, four areas of deterrence theory and policymaking: the underlying assumptions that shape deterrence practice; the enduring value of extended deterrence; the impact of emerging technologies; and the ‘blurring’ of the lines between conventional and nuclear weapons.
  • Nuclear deterrence theory, with its roots in the Cold War era, may not account for all eventualities in security and defence in the 21st century, given the larger number of nuclear actors in a less binary geopolitical context. It is clear that a number of present factors challenge the overall credibility of ‘classical’ nuclear deterrence, meaning that in-depth analysis is now needed.
  • Uncertainty as to the appetite to maintain the current nuclear weapons policy architecture looms large in discussions and concerns on global and regional security. The demise of the Intermediate-Range Nuclear Forces Treaty, doubts over the potential extension of the New Strategic Arms Reduction Treaty, heightened regional tensions in Northeast and South Asia, together with the current and likely future risks and challenges arising from global technological competition, making it all the more urgent to examine long-held assumptions in the real-world context.
  • Extended deterrence practices differ from region to region, depending on the domestic and regional landscape. Increased focus on diplomatic capabilities to reduce risks and improve the long-term outlook at regional level, including by spearheading new regional arms-control initiatives, may be a viable way forward. Addressing the bigger picture – notably including, on the Korean peninsula, Pyongyang’s own threat perception – and the links between conventional and nuclear missile issues will need to remain prominent if long-term and concrete changes are to take hold.
  • Most states have long held nuclear weapons to be ‘exceptional’: their use would represent a dramatic escalation of a conflict that must never be attained. Latterly, however, some officials and scholars have made the case that the impact of the use of a low-yield nuclear weapon would not be entirely distinct from that of a large-scale conventional attack. This blurring of lines between conventional and nuclear deterrence strips nuclear weapons of their exceptional nature, in a context in which states are faced with diverse, complex and concurrent threats from multiple potential adversaries that are able to synchronize non-military and military options, up to and including nuclear forces. The use of nuclear weapons risks becoming a ‘new normal’, potentially reducing the threshold for use – to cyberattacks, for example. This has direct implications for discussions around strategic stability. 
  • While emerging technologies may offer tremendous opportunities in the modernization of nuclear weapons, they also present major risks and destabilizing challenges. Artificial intelligence, automation, and other developments in the cyber sphere affect dynamics on both the demand and supply sides of the nuclear deterrence equation. States and alliance such as NATO must adapt their deterrence thinking in light of these technological developments, and define their primary purpose and priorities in this shifting security context. Resilience planning, adaptation to the evolving security environment, threat anticipation, and consistent crisis management and incident response – as well as thinking about the mitigation measures necessary to prevent conflict escalation should deterrence fail – will all be critical in upholding nuclear deterrence as both policy and practice.