TRB’s Airport Cooperative Research Program (ACRP) Conference Proceedings on the Web 23: Economic and Social Sustainability at Airports is a compilation of the presentations and a summary of the ensuing discussions at May 7-8, 2018, forum in Washington, D.C. The meeting brought together individuals from airports, airlines, academia, consulting, local and regional government, general sustainability professionals, and others. The forum included sessions on social sustainability, economic sustainability, key...

TRB’s Airport Cooperative Research Program (ACRP) Conference Proceedings on the Web 23: Economic and Social Sustainability at Airports is a compilation of the presentations and a summary of the ensuing discussions at May 7-8, 2018, forum in Washington, D.C. The meeting brought together individuals from airports, airlines, academia, consulting, local and regional government, general sustainability professionals, and others. The forum included sessions on social sustainability, economic sustainability, key...

The Marine Board of the National Academies of Sciences, Engineering, and Medicine (National Academies) is seeking nominations for new members to be appointed to three-year terms that would commence on November 1, 2020. There will be five (5) vacancies on the Board in 2020 and there is particular interest in candidates with expertise in the following areas: Naval Architecture and Naval Engineering Shipbuilding/Shipyard Operations Vessel Pilotage and Harbor Operations Seaport Administration, Planning, and ...

In the Columbus City Schools, Ohio's largest school district, 62% of students have the required technology to learn online. The district is not alone. Schools around the state are on the hunt for online resources to close the gap -- and turning to corporate America and the public for help.

Charles Burns je magorický komiksový génius, jehož knihy vás nenechají chladnými. Někomu mohou být odporné, jiný se v nich bude blaženě pitvat a snažit se o interpretaci autorových výpotků. Je pravda, že podivnost se v jeho komiksech stupňuje. Teď máme jako druzí na světě – dříve než Američané a Britové – možnost pohroužit se do prvního dílu jeho nové trilogie.

Finished Comics Characters DC Comics: Grayson, Richard ‘Dick’ (Nightwing/Robin); DC Comics: Death Moved Comics Comic Book Series Johnny the Homicidal Maniac (JtHM) (All) Relationships DC Comics: Kyle, Selina (Catwoman) and Bruce Wayne (Batman); Marvel Comics: Hardy, Felicia (Black Cat) and Peter Parker (Spider-Man) Closed Comics (Open for application) There are no closed forms to process […]

EPISODE SUMMARY Today's show is brought to you by Wacom — makers of the incredible Wacom One! This week, the ComicLab guys talk shop with Gale Galligan, creator of the bestselling Babysitter's Club graphic novels. See all of Gale's latest at Galesaur.com. EPISODE NOTES Today's show is brought to you by Wacom — makers of the incredible Wacom One! This week, the ComicLab guys talk shop with Gale Galligan, creator of the bestselling Babysitter's Club graphic novels.

EPISODE SUMMARY This week, Dave and Brad talk about the best Content Management System (CMS) for publishing webcomics. Toocheke is brand new, and Brad's a big fan. EPISODE NOTES Today's show is brought to you by Wacom — makers of the incredible Wacom One! This week, Dave and Brad talk about the best Content Management System (CMS) for publishing webcomics. Toocheke is brand new, and Brad's a big fan. Questions asked and topics covered... Toocheke i

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Microsoft, Cisco, Google etc gang up to form Open RAN Policy Coalition

Some of America’s super-corps have remembered how the US became the dominant global technology force it is, and have vowed to use innovation over threats to counter Chinese dominance in 5G markets.…

Для того, чтобы узнать дату, необходимо решить несложную задачу.

Компания Xiaomi осенью прошлого года выпустила смартфон Mi Note 10, но обновление Android 10 добралось до аппарата только сейчас.

Компания Xiaomi, неожиданно для всех, объявила дату анонса очередного смартфона из линейки Redmi K30.

Мы уже не раз писали о том, что компания Xiaomi готовит к выходу бюджетный смартфон Redmi 9. Сейчас в сети появилась очередная утечка, намекающая на его скорый анонс.

Экспедиционная группа из Китая поднялась на гору Эверест и решила там же протестировать в экстремальных условиях камеры смартфонов.

Daron Acemoglu of MIT and Pascual Restrepo of Boston University find that robots really do decrease human employment. As robots and other computer-assisted technologies take over tasks previously performed by labor, there is increasing concern about the future of jobs and wages. We analyze the effect of the increase in industrial robot usage between 1990 and 2007 on US local labor markets. Using a model in which robots compete against human labor in the production of different tasks, we show that robots may reduce employment and wages, and that the local labor market effects of robots can be estimated by regressing the change in employment and wages on the exposure to robots in each local labor market—defined from the national...

Familial dysautonomia (FD) is the most prevalent form of hereditary sensory and autonomic neuropathy (HSAN). In FD, a germline mutation in the Elp1 gene leads to Elp1 protein decrease that causes sympathetic neuron death and sympathetic nervous system dysfunction (dysautonomia). Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neuron survival is very poorly understood. Here, we identified a cytoplasmic function for Elp1 in sympathetic neurons that was essential for retrograde nerve growth factor (NGF) signaling and neuron target tissue innervation and survival. Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylation (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex. In the absence of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulted in retrograde signaling failure and neuron death. Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-dependent retrograde signaling, and in an animal model of FD it rescued abnormal sympathetic target tissue innervation. These results suggest that regulation of retrograde NGF signaling in sympathetic neurons by Elp1 may explain sympathetic neuron loss and physiologic dysautonomia in patients with FD.

Approximately half of the world’s population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori–infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We found that H. pylori compromises key tumor suppressor mechanisms: the host stress and apoptotic responses. Our studies showed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host proapoptotic factor Siva1. This process is mediated by the PI3K/Akt pathway. Inhibition of Siva1 by H. pylori increases survival of human cells with damaged DNA. It occurs in a strain-specific manner and is associated with the ability to induce gastric tumor.

Эксперты из DxOMark протестировали камеры новых смартфонов iPhone 11 Pro и 11 Pro Max, и в результате испытаний новинки от компании Apple оказались недостаточно хороши, чтобы возглавить рейтинг. В общ...

Online criminals have been systematically targeting TurboTax, filing fraudulent tax returns of individuals, and diverting their tax refunds to prepaid debit, cards, stealing their personal information, and using and impairing their credit ratings. Continue reading →

THE AMERICAN PEOPLE IN THIS PARTICULAR MOMENT IN OUR HISTORY MUST MAKE A VERY FUNDAMENTAL DECISION, AND THAT DECISION IS DO WE CONTINUE THE STATUS QUO WHICH INCLUDES A 40-YEAR DECLINE OF OUR MIDDLE CLASS AND A HUGE AND GROWING GAP BETWEEN THE VERY, VERY RICH AND EVERYONE ELSE, OR DO WE FIGHT FOR A BOLD AND MEANINGFUL ECONOMIC AGENDA THAT CREATES JOBS, RAISES WAGES, PROTECTS OUR ENVIRONMENT AND PROVIDES HEALTH CARE FOR EVERY AMERICAN Continue reading →

Sen. Bernie Sanders (I-Vt.) warns not to underestimate him in the 2016 Democratic race for the White House. Sanders, who is formally launching his campaign Tuesday, said he has a strong message. Continue reading →

“Thank you all very much for being here and for all the support that you have given me over the years: as the mayor of this great city, as Vermont’s only congressman and now as a U.S. senator. Thanks also … Continue reading →

An Offer in Compromise is an agreement between the taxpayer and the government that settles a tax liability for payment of less than the full amount owed. The Internal Revenue Service will generally accept an Offer in Compromise when it … Continue reading →

European Union leaders have offered Britain a Brexit extension until May 22.

1-800-Flowers.com, Inc. (NASDAQ: FLWS) Gifts When you Need, an online gift concierge for the leading provider of floral and gourmet gifts, may help shoppers uncover the perfect gift for Moms this year. Data from thousands of customers using GWYN powered by IBM Watson (NYSE: IBM) gives insight on hot gifts picks for Mother’s Day.