Actor Dwayne Johnson (L) and Simone Alexandra Johnson attend the People's Choice Awards 2017 at Microsoft Theater on January 18, 2017 in Los Angeles, California. ; Credit: Christopher Polk

When Dwayne "The Rock" Johnson debuted his Hollywood persona in World Wrestling Entertainment in 2003, he was two years removed from his first successful protagonist role in "The Scorpion King" and on the heels of more film success with roles in "The Rundown" and "Walking Tall." 

Little did anyone foresee that "Hollywood" Rock would buoy the overall representation for Asian and Pacific Islanders in popular film for the next 20 years.

Last week, the USC Annenberg Inclusion Initiative released a report documenting the prevalence of Asian and Pacific Islanders both on-and off-screen across the top-grossing films each year from 2007 to 2019.  Of the 1,300 films examined, only 44 featured API actors playing lead roles, nearly a third of which were played by Johnson. 

The report offers more staggering statistics:

• In 2019, over a quarter of API characters in the top-grossing films died. Most died by drowning, explosions, stabbing or suicides

• Of the over 51,000 speaking characters in the 1,300 films examined, only 6% were Asian, Asian American or Native Hawaiian/Pacific Islanders

• Only 50 of the 1,447 directors in the 1,300 films examined were of API heritage.

• In 2019, 67% of API characters played stereotyped roles

The release of this report comes at a time of rising anti-Asian hate crimes nationally, and the authors of the report believe the portrayal of Asian and Pacific Islanders in mass media contributes to that. Today on FilmWeek, we delve into the study's findings and discuss the history of API filmmakers and actors in Hollywood.

Guests: 

Nancy Wang Yuen, professor of sociology at Biola University in La Mirada; she is co-author of “The Prevalence and Portrayal of Asian and Pacific Islanders Across 1,300 Popular Films”; she tweets @nancywyeun

Justin Chang, film critic for the Los Angeles Times and NPR’s Fresh Air; he tweets @JustinCChang

This content is from Southern California Public Radio. View the original story at SCPR.org.

Vancouver-based minerals explorer Prosper Gold Corp. (TSVX: PGF; OTCQB: PGXFF) is focused on its district-scale Cyprus copper-gold project in north-central British Columbia. One analyst says the results of a recent geophysical survey put the stock in an excellent position.

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Needle pricks not your thing? A team of National Science Foundation-funded scientists is developing wearable skin sensors that can detect what's in your sweat. They hope that one day, monitoring perspiration could bypass the need for more invasive procedures like blood draws, and provide real-time updates on health problems such as dehydration or fatigue. In a new paper, the team describes a new sensor design that can be rapidly manufactured using a "roll-to-roll" processing technique that essentially prints the sensors onto a sheet of plastic like words on a newspaper. They used the sensors to monitor the sweat rate, and the electrolytes and metabolites in sweat, from volunteers who were exercising, and others who were experiencing chemically induced perspiration. The new sensors contain a spiraling microscopic tube, or microfluidic, that wicks sweat from the skin. By tracking how fast the sweat moves through the microfluidic, the sensors can report how much a person is sweating, or their sweat rate. The microfluidics are also outfitted with chemical sensors that can detect concentrations of electrolytes like potassium and sodium, and metabolites like glucose.

Image credit: Bizen Maskey/Sunchon National University

Source: Dr. David Nierengarten 11/07/2024

TScan Therapeutics Inc. (TCRX:NASDAQ) Phase 1 ALLOHA study, evaluating its lead therapeutic candidates TSC-100 and TSC-101 in hematologic malignancies, showed patients continuing to have a positive response after one year, reported Wedbush analyst Dr. David Nierengarten in a Nov. 5 research note. TSC-100 and TSC-101 are T-cell receptor-engineered T-cell therapies (TCR-Ts).

"We see a catalyst-rich next few months ahead with data building in prominence on stock impact," Nierengarten wrote.

87% Return Potential

Wedbush has a US$10 per share target price on the Massachusetts-based biotech, trading at the time of the report at about US$5.36 per share, noted the analyst. The difference between these figures implies an 87% return potential for investors.

TScan Therapeutics remains rated Outperform.

Durability of Response Data

Nierengarten presented the clinical trial's latest results. As of the July 8, 2024 data cutoff date, in Phase 1 of ALLOHA, 16 patients with hematologic tumors had been administered TSC-100 or TSC-101, and 11 patients had been given a placebo. Median follow-ups had occurred at 5.8 months and 5.3 months, respectively.

At the time, none of the patients in the treatment arm had had a relapse. In the control arm, however, three, or 27% of, the 11 patients had, and the median time to relapse was 159 days. The analyst explained that this is typical for patients receiving a hematopoietic stem cell transplant after reduced-intensity conditioning.

One year out from treatment, five patients were evaluable, and all remained relapse free and minimal residual disease negative at the time. These data underscore the durability of response to this TCR-T treatment, Nierengarten commented. Its safety profile was shown to be favorable still, with no patients experiencing dose-limiting toxicities or adverse events associated with allogeneic hematopoietic cell transplantation.

"Enrollment continues in dose expansion cohorts, and results could support a registrational trial as early as 2025, pending regulatory feedback," Nierengarten wrote.

On the Horizon

TScan Therapeutics has several catalysts related to its clinical programs on the horizon, which Nierengarten listed.

On Nov. 8 and 9, the company will present preclinical data in the poster sessions at the annual Society for Immunotherapy of Cancer meeting. One poster will show in vitro combinatorial data for T-Plex, TScan's cellular therapy for treating solid tumors. It is comprised of two to three different TCR-Ts that target different tumor antigens on different human leukocyte antigen (HLA) types.

A second poster will detail the expansion of ImmunoBank, the biotech's diverse bank of therapeutic T-cell receptors (TCRs) that recognize diverse targets and are associated with multiple HLA types. The third will depict development of a target agnostic platform to evaluate how TCR-Ts affect primary human tissues.

On Dec. 9, TScan Therapeutics will present updated one-year data from ALLOHA, at the American Society for Hematology Annual Meeting in December.

By year-end, the biotech will announce initial data from administering singleplex therapy, cell therapy engineered using a single TCR, to patients with solid tumors. This treatment is being given to establish safety before administering multiplex therapy, cell therapy engineered from multiple TCRs.

In 2025, TScan Therapeutics will provide long-term duration of response data for multiplex therapy in solid tumors and will potentially commence a registrational trial for TSC-100 and TSC-101.

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Disclosures for Wedbush, TScan Therapeutics Inc., November 5, 2024

Analyst Certification We, David Nierengarten, Martin Fan and Dennis Pak, certify that the views expressed in this report accurately reflect our personal opinions and that we have not and will not, directly or indirectly, receive compensation or other payments in connection with our specific recommendations or views contained in this report.

Company Specific Disclosures This information is subject to change at any time. 1. WS makes a market in the securities of TScan Therapeutics, Inc.. 6. WS is acting as a financial advisor for TScan Therapeutics, Inc..

Wedbush disclosure price charts are updated within the first fifteen days of each new calendar quarter per FINRA regulations. Price charts for companies initiated upon in the current quarter, and rating and target price changes occurring in the current quarter, will not be displayed until the following quarter. Additional information on recommended securities is available on request. Disclosure information regarding historical ratings and price targets is available: Research Disclosures *WS changed its rating system from (Strong Buy/ Buy/ Hold/ Sell) to (Outperform/ Neutral/ Underperform) on July 14, 2009. Applicable disclosure information is also available upon request by contacting the Research Department at (212) 833-1375, by email to leslie.lippai@wedbush.com. You may also submit a written request to the following: Wedbush Securities, Attn: Research Department, 142 W 57th Street, New York, NY 10019.

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( Companies Mentioned: TCRX:NASDAQ, )

Operationally, the company's renewable energy generation was up 397% year over year. Discover the many potential catalysts for the stock.

For the last month, Frank Galaviz has wondered when running water will return to his town.

The 77-year-old resident of Teviston — a small rural community in Central California — has been forced to depend on stored and bottled water after the pump in the town's only functioning well broke down in early June. Since then, residents have had to travel to neighboring towns to shower or depend on the town's water storage tanks for their daily needs.

Temperatures continue to reach into triple digits as a brutal heat wave sweeps across the West Coast. The ongoing drought only exacerbates the problem, Galaviz says.

"[My wife and I] have lived through many challenges," he says. "We both have survived cancer, but we will not be able to survive without water. This is a problem that is not going away."

Teviston sits between the cities of Fresno and Bakersfield in the San Joaquin Valley and is home to mostly Latino farmworkers. Normal days in town are usually slow-paced and idyllic, Galaviz says, with many residents commuting to the nearby towns and cities on business. Now, they leave to find more water.

This is not the first time Galaviz or his neighbors have struggled with a broken well. He says two other wells had broken down in previous years and had not been repaired. A new, more modern well is in the works, but Galaviz estimates its completion is still a few years off.

The community continues waiting for repair parts to arrive in hopes it will fix the current well's pump, he added, a process that could take a few weeks.

"It is not normal to not be able to flush toilets," he says. "It's not normal to not be able to take a shower."

Residents have managed to come up with a temporary fix, using their water storage tanks to offer relief.

"We were able to get some of the water pressure back," Galaviz said. "We put a submersible pump into one of our old wells and we're forcing water from the storage tanks through that system. But it's not a permanent fix."

Rural Latino communities in California have been particularly vulnerable to drought conditions, according to a report from the state Legislative Analyst's Office.

"Having no water equals bad health," state Sen. Melissa Hurtado, who serves California's 14th District, tells Weekend Edition. Hurtado says her bill, SB 559, would allot $785 million to fund and repair water supply infrastructure. One of the waterways posed for fixing is the Friant-Kern canal, which supplies Teviston and the towns around it. Over the years, the canal has become subject to subsidence — a condition that has caused some parts of the canal to sink and means it can't deliver as much water.

"SB 559 would help fix the canal so that the basin and the communities that rely on water here would be able to have more access to it," Hurtado says.

Galaviz has spent the last few weeks knocking on doors to check in on neighbors and trying to organize help.

"I have a neighbor whose daughter has medical problems. She needs drinking water, pure water," he says. "It hurts to see people suffering."

Hafsa Fathima and Jan Johnson produced and edited the audio story.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Bharti Airtel has awarded a multi-million-dollar contract to IBM to deploy a blockchain -based pan India network which will allow the telco to protect its 284 million subscribers from pesky calls and messages

Through a series of ambitious initiatives and strategic investments, India is actively working to overcome barriers and create a level playing field for technology adoption. From expanding connectivity infrastructure to investing in digital literacy programs, the nation is leaving no stone unturned in its pursuit of equitable access to technology.

As of January 2, 2010 restaurants, bars and other businesses that serve food and drink in Catawba County became smoke-free. Many health advocates and local residents are pleased that they can now enjoy a healthier dining experience. The ban is a result of a new law that prohibits smoking in all restaurants and bars across North Carolina.

In the fall of 2009, as a part of the Catawba Aging Leadership Planning Project, Catawba County, along with aging service providers, volunteers and local municipalities developed a �Livable & Senior Friendly Community Survey�. This survey was widely distributed throughout Catawba County and targeted the County�s Senior Community, their caregivers and professionals in the aging field. The purpose of the survey was to obtain current and relevant information on the quality of life of seniors. Obtaining this information is important when looking toward the future of Catawba County.

Proper dental care and routine trips to the dentist help to guarantee that children and adults not only have a healthy smile, but a healthy body as well. To help ensure that every child in Catawba County has access to dental care, Catawba County Public Health Dental Practice serves as a resource for children ages 4 to 17.

Children learn their habits, attitudes and beliefs from their parents and other caregivers, and that includes their willingness to try new and healthy foods. The American Dietetic Association and Catawba County Women, Infants, and Children (WIC) encourages adults to be good role models and teach children how to appreciate nutrition and enjoy healthful eating.

When it comes to air quality, many believe it's only an issue during the summer. Air quality remains a problem year round, with ozone being a concern in the summer and particulate matter posing a problem year round. Public Health is working with local officials to raise the importance of air quality awareness and what citizens can do to help improve air quality.

Catawba County has upgraded a feed from its 911 Center of the information on calls regarding traffic incidents. The feed shows the type of incident reported, such as a vehicle accident, stranded motorist or vehicle fire, and gives the location of the incident. Only traffic related incidents are reported through this feed.

Lindsey Smith was recognized by the North Carolina Society for Public Health Education as a new health educator in North Carolina who has made outstanding contributions to the profession.

Residents and businesses affected by severe storms and tornado on Oct. 26 in Catawba County can apply for low-interest disaster loans from the U.S. Small Business Administration, SBA Administrator Karen G. Mills announced today. Mills made the loans available in response to a letter from North Carolina Gov. Beverly E. Perdue on Nov. 12, requesting a disaster declaration by the SBA. The declaration covers Lincoln County and the adjacent counties of Burke, Catawba, Cleveland, Gaston, Iredell and Mecklenburg in North Carolina.

Between February 16 and 24, 2011, more than 2,500 students in Catawba County�s three public school systems received the 2010-11 flu vaccine due to a successful partnership between the schools and Catawba County Public Health. School nurses collected permission forms from parents and coordinated flu vaccine mini-clinics at 43 schools.

�Catawba Communities,� a monthly show which will feature information about programs and services provided by local governments, school systems and associated agencies across Catawba County, will premiere on Charter Communications� Government Channel (Channel 3) on Tuesday, August 23, 2011, at 8:00 p.m.

Internal Systems Analyst Scott Klinger was recognized, in part, for integrating a new billing program that resulted in improved efficiencies across the organization.

The expansion will more than double clinic space. It will allow the clinic to provide routine dental services, such as cleanings, fillings, sealants, and extractions, to an additional 1,500 children and young adults. During the renovation, the current dental practice will remain open and operate under current hours

The program of the North Carolina Department of Transportation provides limited funds for low-income persons who need to maintain or insure their car so they can continue working. It is administered by Catawba County Social Services

A new agreement extends borrowing privileges at Lenoir-Rhyne University Library to registered users of Hickory Public and Catawba County Libraries.

The Catawba County Library System has received two awards from the North Carolina Public Library Directors� Association. Library Director Karen Foss was on hand to accept honors for the new Conover Branch facility and Battle of the Books programming presented at the NCPLDA annual awards banquet December 6 in Winston-Salem.

Catawba County Public Health, in partnership with its Women, Infants, and Children (WIC) program and Catawba County Health Partners� Eat Smart Move More Catawba County coalition, is launching a farmers market May 2. The market will be held in Public Health�s parking lot Thursdays from 11:00 a.m. to 2:00 p.m. and is open to the public.

Catawba County Public Health's annual report, emergency preparedness outreach have won national honors from the National Association of County Information Officers.

Catawba County offers electronics and paint recycling, year round, at Blackburn Landfill during regular landfill operating hours, as of July 1.

Article by Catawba County Public Health School Nurse Margaret Sides on vision screenings for students is published nationally.

Many Catawba County residents will be able to recycle more items beginning November 4.

Catawba County Public Health has earned reaccreditation from the North Carolina Local Health Department Accreditation Board.

Dental care was recently provided for hundreds of children by Catawba County Public Health.

A scientifically accurate and valid epidemiologic study of reproductive problems among the families of veterans exposed to radiation from atomic bombings and nuclear weapons tests is not feasible, concluded an Institute of Medicine (IOM) committee in a new report.

More targeted aircraft testing and simulation should be conducted to uncover design characteristics in new flight control systems that -- in rare circumstances -- may mislead pilots and result in unstable or dangerous flight conditions, says a new report by a National Research Council committee.

The federal government should not increase the maximum level of copper allowed in drinking water, because higher levels could lead to liver poisoning in infants and children with certain genetic disorders.

While the U.S. Environmental Protection Agencys guideline for protecting the public from a toxic form of mercury is justifiable based on the latest scientific evidence, some children of women who consume large amounts of fish and seafood during pregnancy may be at special risk of neurological problems.

Darkly colored, carotene-rich fruits and vegetables -- such as carrots, sweet potatoes, and broccoli -- provide the body with half as much vitamin A as previously thought.

As the recent spread of West Nile virus and the anthrax scare of 2001 dramatically illustrate, America faces a variety of new health challenges in the 21st century, along with a number of persistent problems, such as racial disparities in health status and care delivery.

Scientific evidence links mold and other factors related to damp conditions in homes and buildings to asthma symptoms in some people with the chronic disorder, as well as to coughing, wheezing, and upper respiratory tract symptoms in otherwise healthy people, says a new report from the Institute of Medicine of the National Academies.

Use of protective face coverings will be one of many strategies used to slow or prevent transmission of the flu virus in the event of a pandemic, even though scientific evidence about the effectiveness of inexpensive, disposable medical masks and respirators against influenza is limited.

A limited body of evidence suggests an association between military service and later development of amyotrophic lateral sclerosis (ALS), a rare but fatal neurodegenerative disorder, says a new report from the Institute of Medicine.

A new report from the Institute of Medicine finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing high blood pressure in some veterans.

Good morning. I am Dr. Alice Gast and I am here today with Dr. David Relman as the chair and vice chair of the Committee on the Review of the Scientific Approaches Used During the FBI’s Investigation of the 2001 Bacillus anthracis Mailings.

Evidence exists that people who lived or worked at Camp Lejeune Marine Base in North Carolina between the 1950s and 1985 were exposed to the industrial solvents tricholorethylene (TCE) or perchloroethylene (PCE) in their water supply, but strong scientific evidence is not available to determine whether health problems among those exposed are due to the contaminants, says a new report from the National Research Council.

A new report from the Institute of Medicine finds suggestive but limited evidence that exposure to Agent Orange and other herbicides used during the Vietnam War is associated with an increased chance of developing ischemic heart disease and Parkinsons disease for Vietnam veterans.

A National Research Council committee asked to examine the scientific approaches used and conclusions reached by the Federal Bureau of Investigation during its investigation of the 2001 Bacillus anthracis mailings has determined that it is not possible to reach a definitive conclusion about the origins of the anthrax in letters mailed to New York City and Washington, D.C., based solely on the available scientific evidence.

As of today all PDF versions of books published by the National Academies Press will be downloadable to anyone free of charge. This includes a current catalog of more than 4,000 books plus future reports produced by the Press.

An analysis of more than 1,000 research articles concluded that few health problems are caused by or clearly associated with vaccines.

Educational and business leaders want todays students both to master school subjects and to excel in areas such as problem solving, critical thinking, and communication

The U.S. electric power delivery system is vulnerable to terrorist attacks that could cause much more damage to the system than natural disasters such as Hurricane Sandy, blacking out large regions of the country for weeks or months and costing many billions of dollars, says a newly released report by the National Research Council.