the

Exploring the potential of sorghum with reference to its bioactivite, physicochemical properties and potential health benefits

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04128C, Review Article
Sakshi Singh, Mehvish Habib, David J McClements, Khalid Bashir, Shumaila Jan, Kulsum Jan
Sorghum is a resilient and adaptable cereal grain recognized for its rich nutritional profile. It is a valuable source of dietary fiber (around 6%), protein (9-13%), and essential minerals such...
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the

Summer–autumn tea promotes adipocyte browning and thermogenesis in association with gut microbiota regulation in high-fat diet-fed mice

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03826F, Paper
Chengcheng Yang, Luyao Liu, Yao Du, Lu Zhao, Lu Liu, Xingbin Yang, Yan Zhao
This study revealed for the first time the anti-obesity effect of summer–autumn tea aqueous extract (SATE) and its underlying mechanism.
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Gastroprotective effects of Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 against ethanol-induced gastric ulcers via regulation of the immune response and gut microbiota in mice

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04106B, Paper
Yun-En Huang, Sheng-Yi Chen, Tsung-Ju Li, You-Shan Tsai, Chin-Chu Chen, Gow-Chin Yen
Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 exert gastroprotective effects against ethanol-induced gastric ulcers through multiple mechanisms.
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Anti-obesity and other health benefits of bioprocessed black rice bran in combination with green tea extract in 3T3-L1 preadipocyte cells and in mice on a high-fat diet

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03210A, Paper
Ki Sun Kwon, Eun Seok Lee, Kyung Hee Lee, Woon Sang Hwang, Wha Young Lee, Jae Jung Kim, Jeanman Kim, Sang-Jong Lee, Sung Phil Kim, Mendel Friedman
Black rice bran, a waste product from the commercial milling of black rice that removes the bran and germ and leaves the starchy endosperm, contains bioactive anthocyanin, phenolic, and phytosteroid...
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the

Enzymatic treatment to decrease the allergenicity of Pru p 3 from peach

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03052D, Paper
Open Access
Ana Pilar Tobajas, Ana Agulló-García, Jose Luis Cubero, Carlos Colás Sanz, Alba Civera, Clara Esteban, L. Sanchez, M. D. Perez
Pru p 3, a member of the Lipid Transfer Protein family, is considered a major allergen from peach and it often induces serious allergic reactions in peach allergic individuals. The...
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the

Polyphenols for stroke therapy: the role of oxidative stress regulation

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO01900H, Review Article
Yusong Luo, Ruolan Liu, Guoqiang Yuan, Yawen Pan
Molecular mechanisms of the antioxidant effects of polyphenols in stroke.
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Aspartate restrains thermogenesis by inhibiting the AMPK pathway in adipose tissues

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03614J, Paper
Shengjun Dong, Mengxin Jiang, Qinglei Sun, Junqing Xu, Lei Zhang, Lei Han, Yan-na Li, Zhengtong Zhou, Yingjiang Xu
We evaluated the potential effects of aspartate on brown adipose tissue function.
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the

Preparation and characterization of white shrimp hydrolysate-xylooligosaccharides Maillard products and their in vivo promotive effects of zinc absorption in mice

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO03709J, Paper
Shijie Dou, Xuening Yu, Yuewen Xu, Xiaoyang Liu, Fawen Yin, Deyang Li, Da-Yong Zhou
The Maillard reaction products, as a kind of glycosylation-based reaction, possess the metal-chelating ability. In this study, the white shrimp hydrolysate (WH) and xylooligosaccharides (XOS) were used to prepare the...
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the

Bioactive compounds regulate appetite through the melanocortin system: a review

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04024D, Review Article
Yujia Niu, Wancong Yu, Xiaohong Kou, Shuqi Wu, Mengyi Liu, Chenlong Chen, Jiaxin Ji, Ying Shao, Zhaohui Xue
The melanocortin system is regulated by long-term and short-term regulatory hormones and nutrients. Bioactive compounds influence appetite through multiple pathways: central nervous system, peripheral hormones, and intestinal microbiota.
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Goat milk derived small extracellular vesicles ameliorate LPS-induced intestinal epithelial barrier dysfunction, oxidative stress, and apoptosis by inhibiting the MAPK signaling pathway

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04067H, Paper
Feng Gao, Xin Zhang, Zhiming Xu, Kang Zhang, Fusheng Quan
Intestinal injury is often accompanied by epithelial barrier dysfunction, oxidative stress, and apoptosis.
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the

Impact of pH on the fabrication of egg white reinforced soy protein composite microgels for gastrointestinal delivery purposes

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03997A, Paper
Feng Liu, Yi Liu, Suyun Zhang, Gang Liu, Christos Ritzoulis, Yue Zhang
Protein molecules such as soy protein isolate (SPI) and egg white (EW) are highly promising materials for developing hydrogels (especially micro/nanogels) for the encapsulation, protection and controlled release of bioactive substances.
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the

Investigation of the hypoglycemic bioactive components of Phyllanthi Fructus through biological assessment combined with ultrafiltration affinity mass spectrometry

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04198D, Paper
Yifan Zhang, Qiang Yu, Peng Tan, Shimin Tian, Jun-zhi Lin, Mengqi Li, Li Han, Haozhou Huang, Ding-kun Zhang
Phyllanthi Fructus (PF) is a tropical fruit with the potential to effectively reduce postprandial blood glucose, making it highly promising for the development of functional foods. However, the lack of...
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the

Protein-bound AGEs derived from methylglyoxal induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO00364K, Paper
Gang Yu, Jianxin He, Zhongshan Gao, Linglin Fu, Qiaozhi Zhang
Protein-bound advanced glycation end-products (AGEs) induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism.
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the

The quercetin metabolite 4-methylcatechol causes vasodilation via voltage-gated potassium (KV) channels

Food Funct., 2024, 15,11047-11059
DOI: 10.1039/D3FO04672A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Patrícia Dias, Rudy Salam, Jana Pourová, Marie Vopršalová, Lukáš Konečný, Eduard Jirkovský, Jurjen Duintjer Tebbens, Přemysl Mladěnka
One of important metabolites of dietary polyphenols is 4-methylcatechol (4-MC). This compounds causes vasodilation likely due to an effect on voltage-dependent potassium channels (KV) as suggested by our ex vivo and in silico docking study.
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the

Influence of dairy matrix on the prebiotic effects of inulin related to gut metabolic activity and bone health

Food Funct., 2024, 15,11129-11140
DOI: 10.1039/D4FO01635A, Paper
Xiaorui Zhao, Weiwei He, Louise M. A. Jakobsen, Farhad M. Panah, Banny Silva Barbosa Correia, Dennis Sandris Nielsen, Axel K. Hansen, Hanne Christine Bertram
This study investigated if the prebiotic efficacy of inulin depends on the dairy matrix used as vehicle.
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the

Lactobacillus plantarum 69-2 combined with α-lactalbumin hydrolysate alleviates DSS-induced ulcerative colitis through the TLR4/NF-κB inflammatory pathway and the gut microbiota in mice

Food Funct., 2024, 15,10987-11004
DOI: 10.1039/D4FO02975E, Paper
Yue Ma, Chuanbing Hu, Jing Zhang, Cong Xu, Lizhi Ma, Yunhe Chang, Muhammad Altaf Hussain, Jiage Ma, Juncai Hou, Zhanmei Jiang
Ulcerative colitis (UC), an inflammatory bowel disease, seriously affects people's quality of life.
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the

Aronia melanocarpa extract extends the lifespan and health-span of Caenorhabditis elegans via mitogen-activated protein kinase 1

Food Funct., 2024, 15,11020-11035
DOI: 10.1039/D4FO02479F, Paper
Huan Zhang, Zhigang Zhu, Wenjing Wei, Zekun Liu, Huiji Zhou, Yueling Gong, Xinlei Yan, Jun Du, Houkai Li, Liang Chen, Lili Sheng
Aronia melanocarpa (AM) was shown to promote the lifespan and health-span of C. elegans via the PMK-1 pathway, highlighting the potential of AM as a dietary supplement for delaying aging.
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the

Lacticaseibacillus plantarum postbiotics prepared by the combined technique of pasteurization and ultrasound: effective measures to alleviate obesity based on the SCFAs-GPR41/GPR43 signaling pathway

Food Funct., 2024, 15,11005-11019
DOI: 10.1039/D4FO03591G, Paper
Chao Miao, Linge Wang, Huabing Wang, Yu Shen, Chaoxin Man, Wei Zhang, Yu Zhang, Qianyu Zhao, Yujun Jiang
Postbiotics prepared by ultrasound and pasteurization are used for the alleviation of obesity.
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the

Adherence to the Mediterranean diet is associated with reduced chronic pancreatitis risk: a longitudinal cohort study

Food Funct., 2024, 15,11072-11082
DOI: 10.1039/D4FO02588A, Paper
Open Access
Chunhua Zhou, Jiawei Geng, Hanyi Huang, Lintao Dan, Zhipeng Wu, Xixian Ruan, Yao Zhang, Jie Chen, Jing Sun, Duowu Zou
The role of diet on the risk of chronic pancreatitis (CP) is understudied.
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the

Dynamic changes in the gel properties, microbial community, and volatile flavor profile of Spanish mackerel (Scomberomorus niphonius) sausages inoculated with Lactiplantibacillus plantarum CY1-2

Food Funct., 2024, 15,11060-11071
DOI: 10.1039/D4FO03841J, Paper
Xinran Lv, Wenyu Wu, Shuilin Liu, Lili Ding, Anqi Ren, Le An, Fengling Bai, Jianrong Li, Xuepeng Li, Shumin Yi
This study aimed to examine the dynamic changes in the gel properties, microbial diversity, and volatile flavor compounds (VFCs) of Spanish mackerel sausages inoculated with Lactiplantibacillus plantarum CY1-2 during fermentation.
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the

Metagenomic and transcriptomic profiling of the hypoglycemic and hypotriglyceridemic actions of Tremella fuciformis-derived polysaccharides in high-fat-diet- and streptozotocin-treated mice

Food Funct., 2024, 15,11096-11114
DOI: 10.1039/D4FO01870B, Paper
Xiaofei Xu, Xiaofei Liu, Liyan Liu, Jin Chen, Jingjing Guan, Donghui Luo
Tremella fuciformis polysaccharides exhibit hypoglycemic and hypotriglyceridemic activities through altering the taxonomic and functional attributes of the gut microbiota and modulating gene expression in the liver.
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the

Regulation of redox enzymes by nutraceuticals: a review of the roles of antioxidant polyphenols and peptides

Food Funct., 2024, 15,10956-10980
DOI: 10.1039/D4FO03549F, Review Article
Joy I. Obeme-Nmom, Raliat O. Abioye, Samanta S. Reyes Flores, Chibuike C. Udenigwe
Several nutraceutical compounds, such as polyphenols and peptides, modulate the enzymatic antioxidant defence system, providing an avenue for the development of multifunctional functional foods.
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the

Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP–PS1 transgenic mice

Food Funct., 2024, 15,11236-11251
DOI: 10.1039/D4FO03355H, Paper
Yan Shao, Fei Li, Bo Zou, Yanling Jin, Xiaoyang Wang, Liting Wang, Youying Huang, Yu Xie, Wei Sun, Jing X. Kang, Kai Liu, Yi Huang, Wei Huang, Bin Wang
Our study showed that MAG upregulation might be the new regulatory mechanism for omega-3 PUFAs to exert AD protective effects, which is helpful for expanding our understanding of the health-promoting effects of omega-3 PUFAs.
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the

Human milk oligosaccharides and milk fat globule membrane reduce allergic reactions in mice through the modulation of gut microbiota and metabolic functions

Food Funct., 2024, 15,11252-11265
DOI: 10.1039/D4FO03851G, Paper
Xinzhang Chen, Shengjun Yang, Zhengtao Guo, Bailiang Li, Zhongjiang Wang, Lianzhou Jiang
Human milk oligosaccharides (HMOs) and the milk fat globule membrane (MFGM) represent novel treatments for cow's milk allergy (CMA).
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the

Development of Pickering water-in-oil emulsions using a dual stabilization of candelilla wax and acylated EGCG derivatives to enhance the survival of probiotics (Lactobacillus plantarum) powder

Food Funct., 2024, 15,11141-11157
DOI: 10.1039/D4FO01342E, Paper
Zhaojuan Shi, Jun Wu, Xingting Wang, Tongqiao Nie, Qingmei Zeng, Chuanxun Yuan, Risheng Jin
Candelilla wax reinforced the stability of Pickering W/O emulsions with a three-dimensional crystal network. The oil phase volume fraction of the emulsions showed dramatic differences in protecting probiotic viability from environmental stresses.
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the

Maternal n-3 fatty acid supplementation has an immediate impact on the human milk fatty acid composition

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02548B, Paper
Yannan He, Lin Chen, Miao Miao, Yongmei Dai, Li Qin, Jing Lin, Yumei Qi, Huijuan Xiao, Yajun Qiu, Xiaohong Zhang, Hailan Sun, Jianing Wang, Meng-yan Xu, Ping Tan, Bo Yang, Guiju Sun, Feng Zhao, Duo Li
Fatty acids are essential components in breast milk with mutable characteristics.
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the

Ellagic acid ameliorates alcohol-induced cognitive and social dysfunction through the gut microbiota-mediated CCL21-CCR7 axis

Food Funct., 2024, 15,11186-11205
DOI: 10.1039/D4FO03985H, Paper
Hongbo Zhang, Min Luo, Yinuo Li, Lu Liu, Ji Bian, Lan Gong, Caian He, Lin Han, Min Wang
EA enhanced the abundance of beneficial bacteria as well as their derived metabolites, thereby inhibiting chronic alcohol-induced neuroinflammation via regulation of the gut microbiota-mediated CCL21-CCR7 axis, ultimately ameliorating AICSD.
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the

The co-fermentation of whole-grain black barley and quinoa improves murine cognitive impairment induced by a high-fat diet via altering gut microbial ecology and suppressing neuroinflammation

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02704C, Paper
Fenfen Wei, Huibin Jiang, Chuang Zhu, Lingyue Zhong, Zihan Lin, Yan Wu, Lihua Song
A high-fat diet (HFD) is associated with various adverse health outcomes, including cognitive impairment and an elevated risk of neurodegenerative conditions.
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Lacticaseibacillus paracasei JM053 alleviates osteoporosis in rats by increasing the content of soy isoflavone aglycones in fermented soymilk

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04381B, Paper
Yaping Zheng, Shasha Cheng, Hongxuan Li, Yilin Sun, Ling Guo, Chaoxin Man, Yu Zhang, Wei Zhang, Yujun Jiang
Lacticaseibacillus paracasei JM053 has a high ability to convert soy isoflavones and can be used as a fermentation strain to ferment soymilk, thereby increasing the content of free aglycones in...
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the

A novel method for exploration and prediction of the bioactive target of rice bran-derived peptide (KF-8) by integrating computational methods and experiments

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02493A, Paper
Rui Liang, Fangliang Song, Ying Liang, Yanpeng Fang, Jianqiang Wang, Yajuan Chen, Zhongxu Chen, Xiaorong Tan, Jie Dong
The diagram of the strategy to explore peptide targets based on model predictions and experiments.
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the

Correction: Using integrated transcriptomics and metabolomics to explore the effects of infant formula on the growth and development of small intestinal organoids

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO90094D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xianli Wang, Yuxin Jing, Chengdong Zheng, Chenxuan Huang, Haiyang Yao, Zimo Guo, Yilun Wu, Zening Wang, Zhengyang Wu, Ruihong Ge, Wei Cheng, Yuanyuan Yan, Shilong Jiang, Jianguo Sun, Jingquan Li, Qinggang Xie, Xiaoguang Li, Hui Wang
To cite this article before page numbers are assigned, use the DOI form of citation above.
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the

Oral administration of cranberry-derived exosomes attenuates murine premature ovarian failure in association with changes in the specific gut microbiota and diminution in ovarian granulosa cell PANoptosis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03468F, Paper
Open Access
Zeyu Cui, Te Liu, Yichao Wen, Weihao Li, Jianghong Xu, Yingjuan Chen, Danping Chen, Ying Zhu
We confirmed that oral administration of cranberry-derived exosomes attenuated murine POF by modulating the gut microbiota and decreasing ovarian granulosa cell PANoptosis.
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the

Facing up to the result and realities of Nov 5

A lot of back-room games could unfold after the November elections. The Trump camp is already laying the ground




the

Letters to the Editor dated October 25, 2024 




the

Can Israel sustain the economic pressures of war?

Without a swift ceasefire, Israel’s economic outlook appears bleak, with long-term consequences for the wider region as well




the

Below the Line




the

The angst over China’s slowdown

Though China’s growth has slowed in recent years, its dire consequences and impact on world economy are exaggerated




the

Letters to the Editor dated October 28, 2024




the

IPEF: A bet for the long term

Tightrope walk. India needs to balance its political and economic interests in an geo-politically uncertain world




the

Which States are leading the race towards renewables in India?

India with 300 days of sunshine each year, possesses vast solar energy potential. The National Institute of Energy estimated the country’s solar potential at 748 GW, assuming solar PV modules cover 3% of the geographical surface. Solar energy is expected to be the main driver pushing India closer to its renewable energy targets. Diving deep into the state-wise push towards solar energy. Rajasthan, Gujarat, Tamil Nadu and Karnataka are the leading States in India, both in terms of installed capacities and power generation, in the solar segment. Also, with respect to solar energy projects, Rajasthan and Gujarat lead in terms of the capacities added since FY22 and projects in pipeline




the

Iran and the October Surprise of 2024

With the Biden administration going soft on Netanyahu, Democrats’ hold on Arab-American vote seems to be slipping




the

Letters to the Editor dated October 30, 2024




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Librarians’ vital role in the world of academics

Their part in fostering knowledge is invaluable




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Pitfalls of Congress playing the caste card

The Congress’ caste politics will only help the BJP, particularly at the national level




the

Below the line




the

Another star makes a political debut

Vijay’s entry adds an interesting twist to the 2026 TN elections



  • From the Viewsroom

the

Understanding the election process: How is the US President elected?

While citizens cast their votes, the actual selection of the president is determined by the Electoral College




the

Letters to the Editor dated November 4, 2024




the

Letters to the Editor dated November 5, 2024




the

Migrants locked out of the West

The West is grappling with an influx of illegal immigrants, driven as they are by crises and instability in their countries