A novel soybean variety, designated XB32T13 is provided. Also provided are the seeds of soybean variety XB32T13, cells from soybean variety XB32T13, plants of soybean XB32T13, and plant parts of soybean variety XB32T13. Methods provided include producing a soybean plant by crossing soybean variety XB32T13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB32T13, methods for producing other soybean varieties or plant parts derived from soybean variety XB32T13, and methods of characterizing soybean variety XB32T13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB32T13 are further provided.

A novel soybean variety, designated XB52J13 is provided. Also provided are the seeds of soybean variety XB52J13, cells from soybean variety XB52J13, plants of soybean XB52J13, and plant parts of soybean variety XB52J13. Methods provided include producing a soybean plant by crossing soybean variety XB52J13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB52J13, methods for producing other soybean varieties or plant parts derived from soybean variety XB52J13, and methods of characterizing soybean variety XB52J13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB52J13 are further provided.

A novel soybean variety, designated XB47X13 is provided. Also provided are the seeds of soybean variety XB47X13, cells from soybean variety XB47X13, plants of soybean XB47X13, and plant parts of soybean variety XB47X13. Methods provided include producing a soybean plant by crossing soybean variety XB47X13 with another soybean plant, methods for introgressing a transgenic trait, a mutant trait, and/or a native trait into soybean variety XB47X13, methods for producing other soybean varieties or plant parts derived from soybean variety XB47X13, and methods of characterizing soybean variety XB47X13. Soybean seed, cells, plants, germplasm, breeding lines, varieties, and plant parts produced by these methods and/or derived from soybean variety XB47X13 are further provided.

A novel maize variety designated PH1TWW and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1TWW with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1TWW through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1TWW or a locus conversion of PH1TWW with another maize variety.

A novel maize variety designated PH1M9D and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1M9D with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1M9D through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1M9D or a locus conversion of PH1M9D with another maize variety.

The present invention provides an inbred corn line designated FX6815, methods for producing a corn plant by crossing plants of the inbred line FX6815 with plants of another corn plant. The invention further encompasses all parts of inbred corn line FX6815, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line FX6815, and plants produced according to these methods.

The invention relates to compounds that specifically bind a T1R1/T1R3 or T1R2/T1R3 receptor or fragments or sub-units thereof. The present invention also relates to the use of hetero-oligomeric and chimeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.

A system for radioisotope production uses fast-neutron-caused fission of depleted or naturally occurring uranium targets in an irradiation chamber. Fast fission can be enhanced by having neutrons encountering the target undergo scattering or reflection to increase each neutron's probability of causing fission (n, f) reactions in U-238. The U-238 can be deployed as one or more layers sandwiched between layers of neutron-reflecting material, or as rods surrounded by neutron-reflecting material. The gaseous fission products can be withdrawn from the irradiation chamber on a continuous basis, and the radioactive iodine isotopes (including I-131) extracted.

Polypeptides capable of binding human IL-13 and/or of binding human IL-4 in the presence of IL-4 Rα can be used in medicine, in diagnosis and in screening for agonists/antagonists of IL-13/IL-4. One such polypeptide is shown in FIG. 1.

Compounds of Formula I, including pharmaceutically acceptable salts, as well as compositions containing these compounds, have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

A novel crystalline hybrid solid with a mixed organic-inorganic matrix is described which has a three-dimensional structure containing an inorganic framework with metallic centers based on zinc connected together via deprotonated organic ligands constituted by the entity —O2C—C6H2—(O)2—CO2. This novel solid is termed IM-21 and has an X-ray diffraction diagram as given below.

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.

A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.

Described herein are methods and compositions for treatment of immune-related diseases or disorders by modulating DD1α activity, alone or in combination with modulation of PD-1 activity. In some embodiments, the methods and compositions described herein are directed to treatment of cancer and/or infections (e.g., bacterial infection, and/or fungal infection). In some embodiments, the methods and compositions described herein are directed to treatment of autoimmune diseases and/or inflammation. In some embodiments, the methods and compositions described herein are directed to treatment of asthma, and allergy. Methods for identifying patients who are more likely to be responsive to and benefit from an immunotherapy that targets DD1α and/or PD-1 activity or expression are also described herein.

A method for processing explosives containing a high loading of CL-20 may advantageously include a binder system having naphthenic oil and/or paraffinic oil. Solid energetic ingredients are added into the binder system and mixed to form a free-flowing suspension in which the solid energetic ingredients are homogeneously mixed and coated with the binder system. The binder system is then cured and cast to form a cross-linked explosive.

The invention relates to a cluster arm arrangement for the intermediate roll sets of 18 HS roll stands, wherein arranged between the chock at the operating side and the chock at the drive side are cluster arms which are pivotable laterally of the intermediate roll and in which the lateral backing rolls are integrated for support of the working rolls in the stand. In that case, arranged between the chock (1) and the cluster arm (2) is a pivot pin (3), which is fixedly connected with the cluster arm and about the axis of which the cluster arm (2) is pivotable, and a locking means for the cluster arm (2) as well as an abutment (6) with a restoring spring (6) are operatively arranged on the pivot pin (3) as a compact unit in the region between the cluster arm (2) and chock (1).

The present invention relates to the use of 1,1-diethoxyethane for increasing the knocking resistance of low-boiling gasoline with an initial boiling point (IBP) of 80° C. to 120° C. by at least 40 units (Research Octane Number).

John Waters, the venerable sultan of sleaze who we recently visited at home in San Francisco, presided over this year's Burger Boogaloo festivities in Oakland's Mosswood Park. He was the consummate host.…

A recent boxing showcase at a defunct West Oakland train station captured the historic spirit of the site. On Saturday June 11, Osric Pratt Promotions presented Unfinished Business, a showcase of Northern California boxing culture at the historic 16th Street train station in West Oakland. The event consisted of seven boxing matches, interspersed with hip-hop and poetry performances.…

Recently, a video where a woman called the police on a Black family who was barbecuing at Lake Merritt went viral, and several local and national outlets published pieces on the outraging incident.…

Here are photos from today's Warriors' championship parade.

Hillary Clinton is the subject of a new documentary series on Hulu. It's fair to describe Hillary as a warts-and-all portrait. The four-part documentary shuttles between the 2016 presidential campaign and Hillary Rodham Clinton's life.…

Just in time to celebrate its ten-year anniversary, popular Filipino-fusion food truck Señor Sisig has established a long-term location in Oakland.

The brand-new spot is at 3331 Fruitvale Ave. in the Dimond District.…

This month alone, Oakland-based, family-owned Mr. Espresso has already donated over 2,500 pounds of coffee to COVID-19 relief efforts all over the Bay Area.

During the first two weeks of April, the 42-year-old company — founded in Alameda by enterprising Italian-born Carlo Di Ruocco and now renowned as the first and currently only outfit in the nation that uses oak wood to roast its beans — has given coffee to the Alameda County Community Food Bank and San Francisco-Marin Food Bank, Frontline Foods, East Bay FeedER, Clinica de La Raza, St. Anthony’s Dining Room, Loaves and Fishes Family Kitchen, and other food-, health-, homeless-, youth-, and family-assistance programs.…

The city's 911 system can leave callers waiting for more than 120 seconds before an operator ever answers. Seconds of delay in an emergency can lead to death. As a result, 911 calls are supposed to be answered quickly.…

Weeks have passed, and DJs the world over have settled into the reality of sheltering in place. As efforts to combat COVID-19 push on, the masses are staying at home. Clubs have shuttered their doors, bars and restaurants are no more, and non-essential businesses are closed. But in this primetime of social distancing, there has […]

The post Streaming L(o)ive In The Time of COVID-19: What’s the future for DJ live streaming? appeared first on DJ TechTools.

Coming on the heels of the AB5 trauma, the coronavirus lockdown poses an extra economic threat. The COVID-19 pandemic has affected all facets of life in California and the world.…

ARIES March 21-April 19 “If all the world’s a stage, where the hell is the teleprompter?” asks aphorist Sami Feiring. In my astrological opinion, you Aries are the least likely of all the signs to identify with that perspective.…

The present invention relates to an optical clear resin and a method for producing a liquid optical clear photo-curable adhesive.

News you don't want to miss for April 7:

1. A nursing home in Orinda is being hit hard by a covid-19 outbreak that has infected 49 people, including 27 residents and 22 staff members, the East Bay Times reports.…

News you don't want to miss for April 9:

1. Six residents at a nursing home in Hayward have died from covid-19, the East Bay Times reports.…

News you don't want to miss for Easter Weekend:

Oakland will temporarily close 74 miles of city streets to automobile traffic in an effort to give ample space for pedestrians, bike riders, and runners during the covid-19 shelter in place, The Guardian reports.…

News you don't want to miss for April 13:

1. "If the country’s most popular coronavirus model proves accurate, California will reach the peak of its outbreak this Wednesday," the San Francisco Chronicle reports, when it will reach a predicted 66 deaths.…

News you don't want to miss for April 14:

1. Six of the 15 confirmed covid-19 cases at Santa Rita Jail have recovered, the East Bay Times reports.…

News you don't want to miss for April 15:

1. The number of covid-19 deaths in Alameda County increased from 23 to 36 over a two-day period, SFGate reports.…

News you don't want to miss for April 20:

1. Fifty-one employees at Safeway's distribution warehouse in Tracy have been infected with covid-19, including one death, the San Francisco Chronicle reports.…

News you don't want to miss for April 21:

1. Those who suffer the effects of poor air quality are at greater risk of complications associated with the coronavirus, the San Francisco Chronicle reports.…

News you don't want to miss for April 24:

1. San Francisco Mayor London Breed provided a hint on Friday that the city's shelter in place order will be extended past May 4, possibly weeks or a month, KPIX reports.…

News you don't want to miss for April 27:

1. Alameda County, along with five other Bay Area counties, announced the shelter in place order will be extended through the end of May, the San Francisco Chronicle reports.…

News you don't want to miss for April 30:

1. The five fired Oakland police officers involved in the shooting of Joshua Pawlik in 2018 were reinstated after it was found the Oakland Police Commission violated the Brown Act, the state law for transparency in public meetings, KPIX reports.…

News you don't want to miss for May 1:

1. Oakland's lawsuit against the Raiders and the NFL over the team's relocation to Las Vegas was dismissed by a federal court judge on Thursday, according to Bleacher Report.…

“I am not a number. I am a free man!” I’m afraid not, you’re a number… when it comes to credit scoring anyway. The famous cry for help of the eponymous Prisoner from the cult 1960s TV show of the 1960, could have been written for today’s world of mass computer assessed finance.

'Tax-Free Childcare' is a confusing and inaccurately named scheme that launched in April 2017. It can be worth thousands of pounds, but only 250,000 of the 1.5 million eligible families are collecting it.

A YOUNG driver caught with more than 15 times the legal amount of party drug ecstasy in his system has been banned from the roads.

Mis-sold Wonga customers have been legally robbed.

IT’S the “life-saving” organisation that is slowly emerging from the shadows.

WINCHESTER Sings! a local community choir, held a fundraising evening in May to raise money for Winchester & District Young Carers (WYC).