po Opportunities and Challenges for Biosimilars: What's on the Horizon in the Global Insulin Market? By clinical.diabetesjournals.org Published On :: 2012-10-01 Lisa S. RotensteinOct 1, 2012; 30:138-150Features Full Article
po Empowerment and Self-Management of Diabetes By clinical.diabetesjournals.org Published On :: 2004-07-01 Martha M. FunnellJul 1, 2004; 22:123-127Feature Articles Full Article
po Hypoglycemia in Type 1 and Type 2 Diabetes: Physiology, Pathophysiology, and Management By clinical.diabetesjournals.org Published On :: 2006-07-01 Vanessa J. BriscoeJul 1, 2006; 24:115-121Feature Articles Full Article
po Case Study: Postsexual Penile Ulcer as a Symptom of Diabetes By clinical.diabetesjournals.org Published On :: 2005-10-01 Nehman LauderOct 1, 2005; 23:191-192Case Studies Full Article
po Hypoglycemia? Low Blood Glucose? Low Blood Sugar? By clinical.diabetesjournals.org Published On :: 2012-01-01 Jan 1, 2012; 30:38-38Patient Information Full Article
po The Disparate Impact of Diabetes on Racial/Ethnic Minority Populations By clinical.diabetesjournals.org Published On :: 2012-07-01 Edward A. ChowJul 1, 2012; 30:130-133Diabetes Advocacy Full Article
po Plasma Lipidome and Prediction of Type 2 Diabetes in the Population-Based Malmö Diet and Cancer Cohort By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Type 2 diabetes mellitus (T2DM) is associated with dyslipidemia, but the detailed alterations in lipid species preceding the disease are largely unknown. We aimed to identify plasma lipids associated with development of T2DM and investigate their associations with lifestyle. RESEARCH DESIGN AND METHODS At baseline, 178 lipids were measured by mass spectrometry in 3,668 participants without diabetes from the Malmö Diet and Cancer Study. The population was randomly split into discovery (n = 1,868, including 257 incident cases) and replication (n = 1,800, including 249 incident cases) sets. We used orthogonal projections to latent structures discriminant analyses, extracted a predictive component for T2DM incidence (lipid-PCDM), and assessed its association with T2DM incidence using Cox regression and lifestyle factors using general linear models. RESULTS A T2DM-predictive lipid-PCDM derived from the discovery set was independently associated with T2DM incidence in the replication set, with hazard ratio (HR) among subjects in the fifth versus first quintile of lipid-PCDM of 3.7 (95% CI 2.2–6.5). In comparison, the HR of T2DM among obese versus normal weight subjects was 1.8 (95% CI 1.2–2.6). Clinical lipids did not improve T2DM risk prediction, but adding the lipid-PCDM to all conventional T2DM risk factors increased the area under the receiver operating characteristics curve by 3%. The lipid-PCDM was also associated with a dietary risk score for T2DM incidence and lower level of physical activity. CONCLUSIONS A lifestyle-related lipidomic profile strongly predicts T2DM development beyond current risk factors. Further studies are warranted to test if lifestyle interventions modifying this lipidomic profile can prevent T2DM. Full Article
po Severe Hypoglycemia and Cognitive Function in Older Adults With Type 1 Diabetes: The Study of Longevity in Diabetes (SOLID) By care.diabetesjournals.org Published On :: 2020-02-20T11:55:29-08:00 OBJECTIVE In children with type 1 diabetes (T1D), severe hypoglycemia (SH) is associated with poorer cognition, but the association of SH with cognitive function in late life is unknown. Given the increasing life expectancy in people with T1D, understanding the role of SH in brain health is crucial. RESEARCH DESIGN AND METHODS We examined the association between SH and cognitive function in 718 older adults with T1D from the Study of Longevity in Diabetes (SOLID). Subjects self-reported recent SH (previous 12 months) and lifetime history of SH resulting in inpatient/emergency department utilization. Global and domain-specific cognition (language, executive function, episodic memory, and simple attention) were assessed. The associations of SH with cognitive function and impaired cognition were evaluated via linear and logistic regression models, respectively. RESULTS Thirty-two percent of participants (mean age 67.2 years) reported recent SH and 50% reported lifetime SH. Compared with those with no SH, subjects with a recent SH history had significantly lower global cognition scores. Domain-specific analyses revealed significantly lower scores on language, executive function, and episodic memory with recent SH exposure and significantly lower executive function with lifetime SH exposure. Recent SH was associated with impaired global cognition (odds ratio [OR] 3.22, 95% CI 1.30, 7.94) and cognitive impairment on the language domain (OR 3.15, 95% CI 1.19, 8.29). CONCLUSIONS Among older adults with T1D, recent SH and lifetime SH were associated with worse cognition. Recent SH was associated with impaired global cognition. These findings suggest a deleterious role of SH on the brain health of older patients with T1D and highlight the importance of SH prevention. Full Article
po The Association Between Poor Glycemic Control and Health Care Costs in People With Diabetes: A Population-Based Study By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To analyze the differences in health care costs according to glycemic control in people with type 2 diabetes. RESEARCH DESIGN AND METHODS Data on health care resource utilization from 100,391 people with type 2 diabetes were extracted from the electronic database used at the Catalan Health Institute. Multivariate regression models were carried out to test the impact of glycemic control (HbA1c) on total health care, hospital admission, and medication costs; model 1 adjusted for a variety of covariates, and model 2 also included micro- and macrovascular complications. Glycemic control was classified as good for HbA1c <7%, fair for ≥7% to <8%, poor for ≥8% to <10%, and very poor for ≥10%. RESULTS Mean per patient annual direct medical costs were 3,039 ± SD 6,581. Worse glycemic control was associated with higher total health care costs: compared with good glycemic control, health care costs increased by 18% (509.82) and 23% (661.35) in patients with very poor and poor glycemic control, respectively, when unadjusted and by 428.3 and 395.1, respectively, in model 2. Medication costs increased by 12% in patients with fair control and by 28% in those with very poor control (model 2). Patients with poor control had a higher probability of hospitalization than those with good control (5% in model 2) and a greater average cost when hospitalization occurred (811). CONCLUSIONS Poor glycemic control was directly related to higher total health care, hospitalization, and medication costs. Preventive strategies and good glycemic control in people with type 2 diabetes could reduce the economic impact associated with this disease. Full Article
po Diabetic Neuropathy Is a Substantial Burden in People With Type 1 Diabetes and Is Strongly Associated With Socioeconomic Disadvantage: A Population-Representative Study From Scotland By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To assess the contemporaneous prevalence of diabetic peripheral neuropathy (DPN) in people with type 1 diabetes (T1D) in Scotland and study its cross-sectional association with risk factors and other diabetic complications. RESEARCH DESIGN AND METHODS We analyzed data from a large representative sample of adults with T1D (N = 5,558). We assessed the presence of symptomatic neuropathy using the dichotomized (≥4) Michigan Neuropathy Screening Instrument Patient Questionnaire score. Logistic regression models were used to investigate associations between DPN and risk factors, as well as with other complications. RESULTS The burden of DPN is substantial with 13% prevalence overall. Adjusting for attained age, diabetes duration, and sex, the odds of DPN increased mainly with waist-to-hip ratio, lipids, poor glycemic control (odds ratio 1.51 [95% CI 1.21–1.89] for levels of 75 vs. 53 mmol/mol), ever versus never smoking (1.67 [1.37–2.03]), and worse renal function (1.96 [1.03–3.74] for estimated glomerular filtration rate levels <30 vs. ≥90 mL/min/1.73 m2). The odds significantly decreased with higher HDL cholesterol (0.77 [0.66–0.89] per mmol/L). Living in more deprived areas was associated with DPN (2.17 [1.78–2.65]) for more versus less deprived areas adjusted for other risk factors. Finally, individuals with prevalent DPN were much more likely than others to have other diabetes complications. CONCLUSIONS Diabetic neuropathy remains substantial, particularly affecting those in the most socioeconomically deprived groups. Those with clinically manifest neuropathy also have a higher burden of other complications and elevated levels of modifiable risk factors. These data suggest that there is considerable scope to reduce neuropathy rates and narrow the socioeconomic differential by better risk factor control. Full Article
po Lottery winner's prankster past made wife skeptical of $250,000 jackpot By www.upi.com Published On :: Wed, 06 May 2020 16:07:33 -0400 A South Carolina man had extra trouble convincing his wife that his $250,000 lottery win was legitimate due to her memories of a past prank. Full Article
po Look: Police, firefighters fish baby geese out of highway storm sewer By www.upi.com Published On :: Thu, 07 May 2020 13:08:39 -0400 Police and firefighters in Michigan came to the rescue of a family of baby geese that wandered out onto a busy highway and fell into a storm sewer. Full Article
po Iowa man receives postcard mailed 33 years earlier By www.upi.com Published On :: Thu, 07 May 2020 13:35:11 -0400 An Iowa man who received a postcard from his sister said he was surprised to note the card had been mailed in 1987. Full Article
po Fortune cookie numbers earn $2 million lottery jackpot after 5 years By www.upi.com Published On :: Thu, 07 May 2020 15:48:47 -0400 A North Carolina man said the lottery numbers he took from a fortune cookie earned him a $2 million jackpot after five years of using them to play Mega Millions. Full Article
po Look: Police investigating loose camel report find escaped emu instead By www.upi.com Published On :: Fri, 08 May 2020 11:11:01 -0400 Police in the Netherlands said officers responding to reports of a loose camel ended up capturing an emu running wild through the city of Rotterdam. Full Article
po Men take Guinness record for ping pong ball catches in shaving cream By www.upi.com Published On :: Fri, 08 May 2020 11:21:28 -0400 A pair of Idaho men tackled an unusual Guinness World Record by most table tennis balls caught in shaving foam on the head in 30 seconds (team of 2). Full Article
po Police, public works employees rescue deer from soccer net By www.upi.com Published On :: Fri, 08 May 2020 14:24:42 -0400 Police and public works employees in Wisconsin came to the rescue of a deer that found itself struggling to escape a soccer net. Full Article
po After Deportation, Some Congolese Returnees Face Detention and Extortion By www.migrationpolicy.org Published On :: Wed, 22 May 2019 17:22:03 -0400 This article explores post-deportation dynamics and challenges returnees face in the Democratic Republic of the Congo (DRC). Even as European countries focus on increasing returns of migrants deemed not to have a right to stay, little attention has been given to conditions at return—even to a country such as the DRC where allegations of serious human-rights violations against returned migrants have been reported for years. Full Article
po 16th Annual Immigration Law and Policy Conference By www.migrationpolicy.org Published On :: Tue, 28 May 2019 12:18:53 -0400 The 16th annual conference features thoughtful policy and legal analysis and discussion of the most important immigration topics from leading government officials, attorneys, researchers, advocates, and others. Full Article
po Democrats Under Pressure: Political Calendar Exposes Ideological Differences on Immigration By www.migrationpolicy.org Published On :: Wed, 24 Jul 2019 17:39:12 -0400 Ideological differences in the Democratic Party over immigration that were once masked by unity against President Trump’s border wall and immigration agenda are now being exposed as Democratic presidential candidates seek to stand out in a crowded field and amid controversy over an emergency border spending bill. As the 2020 electoral calendar accelerates, how the party navigates the gulf between its most liberal and conservative wings will become a greater challenge for its leaders. Full Article
po From Control to Crisis: Changing Trends and Policies Reshaping U.S.-Mexico Border Enforcement By www.migrationpolicy.org Published On :: Fri, 02 Aug 2019 12:09:41 -0400 How did the U.S. border enforcement picture go in the span of two years from the lowest levels of illegal immigration since 1971 to a spiraling border security and humanitarian crisis? This report draws on enforcement and other data as well as analysis of changing migration trends and policies to tell this story. The authors outline key elements for a new strategy that can succeed over the long term. Full Article
po Crisis in the Courts: Is the Backlogged U.S. Immigration Court System at Its Breaking Point? By www.migrationpolicy.org Published On :: Tue, 01 Oct 2019 12:31:23 -0400 With a backlog of more than 1 million removal cases, the U.S. immigration court system is in crisis. Pressure from external forces, internal challenges, and lagging resources for the courts at a time of massive increases in spending on immigration enforcement have contributed to the backlog. This article explores how the system got to the breaking point, and what opportunities for reform exist. Full Article
po Evidence-Informed Clinical Practice Recommendations for Treatment of Type 1 Diabetes Complicated by Problematic Hypoglycemia By care.diabetesjournals.org Published On :: 2015-06-01 Pratik ChoudharyJun 1, 2015; 38:1016-1029Type 1 Diabetes at a Crossroads Full Article
po Loss of Incretin Effect Is a Specific, Important, and Early Characteristic of Type 2 Diabetes By care.diabetesjournals.org Published On :: 2011-05-01 Jens J. HolstMay 1, 2011; 34:S251-S257Diabetes Treatments Full Article
po Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006-2013 By care.diabetesjournals.org Published On :: 2017-04-01 Kasia J. LipskaApr 1, 2017; 40:468-475Emerging Science and Concepts for Management of Diabetes and Aging Full Article
po New Insulin Glargine 300 Units/mL Versus Glargine 100 Units/mL in People With Type 2 Diabetes Using Oral Agents and Basal Insulin: Glucose Control and Hypoglycemia in a 6-Month Randomized Controlled Trial (EDITION 2) By care.diabetesjournals.org Published On :: 2014-12-01 Hannele Yki-JärvinenDec 1, 2014; 37:3235-3243Emerging Technologies and Therapeutics Full Article
po Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia By care.diabetesjournals.org Published On :: 2016-07-01 Bernhard J. HeringJul 1, 2016; 39:1230-1240Emerging Technologies and Therapeutics Full Article
po National Standards for Diabetes Self-Management Education and Support By care.diabetesjournals.org Published On :: 2014-01-01 Linda HaasJan 1, 2014; 37:S144-S153National Standards Full Article
po Characterization of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and Subjects With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2013-10-01 Ralph A. DeFronzoOct 1, 2013; 36:3169-3176Emerging Technologies and Therapeutics Full Article
po Exploring the Potential of the SGLT2 Inhibitor Dapagliflozin in Type 1 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Pilot Study By care.diabetesjournals.org Published On :: 2015-03-01 Robert R. HenryMar 1, 2015; 38:412-419Evolving Tactics With Inhibition of Sodium-Glucose Cotransporters Full Article
po Prevalence of Hyper- and Hypoglycemia Among Inpatients With Diabetes: A national survey of 44 U.S. hospitals By care.diabetesjournals.org Published On :: 2007-02-01 Deborah J. WexlerFeb 1, 2007; 30:367-369BR Epidemiology/Health Services/Psychosocial Research Full Article
po Efficacy and Safety of Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, as Add-on to Insulin in Patients With Type 1 Diabetes By care.diabetesjournals.org Published On :: 2015-12-01 Robert R. HenryDec 1, 2015; 38:2258-2265Special Article Collection: Insulin Full Article
po Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study By care.diabetesjournals.org Published On :: 2016-01-01 Joseph HensonJan 1, 2016; 39:130-138IDF-ADA Translational Symposium Full Article
po New Insulin Glargine 300 Units/mL Versus Glargine 100 Units/mL in People With Type 2 Diabetes Using Basal and Mealtime Insulin: Glucose Control and Hypoglycemia in a 6-Month Randomized Controlled Trial (EDITION 1) By care.diabetesjournals.org Published On :: 2014-10-01 Matthew C. RiddleOct 1, 2014; 37:2755-2762Emerging Technologies and Therapeutics Full Article
po Dietary Sugar and Body Weight: Have We Reached a Crisis in the Epidemic of Obesity and Diabetes?: Health Be Damned! Pour on the Sugar By care.diabetesjournals.org Published On :: 2014-04-01 George A. BrayApr 1, 2014; 37:950-956Current Concepts of Type 2 Diabetes Prevention Full Article
po Liraglutide, a Long-Acting Human Glucagon-Like Peptide-1 Analog, Given as Monotherapy Significantly Improves Glycemic Control and Lowers Body Weight Without Risk of Hypoglycemia in Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2007-06-01 Tina VilsbøllJun 1, 2007; 30:1608-1610BR Emerging Treatments and Technologies Full Article
po Sodium-Glucose Cotransporter 2 Inhibition and Glycemic Control in Type 1 Diabetes: Results of an 8-Week Open-Label Proof-of-Concept Trial By care.diabetesjournals.org Published On :: 2014-05-01 Bruce A. PerkinsMay 1, 2014; 37:1480-1483Novel Communications in Diabetes Full Article
po Standardizing Clinically Meaningful Outcome Measures Beyond HbA1c for Type 1 Diabetes: A Consensus Report of the American Association of Clinical Endocrinologists, the American Association of Diabetes Educators, the American Diabetes Association, the Endo By care.diabetesjournals.org Published On :: 2017-12-01 Gina AgiostratidouDec 1, 2017; 40:1622-1630Continuous Glucose Monitoring and Risk of Hypoglycemia Full Article
po Lipoprotein Physiology in Nondiabetic and Diabetic States: Relationship to Atherogenesis By care.diabetesjournals.org Published On :: 1991-09-01 Henry N GinsbergSep 1, 1991; 14:839-855Diet and Diabetes Full Article
po Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis By care.diabetesjournals.org Published On :: 2016-07-01 Sunder MudaliarJul 1, 2016; 39:1115-1122Diabetes Care Symposium Full Article
po Improved Glycemic Control in Poorly Controlled Patients with Type 1 Diabetes Using Real-Time Continuous Glucose Monitoring By care.diabetesjournals.org Published On :: 2006-12-01 Dorothee DeissDec 1, 2006; 29:2730-2732BR Emerging Treatments and Technologies Full Article
po Relationship of Glucose Tolerance and Plasma Insulin to the Incidence of Coronary Heart Disease: Results from Two Population Studies in Finland By care.diabetesjournals.org Published On :: 1979-03-01 Kalevi PyöräläMar 1, 1979; 2:131-141Proceedings of the Kroc Foundation International Conference on Epidemiology of Diabetes and its Macrovascular Complications Full Article
po CV Protection in the EMPA-REG OUTCOME Trial: A "Thrifty Substrate" Hypothesis By care.diabetesjournals.org Published On :: 2016-07-01 Ele FerranniniJul 1, 2016; 39:1108-1114Diabetes Care Symposium Full Article
po Prevalence and Determinants of Glucose Intolerance in a Dutch Caucasian Population: The Hoorn Study By care.diabetesjournals.org Published On :: 1995-09-01 Johanna M MooySep 1, 1995; 18:1270-1273Short Report Full Article
po Psychosocial Care for People With Diabetes: A Position Statement of the American Diabetes Association By care.diabetesjournals.org Published On :: 2016-12-01 Deborah Young-HymanDec 1, 2016; 39:2126-2140Psychosocial Research and Care in Diabetes Full Article
po Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society By care.diabetesjournals.org Published On :: 2013-05-01 Elizabeth R. SeaquistMay 1, 2013; 36:1384-1395Scientific Statement Full Article
po India police: Security forces kill top militant commander in Kashmir By www.upi.com Published On :: Wed, 06 May 2020 16:05:42 -0400 Police in India said security forces killed a top Hizbul Mujahideen commander amid a series of gunfights in the disputed Jammu and Kashmir region on Wednesday. Full Article
po Latin American business leaders optimistic about region’s post-pandemic economy By www.upi.com Published On :: Wed, 06 May 2020 18:44:51 -0400 Despite worrying economic projections, business leaders in Latin America remain optimistic about post-pandemic economy. Full Article
po Australian Cardinal George Pell knew of child abuse, report says By www.upi.com Published On :: Thu, 07 May 2020 07:21:04 -0400 Pell, a former Vatican treasurer, was aware of child abuse being committed by clergy by 1973, contrary to his long-held assertions that he knew nothing about the accusations. Full Article
po Report: South Korea tested new ballistic missile with larger warhead By www.upi.com Published On :: Thu, 07 May 2020 09:35:46 -0400 South Korea's military tested a ballistic missile capable of carrying a 2-ton warhead in March, according to local reports on Thursday. Full Article
