The simple genetic "heel-prick" test for newborns is saving the lives of children in New South Wales and the ACT, but elsewhere parents say their children aren't being afforded the same chance of survival in the face of rare diseases like Spinal Muscular Atrophy.

Uschi Rowlands grows gourmet mushrooms in Mudgee, NSW, August 2019.

Australia slumps to a 3-0 series defeat in South Africa with a six-wicket loss in Potchefstroom, despite Marnus Labuschagne's maiden ODI century.

The news the Dog on the Tuckerbox had been damaged made national headlines and prompted an outpouring of love for the much-loved pooch. But what is the history of the famous statue?

(United States Ninth Circuit) - Affirmed. The district court denied Plaintiff’s national-interest waiver petition for lack of jurisdiction. Affirming, the panel held that 8 U.S.C. § 1252(a)(2)(B)(ii) strips the federal courts of jurisdiction to review the denial of a national-interest waiver.

(United States Ninth Circuit) - Reversed summary judgment in favor of the Defendant. Plaintiff brought suit against Defendant under the Americans with Disabilities Act. Plaintiff, who is deaf, requested an American Sign Language interpreter at Defendants' continuing educations courses. Held that while a public accommodation must furnish appropriate assistance to individuals with disabilities, specific aid is not required, but there was an issue of material fact as to whether effective communication was offered to Plaintiff even if different than that requested.

(United States Ninth Circuit) - Reinstated a consumer's proposed class action lawsuit against a manufacturer of nutritional supplements. Held that the federal Food, Drug, and Cosmetic Act did not preempt the consumer's California law claims that the company made false or misleading statements about the source of the protein in one of its muscle-building products. Reversed dismissal and remanded for further proceedings.

(California Court of Appeal) - In a suit brought by operators of recycling centers where beverage containers sold in California may be redeemed for their California Redemption Value, against companies that sell or distribute beverages containers in California, contending that defendants knowingly and "falsely" label beverage containers sold both inside and outside California with "CA CRV," "California Redemption Value," or similar labels when, in fact, under California law, only containers purchased inside California may be redeemed in California, and alleging common law tort claims against defendants for fraud, negligent misrepresentation, strict products liability, interference with prospective economic advantage and business relations, and breach of express warranty, the trial court's judgment of dismissal is affirmed where the injunctive and compensatory relief plaintiffs seek cannot be awarded by a California court because it would violate the "dormant" commerce clause of the federal Constitution.

Puscifer have been teasing fans via social media and they have now delivered with a brand new song and music video

(United States Ninth Circuit) - Affirmed. The district court denied Plaintiff’s national-interest waiver petition for lack of jurisdiction. Affirming, the panel held that 8 U.S.C. § 1252(a)(2)(B)(ii) strips the federal courts of jurisdiction to review the denial of a national-interest waiver.

"Go on, moron, ignore the evidence / Skid in to Armageddon"

The post PUSCIFER Remains Positive On New Song "Apocalyptical" appeared first on Metal Injection.

(United States Ninth Circuit) - Affirmed the dismissal of a private antitrust action brought by consumers seeking to enjoin the largest U.S. beer producer from acquiring the second largest. The consumers argued in this action brought under section 7 of the Clayton Act that the merger would lessen competition in the U.S. beer market. Concluding that they failed to state a claim, the Ninth Circuit emphasized that the U.S. Department of Justice, as a condition of approving the merger, had required the company being acquired to divest entirely its domestic beer business.

Kevin Hart makes a case for watching RHOH all Fall 2016.

Meow!

It's hard out here for a pimp.

This perfect summer starter combines crispy white bread with a lemony aromatic tomato salsa and creamy burrata cheese.

craving more? check out TasteSpotting

Facioscapulohumeral muscular dystrophy (FSHD) results from expression of the full-length double homeobox 4 (DUX4-FL) retrogene in skeletal muscle. However, even in cases of severe FSHD the presence of DUX4 is barely detectable. In this issue of the JCI, Bosnakovski et al. used an inducible, muscle-specific human DUX4 to reproduce the low-level, sporadic DUX4 expression of human FSHD muscle as well the myopathology seen in human FSHD disease. Notably, dysregulated fibroadipogenic progenitors accumulated in affected muscles, thus providing a mechanism for the replacement of muscle by fibrosis and fat.

Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control. Mutations in the lamin A/C gene cause several diseases belonging to the class of laminopathies, including muscular dystrophies. Nevertheless, molecular mechanisms involved in the pathogenesis of lamin A–dependent dystrophies are still largely unknown. The polycomb group (PcG) of proteins are epigenetic repressors and lamin A interactors, primarily involved in the maintenance of cell identity. Using a murine model of Emery-Dreifuss muscular dystrophy (EDMD), we show here that lamin A loss deregulated PcG positioning in muscle satellite stem cells, leading to derepression of non–muscle-specific genes and p16INK4a, a senescence driver encoded in the Cdkn2a locus. This aberrant transcriptional program caused impairment in self-renewal, loss of cell identity, and premature exhaustion of the quiescent satellite cell pool. Genetic ablation of the Cdkn2a locus restored muscle stem cell properties in lamin A/C–null dystrophic mice. Our findings establish a direct link between lamin A and PcG epigenetic silencing and indicate that lamin A–dependent muscular dystrophy can be ascribed to intrinsic epigenetic dysfunctions of muscle stem cells.

Erowid Exp113948

It's a bumper crop of BonusCash at your local Rite-Aid this week, with not 1, 2, 3, but 4 gaming GC's, and 1 of those gives you even more options!

• Nike, GameStop, Netflix ... $5 BonusCash when you buy $25 of these items.*
• Google Play, AMC Theatres, Apple AppStore/iTunes, Fandango, XBOX, Panera Bread, Regal Theatres ... $6 BonusCash when you buy $30 of these items.*

FYI, "GameStop" is a big win, because not only can you purchase (additional) XBOX, PSN, Nintendo, and Steam credit there, but you order the GC credit from their website, and get a redemption code instantly after checkout.
 
For those who are new to the "Rite-Aid wellness+ reward BonusCash" program, you'll receive the $$$ amount when you purchase the minimum amount specified. Gift-cards within the same bullet-point share the same "limit 2 offers per customer", but you can earn rewards on the other bullet-point lines as well. For example, you can purchase $25 each of GameStop & Netflix (or $50 of GameStop) ... and still be able to purchase another $60 mix of Google & Apple & XBOX, and can stagger your 4 GC purchases throughout the week.

Screenshot of 2 separate GC offers (bullet points) included here:

• if you've met the limit of 2 items per BonusCash group with the current transaction, or
• if the transaction you're about to complete exceeds the limit of 2 per week, or
• when your BonusCash rewards will expire.

Luckily the mobile RiteAid app (and website) list your individual accumulation & cashing out on a per transaction basis, so that's a good way to keep tabs on the expiration dates, since you only get 30 days to spend the BonusCash once earned. Good luck!