Berlin ; Heidelberg : Springer-Verlag Berlin Heidelberg, 2006

City archaeologists and history students discover fragments of burial urns, ring stands belonging to the megalithic period in Sulapuram Village near Madurai

... And sometimes, that's enough, says Sreehari Nair.

The event, organized by the Surfing Swami Foundation and hosted by the Mantra Surf Club, will feature top Indiansurfers competing in various categories

Added surface glycine residues cause partial unfolding that adapts enyzyme to low temperatures

Multifunctional surfaces could control liquid and particle movement in microfluidics or pipes

Investigators are using additional video footage to reconstruct the February afternoon that Ahmaud Arbery was fatally shot in a quiet southern Georgia neighborhood.

Investigators are using additional video footage to reconstruct the February afternoon that Ahmaud Arbery was fatally shot in a quiet southern Georgia neighborhood.

The 26-year-old surfer was pronounced dead at the scene near Manresa State Beach, California parks officials said.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

He was surfing off Manresa State Beach on the northern end of Monterey Bay.

A French surfer has survived a shark attack in Australia with only minor leg injuries by punching it twice, local media reported.

Along with Windows 8, Microsoft's Surface RT tablet is here. The slate uses chips that typically power smartphones but Windows runs quite well on it and the hardware is extremely well made and -- dare I say it -- sexy? See for yourself in this early look.

The stretch of state beach where the attack took place was closed for five days.

Microsoft this week revealed the new Microsoft Surface Go 2 and Surface Book 3 convertible tablet PCs. Microsoft Surface Go 2 Microsoft’s Surface Go fills the role of an affordable tablet PC that can run the full Windows 10 operating system. Its lower pricing was especially attractive to the education and front-line sectors. The Surface…

Researchers led by Albert-László Barabási used network-based models to discover existing drugs that might take on COVID-19