This Metasploit module exploits a vulnerability on the lrFileIOService ActiveX, as installed with HP LoadRunner 11.50. The vulnerability exists in the WriteFileString method, which allow the user to write arbitrary files. It's abused to drop a payload embedded in a dll, which is later loaded through the Init() method from the lrMdrvService control, by abusing an insecure LoadLibrary call. This Metasploit module has been tested successfully on IE8 on Windows XP. Virtualization based on the Low Integrity Process, on Windows Vista and 7, will stop this module because the DLL will be dropped to a virtualized folder, which isn't used by LoadLibrary.

Warwickshire Aviation Ltd & 6 Ors v Littler Investments Ltd [2019] EWHC 633 Tenants of an airfield recently failed in their appeal to the High Court to show that their landlord wasn’t able to oppose new leases being granted to them pursuan...

Reforming state-owned enterprises can be an extraordinarily complex activity but it is underpinned by a single clear goal.

Microchip’s Low-Power Radiation-Tolerant (RT) PolarFire FPGA Enables High-Bandwidth Space Systems with Lower Total System Cost

Microchip Unveils Family Details and Opens Early Access Program for RISC-V Enabled Low-Power PolarFire SoC FPGA Family

Ocean Outbreak unveils the little-known diseases wreaking havoc in the seas and the book does a first-rate job of inspiring readers at the same time

West Africa's waters are a hotspot for illegal fishing, says conservationist Justine Dossa. She is working to change fishing practices and tackle pollution

Title: Kyprolis (carfilzomib)
Category: Medications
Created: 4/27/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM

Organic anion transporter 1 (OAT1), expressed at the basolateral membrane of renal proximal tubule epithelial cells, mediates the renal excretion of many clinically important drugs. Previous study in our laboratory demonstrated that ubiquitin conjugation to OAT1 leads to OAT1 internalization from the cell surface and subsequent degradation. The current study showed that the ubiquitinated OAT1 accumulated in the presence of the proteasomal inhibitors MG132 and ALLN rather than the lysosomal inhibitors leupeptin and pepstatin A, suggesting that ubiquitinated OAT1 degrades through proteasomes. Anticancer drugs bortezomib and carfilzomib target the ubiquitin-proteasome pathway. We therefore investigate the roles of bortezomib and carfilzomib in reversing the ubiquitination-induced downregulation of OAT1 expression and transport activity. We showed that bortezomib and carfilzomib extremely increased the ubiquitinated OAT1, which correlated well with an enhanced OAT1-mediated transport of p-aminohippuric acid and an enhanced OAT1 surface expression. The augmented OAT1 expression and transport activity after the treatment with bortezomib and carfilzomib resulted from a reduced rate of OAT1 degradation. Consistent with this, we found decreased 20S proteasomal activity in cells that were exposed to bortezomib and carfilzomib. In conclusion, this study identified the pathway in which ubiquitinated OAT1 degrades and unveiled a novel role of anticancer drugs bortezomib and carfilzomib in their regulation of OAT1 expression and transport activity.

Some of this year's Oscar nominees, including Andrew Garfield and Michael Shannon, react to news of their nomination.

A string of other stars, like Emma's friends Octavia Spencer and Jonah Hill, have also contributed to the #WeThriveInside campaign

A drop in demand from overseas markets and restaurants at home means 2020 could be the first year without overfishing in European waters.

The world has changed for AFL players — like everybody else — thanks to coronavirus. They're taking a while to process the fact, writes Offsiders' Richard Hinds.

The Geelong star and AFL Players' Association president says cramming 16 rounds into 10 weeks is not ideal, but it may be the model the league has to adopt to get the 2020 season completed after the coronavirus shutdown.

He has claimed almost every individual honour there is in the AFL, but the highest goal continues to drive the Geelong star even during this uncertain 2020 season — a maiden premiership victory.

Five St. Mary’s County, Md., commercial fisherman pleaded guilty today to illegally overfishing striped bass also known as rockfish.

A Fairfield, Calif., couple was indicted today by a federal grand jury in Sacramento, Calif., on federal civil rights charges related to an alleged bias-motivated assault on an Indian-American couple. The two-count indictment alleges that on the evening of July 14, 2007, Joseph and Georgia Silva committed a bias-motivated assault on another couple at a public beach in South Lake Tahoe, Calif.

A U.S. Army contractor was indicted today for stabbing another individual with a knife at Kandahar Airfield in Afghanistan.

Sean T. Brehm, 44, of Capetown, South Africa, pleaded guilty before U.S. District Judge Anthony J. Trenga to assault resulting in serious bodily injury.

A U.S. Army contractor was sentenced today to 42 months in prison for stabbing another individual with a knife at Kandahar Airfield in Afghanistan.

Patrick W. Boyd, 44, of Gainesville, Fla., was sentenced by U.S. District Judge Matthew F. Kennelly of the Northern District of Illinois.

John Mihalczo, 47, of Homosassa, Fla., was sentenced by U.S. District Judge Matthew F. Kennelly of the Northern District of Illinois.

A former Major in the U.S. Army National Guard who was deployed to Bagram Airfield, Afghanistan, was sentenced to 60 months in prison for receiving bribes from military contractors in exchange for fraudulently verifying the receipt of concrete bunkers and barriers that were never received.

Former Sergeant Charles O. Finch, 45, of Milalani, Hawaii, was sentenced yesterday by U.S. District Judge Leslie E. Kobayashi in the District of Hawaii to 51 months in prison and three years of supervised release and was ordered to pay $200,000 in restitution to the Department of Defense.

Baños-Moreno, María-José and Valentín-Ruiz, Francisco-José and Blázquez-Martín-de-las-Mulas, Antonio e-EMGDE, RIC, NEDA y las normas de codificación: más allá de un perfil de aplicación en archivos., 2019 . In IV Congreso ISKO España-Portugal, Barcelona, 11-12 de julio de 2019. [Conference paper]

Why does this not surprise me?

"Surfboards of

An alarming case study in the North Atlantic bolsters Greenpeace's call for a Global Ocean Treaty.

The Buchstabenmuseum is an NGO dedicated to preserving, restoring and exhibiting old signs from Berlin and around the world. Its owners save obsolete letters from the dump and instead tell their stories. It is a museum like no other!

Hellboy
U/A: Action, Adventure, Fantasy
Director: Neil Marshall
Cast: David Harbour, Ian McShane, Milla Jovovich, Sasha Lane, Daniel Dae Kim
Rating: 

This latest adaptation of the Mike Mignola comic book is a reboot and not a sequel. Most of the sequences and plot points take for granted that- the viewer is familiar with the story. This film has a rather peculiar blend of history, myth, supernatural and occult playing peekaboo in a narrative that opens up in the past and flashes forward to the post-modern present with rather too much haste. We see a time when everything is acceptable including the paranormal, the other-worldly, different dimensions and the freak. We see Hellboy with horns, crimson skin, and thorny attitude passed out in a Mexican bar or observing a wrestling match and he doesn't raise any eyebrows. And just as we get familiar with the characters and interested in the theme we are subjected to a flashback and that's the pattern we are exposed to throughout this rather jerky, coarse re-imagining of the Hellboy universe. The real problem here is that there's just too much back story and not much of going forward.

Hellboy of course looks more or less the same. The overall look is replicated from the original – this one though looks more worn and unkempt. Hellboy (David Harbour) works with his adoptive father Professor Broom (Ian McShane) at the B.P.R.D, an organization devoted to investigating and generally exterminating paranormal threats. The gruff Superhero heads to England when called upon by the Osiris club to help nullify the Blood Queen's(Milla Jovovich) demonic plot to resurrect herself and bring ruin upon the world.

Check out the trailer here:

The narrative jumps from one plot point to another without acquiring much coherence. We get it that the Blood Queen is part of the main conflict here but by the time she gets into her stride the narrative gets all rushed up and the ensuing melee doesn't have much engagement. Andrew Cosby's screenplay writes in some inner conflict for Hellboy but it doesn't translate all that well on screen. Even the other main characters don't have smooth enough arcs. Neil Marshall is no Guillermo Del Toro and his vision for the action here is also not consistent enough- even though there are a few flashes of brilliance. David Harbour's performance, lacks the confident stamp of authority that Ron Perlman's did. Some of the CGI effects are good but there are moments when they look conspicuous and patched on. Too many characters, too many plot threads and just as many merges between the unimaginable, plagues this tale of a superhero winding his way through tales of legends and destiny - ending it with cataclysmic bedlam that works out to be a rather chaotic gory mess!

Also Read: Milla Jovovich said yes to Hellboy for this reason

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After Race 3 (2018), Jacqueline Fernandez had been missing from the scene, barring sporadic appearances in music videos with Badshah and Bigg Boss contestant Asim Riaz. So where has she been all this while? "For now, I am at a farm far away," she laughs, alluding to spending the lockdown at Salman Khan's Panvel farmhouse. "On a serious note, I went through a period where I needed to reinvent myself."

A still from Mrs Serial Killer

The actor considers Mrs Serial Killer, the crime thriller that dropped on Netflix yesterday, her first step in "rebooting myself." "I have always done mainstream films, and was tired of playing chirpy and superficial characters. I was keen to attempt something dark and complex. So when Shirish [Kunder, director] said that Manoj [Bajpayee] would be my co-star in Mrs Serial Killer, I jumped at the idea." Fernandez admits she was a bundle of nerves on the first day of shoot. "I was excited as well as petrified about working with Manoj. Going by his films, I felt he would be a strict actor. But we had a great time on the set. I had to unlearn several things while working with him."

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Ahead of her first trip to India, biker Leslie Porterfield, the world's fastest woman on two wheels, relives her record, worst crash and the growing number of Indian women on the riding circuit

At 16, Texas-based Leslie Porterfield bought a Yamaha Virago 1000, her first motorcycle, as an inexpensive mode of transport. It arrived in a box, and most people told her she wouldn't be able to get it running. However, she bought a manual, sought the advice of local mechanics, and put it together.

Leslie Porterfield

In fact, Porterfield loved riding it so much that just a year later, she went on to buy a sports bike (Honda CBR600). This was in the early '90s. "That's when my interest in racing began," recalls the 41-year-old mother of twins. She holds the Guinness World Record for being the fastest woman in the world on a motorcycle, which she set in 2008 with a speed of 232.522mph at Bonneville Salt Flats in Utah, USA.

On November 24 and 25, Porterfield will be in Goa for the fifth edition of India Bike Week, a fest that will witness a gathering of over 20,000 bikers to celebrate all things riding. Here, she will host a motorcycle stand and present awards for various achievements. Excerpts from an email interview:

Tell us about your most interesting motorcycle journeys.
Motorcycles gave me a sense of freedom and connection with nature while riding. One of my favourite trips was to the Baja 1000 (off-road race in Mexico's Baja California Peninsula) in 2005. I was on a dirt bike for the first time, and realised how difficult the race is. I went through 20 miles of deep sand whoops and fell 20 times. I have never been so sore. Another one is from the time I was 17, when I rode for 1,500 miles from Dallas to Los Angeles. On my way back, I was tired. I was riding at about 120mph. Unfortunately, I passed a police car and didn't see it. They set up a roadblock on the highway. When I stopped, I realised there were four police cars behind me. They were mad after chasing me for so long. I was lucky; the officer let me go without a citation. This prompted me to hit the racetrack.

What challenges have you faced in your racing career?
During my first year [2007] in Land Speed Racing [at Bonneville Salt Flats, Utah], the salt was in poor condition - wet, sludgy and hard to get traction. My bike got into a speed wobble at over 200mph. I tried to save it, but ended up coming off the bike at over 100mph. It was the worst wreck I've been in. I was unconscious, with seven broken ribs and a punctured lung. Fortunately, I recovered and made a point of testing different set-ups for the bike. I didn't push myself to make runs when conditions were bad. Racing comes with risks, which I try to minimise.

How did you crack the world record in Utah in 2008?
I had to make an effort to not think about what could go wrong, and put the accident out of my mind. I focused solely on what I needed to do to achieve my record. To set a land speed record, you have to make two runs — one in each direction - holding your top speed for a mile. My bike's engine was hot and as I entered the measured mile at full throttle, it started to sound rough. By the end, I had set the record but blown my engine, and there was oil everywhere!

What's your take on Indian motorcycle culture?
It's fascinating. The selection of motorcycles is vast, and I love that more women in India are riding motorcycles now. When I started in the '90s, men dominated the speed and racing scene; it was difficult for women to break into it.

Is Mumbai part of your itinerary?
I hope to see it during my visit. It is such a diverse city with much history. I've wanted to visit India for some time. I can't wait to experience its architecture, art, culture and beauty. I love Indian food, but have tried it only in America.

What kind of bikes do you ride now?
I have a Honda CBR1000, and several classic bikes from the '60s. I enjoy restoring old bikes. They aren't very fast, but they are a lot of fun.

Tips
>> Invest in proper motorcycle gear.
>> Never quit learning. Take up rider courses. Even if you have no desire to race, a day on the track with guidance will make you a better and safer rider.