A spicey version of a winter favourite

I have clear memories of being about four year's old standing on a little stool next to my mum while she made batches of these golden scones. I always loved being in the kitchen with her and she was endlessly patient, letting me help mix, stir, roll and shape all manner of things (in this case turning a blind eye when I smuggled little nuggets raw dough and dates into my mouth.) We would chat away as we went and she would explain to me what she was doing. I remember to this day her telling me the secret to making good scones was to use the lightest touch possible when you're mixing the dough together...we had no food processor then so everything was mixed by hand and I loved rubbing the flour and butter together, lifting my hands high as she had taught me to help keep the scones light. Although I whiz these up in a processor now, every so often I make a batch by hand, and am immediately whisked back into that childhood kitchen and can almost feel and see Cooee, my mum, beside me in her wonderful cinch-waisted 60's polka dot dress...it's a wonderful image.

1.2kg butternut pumpkin, peeled, cut into 2cm pieces 2 tablespoons olive oil 1 tablespoon chopped fresh sage, plus 12 whole leaves to serve 1/4 teaspoon freshly grated nutmeg 350g ricotta 1 egg 1 cup grated parmesan, plus extra to serve 8 fresh lasagne sheets 100g unsalted butter 2 tablespoons chopped walnuts

Op-ed by Agustín Carstens published in the Financial Times on 29 March 2020.

Treatment of Mycobacterium avium complex pulmonary disease (MAC-PD) is challenging partly due to high efflux pump expression. Thioridazine might block these efflux pumps. We explore thioridazine's efficacy against M. avium using minimum inhibitory concentrations (MICs), time-kill combination assays, ex vivo macrophage infection assays and efflux assays. Thioridazine is bactericidal against M. avium, inhibits intracellular growth at 2x MIC and blocks ethidium bromide efflux. However, its toxicity and low plasma concentrations, make it unlikely to add efficacy to MAC-PD therapy.

Google Assistant Scheduled Actions lets you schedule actions in advance—so you can tell your coffee maker to start at 6 a.m. or your air conditioner to stop at 10 p.m.

If you notice, pumpkin has several appetising sweet and savoury dishes in the western countries in form of salad, soup and pies. Keeping this in mind, we bring you a recipe that will make the simple...

The details may be technical, but the concepts are clear when it comes to analyzing seasonal retail data

As the sun sets on California’s solar farms, a backup energy source deep in the Sierra Nevada Mountains springs to life.

Voith has received an order for the Ritom pumped storage power plant in Switzerland, which began operating in 1920 and will be replaced with a new facility.

A report recently released by the U.S. Department of Energy defines and evaluates cost and performance parameters of six battery energy storage technologies (BESS) and four non-BESS storage technologies.

The Australian Renewable Energy Agency (ARENA), on behalf of the Australian government, has announced up to $40 million in funding towards the deployment of a pumped hydro energy storage (PHES) project in South Australia.

Hydro Tasmania says it is accelerating detailed investigation of three key opportunities for pumped storage hydro development in the state as part of the Battery of the Nation initiative. Work has begun on a full feasibility assessment of pumped hydro development opportunities at Lake Cethana and Lake Rowallan in the northwest and near Tribute Power Station on the West Coast.

The Lithuanian Business Support Agency (LSBA) has granted €235,000 (US$267,500) to support development of an experimental floating solar photovoltaic power plant at the existing 900-MW Kruonis pumped-storage hydroelectric plant in Lithuania.

As the sun sets on California’s solar farms, a backup energy source deep in the Sierra Nevada Mountains springs to life.

Utilities are a natural partner for the geothermal heat pump (GHP) industry. Why? Because utilities have a broad consumer base and infrastructure, and need to both build load (sales) and levelize that demand to make the most efficient use of their electrical generation capacity throughout the year.  GHPs are a technology that fills that niche.

Engineering firm Lahmeyer International GmbH and sub-consultant Manitoba Hydro International have been awarded a contract by Tanahu Hydropower Ltd. to provide a number of services associated with the development of the 140-MW Tanahu pumped-storage project in Nepal.

Development-ready sites, with existing reservoirs for new pumped hydro energy storage plants, offer generation potential of 2,291 GWh, according to a newly released report from the eStorage Project.

Hydroelectric power developer Snowdonia Pumped Hydro has withdrawn its application for environmental permits for the 99.9-MW Glyn Rhonwy pumped-storage plant from Natural Resources Wales.

There are a total of about 530,000 potentially feasible pumped hydro energy storage sites worldwide, with a total storage potential of about 22 million GWh. These astonishing numbers come from a report recently released by Professor Andrew Blakers and other researchers with Australian National University’s RE100 Group.

Genex Power Limited has secured all environmental approvals required to develop the 250-MW Kidston Pumped Storage Hydro Project (K2-Hydro).

Genex Power Limited has signed a share subscription agreement (SSA) with Electric Power Development Co Ltd, trading as J-POWER, for a conditional investment of up to AUD$25 million (US$17.5 million).

As the sun sets on California’s solar farms, a backup energy source deep in the Sierra Nevada Mountains springs to life.

A report recently released by the U.S. Department of Energy defines and evaluates cost and performance parameters of six battery energy storage technologies (BESS) and four non-BESS storage technologies.

The Australian Renewable Energy Agency (ARENA), on behalf of the Australian government, has announced up to $40 million in funding towards the deployment of a pumped hydro energy storage (PHES) project in South Australia.

Hydro Tasmania says it is accelerating detailed investigation of three key opportunities for pumped storage hydro development in the state as part of the Battery of the Nation initiative. Work has begun on a full feasibility assessment of pumped hydro development opportunities at Lake Cethana and Lake Rowallan in the northwest and near Tribute Power Station on the West Coast.

As the sun sets on California’s solar farms, a backup energy source deep in the Sierra Nevada Mountains springs to life.

For years, Western companies have struggled to profit from a Chinese consumer market that thrives on cheap knock-offs of iconic brands. But that frustration is now turning into optimism, as local courts begin to stamp out thieves and cheats, lawyers say.More companies are filing intellectual property (IP) lawsuits amid a shift in attitude towards protecting original ideas, trademarks and patents, according to official data. The rush has accelerated after the phase-one trade deal in the US-China…

Title: FDA Targets Safety Problems With Infusion Drug Pumps
Category: Health News
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Last Editorial Review: 4/26/2010 12:00:00 AM

Title: Steroids Could Harm Heart's Pumping Ability
Category: Health News
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Title: Patch Pump Device Could Offer Cheaper Insulin Delivery
Category: Health News
Created: 4/1/2020 12:00:00 AM
Last Editorial Review: 4/2/2020 12:00:00 AM

ABSTRACT

Transporters belonging to the chromosomally encoded resistance-nodulation-division (RND) superfamily mediate multidrug resistance in Gram-negative bacteria. However, the cotransfer of large gene clusters encoding RND-type pumps from the chromosome to a plasmid appears infrequent, and no plasmid-mediated RND efflux pump gene cluster has yet been found to confer resistance to tigecycline. Here, we identified a novel RND efflux pump gene cluster, designated tmexCD1-toprJ1, on plasmids from five pandrug-resistant Klebsiella pneumoniae isolates of animal origin. TMexCD1-TOprJ1 increased (by 4- to 32-fold) the MICs of tetracyclines (including tigecycline and eravacycline), quinolones, cephalosporins, and aminoglycosides for K. pneumoniae, Escherichia coli, and Salmonella. TMexCD1-TOprJ1 is closely related (64.5% to 77.8% amino acid identity) to the MexCD-OprJ efflux pump encoded on the chromosome of Pseudomonas aeruginosa. In an IncFIA plasmid, pHNAH8I, the tmexCD1-toprJ1 gene cluster lies adjacent to two genes encoding site-specific integrases, which may have been responsible for its acquisition. Expression of TMexCD1-TOprJ1 in E. coli resulted in increased tigecycline efflux and in K. pneumoniae negated the efficacy of tigecycline in an in vivo infection model. Expression of TMexCD1-TOprJ1 reduced the growth of E. coli and Salmonella but not K. pneumoniae. tmexCD1-toprJ1-positive Enterobacteriaceae isolates were rare in humans (0.08%) but more common in chicken fecal (14.3%) and retail meat (3.4%) samples. Plasmid-borne tmexCD1-toprJ1-like gene clusters were identified in sequences in GenBank from Enterobacteriaceae and Pseudomonas strains from multiple continents. The possibility of further global dissemination of the tmexCD1-toprJ1 gene cluster and its analogues in Enterobacteriaceae via plasmids may be an important consideration for public health planning.

IMPORTANCE In an era of increasing concerns about antimicrobial resistance, tigecycline is likely to have a critically important role in the treatment of carbapenem-resistant Enterobacteriaceae, the most problematic pathogens in human clinical settings—especially carbapenem-resistant K. pneumoniae. Here, we identified a new plasmid-borne RND-type tigecycline resistance determinant, TMexCD1-TOprJ1, which is widespread among K. pneumoniae isolates from food animals. tmexCD1-toprJ1 appears to have originated from the chromosome of a Pseudomonas species and may have been transferred onto plasmids by adjacent site-specific integrases. Although tmexCD1-toprJ1 still appears to be rare in human clinical isolates, considering the transferability of the tmexCD1-toprJ1 gene cluster and the broad substrate spectrum of TMexCD1-TOprJ1, further dissemination of this mobile tigecycline resistance determinant is possible. Therefore, from a "One Health" perspective, measures are urgently needed to monitor and control its further spread. The current low prevalence in human clinical isolates provides a precious time window to design and implement measures to tackle this.

The biological carbon pump (BCP) comprises wide-ranging processes that set carbon supply, consumption, and storage in the oceans’ interior. It is becoming increasingly evident that small changes in the efficiency of the BCP can significantly alter ocean carbon sequestration and, thus, atmospheric CO2 and climate, as well as the functioning...

Manogepix is a broad-spectrum antifungal agent that inhibits glycosylphosphatidylinositol (GPI) anchor biosynthesis. Using whole-genome sequencing, we characterized two efflux-mediated mechanisms in the fungal pathogens Candida albicans and Candida parapsilosis that resulted in decreased manogepix susceptibility. In C. albicans, a gain-of-function mutation in the transcription factor gene ZCF29 activated expression of ATP-binding cassette transporter genes CDR11 and SNQ2. In C. parapsilosis, a mitochondrial deletion activated expression of the major facilitator superfamily transporter gene MDR1.

Yeah, I’ll have a venti double dirty chai pumpkin spice latte to go, no foam. What do you mean you don’t have an espresso machine?...

To avoid arsenic contamination, many Bangladeshi households access water via private wells drilled to 300 feet or less, beneath impermeable clay layers. Such clay layers have been thought to protect groundwater in the underlying aquifers from the downward flow of contaminants. However, a new study suggests that such clay layers do not always protect against arsenic, and could even be a source of contamination in some wells.

Water utility workers in El Paso, Texas were forced to unclog pumps over 20 times in 24 hours after residents refused to heed their call to refrain from flushing personal protective equipment and other coronavirus-related items down the toilet.

Investigations will begin into how a number of dams in drought-ravaged parts of NSW came to be filled during a ban on pumping water along parts of the Murray-Darling earlier this year.

Phillip Windom Offill Jr., 51, of Dallas, was indicted on March 12, 2009, and today was found guilty of one count of conspiracy to commit registration violations, securities fraud and nine counts of wire fraud.

Jaisankar Marimuthu, a native of Chennai, India, pleaded guilty to one count of conspiracy to commit wire fraud, securities fraud, computer fraud and aggravated identity theft, and to one count of aggravated identity theft.

David B. Stocker, 50, of Phoenix pleaded guilty on March 11, 2009, in U.S. District Court in Alexandria, Va., for his participation in a stock manipulation conspiracy known as a "pump-and-dump" scheme.

An Indian national was sentenced today to 81 months in prison on conspiracy and aggravated identity theft charges arising from an international fraud scheme to "hack" into online brokerage accounts in the United States and use those accounts to manipulate stock prices.

A securities attorney and a former stock broker were sentenced today to 188 months and 151 months in prison, respectively, for their roles in an extensive pump-and-dump stock manipulation scheme.

Nutrition 21, LLC has announced its Nitrosigine® is now featured in EVERTRAIN PRE, a recently launched pre-workout supplement designed to provide athletes with sustained energy, superior focus and increased endurance.

It's in the Fearless Leader's latest move to a planned economy that runs on coal.

The city is getting bike lanes and light rail transit, and their new apparatuses are chosen to better fit the streetscape.

These delicious dessert squares skip the crust and the refined sugar. They're quick and easy to make for lightly sweet snacks during fall and winter.

Since pumpkins generally require around 75 to 100 frost-free days, it's a good idea to get a jumpstart on planting them.