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Larry Brown’s Contributions to Parametric Inference, Decision Theory and Foundations: A Survey

James O. Berger, Anirban DasGupta.

Source: Statistical Science, Volume 34, Number 4, 621--634.

Abstract:
This article gives a panoramic survey of the general area of parametric statistical inference, decision theory and foundations of statistics for the period 1965–2010 through the lens of Larry Brown’s contributions to varied aspects of this massive area. The article goes over sufficiency, shrinkage estimation, admissibility, minimaxity, complete class theorems, estimated confidence, conditional confidence procedures, Edgeworth and higher order asymptotic expansions, variational Bayes, Stein’s SURE, differential inequalities, geometrization of convergence rates, asymptotic equivalence, aspects of empirical process theory, inference after model selection, unified frequentist and Bayesian testing, and Wald’s sequential theory. A reasonably comprehensive bibliography is provided.




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Models as Approximations II: A Model-Free Theory of Parametric Regression

Andreas Buja, Lawrence Brown, Arun Kumar Kuchibhotla, Richard Berk, Edward George, Linda Zhao.

Source: Statistical Science, Volume 34, Number 4, 545--565.

Abstract:
We develop a model-free theory of general types of parametric regression for i.i.d. observations. The theory replaces the parameters of parametric models with statistical functionals, to be called “regression functionals,” defined on large nonparametric classes of joint ${x extrm{-}y}$ distributions, without assuming a correct model. Parametric models are reduced to heuristics to suggest plausible objective functions. An example of a regression functional is the vector of slopes of linear equations fitted by OLS to largely arbitrary ${x extrm{-}y}$ distributions, without assuming a linear model (see Part I). More generally, regression functionals can be defined by minimizing objective functions, solving estimating equations, or with ad hoc constructions. In this framework, it is possible to achieve the following: (1) define a notion of “well-specification” for regression functionals that replaces the notion of correct specification of models, (2) propose a well-specification diagnostic for regression functionals based on reweighting distributions and data, (3) decompose sampling variability of regression functionals into two sources, one due to the conditional response distribution and another due to the regressor distribution interacting with misspecification, both of order $N^{-1/2}$, (4) exhibit plug-in/sandwich estimators of standard error as limit cases of ${x extrm{-}y}$ bootstrap estimators, and (5) provide theoretical heuristics to indicate that ${x extrm{-}y}$ bootstrap standard errors may generally be preferred over sandwich estimators.




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An Overview of Semiparametric Extensions of Finite Mixture Models

Sijia Xiang, Weixin Yao, Guangren Yang.

Source: Statistical Science, Volume 34, Number 3, 391--404.

Abstract:
Finite mixture models have offered a very important tool for exploring complex data structures in many scientific areas, such as economics, epidemiology and finance. Semiparametric mixture models, which were introduced into traditional finite mixture models in the past decade, have brought forth exciting developments in their methodologies, theories, and applications. In this article, we not only provide a selective overview of the newly-developed semiparametric mixture models, but also discuss their estimation methodologies, theoretical properties if applicable, and some open questions. Recent developments are also discussed.




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Allometric Analysis Detects Brain Size-Independent Effects of Sex and Sex Chromosome Complement on Human Cerebellar Organization

Catherine Mankiw
May 24, 2017; 37:5221-5231
Development Plasticity Repair




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Daily Marijuana Use Is Not Associated with Brain Morphometric Measures in Adolescents or Adults

Barbara J. Weiland
Jan 28, 2015; 35:1505-1512
Neurobiology of Disease




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Olli Rehn: A globally symmetric crisis calls for a globally coordinated and forceful policy response

Remarks by Mr Olli Rehn, Governor of the Bank of Finland, at the Reinventing Bretton Woods Committee Panel Discussion on "The world economy transformed: Reflections on policy responses and the future post pandemic monetary architecture", in the context of the virtual IMF Spring Meetings, Washington DC, 17 April 2020.




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Performance Metrics After Changes in Screening Protocol for Congenital Hypothyroidism

Significant variation in congenital hypothyroidism screening operations/performance has been observed in the United States. The origin of this variation remains unknown, in part because of a lack of evaluation. Accordingly, debates persist about optimal screening operations including laboratory testing methods.

Four distinct screening protocols applied to Michigan resident infants are compared in detecting congenital hypothyroidism overall and specific to cases characterized by high initial thyrotropin concentrations thought to have a more severe form of the disease. (Read the full article)




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Comparison of One-Tier and Two-Tier Newborn Screening Metrics for Congenital Adrenal Hyperplasia

The false-positive rate of newborn screening for classic congenital adrenal hyperplasia (CAH) remains high and has not been significantly improved by adjusting 17α-hydroxyprogesterone cutoff values for birth weight and/or gestational age. In response, 4 states have initiated second-tier steroid profile screening.

Under second-tier screening, the false-positive rate remains high, and classic CAH cases missed by screening (false-negatives) occur more frequently than reported. Physicians are cautioned that a negative screen does not necessarily rule out CAH. (Read the full article)




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Symmetrical and Asymmetrical Growth Restriction in Preterm-Born Children

Fetal growth restriction, particularly in preterm children, is associated with delayed development and poor growth. Knowledge about the consequences of fetal growth restriction if classified by symmetry is lacking, especially in preterm children.

In preterm children, symmetric and asymmetric growth restriction at birth results in poorer growth later in life. Both groups are at considerable risk of developmental delay because their long-term development is independent of their head circumference at birth. (Read the full article)




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ONGC, OIL earnings to decline, credit metrics weaken due to lower oil prices: Moody’s

Oil prices in the international markets last month slumped to a two-decade low of USD 18 per barrel before rebounding by some measure.




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From Pumpkin Spice Metrics to Year-Round Loyalty

The details may be technical, but the concepts are clear when it comes to analyzing seasonal retail data




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The geometric distribution in SAS

I have written several articles about how to work with continuous probability distributions in SAS. I always emphasize that it is important to be able to compute the four essential functions for working with a statistical distribution. Namely, you need to know how to generate random values, how to compute [...]

The post The geometric distribution in SAS appeared first on The DO Loop.




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Canada Requires Biometrics of Foreigners to Apply for Permanent Residence

Canada has opened Service centers across the country for taking biometrics related to foreign nationals who apply to stay in it.A New Approach for EfficiencyBefore December 3rd, such immigration candidates, who were applying away from Canada, needed…




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Incisive Metrics Center User Guide

Hi Team,

I would like to download "Incisive Metrics Center User Guide", I could not find in the cadence/support/manuals. Can you please provide me the link or path to download the same ? I am doing functional coverage with IMC. 

Thank You,

Mahesh




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IntelliGen Statistics Metrics Collection Utilility

As noted in white papers, posts on the Team Specman Blog, and the Specman documentation, IntelliGen is a totally new stimulus generator than the original "Pgen" and, as a result, there is some amount of effort needed to migrate an existing verification environment to fully leverage the power of IntelliGen.  One of the main steps in migrating code is running the linters on your code and adressing the issues highlighted. 

Included below is a simple utility you can include in your environment that allows you to collect some valuable statistics about your code base to allow you to better gauge the amount of work that might be required to migrate from Pgen to IntelliGen.  The ICFS statistics reported are of particular benefit as the utility not only identifies the approximate number of ICFSs in the environment, it also breaks the total number down according to generation contexts (structs/units and gen-on-the-fly statements) allowing you to better focus your migration efforts. 

IMPORTANT: Sometimes a given environment can trigger a large number of IntelliGen linting messages right off the bat.  Don't let this freak you out!  This does not mean that migration will be a long effort as quite often some slight changes to an environment remove a large number of identified issues.  I recently encountered a situation where a simple change to three locations in the environment, removed 500+ ICFSs!

The methods included in the utility can be used to report information on the following:
- Number of e modules
- Number of lines in the environment (including blanks and comments)
- Number and type of IntelliGen Guidelines linting messages
- Number of Inconsistently Connected Field Sets (ICFSs)
- Number of ICFS contexts and how many ICFSs per context
- Number of soft..select overlays found in the envioronment
- Number of Laces identified in the environment


To use the code below, simply load it before/after loading e-code and then
you can execute any of the following methods:

- sys.print_file_stats()             : prints # of lines and files
- sys.print_constraint_stats()   : prints # of constraints in the environment
- sys.print_guideline_stats()    : prints # of each type of linting message
- sys.print_icfs_stats()            : prints # of ICFSs, contexts and #ICFS/context
- sys.print_soft_select_stats() : prints # of soft select overlay issues
- sys.print_lace_stats()           : *Only works for SPMNv6.2s4 and later* prints # of laces identified in the environment

Each of the above calls to methods produces it's own log files (stored in the current working directory) containing relevant information for more detailed analysis.
- file_stats_log.elog : Output of "show modules" command
- constraint_log.elog : Output of the "show constraint" command
- guidelines_log.elog : Output of "gen lint -g" (with notification set to MAX_INT in order to get all warnings)
- icfs_log.elog       : Output of "gen lint -i" command
- soft_select_log.elog: Output of the "gen lint -s" command
- lace_log.elog       : Output of the "show lace" command


Happy generating!

Corey Goss




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Extracting 1dB bandwidth from parametric sweep-DFT results

Hi all,

I am using ADE assembler.

I ran transient simulation and swept the input frequency (Fin) of the circuit. And I use Spectrum Measurement to return a value of the fundamental tone magnitude (Sig_fund) for each sweep point. 

Previously, I use "plot across design points" to plot both "Fin" and "Sig_fund", and then use "Y vs Y" to get a waveform of Sig_fund vs Fin. Measure the 1dB Bandwidth with markers. 

Can I realized above measurement with an expression in "output setup" ? And how?

I know to set the "Eval type" to "sweep" to process the data across sweep points. But here, it has to return an interpolated value from "Fin" with a criteria "(value(calcVal("Sig_fund"  0) - 1)". I am not sure whether it can be done in ADE assembler.

Thanks and regards,

Yutao







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European Union Backs Biometric Passports




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US Names The Day For Biometric Passports




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South Africa Rolls Out Biometric Passports




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Nanometrics Centaur / TitanSMA Unauthenticated Remote Memory Leak

An information disclosure vulnerability exists when Centaur and TitanSMA fail to properly protect critical system logs such as 'syslog'. Additionally, the implemented Jetty version (9.4.z-SNAPSHOT) suffers from a memory leak of shared buffers that was (supposedly) patched in Jetty version 9.2.9.v20150224.




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Nanometrics Centaur 4.3.23 Memory Leak

Nanometrics Centaur version 4.3.23 suffers from an unauthenticated remote memory leak vulnerability.




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Live Webinar | Strong Customer Authentication: The role of Biometrics in PSD2




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Live Webinar | Strong Customer Authentication: The role of Biometrics in PSD2




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Live Webinar | Strong Customer Authentication: The role of Biometrics in PSD2




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Live Webinar | Strong Customer Authentication: The role of Biometrics in PSD2




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Live Webinar | Strong Customer Authentication: The role of Biometrics in PSD2




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Live Webinar | Strong Customer Authentication: The role of Biometrics in PSD2




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Live Webinar | Strong Customer Authentication: The role of Biometrics in PSD2




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Top-Cited Articles from Dental Education Journals, 2009 to 2018: A Bibliometric Analysis

The number of citations an article receives is an important indicator to quantify its influence in its field. The aim of this study was to identify and analyze the characteristics of the 50 top-cited articles addressing dental education published in two journals dedicated to dental education (European Journal of Dental Education and Journal of Dental Education). The Web of Science database was searched to retrieve the 50 most-cited articles from the two journals in December 2018. The top-cited articles were analyzed for journal of publication, number of citations, institution and country of origin, year of publication, study type, keywords, theme and subtheme, and international collaborations. The results showed the 50 top-cited articles were cited between 24 and 146 times each. The majority of these top-cited articles (n=34) were published in the Journal of Dental Education. Half (n=25) of the articles were by authors in the U.S. The most common study types were surveys (n=26) and reviews (n=10). The main themes of these top-cited articles were curriculum and learner characteristics. This bibliometric analysis can serve as a reference for recognizing studies with the most impact in the scholarship of dental education.




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Metrics that matter for assessing the ocean biological carbon pump [Environmental Sciences]

The biological carbon pump (BCP) comprises wide-ranging processes that set carbon supply, consumption, and storage in the oceans’ interior. It is becoming increasingly evident that small changes in the efficiency of the BCP can significantly alter ocean carbon sequestration and, thus, atmospheric CO2 and climate, as well as the functioning...




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Effects of Continuous Glucose Monitoring on Metrics of Glycemic Control in Diabetes: A Systematic Review With Meta-analysis of Randomized Controlled Trials

BACKGROUND

Continuous glucose monitoring (CGM) provides important information to aid in achieving glycemic targets in people with diabetes.

PURPOSE

We performed a meta-analysis of randomized controlled trials (RCTs) comparing CGM with usual care for parameters of glycemic control in both type 1 and type 2 diabetes.

DATA SOURCES

Many electronic databases were searched for articles published from inception until 30 June 2019.

STUDY SELECTION

We selected RCTs that assessed both changes in HbA1c and time in target range (TIR), together with time below range (TBR), time above range (TAR), and glucose variability expressed as coefficient of variation (CV).

DATA EXTRACTION

Data were extracted from each trial by two investigators.

DATA SYNTHESIS

All results were analyzed by a random effects model to calculate the weighted mean difference (WMD) with the 95% CI. We identified 15 RCTs, lasting 12–36 weeks and involving 2,461 patients. Compared with the usual care (overall data), CGM was associated with modest reduction in HbA1c (WMD –0.17%, 95% CI –0.29 to –0.06, I2 = 96.2%), increase in TIR (WMD 70.74 min, 95% CI 46.73–94.76, I2 = 66.3%), and lower TAR, TBR, and CV, with heterogeneity between studies. The increase in TIR was significant and robust independently of diabetes type, method of insulin delivery, and reason for CGM use. In preplanned subgroup analyses, real-time CGM led to the higher improvement in mean HbA1c (WMD –0.23%, 95% CI –0.36 to –0.10, P < 0.001), TIR (WMD 83.49 min, 95% CI 52.68–114.30, P < 0.001), and TAR, whereas both intermittently scanned CGM and sensor-augmented pump were associated with the greater decline in TBR.

LIMITATIONS

Heterogeneity was high for most of the study outcomes; all studies were sponsored by industry, had short duration, and used an open-label design.

CONCLUSIONS

CGM improves glycemic control by expanding TIR and decreasing TBR, TAR, and glucose variability in both type 1 and type 2 diabetes.




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Gastrin Blocks Symmetric Stem-Cell Division and Gastric Tumorigenesis [Gastric Cancer]

Symmetric division of stem cells positive for gastrin receptor CCK2R is linked to gastric cancer.




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Advanced ADC Histogram, Perfusion, and Permeability Metrics Show an Association with Survival and Pseudoprogression in Newly Diagnosed Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium [FUNCTIONAL]

BACKGROUND AND PURPOSE:

Diffuse intrinsic pontine glioma is a lethal childhood brain cancer with dismal prognosis and MR imaging is the primary methodology used for diagnosis and monitoring. Our aim was to determine whether advanced diffusion, perfusion, and permeability MR imaging metrics predict survival and pseudoprogression in children with newly diagnosed diffuse intrinsic pontine glioma.

MATERIALS AND METHODS:

A clinical trial using the poly (adenosine diphosphate ribose) polymerase (PARP) inhibitor veliparib concurrently with radiation therapy, followed by maintenance therapy with veliparib + temozolomide, in children with diffuse intrinsic pontine glioma was conducted by the Pediatric Brain Tumor Consortium. Standard MR imaging, DWI, dynamic contrast-enhanced perfusion, and DSC perfusion were performed at baseline and approximately every 2 months throughout treatment. ADC histogram metrics of T2-weighted FLAIR and enhancing tumor volume, dynamic contrast-enhanced permeability metrics for enhancing tumors, and tumor relative CBV from DSC perfusion MR imaging were calculated. Baseline values, post-radiation therapy changes, and longitudinal trends for all metrics were evaluated for associations with survival and pseudoprogression.

RESULTS:

Fifty children were evaluable for survival analyses. Higher baseline relative CBV was associated with shorter progression-free survival (P = .02, Q = 0.089) and overall survival (P = .006, Q = 0.055). Associations of higher baseline mean transfer constant from the blood plasma into the extravascular extracellular space with shorter progression-free survival (P = .03, Q = 0.105) and overall survival (P = .03, Q = 0.102) trended toward significance. An increase in relative CBV with time was associated with shorter progression-free survival (P < .001, Q < 0.001) and overall survival (P = .004, Q = 0.043). Associations of longitudinal mean extravascular extracellular volume fraction with progression-free survival (P = .03, Q = 0.104) and overall survival (P = .03, Q = 0.105) and maximum transfer constant from the blood plasma into the extravascular extracellular space with progression-free survival (P = .03, Q = 0.102) trended toward significance. Greater increases with time were associated with worse outcomes. True radiologic progression showed greater post-radiation therapy decreases in mode_ADC_FLAIR compared with pseudoprogression (means, –268.15 versus –26.11, P = .01.)

CONCLUSIONS:

ADC histogram, perfusion, and permeability MR imaging metrics in diffuse intrinsic pontine glioma are useful in predicting survival and pseudoprogression.




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RoMeLa's Newest Robot Is a Curiously Symmetrical Dynamic Quadruped

With four legs but no back or front, ALPHRED 2 can run, jump, and punch through boards in any direction




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RPG Cast – Episode 524: “Overhead Isometricy Game”

Alex, Johnathan, and Chris run through the past two weeks of news, bemoan the lack of time to play games, and then commit to not trying to play anything new. Ring Fit Adventure wins RPG of the year. But seriously, why isn't Shining Force II on that thing?




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Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape




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Does multiparametric imaging with <sup>18</sup>F-FDG-PET/MRI capture spatial variation in immunohistochemical cancer biomarkers in head and neck squamous cell carcinoma?




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Asymmetrical shingle-clad laneway house is inspired by houseboat design

This modern laneway house is now home to a client who wants to look after her aging parents.




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Architectural Sand Castles are Geometric Wonders

These sand "castles" are not your usual holiday beach creations.




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Walkscore Rates the Most Walkable Cities In America. Is It A Useful Metric?

Yesterday I wrote about a mom who was convicted of vehicular homicide after her son was killed by a drunk hit-and-run, because she crossed the street from a bus stop without walking almost half a mile to the traffic light. Today Walkscore has released




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Parametrically designed egg-shaped observatory lets you watch local wildlife

Situated in a nature reserve along the Dutch coast, this unique structure not only serves as an observation post, it also provides extra bird habitats.






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Suhani Parekh's sculpted jewellery is perfectly geometric


Deepika Padukone

We were first introduced to Suhani Parekh of Misho Designs last year, when we did a feature on the "cool gangs" that knew the best of where to eat, drink and soak in art, around the city. When we hung out with Parekh and her friends - curator Arshiya Lokhandwala and artistes Justin Ponmany and Prajakta Potnis - she seemed like someone to watch out for. One year later, we can't help, but be in awe of her steady rise.


Suhani Parekh flaunting one of her designs

If you are a social media buff, there is no way you have missed Misho Designs and all the people wearing it. Rihanna has worn it and so has Kim Kardashian. Back home, it's Deepika Padukone, Masaba Gupta and Aishwarya Rai. "I was a sculptor, so I hadn't ever thought of jewellery. I used to design some pieces for myself and then, as people saw me wearing them, they said, can you make us a pair. It's then that we just decided to sit down and make more," says Parekh, who studied to be a sculptor at Goldsmiths University in London.

It was winning a fashion magazine award for being a young designer of note that put Parekh firmly in the spotlight. "I think every young designer needs a platform that helps them put themselves out there. It was a turning point for me," the Shivaji Park resident tells us.

Misho's aesthetic, which Parekh has described as "wearable sculpture", is characterised by architectural forms and chic geometric shapes. She is inspired by Bauhaus ideology and Japanese minimalism, and names Misho after an ancient Japanese Bonsai technique, which means the process by which a seed turns into a Bonsai tree.

Parekh insists that being consistent, and staying true to one's design language has helped her brand. "I think you have to recognise where there is a gap in the market. We have lovely traditional jewellery, but how does one buy edgy pieces. I think Misho filled that void. And so, when we sent out the jewellery for fashion shoots or to a celebrity, who was on a promotion spree, they got chosen, and I am grateful for that."

It is through social media network, Instagram, that Parekh really connects with her audience. The designer, who has around 16k followers, says that it's about constantly innovating. "You can't keep doing the same thing, you need to keep pushing the envelope," she says. She also shares an important insight about the site. "Instagram likes people not products. There is a tricky balance between the two. So, what we at Misho do is, that we don't bombard people with the same kind of posts. We post around three to four times a week, and keep mixing it up. We are exposed to so many different kinds of images, and over-posting is a no-no." But, the most important lesson Parekh says is also about connecting and interacting with the audience. "I talk to people all the time, and respond to the comments. It's the best way to reach out directly."

Catch up on all the latest Mumbai news, crime news, current affairs, and also a complete guide on Mumbai from food to things to do and events across the city here. Also download the new mid-day Android and iOS apps to get latest updates





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Facebook Buys Emotion Detection Startup FacioMetrics

Facebook has acquired emotion detection start-up FacioMetrics to push its artificial intelligence (AI) research into building facial gesture controls.




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New econometric estimates of long-term growth effects of different areas of public spending

Using panel data for OECD countries, this study investigates the extent to which changes in government spending on education, health and other areas influence long-term growth.




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Karlie Kloss steps out wearing nude asymmetric gown for PFW

She's one of the most sought after models in the world - and Karlie Kloss looked incredible when she stepped out in Paris on Thursday.