Chagas disease, caused by the protozoan Trypanosoma cruzi, is one of the main causes of death due to cardiomyopathy and heart failure in Latin American countries. The treatment of Chagas disease is directed at eliminating the parasite, decreasing the probability of cardiomyopathy, and disrupting the disease transmission cycle. Benznidazole (BZ) and nifurtimox (NFX) are recognized as effective drugs for the treatment of Chagas disease by the World Health Organization, but both have high toxicity and limited efficacy, especially in the chronic disease phase. At low doses, aspirin (ASA) has been reported to protect against T. cruzi infection. We evaluated the effectiveness of BZ in combination with ASA at low doses during the acute disease phase and evaluated cardiovascular aspects and cardiac lesions in the chronic phase. ASA treatment prevented the cardiovascular dysfunction (hypertension and tachycardia) and typical cardiac lesions. Moreover, BZ+ASA-treated mice had a smaller cardiac fibrotic area than that in BZ-treated mice. These results were associated with an increase in the number of eosinophils and reticulocytes and level of nitric oxide in the plasma and cardiac tissue of ASA-treated mice relative to respective controls. These effects of ASA and BZ+ASA in chronically infected mice were inhibited by pretreatment with the LXA₄ receptor antagonist, Boc-2, indicating that the protective effects of ASA are mediated by ASA-triggered lipoxin. These results emphasize the importance of exploring new drug combinations for treatments of acute phase of Chagas disease that are beneficial for chronic patients.

BACKGROUND AND OBJECTIVES:

The albuterol dropper bottle used to prepare solutions for continuous nebulization contains the preservative benzalkonium chloride (BAC). BAC, by itself, has been shown to cause bronchospasm. We hypothesized that BAC would decrease the therapeutic efficacy of albuterol in patients with acute asthma exacerbations.

During the COVID-19 pandemic, however, the daily work routine for tailors and apprentices looks a bit different than usual: for several weeks, they have been producing hand-crafted masks for use of...

The new Mercedes-Benz E-Class Elite is the range-topping model and gets a new engine, additional features and more.

The Mercedes-Benz Merc From Home initiative helps eliminate human contact and promotes transparency with respect to vehicle availability and prices.

The GLA-Class is expected to be launched in India soon as the German brand has displayed the vehicle on its India website.

While the factory has restarted operations, it is at a partial stage and same is the case with dealerships.

The new Audi A6 is available with just a petrol engine under its hood. As before, this luxury sedan continues to compete with the likes of BMW 5 Series, Mercedes-Benz E-Class and the Jaguar XF.

The Audi Q8 now stands as the flagship SUV from the German automaker in India. It will find its place above the Q7 in the brand's product line-up. The competition will include the likes of Mercedes-Benz GLS and the BMW X7.

These are halcyon days for fleet-footed crossover SUVs. Saucy ‘utes like the 2020 Mercedes-Benz GLC 43 AMG hardly look like they’re just as quick as their smaller siblings but stopwatches don’t lie. In the example above, Mercedes says the GLC43 crossover takes just 4.7 seconds from 0-60 mph compared to the C43 sedan’s time...

Many car buyers aspire to own a Mercedes-Benz. The cars are a symbol of quality, bulletproof German engineering, and, yes, status. But if you can’t get the lord to buy you a Mercedes-Benz, you have to do it yourself, and that can really stretch the budget. Mercedes answers that issue with its two lowest-priced cars, the A-Class and...

The Environment Ministry is fining Mercedes-Benz W77.6 billion for illegally tampering with emissions tests, the biggest fine ever for a carmaker here (US$1=W1,225). The ministry on Wednesday said Mercedes-Benz, Nissan and Porsche tampered with the emissions of around 40,000 diesel cars sold in Kore...

At HARMAN, our Connected Car division designs, engineers and innovates every day to provide connected solutions for our most valued partners, and our compute model integration with Mercedes-Benz is no exception. Earlier this year, the luxury vehicle ...

Fluoroquinolones are reported to possess immunomodulatory activity; hence, a novel benzoquinolizine fluoroquinolone, levonadifloxacin, was evaluated in lipopolysaccharide-stimulated human whole-blood (HWB) and mouse acute lung injury (ALI) models. Levonadifloxacin significantly mitigated the inflammatory responses in an HWB assay through inhibition of proinflammatory cytokines and in the ALI model by lowering lung total white blood cell count, myeloperoxidase, and cytokine levels. The immunomodulatory effect of levonadifloxacin, along with promising antibacterial activity, is expected to provide clinical benefits in the treatment of infections.

Real Madrid striker Karim Benzema has ruled out a return to former club Lyon in the near future and insists he wants to 'keep making history' with Los Blancos.

A Danish study of more than 200,000 patients has concluded that individuals with affective disorders who use benzodiazepines and other anxiolytics are not at increased risk of developing dementia.
Medscape Medical News

Another very good reason to get fossil fuel powered cars out of our cities.

Daimler, which owns Mercedes-Benz, says it took "robust and best practice safety measures" to ensure that the reopening of the plant was safe for its 4,200 workers.

Luxury automotive major Mercedes Benz today said it will hire 1,000 engineers in the country next year for its research and development (R&D) initiatives in India.

Imports of Crude Benzene in Japan increased to 82.65 JPY Million in March from 82.10 JPY Million in January of 2020. Imports of Crude Benzene in Japan averaged 301.92 JPY Million from 1988 until 2020, reaching an all time high of 1530.70 JPY Million in August of 2006 and a record low of 0 JPY Million in December of 1995. This page includes a chart with historical data for Japan Imports of Crude Benzene.

The 32-year-old is viewed as an ideal replacement for the Uruguayan, who has failed to agree a new deal at the Parc des Princes and is set to depart on a free transfer this summer.

London-based Charlie van Straubenzee, who was one of Prince Harry's ushers, welcomed daughter Clover on Wednesday last week, reports The Sunday Times.

The boxer, who announced last month his return to the ring, gave the 19-year-old a Mercedes-Benz G63, as revealed by a post on her Instagram story displaying her shock at the present.

Floyd Mayweather revealed he gifted his oldest daughter, Iyanna, a $152,500 car for Christmas. Instagram photos show the car as a 2020 AMG G 63 SUV built by Mercedes-Benz.

Real Madrid striker Karim Benzema has threatened to switch his international allegiance after not being called up to the French squad again.

Rebel Wilson picked up some food - and a parking ticket - as she stepped out in Los Angeles on Tuesday. 

Karim Benzema missed the Spanish Super Cup win over Atletico Madrid with a bruised leg while Luka Jovic has not been involved in training since Real Madrid came back from Saudi Arabia.

The 1960 300 SL Roadster, now listed for $1.095 million through a classic car dealer in New York City, was discovered in storage by relatives of an Indiana man who recently passed away.

The singer, 25, looked effortlessly cool as he turned the car out of Nancy Hoover Pohl Overlook at Fryman Canyon viewpoint with a male pal in the passenger seat.

South African traditional leader, Chief Tshekede Pitso, 72, was buried inside his Mercedes Benz with his hands clasped on the wheel. The United Democratic Movement politician died of old age.

The Real Madrid striker has not featured for France since back in 2015, with Deschamps choosing to axe him from the squad following the controversy with compatriot Mathieu Valbuena.

Karim Benzema has been a consistent goalscorer in his professional career and has represented France over 80 times, but the former Lyon marksman hasn't played for Les Bleus since 2015.

Calls are growing for Karim Benzema to earn a recall for France - four years after earning the last of his 81 caps. He's been exiled since his involvement in blackmail of Mathieu Valbuena.

Calls have been growing for the in-form Real Madrid striker to earn his first call-up since 2015 in recent weeks. But Le Graet is determined that the 31-year-old will not be seen in a Les Bleus shirt again.

Real Madrid striker Karim Benzema has threatened to switch his international allegiance after not being called up to the French squad again.

Benzema's hopes of a return to the France fold were shot down by its FA president Noel Le Graet last week. Calls had been growing for the in-form Madrid striker to earn his first call-up since 2015.

PETE JENSON: Zinedine Zidane may have been able to reignite the debate on whether France are foolish to overlook in-form Karim Benzema - but it would take something huge to bring change.

The Court of Cassation, the highest-ranked court in the French justice system, assembled on Monday afternoon with 19 magistrates to try and settle a case which first emerged four years ago.

SPECIAL REPORT BY DANIEL MATTHEWS IN LYON: To many in France, the 32-year-old is a footballing pariah. At Real Madrid, however, Benzema is approaching immortality.

Karim Benzema has taken a swipe at Olivier Giroud, implying the Chelsea striker who replaced him in the France national team is an inferior player.  The 32-year-old has not played for Les Blues since 2015.

Benzema used an unflattering motor racing analogy to describe the perceived difference in quality between himself and Chelsea striker Giroud, who replaced him in the France team.

Benzema took a swipe at Giroud as the 'go-kart' to his 'Formula One' to describe what he believes is a difference in quality between himself and Giroud, who replaced him in the France team.

Although Karim Benzema is looking to switch allegiances after being snubbed for the French national team once again, it appears he won't be going to play for Algeria. 

It's not every day an international luxury car company holds the global launch of its latest model in Britain — and brings over its top brass to do the honours.

Mercedes-Benz' new flagship S-Class limousine, pictured, could be the cleverest car on the road; it can 'see' potholes and bumps ahead, writes RAY MASSEY.

All roads lead to Germany next week as the Frankfurt Motor Show gets under way. Mercedes-Benz will be showing off its first-ever SUV.

This is not so much a van as a luxurious business-class aircraft cabin on wheels. I had to ferry three adults, two growing teenagers, and luggage.