S. Ghods, S. Waddell, E. Weller, C. Renteria, H.-Y. Jiang, J. M. Janak, S. S. Mao, T. J. Linley, and D. Arola

Fish scales serve as a dermal armor that provides protection from physical injury. Due to a number of outstanding properties, fish scales are inspiring new concepts for layered engineered materials and next-generation flexible armors. While past efforts have primarily focused on the structure and mechanical behavior of ontogenetic scales, the structure-property relationships of regenerated scales have received limited attention. In the present study, common carp (Cyprinus carpio) acquired from the wild were held live in an aquatic laboratory at 10° and 20°C. Ontogenetic scales were extracted from the fish for analysis, as well as regenerated scales after approximately 1 year of development and growth. Their microstructure was characterized using microscopy and Raman spectroscopy, and the mechanical properties were evaluated in uniaxial tension to failure under hydrated conditions. The strength, strain to fracture and toughness of the regenerated scales were significantly lower than those of ontogenetic scales from the same fish, regardless of the water temperature. Scales that regenerated at 20°C exhibited significantly higher strength, strain to fracture and toughness than those regenerated at 10°C. The regenerated scales exhibited a highly mineralized outer layer, but no distinct limiting layer or external elasmodine; they also possessed a significantly lower number of plies in the basal layer than in the ontogenetic scales. The results suggest that a mineralized layer develops preferentially during scale regeneration with the topology needed for protection, prior to the development of other qualities.

Dual amylin and calcitonin receptor agonists (DACRAs) are novel candidates for treatment of type 2 diabetes and obesity because of their beneficial effects on body weight, blood glucose, insulin sensitivity, and food preference, at least short-term. DACRAs activate the receptors for a prolonged time period, resulting in metabolic effects superior to those of amylin. Because of the prolonged receptor activation, different dosing intervals and, hence, less frequent receptor activation might change the efficacy of DACRA treatment in terms of weight loss and food preference. In this study, we compared daily dosing to dosing every other day with the aim of understanding the optimal balance between efficacy and tolerability. Obese and lean male Sprague-Dawley rats were treated with the DACRA KBP-088, applying two different dosing intervals (1.5 nmol/kg once daily and 3 nmol/kg every other day) to assess the effect on body weight, food intake, glucose tolerance, and food preference when given the choice between chow (13% fat) and a high-fat diet (60% fat). Treatment with KBP-088 induced significant weight loss, reduction in adiposity, improvement in glucose control, and altered food preference toward food that is less calorie-dense. KBP-088 dosed every other day (3 nmol/kg) was superior to KBP-088 once daily (1.5 nmol/kg) in terms of weight loss and improvement of food preference. The beneficial effects were evident in both lean and obese rats. Hence, dosing KBP-088 every other day positively affects overall efficacy on metabolic parameters regardless of the lean/obese state, suggesting that less-frequent dosing with KBP-088 could be feasible.

Behavioral flexibility is important in a changing environment. Previous research suggests that systems consolidation, a long-term poststorage process that alters memory traces, may reduce behavioral flexibility. However, exactly how systems consolidation affects flexibility is unknown. Here, we tested how systems consolidation affects: (1) flexibility in response to value changes and (2) flexibility in response to changes in the optimal sequence of actions. Mice were trained to obtain food rewards in a Y-maze by switching nose pokes between three arms. During initial training, all arms were rewarded and mice simply had to switch arms in order to maximize rewards. Then, after either a 1 or 28 d delay, we either devalued one arm, or we reinforced a specific sequence of pokes. We found that after a 1 d delay mice adapted relatively easily to the changes. In contrast, mice given a 28 d delay struggled to adapt, especially for changes to the optimal sequence of actions. Immediate early gene imaging suggested that the 28 d mice were less reliant on their hippocampus and more reliant on their medial prefrontal cortex. These data suggest that systems consolidation reduces behavioral flexibility, particularly for changes to the optimal sequence of actions.

From a behavioral perspective, therapeutic inertia can happen when obstacles to changing a diabetes treatment plan outweigh perceived benefits. There is a complex interaction of important treatment-related obstacles for people with diabetes (PWD), their treating health care professional (HCP), and the clinical setting in which they interact. Tipping the scales toward more effective action involve strategies that increase perceptions of the benefits of treatment intensification while addressing important obstacles so that treatment changes are seen by both PWD and HCPs as worthwhile and achievable.

Real-time continuous glucose monitoring (CGM) use may lead to behavioral modifications in food selection and physical activity, but there are limited data on the utility of CGM in facilitating lifestyle changes. This article describes an 18-item survey developed to explore whether patients currently using CGM believe the technology has caused them to change their behavior.

Lipids are essential building blocks of cell membranes, which control the exchange of substances and energy between a cell and its environment. Developed at the Moscow Institute of Physics and Technology, a new open-source software tool PCAlipids aims to analyze lipid behavior.

(MedPage Today) -- Witnessing ultraviolet (UV) radiation-induced facial aging firsthand may be a useful tool to convince youth to slather on the sunscreen, a new study suggested. In a randomized trial of high school teens in southeast Brazil...

In ramping up diplomatic pressure, China is trying to control the narrative of the pandemic.

The popular idea that avoiding losses is a bigger motivator than achieving gains is not supported by the evidence

The success of nearly all public- and private- sector policies hinges on the behavior of individuals, groups, and organizations. Today, such behaviors are better understood than ever, thanks to a growing body of practical behavioral science research. However, policymakers often are unaware of behavioral science findings that may help them craft and execute more effective…

A study has found that the more exposure a person has to the natural world, the more inclined they are to make eco-friendly choices.

New research published in the online journal PLoS ONE demonstrates for the first time that a non-human adult animal species regularly engages in oral sex behavior. While the behavior has

"We're going to return to a different economic environment. We're going to return to different business models," AT&T President and COO John Stankey told CNBC.

On the one hand the Australian market is making new 10 year highs, on the other, the Australian dollar has broken a long term uptrend and is rapidly moving towards 12-month, and potentially, two-year lows.

If you're like anyone else, it's hard to escape garbage moments made possible by shortsighted people who aren't thinking with everyone's best interest in mind. There are crook landlords, people stealing crap, and some massive disrespect just floating around the world. This trashiness belongs on Garbage Island.

Adolescent sexual risk behavior is lowered with involvement of parents and healthcare providers, stated new study. Now, a randomized clinical trial

In people with Parkinson's disease, cognitive-behavioral therapy by telephone was found to be effective for treating depression, revealed study published

Parent-based treatment known as SPACE (Supportive Parenting for Anxious Childhood Emotions) is as efficacious as individual cognitive-behavioral therapy

New study finds more evidence for the efficacy of a telehealth-delivered behavioral intervention in treating language problems in youth with fragile X syndrome (FXS).

Parents and caregivers who adopt a more flexible approach to their children's learning can reduce behavioral challenges during the toddler years, reports a new study.

Dr. Deborah Birx called the crowds who gathered this week in the Michigan state capitol without masks 'devastatingly worrisome.'

Reddit has become infamous for its abusive and toxic users. The site has revised its policies on bullying and harassment in an attempt to combat the anti-social behavior of many of its users.

Sexual interests, behaviours, and temperament of each person vary from one another. Astrologers imply the idea that there is a strong relation between one's sun sign and their sexual behaviours. It is not only the sun signs but also the place

How B2B Buyer Behavior Has Changed in Light of COVID-19, and What Marketers and Sellers Can Do Now
82 percent of B2B buyers said they were concerned or strongly concerned about the possibility of a pandemic-sparked recession, while 30 percent have reported spending more on videoconferencing software — two of several findings of interest to digital marketers in a recently-released survey examining B2B buyer shifts. eMarketer

How Bad Data Hurts B2B Companies [Infographic]
Just 33 percent of marketers say they can rely on their customer relationship management (CRM) software, and 88 percent said that bad data has a direct impact on their company's bottom line — two of the findings in a new infographic look at the effect of poor data on B2B firms. MarketingProfs

The Evolving Discussion Around COVID-19 and How Brands Have Responded [Infographic]
Brands have used Twitter the most often to mention the global health crisis, according to recently-released survey data examining how brands are using social media in crisis management planning. Social Media Today

Social Media Users Value Brands Responsive To COVID-19 Crisis
83% of social media users expect brands to address the health crisis in their ads, with 31 percent saying they appreciate brands offering products suited for remote work, 28 percent promoting social distancing, and 24 percent mentioning brand philanthropic efforts, according to newly-released survey data of interest to marketers. MediaPost

Why It Takes So Long to Apply Data-Driven Insights to Campaigns
Just 5 percent of marketers say they can immediately go from data gathering to actionable intelligence, while 31 do so later than they would like, and some 3 percent take so long that the output is irrelevant, according to new survey data. MarketingProfs

Instagram Live Streams Can Now Be Viewed on the Web
Facebook-owned Instagram has made it possible for its users to view its previously app-only Instagram Live video streams from its website, bringing marketers a new cross-promotion opportunity with the feature, the firm recently announed. Social Media Today

Twitter notifies users that it’s now sharing more data with advertisers
Twitter has notified its users that a previously available user privacy ad interaction sharing option has been shuttered for all, in a move that will bring more audience data to advertisers, the firm recently announced. The Verge

What Customers Need to Hear from You During the COVID Crisis
The types of brand stories companies should be telling their customers include those that put solutions before sales, according to a new examination by Harvard Business School of interest to B2B marketers. Harvard Business School

Facebook Has Launched a New Tournaments Option for People to Create Their Own Gaming Events
With online gaming forecast to produce $196 billion by 2022, a recent move by social giant Facebook allowing its users to create their own private or public gaming events could bring brands new opportunities for reaching its sizable gaming audience. Social Media Today

Content Plays Various Roles in Brands’ Customer Engagement Strategies
61 percent of marketing leaders said that interactive branded content communicates brand promise and value, according to recently-released survey data from the Chief Marketing Officer (CMO) Council, with 51 percent saying that it delivers thought-leadership, and 45 percent saying that interactive content helps communicate with customers, partners and prospects. MarketingCharts

ON THE LIGHTER SIDE:

A lighthearted look at digital transformation and organizational change by Marketoonist Tom Fishburne — Marketoonist

Grinning Tim Cook Announces New iPhone Will No Longer Be Compatible With AirPods — The Onion

TOPRANK MARKETING & CLIENTS IN THE NEWS:

• Lee Odden — Leadership and Engagement In a Time of Crisis [Podcast] — Traject
• Amie Krone — Navigating the new world of working at home — Chaska Herald
• Dell, SAP — Building A Perfect B2B Influencer Program During Imperfect Times — Forbes
• Lee Odden — Marketing During a Pandemic – Resources for Small Businesses in the Coronavirus Crisis [Roundup] — Simple Machines

Do you have your own top B2B content marketing or digital advertising stories from the past week? Please let us know in the comments below.

Thanks for taking the time to join us, and we hope that you'll return again next Friday for more of the most relevant B2B and digital marketing industry news. In the meantime, you can follow us at @toprank on Twitter for even more timely daily news. Also, don't miss the full video summary on our TopRank Marketing TV YouTube Channel.

The post Digital Marketing News: Shifting B2B Buyer Behaviors, Brands Evolve Crisis Response, Bad Data’s Effect on B2B Firms, & Twitter Shares New Data With Advertisers appeared first on Online Marketing Blog - TopRank®.

Cham : Springer, c2019.

[S.l.] : SPRINGER NATURE, 2020.

Cham : Springer, c2019.

Cham : Palgrave Macmillan, c2019.

New York, NY : Oxford University Press, 2019.

Cham : Springer, c2019.

McKim, William A., 1945-

McKim, William A., 1945-

Brick, John, 1950- author

Hinkle, Dennis E., author

Hawkins, Del I

Solomon, Michael R

Hoyer, Wayne D

Mooij, Marieke K. de, 1943-

Foxall, Gordon R., author

Online Resource

Online Resource