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[ASAP] Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.9b00561




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[ASAP] Review of Biology and Ecology of Pharmaceutical Marine Sponges<source>Biology and Ecology of Pharmaceutical Marine Sponges</source>. Edited by Ramasamy Santhanam, Santhanam Ramesh, and Anbu Jeba Sunilson. <publisher-name>CRC Press

Journal of Natural Products
DOI: 10.1021/acs.jnatprod.0c00352




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Fun and games with JavaScript

#484 — April 17, 2020

Unsubscribe  :  Read on the Web

???? If you're bored this weekend at all, consider joining the latest Ludum Dare — it's an online game jam that's been taking place for 18 years and more JavaScript entries are appreciated against all the Unity crowd ????

JavaScript Weekly

Writing an 'Emulator' in JavaScript (and Interfacing with Multiple UIs) — This is really neat. Tania built a Chip-8 interpreter in JavaScript and has gone into quite a bit of detail about what was involved here. Lots of neat bits and pieces to pick up from this.

Tania Rascia

jQuery 3.5.0 Released — I know many of you will groan, but I’m delighted when I see a new jQuery release. It’s still so heavily used. No headline features though, this is a security fix for a cross-site scripting vulnerability, plus some tweaks and fixes in preparation for jQuery 4.0 (yes!)

Timmy Willison (jQuery Foundation)

Build a Game of Battleship with TypeScript & Java. Free Course — Join over 2000 developers creating a game of Battleship with TypeScript, Spring Cloud Stream (Java), and PubSub+. This free 30-minute course is a great way to learn the basics of messaging and event-driven architecture with the Aurelia framework.

Solace sponsor

Profiling React.js Performance — Goes into detail on aspects of the React Profiler API, React’s new experimental Interaction Tracing API, and measuring custom metrics using the User Timing API.

Addy Osmani

Userscripts are Fun and Still Very Much Relevant — ‘Userscripts’ are basically JavaScript programs that run in the context of other Web pages so you can add your own features. They were really popular for a while but still exist and are still a neat use case for using JavaScript to improve your Web experience.

Eldad Bercovici

Another Look at What's New in ECMAScript 2020 — We linked to Dr Axel’s roundup recently, but here’s another take, looking at dynamic imports, nullish coalescing, optional chaining, BigInt, and more.

Ianis T.

⚡️ Quick Releases

???? Jobs

JavaScript Developer at X-Team (Remote) — Join the most energizing community for developers. Work from anywhere with the world's leading brands.

X-Team

Senior JavaScript Developer (Warsaw, Relocation Package) — Open source rich text editor used by millions of users around the world. Strong focus on code quality. Join us.

CKEditor

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

???? Tutorials

How To Create a Particle Trail Animation in JavaScript — Particle animations are particularly (sorry) striking.. and in this article, Anna Prenzel shows how to easily create your own such effects with Anime.js.

Smashing Magazine

Strategies for Migrating to TypeScript — A quick overview of some strategies for migrating code bases from JavaScript over to TypeScript.

Dr. Axel Rauschmayer

Developing in a Monorepo While Still Using Webpack — Second part in a series discussing things the team at Etsy learned during the migration of a home-grown, Require.js-based build system to webpack, which took over a year.

Salem Hilal

A More Productive Way to Build Your JavaScript Apps — Write better code, debug it, and test it – all in one place. Try WebStorm. No configuration required.

WebStorm sponsor

▶  Let's Build a Digital Circuit Simulator in JavaScript — A special episode of the Low Level JavaScript series takes us on a brief journey into the world of digital logic.

Low Level JavaScript

How To Set Up an Express API Backend Project with PostgreSQL — A pretty extensive walkthrough of creating an HTTP API using Express with Node.js and Postgres on the backend, then deploying it all on Heroku.

Chidi Orji

Speed Up Your Angular App: 14 Optimization Tips — Tips on how to make your Angular app smaller, faster, and more responsive.

Marcelo Ricardo de Oliveira

Class-Related Types in TypeScript

Dr. Axel Rauschmayer

????▶ A Fireside Chat on the State of Microservices on April 21 — We recently helped The Software House with a developer survey (thanks to those who took it!) and now they’re doing a live chat on the state of microservices next Tuesday featuring Yan Cui, Alessando Vozza, and others.

The Software House

???? Code & Tools

Puppeteer 3.0: It Now Supports Firefox — Best known for as a way to headlessly control Chrome from Node, Puppeteer has recently seen some competition in the form of the cross-browser Playwright recently. But, no fear, Puppeteer is stepping up and can now work cross-browser too. We also learn Puppeteer is migrating to TypeScript.

Mathias Bynens

Open-Source Serverless CMS Powered by React, Node.js and GraphQL API — Build dynamic websites and apps with Webiny. 100% powered by JavaScript. Deploy your sites to AWS Lambda.

Webiny Serverless CMS sponsor

Rome: An Experimental JavaScript Toolchain — A compiler, linter, formatter, bundler, testing framework and more. Started by Sebastian McKenzie (of Babel and Yarn fame), Rome is now a project from the React Native team at Facebook. Related repo.

Facebook

Vime: A New, Modern Media / Video Player for the Web — Aims to be a ‘modern alternative to Video.js and Plyr’: “The idea behind Vime is we want you to control the player, not the other way around.” Modular, tree-shakable, and with potential for a plugin ecosystem. GitHub repo.

Rahim Alwer

Vuln Cost: An Open Source Security Scanner for VS Code — Free Snyk-powered VS Code extension that finds security vulnerabilities in npm packages, providing feedback in-line with your code, such as how many vulnerabilities a package has.

snyk

ip-num: A Library to Work with ASN, IPv4, and IPv6 Numbers — Happy in both Node and the browser.

dadepo

Flip: Animated Flip Counter Plugin to Add a Countdown to a Website — Adds an animated dynamic countdown timer to a page. No dependencies, responsive and mobile friendly, and fits any language, locale, or time zone.

Rik Schennink

The Perfect Partner to MongoDB Atlas. Try It for Free

Studio 3T sponsor

A JavaScript API for Controlling 'Simpsons: Hit & Run' — Including this as a bit of fun if you fancy noodling on something odd. Remote controlling games from JS seems neat, although I suspect just getting this running would take a while..

Tavis Ormandy




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How tiny dependencies can topple the JavaScript Jenga tower

#486 — May 1, 2020

Unsubscribe  :  Read on the Web

JavaScript Weekly

???? I18n Ally: An All-in-One i18n Extension for VS Code — Got some internationalization work to do? I18n Ally gives you inline annotations, automated translations via Google Translate (which you can review), progress indication, etc. Supports React, Angular, Vue and other frameworks.

Anthony Fu

How a Few Lines of Code Broke Lots of Packages — Just under a week ago, people were reporting that create-react-app was broken. The culprit? A tiny change in a tiny dependency: is-promise. Luckily a fix was out very quickly and the creator of is-promise reflects on what happened here. Liran Tal also has some analysis of the situation.

Forbes Lindesay

Identify Front-End Issues Like JavaScript or Network Errors Fast — Datadog’s algorithmic alerts will proactively alert on any client-side issues such as JavaScript and network errors. Optimize the load time of your front-end resources, and detect any UI issues that affect critical user journeys. Try it free with Datadog Synthetics.

Datadog sponsor

Q: A JavaScript 'Quantum Circuit' Simulator — Bring quantum computing to your browser with this JavaScript simulation. If you were never quite sure what your JavaScript code was going to do, now you can formally explore the concept ????

Stewart Smith

Quick bytes:

???? Jobs

Find a Job Through Vettery — Vettery specializes in tech roles and is completely free for job seekers. Create a profile to get started.

Vettery

Senior Full-Stack Developer (Malmö/Sweden) — Every day is different from the next. Join our upbeat Team and work on exciting, major projects using a modern JavaScript stack.

Ortelius AB

???? Tutorials

A Guide to window.location — A breakdown that covers most of the methods and properties available on the DOM’s window.location object.

samantha ming

Implementing Dark Mode in React Apps Using styled-components

Blessing Krofegha

▶  Let's Build a Financial Dashboard App with React (Webinar On‑Demand) — Join TJ VanToll as he walks you through building a responsive Bootstrap-themed Stocks Portfolio app. Check it out today.

Progress KendoReact sponsor

Getting Started with NuxtJS — Learn how to create Vue.js-powered server-side rendered apps with NuxtJS including configuring an app and deploying it on Heroku.

Timi Omoyeni

▶  Learn Svelte: A 16-Part Course on Learning the Popular UI Framework — The course centers around building a chatbot, which is a nice change from the todos and other overused tutorial examples.

noah kaufman

10 Practical JavaScript Tricks — These kinds of lists are usually pretty run of the mill, but this one actually contains some lesser-known quick tips that you may not have seen before.

zander shirley

Moving TinyMCE to Modern JavaScript — The creators of TinyMCE (a popular WYSIWYG HTML editor) have been refactoring its rather legacy JavaScript (the first version came out 17 years ago!) to modern practices.

Joakim Lindkvist

7 JavaScript Design Patterns Every Developer Should Know — This is sort of like a (very) mini version of Addy Osmani’s 2017 book on JS design patterns (which is referenced at the end of the post).

deven rathore

▶  An Introduction to State Machines Using XStateXState is a neat way to work with state machines in JavaScript, Kyle is a neat teacher, and Egghead is a neat platform for unlocking these videos for us too.

Kyle Shevlin

Ride Down Into JavaScript Dependency Hell

AppSignal sponsor

A Collection of Challenging TypeScript Exercises“The goal: Let everyone play with many different TypeScript features and get an overview of TypeScript capabilities and principles.”

Marat Dulin

A Visual Guide to React Mental Models — Different people learn in different ways but good mental models are always valuable and can be helpful if you need to juggle all of the pieces involved in a framework like React.

Obed Parlapiano

Turning Vue Components Into Reusable npm Packages — Outlines how you can reuse Vue components across your projects by automating your process to bundle, test, document, and publish your components.

Sjoerd de voorhoede

???? Code & Tools

jExcel v4: A Vanilla JS Interactive Table / Spreadsheet Control — 4.0 adds support for tabs/workbooks, updating a remote data source with JSON, formula support in a sheet footer, and more. There are lots of demos and examples on the official homepage.

Paul Hodel

Will It CORS? — A handy online tool/wizard for establishing how your (potential) use case will (or won’t!) operate alongside CORS (Cross-Origin Resource Sharing).

HTTP Toolkit

Get Great Visual Feedback & Bug Reports, Even from Non-Technical Folk — Simply click a page element to pin visual feedback with screenshots & metadata. BugHerd = fast and easy bug tracking.

BugHerd sponsor

utfu: Replace Busted Characters From Legacy Text with UTF-8 — Useful when old content contains characters like “— in place of a single quote, and similar legacy text issues.

Daniel Sieradski

Middy 1.0: A Node Middleware Framework for AWS Lambda — Middy’s aim is to make writing serverless functions (hosted on AWS Lambda) easier by providing a familiar middleware abstraction to Node developers.

Luciano Mammino

useWorker() 3.0: A React Hook for Blocking-Free Background Tasks — Makes it easier to throw tasks off to a Web Worker in React.

Alessio Koci

webpack-blocks: Configure webpack using Functional Feature Blocks

Andy Wermke

JZZ: A MIDI Library for Node and the Browser — Send, receive and play MIDI messages from both Node and the browser on Linux, macOS and Windows.

Sema

MDX 1.6: Use JSX in Markdown Documents — This version introduces initial Vue support.

Compositor and Vercel

???? Upcoming Online Events

  • JavaScript Remote Conf 2020 (May 14-15) — Speakers lined up already include Raymond Camden, Christian Heilmann, and Aleksandra Sikora.
  • ESNEXT CONF 2020 (May 18-22) — From the Pika folks (of Snowpack fame). 12 speakers over 5 days so it's a gradual pace.
  • ForwardJS (May 26-29) — A real world event (ForwardJS Ottawa) that has now become a virtual event.
  • CascadiaJS 2020 (September 1-2) — This upcoming online conference is set to take place in September, and the CFP is open now through May 15.




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LIC listing may take about a year, says Finance Secretary Rajiv Kumar

Kumar said the idea behind the listing of LIC was to "bring in more transparency and allow the company to share gains with its stakeholders"




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Budget's much-needed leg-up for small units: CRISIL SME Tracker

An evaluation of 13,000 MSMEs using the CRISIL Quantix database shows that working capital comprises over half of their need for debt




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Power industry hails proposal for smart prepaid metering across the country

Power ministry has been planning it for two years, but with limited success




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Govt not included AGR dues payment in Budget 2020-21: DEA Secretary

15 entities owe the government about Rs 1.47 trillion in past dues -- Rs 92,642 crore in unpaid licence fee and another Rs 55,054 crore in outstanding spectrum usage charges




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Budget 2020 has not accounted for telcos' AGR dues: DEA secretary

But receipts from firms stand at a whopping Rs 1.33 trillion for FY21




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Budget 2020: Rs 2,500 cr not enough for tourism promotion, says industry

Tourism bodies say Indians spending Rs 9,000 cr abroad abroad due to poor domestic infra, which cannot be improved with this allocation




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LIC disinvestment: 100,000 employees stage walk-out across country

There are 13 unions in LIC, and employees and officers affiliated to 11 unions were on protest




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From Efficacy to Effectiveness in the Face of Uncertainty: Indication Creep and Prevention Creep

Interview with Benjamin Djulbegovic, MD, PhD, author of From Efficacy to Effectiveness in the Face of Uncertainty: Indication Creep and Prevention Creep




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Prevention of Melanoma With Regular Sunscreen Use

Interview with June K. Robinson, MD, author of Prevention of Melanoma With Regular Sunscreen Use




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Graduated Driver Licensing and Fatal Crashes Involving 16- to 19-Year-Old Drivers

Interview with Scott V. Masten, PhD, author of Graduated Driver Licensing and Fatal Crashes Involving 16- to 19-Year-Old Drivers




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Effect of Increasing Doses of Saw Palmetto Extract on Lower Urinary Tract Symptoms: A Randomized Trial

Interview with Kevin T. McVary, MD, author of Effect of Increasing Doses of Saw Palmetto Extract on Lower Urinary Tract Symptoms: A Randomized Trial




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Identification of Chronic Obstructive Pulmonary Disease in Lung Cancer Screening Computed Tomographic Scans

Interview with Pim A. de Jong, MD, PhD, author of Identification of Chronic Obstructive Pulmonary Disease in Lung Cancer Screening Computed Tomographic Scans




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Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events

Interview with Martin J. O'Donnell, MB, PhD, author of Urinary Sodium and Potassium Excretion and Risk of Cardiovascular Events




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Prostate Cancer Screening-The Evidence, the Recommendations, and the Clinical Implications

Interview with Roger Chou, MD, author of Prostate Cancer Screening-The Evidence, the Recommendations, and the Clinical Implications




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Universal Screening and Drug Treatment of Dyslipidemia in Children and Adolescents

Interview with Frederick P. Rivara, MD, MPH, author of Universal Screening and Drug Treatment of Dyslipidemia in Children and Adolescents




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Association of Mental Health Disorders With Prescription Opioids and High-Risk Opioid Use in US Veterans of Iraq and Afghanistan

Interview with Karen H. Seal, MD, MPH, author of Association of Mental Health Disorders With Prescription Opioids and High-Risk Opioid Use in US Veterans of Iraq and Afghanistan




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Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk

Interview with Wendie A. Berg, MD, PhD, author of Detection of Breast Cancer With Addition of Annual Screening Ultrasound or a Single Screening MRI to Mammography in Women With Elevated Breast Cancer Risk




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If Accountable Care Organizations Are the Answer, Who Should Create Them?

Interview with Victor R. Fuchs, PhD, author of If Accountable Care Organizations Are the Answer, Who Should Create Them?




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Effect of Screening for Partner Violence on Women's Quality of Life: A Randomized Controlled Trial

Interview with Joanne Klevens, MD, PhD, author of Effect of Screening for Partner Violence on Women's Quality of Life: A Randomized Controlled Trial




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Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol

Interview with Sangeeta Mehta, MD, author of Daily Sedation Interruption in Mechanically Ventilated Critically Ill Patients Cared for With a Sedation Protocol




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Association Between the Initiation of Anti-Tumor Necrosis Factor Therapy and the Risk of Herpes Zoster

Interview with Kevin L Winthrop, MD, MPH, author of Association Between the Initiation of Anti-Tumor Necrosis Factor Therapy and the Risk of Herpes Zoster




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Melatonin Secretion and the Incidence of Type 2 Diabetes

Interview with Ciaran J. McMullan, MD, author of Melatonin Secretion and the Incidence of Type 2 Diabetes




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Long-term Outcomes Following Abdominal Sacrocolpopexy for Pelvic Organ Prolapse

Interview with Linda Brubaker, MD, author of Long-term Outcomes Following Abdominal Sacrocolpopexy for Pelvic Organ Prolapse




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Effect of an Outpatient Antimicrobial Stewardship Intervention on Broad-Spectrum Antibiotic Prescribing by Primary Care Pediatricians: A Randomized Trial

Interview with Jeffrey S. Gerber, MD, PhD, author of Effect of an Outpatient Antimicrobial Stewardship Intervention on Broad-Spectrum Antibiotic Prescribing by Primary Care Pediatricians: A Randomized Trial




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Magnetic Resonance Imaging Screening to Identify Spinal and Paraspinal Infections Associated With Injections of Contaminated Methylprednisolone Acetate

Interview with Anurag N. Malani, MD, author of Magnetic Resonance Imaging Screening to Identify Spinal and Paraspinal Infections Associated With Injections of Contaminated Methylprednisolone Acetate




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Repeat Bone Mineral Density Screening and Prediction of Hip and Major Osteoporotic Fracture

Interview with Sarah D. Berry, MD, author of Repeat Bone Mineral Density Screening and Prediction of Hip and Major Osteoporotic Fracture




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Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana

Interview with Marianna K Baum, PhD, author of Effect of Micronutrient Supplementation on Disease Progression in Asymptomatic, Antiretroviral-Naive, HIV-Infected Adults in Botswana




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Psychiatric Diagnoses and Psychoactive Medication Use Among Nonsurgical Critically Ill Patients Receiving Mechanical Ventilation

Interview with Derek C. Angus, MD, MPH, author of Psychiatric Diagnoses and Psychoactive Medication Use Among Nonsurgical Critically Ill Patients Receiving Mechanical Ventilation




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Screening for Prostate Cancer With the Prostate-Specific Antigen Test: A Review of Current Evidence

Interview with Michael J. Barry, MD, author of Screening for Prostate Cancer With the Prostate-Specific Antigen Test: A Review of Current Evidence




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Web-Based Alcohol Screening and Brief Intervention for University Students: A Randomized Trial

Interview with Nicholas J. Horton, ScD, author of Web-Based Alcohol Screening and Brief Intervention for University Students: A Randomized Trial




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A Systematic Assessment of Benefits and Risks to Guide Breast Cancer Screening Decisions

Interview with Nancy L. Keating, MD, MPH, author of A Systematic Assessment of Benefits and Risks to Guide Breast Cancer Screening Decisions




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of Screening Mammography in Older Women: A Review

Interview with Louise C. Walter, MD and Mara A. Schonberg, MD, MPH, authors of Screening Mammography in Older Women: A Review




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Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease

Interview with Nynne Nyboe Andersen, MD, author of Association Between Tumor Necrosis Factor-α Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease




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Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography

Interview with Sarah M. Friedewald, MD, author of Breast Cancer Screening Using Tomosynthesis in Combination With Digital Mammography




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Screening and Brief Intervention for Drug Use in Primary Care

Interview with Richard Saitz, MD, MPH, author of Screening and Brief Intervention for Drug Use in Primary Care




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Prevalence of Antimicrobial Use in US Acute Care Hospitals, May-September 2011

Interview with Shelley S. Magill, MD, PhD, author of Prevalence of Antimicrobial Use in US Acute Care Hospitals, May-September 2011




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Frozen Fecal Microbiota for C difficile Infection

Interview with Ilan Youngster, MD, MMSc, author of Oral, Capsulized, Frozen Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection




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CAD Screening in Patients With Diabetes Mellitus

Interview with Joseph B. Muhlestein, MD, author of Effect of Screening for Coronary Artery Disease Using CT Angiography on Mortality and Cardiac Events in High-Risk Patients With Diabetes




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Genetic Variant and Vincristine Peripheral Neuropathy in ALL

Interview with William E. Evans, PharmD, author of Association of an Inherited Genetic Variant With Vincristine-Related Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia




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Hospital Credentialing and Privileging of Surgeons

Interview with Justin B. Dimick, MD, MPH, author of Hospital Credentialing and Privileging of Surgeons: A Potential Safety Blind Spot




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Lifetime Benefits and Costs of Colorectal Cancer Screening

Interview with Chyke A. Doubeni, MD, MPH, author of Variation in Adenoma Detection Rate and the Lifetime Benefits and Cost of Colorectal Cancer Screening: A Microsimulation Model







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For Patients: Prostate Cancer Screening

Edward H. Livingston, MD, Deputy Editor of Clinical Reviews and Education and Jon Tilburt, MD, from the Mayo Clinic explain prostate cancer screening. For more information, read the JAMA Patient Page on this topic.