K-pop boy band Bangtan Boys, also known as BTS, will give speeches during a virtual commencement event along with global figures including former U.S. President Barack Obama and his wife Michelle, and pop star Lady Gaga. "Dear Class of 2020," organized by YouTube, will be streamed on June 6 to celeb...

U.S. President Donald Trump is reportedly demanding US$1.3 billion a year to maintain American troops in Korea. That is a whopping 53.3 percent higher than the W1.4 trillion Korea had to pay last year. A senior U.S. official told the Chosun Ilbo on Thursday, "The U.S. faces many difficulties, includ...

The government will stockpile 100 million face masks to prepare for a second wave of coronavirus but will also send them to about 70 countries in need."We've already allocated the budget necessary to stock up 100 million masks," Minister of Food and Drug Safety Lee Eui-kyung said Thursday. "Some 70 ...

Microchip Releases Version 2.1 of TimeProvider 4100 Timing Grandmaster

A llama called Winter could prove useful in the hunt for a treatment for Covid-19, according to US and Belgian scientists who have identified a tiny particle that appears to block the new coronavirus.

The scientists, from Belgium’s VIB-UGent center for medical biotechnology and the University of Texas at Austin, published research on Tuesday in the journal Cell, with the llama in Belgium central to their studies.

The group began four years ago looking into antibodies that might counter the Sars virus, which spread in 2003, and the Mers virus that flared up in 2012.

“The work was a side project in 2016. We thought maybe this was interesting,” said Xavier Saelens, joint leader of the Belgian part of the collaboration. “Then the new virus came and it became potentially more crucial, more important.”

Winter, the llama, was given safe versions of the Sars and Mers viruses and samples of its blood were later taken.

Llamas and other members of camel family are distinct in creating standard antibodies and smaller antibodies, with which scientists can more easily work.

The Belgian part of the research team, also led by Bert Schepens, identified fragments of the smaller antibodies, known as nanobodies, to see which bound most strongly to the virus.

Saelens describes the new coronavirus as the cousin of the Sars virus. Both have a corona, or crown, shape with protein spikes, onto which an antibody can latch.

The team intend to begin tests on animals, with a view to allowing trials with humans to begin by the end of the year. Saelens said negotiations were under way with pharmaceutical companies.

The research is not the first into nanobodies derived from camels or llamas. French group Sanofi paid 3.9 billion euros ($4.23 billion) in 2018 to buy Ghent-based nanobody specialist company Ablynx.

Making himself Exhibit A for reopening the country, President Donald Trump visited an Arizona face mask factory Tuesday, using the trip to demonstrate his determination to see an easing of stay-at-home orders even as the coronavirus remains a dire threat. Trump did not wear a mask despite guidelines saying they should be worn inside the factory at all times.

The decision to wear a mask in public is becoming a political statement — a moment to pick sides in a brewing culture war over containing the coronavirus.

ADB tripled the size of its response to the COVID-19 pandemic to $20 billion and approved measures to streamline its operations for quicker and more flexible delivery of assistance, says ADB President Masatsugu Asakawa.

Registration Now Open for Microchip’s 22nd Annual Worldwide MASTERs Conference

Registration Now Open for Microchip’s 23rd Annual Worldwide MASTERs Conference

CES 2020, LAS VEGAS – JANUARY 6, 2020 – Turn up the volume, because the latest speaker in the JBL portables portfolio is here and it does not disappoint. JBL’s Boombox 2 provides JBL Original Pro Sound with big bass, clear mids and smooth highs in an...

A sophisticated computer simulation of the universe, approximately 1 billion light years across, is modelling tens of thousands of galaxies

We have a refined estimate for the mass of the neutrino, the most abundant massive particle in the Universe: its mass is 500,000 times less than an electron

In September, the 41st Cannes Yachting Festival brought together some of the world’s most dazzling vessels in a luxurious, iconic setting. As the official car of the Cannes Yachting Festival for the second consecutive year, Maserati, together with the...

A campaign in Mexico City to get residents to wear face masks is now reinforced with a new secret weapon: clowns. They're telling metro riders, 'Wear a face mask -- don't be a clown!' as they spray riders' hands with disinfectant. Gavino Garay has more.

June 16 - With attention focused on the world's greatest soccer stars in Brazil, conservationists are working hard to promote the plight of the animal being used as the official World Cup mascot. Known as Fuleco on posters and banners throughout the country, the three-banded armadillo is in decline, and conservation groups say FIFA and the Brazilian government should be doing more during the World Cup to ensure the animal's long term survival. Rob Muir reports.

The late Devonian mass extinction around 375 million years ago may not have really happened, according to an analysis using machine learning

When asteroid Armageddon is upon us, we can't just call Bruce Willis. Meet the people who really do watch the skies – and make detailed plans for our survival

A well-preserved fossilised tail from Spinosaurus suggests this massive dinosaur may have been able to propel itself and hunt for prey in the water

Some of the first dinosaurs may have lived and hunted on the largest delta plain ever discovered, which was 10 times the size of the Amazon river delta

The Permian extinction, which wiped out almost all complex life, may have been caused by the undersides of continents slipping off into Earth’s interior

Many people feel intimidated by the prospect of making pastry, says Sam Wong, but a little understanding can go a long way to successfully making this beautiful rhubarb tart

Banksy's "Girl with a Pierced Eardrum" has been updated for the coronavirus era with the addition of a blue surgical face mask.

Even Tim Gunn, the immaculately dressed fashion mentor from "Project Runway" and Amazon's new competition show "Making the Cut," is finding it hard to get out of his pajamas these days.

Japan's Nintendo Co Ltd said on Thursday its fourth-quarter profit soared 200% due to surging demand for its Switch games console, and that title Animal Crossing: New Horizons shifted a record 13.4 million units in its first six weeks.

Next time you peel yourself a citrus fruit, follow our guide to make your own unique and memorable scientific baubles

Ditch the phone, don't stand too close and strive for optimal eye contact: the evidence-based approach to painless holiday schmoozing

When asteroid Armageddon is upon us, we can't just call Bruce Willis. Meet the people who really do watch the skies – and make detailed plans for our survival

A campaign in Mexico City to get residents to wear face masks is now reinforced with a new secret weapon: clowns. They're telling metro riders, 'Wear a face mask -- don't be a clown!' as they spray riders' hands with disinfectant. Gavino Garay has more.

Even Tim Gunn, the immaculately dressed fashion mentor from "Project Runway" and Amazon's new competition show "Making the Cut," is finding it hard to get out of his pajamas these days.

Former U.S. President Barack Obama, Lady Gaga, LeBron James and K-Pop band BTS are among dozens of celebrities and world leaders who will salute the class of 2020 in virtual U.S. graduation ceremonies replacing the traditional end of high school and college.

Central Japan Railways says its magnetically levitating train has broken its previous world speed record in a test-run at a special track West of Tokyo. Rob Muir reports.

M&A in the pharma sector marches on unabated - AstraZeneca buying a 55 percent stake in biotech Acerta Pharma for $4.0 billion to give it new cancer drugs. Hayley Platt reports.

A campaign in Mexico City to get residents to wear face masks is now reinforced with a new secret weapon: clowns. They're telling metro riders, 'Wear a face mask -- don't be a clown!' as they spray riders' hands with disinfectant. Gavino Garay has more.

A well-preserved fossilised tail from Spinosaurus suggests this massive dinosaur may have been able to propel itself and hunt for prey in the water

Over half the world’s wild tigers now live 5 kilometres from a road, and infrastructure projects planned in Asia could fragment their habitat further

Japan's Nintendo said Thursday it sold 21 million Switch units in the year ended March, smashing its forecast of 19.5 million units, with hit title Animal Crossing: New Horizons shifting 13.4 million units in its first six weeks. Ciara Lee reports

Title: Nipple-Preserving Mastectomies Appear Safe for High-Risk Women: Study
Category: Health News
Created: 4/25/2016 12:00:00 AM
Last Editorial Review: 4/26/2016 12:00:00 AM

Title: California Handgun Sales Spiked After 2 Mass Shootings
Category: Health News
Created: 5/1/2017 12:00:00 AM
Last Editorial Review: 5/2/2017 12:00:00 AM

Title: Are Face Shields Better Than Face Masks for Coronavirus?
Category: Health News
Created: 4/30/2020 12:00:00 AM
Last Editorial Review: 4/30/2020 12:00:00 AM

Title: Trump Signs Massive Relief Package Into Law as U.S. Coronavirus Cases Reach 9,000
Category: Health News
Created: 3/19/2020 12:00:00 AM
Last Editorial Review: 3/19/2020 12:00:00 AM

Title: Gynecomastia (Enlarged Male Breasts)
Category: Diseases and Conditions
Created: 10/7/2009 12:00:00 AM
Last Editorial Review: 11/14/2019 12:00:00 AM

ABSTRACT

Production of metallo-β-lactamases (MBLs), which hydrolyze carbapenems, is a cause of carbapenem resistance in Enterobacteriaceae. Development of effective inhibitors for MBLs is one approach to restore carbapenem efficacy in carbapenem-resistant Enterobacteriaceae (CRE). We report here that sulfamoyl heteroarylcarboxylic acids (SHCs) can competitively inhibit the globally spreading and clinically relevant MBLs (i.e., IMP-, NDM-, and VIM-type MBLs) at nanomolar to micromolar orders of magnitude. Addition of SHCs restored meropenem efficacy against 17/19 IMP-type and 7/14 NDM-type MBL-producing Enterobacteriaceae to satisfactory clinical levels. SHCs were also effective against IMP-type MBL-producing Acinetobacter spp. and engineered Escherichia coli strains overproducing individual minor MBLs (i.e., TMB-2, SPM-1, DIM-1, SIM-1, and KHM-1). However, SHCs were less effective against MBL-producing Pseudomonas aeruginosa. Combination therapy with meropenem and SHCs successfully cured mice infected with IMP-1-producing E. coli and dually NDM-1/VIM-1-producing Klebsiella pneumoniae clinical isolates. X-ray crystallographic analyses revealed the inhibition mode of SHCs against MBLs; the sulfamoyl group of SHCs coordinated to two zinc ions, and the carboxylate group coordinated to one zinc ion and bound to positively charged amino acids Lys224/Arg228 conserved in MBLs. Preclinical testing revealed that the SHCs showed low toxicity in cell lines and mice and high stability in human liver microsomes. Our results indicate that SHCs are promising lead compounds for inhibitors of MBLs to combat MBL-producing CRE.

IMPORTANCE Carbapenem antibiotics are the last resort for control of severe infectious diseases, bloodstream infections, and pneumonia caused by Gram-negative bacteria, including Enterobacteriaceae. However, carbapenem-resistant Enterobacteriaceae (CRE) strains have spread globally and are a critical concern in clinical settings because CRE infections are recognized as a leading cause of increased mortality among hospitalized patients. Most CRE produce certain kinds of serine carbapenemases (e.g., KPC- and GES-type β-lactamases) or metallo-β-lactamases (MBLs), which can hydrolyze carbapenems. Although effective MBL inhibitors are expected to restore carbapenem efficacy against MBL-producing CRE, no MBL inhibitor is currently clinically available. Here, we synthesized 2,5-diethyl-1-methyl-4-sulfamoylpyrrole-3-carboxylic acid (SPC), which is a potent inhibitor of MBLs. SPC is a remarkable lead compound for clinically useful MBL inhibitors and can potentially provide a considerable benefit to patients receiving treatment for lethal infectious diseases caused by MBL-producing CRE.

ABSTRACT

Burkholderia pseudomallei, the founding member of the B. pseudomallei complex (Bpc), is a biothreat agent and causes melioidosis, a disease whose treatment mainly relies on ceftazidime and meropenem. The concern is that B. pseudomallei could enhance its drug resistance repertoire by the acquisition of DNA from resistant near-neighbor species. Burkholderia ubonensis, a member of the B. cepacia complex (Bcc), is commonly coisolated from environments where B. pseudomallei is present. Unlike B. pseudomallei, in which significant primary carbapenem resistance is rare, it is not uncommon in B. ubonensis, but the underlying mechanisms are unknown. We established that carbapenem resistance in B. ubonensis is due to an inducible class A PenB β-lactamase, as has been shown for other Bcc bacteria. Inducibility is not sufficient for high-level resistance but also requires other determinants, such as a PenB that is more robust than that present in susceptible isolates, as well as other resistance factors. Curiously and diagnostic for the two complexes, both Bpc and Bcc bacteria contain distinct annotated PenA class A β-lactamases. However, the protein from Bcc bacteria is missing its essential active-site serine and, therefore, is not a β-lactamase. Regulated expression of a transcriptional penB'-lacZ (β-galactosidase) fusion in the B. pseudomallei surrogate B. thailandensis confirms that although Bpc bacteria lack an inducible β-lactamase, they contain the components required for responding to aberrant peptidoglycan synthesis resulting from β-lactam challenge. Understanding the diversity of antimicrobial resistance in Burkholderia species is informative about how the challenges arising from potential resistance transfer between them can be met.

IMPORTANCE Burkholderia pseudomallei causes melioidosis, a tropical disease that is highly fatal if not properly treated. Our data show that, in contrast to B. pseudomallei, B. ubonensis β-lactam resistance is fundamentally different because intrinsic resistance is mediated by an inducible class A β-lactamase. This includes resistance to carbapenems. Our work demonstrates that studies with near-neighbor species are informative about the diversity of antimicrobial resistance in Burkholderia and can also provide clues about the potential of resistance transfer between bacteria inhabiting the same environment. Knowledge about potential adverse challenges resulting from the horizontal transfer of resistance genes between members of the two complexes enables the design of effective countermeasures.

BACKGROUND Trauma—emotional, physical, and psychological—is common and associated with increased risk behaviors, low rates of care engagement and viral suppression, and overall poor health outcomes for people living with HIV (PLWH). This article presents the results of 15 in-depth, semi-structured interviews with PLWH in the Southeastern United States in which participants identified a trauma and described its long-lasting impact on their lives. Participants' trauma narratives described a wide range of traumas, including childhood sexual abuse, the loss of a loved one, and their HIV diagnosis.

METHODS Systematic qualitative analysis was used to delineate beliefs about causes, symptoms, treatments, quality of life, and health implications of trauma.

RESULTS: Fifteen participants completed semi-structured interviews that lasted on average 32 minutes. Participants described a wide spectrum of personal trauma that occurred both prior and subsequent to their HIV diagnosis. The types of trauma identified included physical, sexual, and psychological abuse inflicted by intimate partners, family members, and/or strangers.

LIMITATIONS A chief limitation of this study is selection bias. Additionally, the participant selection and content of the trauma narratives might have been affected by the surrounding context of the parent study centered on HIV, aging, and psychosocial stress. It is also difficult to interpret the distinction between discrete trauma experiences and the diagnosis of HIV, leading to potential information bias.

CONCLUSION This study highlights the importance of social support in coping with trauma and the effect of trauma on health-related behaviors. It also illustrates the need for additional research on the topic of trauma and trauma-informed care for PLWH. Understanding how different types of trauma affect individuals' lives is necessary to inform recommendations to provide better care for PLWH.

Toward the goal of increasing the throughput of high-resolution mass characterization of intact antibodies, we developed a RapidFire–mass spectrometry (MS) assay using electrospray ionization. We achieved unprecedented screening throughput as fast as 15 s/sample, which is an order of magnitude improvement over conventional liquid chromatography (LC)-MS approaches. The screening enabled...

The apparent detection of an exoplanet orbiting Fomalhaut was announced in 2008. However, subsequent observations of Fomalhaut b raised questions about its status: Unlike other exoplanets, it is bright in the optical and nondetected in the infrared, and its orbit appears to cross the debris ring around the star without...