[Dresden?] : [A.H. Payne?], [between 1800 and 1899]

[Paris], [1807]

[1905?]

[London?], [between 1700 and 1799?]

[London?], [between 1700 and 1799?]

Amsterdam : Uitgegeven by Frans Buffa en Zonen, [between 1843 and 1845]

Amsterdam : Uitgegeven by Frans Buffa en Zonen, [between 1843 and 1845]

[Paris] : [Pillet aîné], [between 1827 and 1839?]

(Printed in Austria)

(Edin.r [Edinburgh] : Printed by A. Mc.Glashon), [1842]

[Paris] : [publisher not identified], 1782.

[London] (Historic Gallery, Pall Mall) : Published by R. Bowyer, June 1804

London : Printed & sold by Thos. & John Bowles, printsellers, [1728]

London : Printed and sold by Thos. and John Bowles, printsellers, [1728]

[London] : [Thomas. Bowles] : [John Bowles], [1728]

[London] : [Tho. Bowles], [1728]

London (No. 29 Newman Street, Oxford Street) : Published ... by V. & R. Green, January 18th 1788

Brian Whiston since 2015 has led the state's education department while it put together its plan under the Every Student Succeeds Act and took control of the state's school takeover district.

The children exposed to high levels of lead-laced drinking water from Michigan's Flint River are entering schools now and the school system is straining to meet their special education needs.

The agreement stems from a class-action civil rights lawsuit filed against the Flint schools, Michigan education department and the Genessee County Intermediate School District.

Back is Martin Luther King Jr.'s "I Have a Dream" speech. Back is Roe v. Wade. Back is climate change. and the word "democratic." A new proposal incorporating those revisions was presented to the Michigan board of education last week.

A handful of districts and other groups are reshaping the after-school space to provide a wide range of social and linguistic supports for newcomer students.

The Washington Capitals on Friday placed Brendan Leipsic on unconditional waivers to terminate his contract after he made disparaging comments about women and teammates in a private social media chat. In a conversation involving his brother and Florida Panthers minor leaguer Jack Rodewald, Leipsic commented on the physical appearances of Vancouver forward Tanner Pearson's wife and Edmonton captain Connor McDavid's girlfriend. The NHL called it ''inexcusable conduct'' and said it would address the matter with the Capitals and Panthers.

The Washington Capitals have placed former Winterhawks wing Brendan Leipsic on unconditional waivers with the intention of his contract being terminated after private messages revealed misogynistic comments. > The Washington Capitals have placed Brendan Leipsic on unconditional waivers for purposes of terminating his contract.https://t.co/UnADibu2yQ

The Washington Capitals decided to part ways with forward Brendan Leipsic on Friday after he made vulgar and disparaging comments on an social media chat group. The 25-year old Canadian was placed on waivers by the NHL club after his Instagram group chat messages were leaked earlier this week. The chat included inappropriate remarks about Edmonton Oilers forward Connor McDavid's girlfriend and the wife of Vancouver Canucks player Tanner Pearson.

Washington announced it is terminating the contract of forward Brendan Leipsic after his mysogynistic comments on Instagram were leaked.

The state's Republican governor is in a pitched battle with the state's educators over the process he used to fire Missouri's commissioner of education.

Former Republican Missouri Gov. Eric Greitens appointed enough board members to have Commissioner Margie Vandeven fired last year, but now that he's gone, the state board decided to hire her back.

Sabrina Ionescu wins the Wooden Award for the second year in a row, becoming the fifth in the trophy's history to win in back-to-back seasons. With the honor, she completes a complete sweep of the national postseason player of the year awards. As a senior, Ionescu matched her own single-season mark with eight triple-doubles in 2019-20, and she was incredibly efficient from the field with a career-best 51.8 field goal percentage.

The reaction on social media has been fierce.

Benjamin Meyer
Jul 3, 2019; 39:5326-5335
Systems/Circuits

Speech by Mr Agustín Carstens, General Manager of the BIS, to the Basler Bankenforum, Basel, 5 September 2019.

Although the etiology of schizophrenia is still unknown, it is accepted to be a neurodevelopmental disorder that results from the interaction of genetic vulnerabilities and environmental insults. Although schizophrenia's pathophysiology is still unclear, postmortem studies point toward a dysfunction of cortical interneurons as a central element. It has been suggested that alterations in parvalbumin-positive interneurons in schizophrenia are the consequence of a deficient signaling through NMDARs. Animal studies demonstrated that early postnatal ablation of the NMDAR in corticolimbic interneurons induces neurobiochemical, physiological, behavioral, and epidemiological phenotypes related to schizophrenia. Notably, the behavioral abnormalities emerge only after animals complete their maturation during adolescence and are absent if the NMDAR is deleted during adulthood. This suggests that interneuron dysfunction must interact with development to impact on behavior. Here, we assess in vivo how an early NMDAR ablation in corticolimbic interneurons impacts on mPFC and ventral hippocampus functional connectivity before and after adolescence. In juvenile male mice, NMDAR ablation results in several pathophysiological traits, including increased cortical activity and decreased entrainment to local gamma and distal hippocampal theta rhythms. In addition, adult male KO mice showed reduced ventral hippocampus-mPFC-evoked potentials and an augmented low-frequency stimulation LTD of the pathway, suggesting that there is a functional disconnection between both structures in adult KO mice. Our results demonstrate that early genetic abnormalities in interneurons can interact with postnatal development during adolescence, triggering pathophysiological mechanisms related to schizophrenia that exceed those caused by NMDAR interneuron hypofunction alone.

SIGNIFICANCE STATEMENT NMDAR hypofunction in cortical interneurons has been linked to schizophrenia pathophysiology. How a dysfunction of GABAergic cortical interneurons interacts with maturation during adolescence has not been clarified yet. Here, we demonstrate in vivo that early postnatal ablation of the NMDAR in corticolimbic interneurons results in an overactive but desynchronized PFC before adolescence. Final postnatal maturation during this stage outspreads the impact of the genetic manipulation toward a functional disconnection of the ventral hippocampal-prefrontal pathway, probably as a consequence of an exacerbated propensity toward hippocampal-evoked depotentiation plasticity. Our results demonstrate a complex interaction between genetic and developmental factors affecting cortical interneurons and PFC function.

Hassan Al-Hassan, a Syrian farmer known to locals as Abu Hasan, remembers how difficult it had been in the past few years in the village of al-Rabeha in the southern governorate of Homs. “Due to lack of water, we could hardly produce anything,” said Abu Hasan. FAO is helping to restore access to water for over 40 000 families – about [...]

Built nearly 4,700 years ago as a tomb for the pharaoh Djoser, the structure underwent more than a decade of on-and-off restorations

After four months of unexpected dimming, the red supergiant star has perked back up, and astronomers may have a new explanation for the fluke

It’s not quite a meat dress, but Kaikaia gaga does boast some impressive horn-like appendages

New research reveals a Tang Dynasty woman's love for sports—and big-eared, braying equids

The suspects were found drunk and hiding under a tarpaulin, reportedly in possession of small stones from the fire-ravaged cathedral

Study suggests alleged exoplanet may have been a cloud of asteroid debris

After missing years of shears, the voluminous creature had ballooned to about five times the size of a typical sheep