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Metal alloy injection molding protrusions

Metal alloy injection molding techniques are described. In one or more implementations, these techniques may also include adjustment of injection pressure, configuration of runners, and/or use of vacuum pressure, and so on to encourage flow of the metal alloy through a mold. Techniques are also described that utilize protrusions to counteract thermal expansion and subsequent contraction of the metal alloy upon cooling. Further, techniques are described in which a radius of edges of a feature is configured to encourage flow and reduce voids. A variety of other techniques are also described herein.




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***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***Cold chamber die casting of amorphous alloys using cold crucible induction melting techniques

Various embodiments provide systems and methods for casting amorphous alloys. Exemplary casting system may include an insertable and rotatable vessel configured in a non-movable induction heating structure for melting amorphous alloys to form molten materials in the vessel. While the molten materials remain heated, the vessel may be rotated to pour the molten materials into a casting device for casting them into articles.




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Segmented receiving housing hole, sliding core, tensioning device and traction mechanism drive

A receiving housing of a hydraulic tensioning device for a traction mechanism drive in an internal combustion engine, having an opening that extends along a longitudinal axis for receiving a piston that is implemented for deflecting a tensioning rail of the traction mechanism drive. The receiving housing is a cast component, and the opening comprises an inner contour having an inner surface that comprises at least first segments and inclines for removing the workpiece from the mold in the opening. The second segments include surfaces that are directed into the inside of the opening and are aligned in parallel with the longitudinal axis. A sliding core is also provided that has an outer contour that is complementary to the inner contour of the opening of the receiving housing and fits into the opening. A traction mechanism drive and tensioning device having a receiving housing of this type are also included.




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Method of producing ingot with variable composition using planar solidification

Molten metal of a first composition is fed into a mold cavity, via a first control apparatus, wherein the control apparatus is open, wherein the feeding includes at least flowing out of a first feed chamber. The first control apparatus is closed. A second control apparatus is opened. Molten metal of a second composition is fed into the mold cavity, via the second control apparatus, wherein at least a portion of the metal of the first composition in the mold cavity is sufficiently molten so that an initial feed of molten metal of the second composition mixes with the molten metal of the first composition in the mold cavity, wherein the feeding includes at least flowing out of a second feed chamber, wherein the second composition is different from the first composition. An ingot is removed from the mold cavity, wherein the ingot as a top section, a middle section, and a bottom section, wherein the bottom section is composed of metal of the first composition, wherein the top section is composed of metal of the second composition, wherein the middle section is composed of a mixture of metal of the first composition and the second composition.




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Method and apparatus for press casting

An apparatus for press casting includes a casting mold formed of a fixed mold and a first moving mold operable to move relative to the fixed mold. The apparatus further includes a second moving mold operable to move relative to the first moving mold. A mold cavity, which forms a cast product, is configured by the fixed mold and the second moving mold. When the first moving mold is moved to a first predetermined position, a molten metal passage and a gas exhaust port, which communicate with the mold cavity, are formed at positions outside the mold cavity. A communication between the mold cavity and the molten metal passage, and the gas exhaust port is cut off by the second moving mold when the second moving mold is moved to a second predetermined position while the first moving mold is maintained at the first predetermined position thereof.




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Method for continuous casting of a metal with improved mechanical strength and product obtained by said method

A new method for continuous casting of molten metal is provided that allows one to obtain an intermediate product such as slab, billet wire, etc. before subsequent thermomechanical treatment (e.g. lamination or annealing), such that its chemical composition is modified by the addition of elements in order to give it greater mechanical strength.




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Method and apparatus for interlocking load carrying elements

A method for interlocking structural steel components with a metal-filled interlock is disclosed herein. The method comprises placing a mold about aligned contoured portions of structural steel components and attaching a crucible and a spout to the mold. The crucible is charged with exothermic reactive metals which are ignited, forming a molten metal filler. The molten metal filler melts a metal plug in the crucible or spout and the molten metal filler flows into the mold and about the aligned contoured portions of the structural steel components. Cooling of the molten metal filler forms a metal-filled interlock. Molds for performing the disclosed method are also disclosed herein.




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Casting core, method for producing same, and method for casting using said core

A casting core resulting from alkaline earth metal oxide particles having an average particle size of 0.8-4 mm being dispersed in a water-soluble alkali metal salt matrix. The casting core can be efficiently produced using a method of dispersing alkaline earth metal hydroxide particles having favorable disintegration properties and a particle size in the range of 1-5 mm in a molten water-soluble alkali metal salt, converting to alkaline earth metal oxide particles by means of dehydration, and casting in a mold, cooling, and hardening.




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Tower pump casting apparatus

A casting apparatus having a main chamber connected to at least one casting tower. The main chamber may contain molten metal and the temperature within the main chamber may be maintained by a furnace. A pump may pump the molten metal up the tower and into an upper pool chamber. A feeder nozzle may feed the molten metal from the upper pool chamber and onto a chilling wheel, which may turn the molten metal into metal flakes.




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Insert casting or tack welding of machinable metal in bulk amorphous alloy part and post machining the machinable metal insert

Provided in one embodiment is a method of forming a connection mechanism in or on a bulk-solidifying amorphous alloy by casting in or on, or forming with the bulk-solidifying amorphous alloy, a machinable metal. The connection mechanism can be formed by machining the machinable metal.




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Insert molding of bulk amorphous alloy into open cell foam

Provided in one embodiment is a method of making use of foams as a processing aid or to improve the properties of bulk-solidifying amorphous alloy materials. Other embodiments include the bulk-solidifying amorphous alloy/foam composite materials made in accordance with the methods.




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Multiple casting apparatus and method

Apparatuses and methods of forming battery parts are disclosed herein. In one embodiment, a method of forming a battery part includes receiving a flowable material into a cavity, and reducing a volume of the cavity while a pin extending through at least a portion of the cavity remains at least generally stationary therein. The method further includes sealing the cavity by slidably engaging at least a portion of the pin with a recess in the piston proximate the end face of the piston.




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Titanium based ceramic reinforced alloy for use in medical implants

A titanium based, ceramic reinforced alloy ingot for use in producing medical implants. An ingot is formed from an alloy having comprising from about 5 to about 35 wt. % niobium, from about 0.5 to about 3.5 wt. % silicon, and from about 61.5 to about 94.5 wt. % of titanium. The alloy has a hexagonal crystal lattice α phase of from about 20 vol % to about 70 vol %, and a cubic body centered β crystal lattice phase of from about 30 vol. % to about 80 vol. %. The ingot has an ultimate tensile strength of about 940 MPa or more, and a Young's modulus of about 150 GPa or less. A molten substantially uniform admixture of a niobium, silicon, and titanium alloy is formed, cast into a shape, and cooled into an ingot. The ingot may then be formed into a medical implant and optionally annealed.




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Cold chamber die casting of amorphous alloys using cold crucible induction melting techniques

Various embodiments provide systems and methods for casting amorphous alloys. Exemplary casting system may include an insertable and rotatable vessel configured in a non-movable induction heating structure for melting amorphous alloys to form molten materials in the vessel. While the molten materials remain heated, the vessel may be rotated to pour the molten materials into a casting device for casting them into articles.




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Fluid purification level control apparatuses and methods

Apparatuses and methods for level control in a fluid purification apparatus. The apparatuses and methods include a fluid purification apparatus and a level sensor that regulates operation of the fluid purification apparatus. The level sensor may further operate a bypass valve or a heater.




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Oil recovery apparatus

A method and apparatus for recovering oil from oil-containing sorbents, such as drill cuttings obtained from drilling with an oil-based mud. The method includes peptizing the substrate with an acid reagent and direct thermal desorption with combustion effluent gases at high temperature under turbulent mixing conditions. Another method disclosed includes upgrading the oil in the substrate to improve one or more of the properties of the recovered oil relative to the oil in the substrate, such as, lower aromatics content, lower sulfur content, lower functional group content, higher saturates, higher viscosity, higher viscosity index, and any combination thereof. The apparatus provides for efficient recovery of oil from the substrate with a short residence time, high throughput, low residual oil content in the treated solids and/or high percentage of oil recovery. The apparatus may be transported to a remote location for on-site treatment of drill cuttings or other oil-containing solids.




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Bituminous froth inline steam injection processing

An inline bitumen froth steam heater system including steam injection and static mixing devices is provided. The system heats and de-aerates input bitumen froth without creating downstream processing problems with the bitumen froth such as emulsification or live steam entrainment. The system is a multistage unit that injects and thoroughly mixes steam with bitumen resulting in output bitumen material having temperature of about 190° F. The system conditions a superheated steam supply to obtain saturated steam at about 300° F. The saturated steam is contacted with bitumen froth flow and mixed in a static mixer stage. The static mixers provide surface area and rotating action that allows the injected steam to condense and transfer its heat to the bitumen froth. The mixing action and increase in temperature of the bitumen froth results in reduction in bitumen viscosity and allows the release of entrapped air from the bitumen froth.




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Apparatus for removing a contaminant from a solvent separation process

The invention is a process and apparatus for removing a contaminant from an aromatic selective solvent. A feed stream comprising an aromatic hydrocarbon and a non-aromatic hydrocarbon is contacted with the aromatic selective solvent in an extractive distillation zone to produce a raffinate stream comprising the non-aromatic hydrocarbon, and a rich solvent stream comprising the aromatic hydrocarbon and the solvent. The rich solvent stream is separated in a second distillation zone to produce an extract stream comprising the aromatic hydrocarbon, and a lean solvent stream comprising the contaminant and the aromatic selective solvent. At least a portion of the lean solvent stream is washed with a non-aromatic hydrocarbon to produce a clean solvent stream, at least a portion of which is passed to at least one of the extractive distillation zone and the second distillation zone.




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Apparatus and methods for utilizing heat exchanger tubes

In one aspect, the present techniques include a heat exchange apparatus including: a) a body comprising an interior cavity, the body including: a first surface and a second surface defining at least a portion of the body and the first surface positioned exterior with respect to the second surface and the interior cavity, and the second surface positioned exterior with respect to the interior cavity and interior with respect to the first surface; b) a first conduit for conveying a fluid to the body; c) a second conduit in fluid communication with the first conduit wherein the second conduit is positioned at least partially within the interior cavity of the body; and d) a joint between the first conduit and the second conduit, wherein the joint moves between a first location and a second location based on the temperature within the interior cavity, wherein at least one of said first location and said second location is positioned intermediate the first surface and the second surface.




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Distillation apparatus

A modular distillation apparatus including at least one heat exchanger that preheats contaminated liquids: a heater that heats the contaminated liquid from the heat exchanger; an evaporator condenser adapted o boil the contaminated liquid coming out of the heater to produce water vapor and contaminant concentrate, and condenser the water vapor into distilled water; a vacuum chamber capable of operating at below atmospheric pressure, the vacuum chamber housing the evaporator condenser and including at least one partition to separate the distilled water from the contaminate concentrate; a vapor compressor operably associated with the vacuum chamber to receive water vapor from the evaporator condenser in the vacuum chamber and pump the water vapor at pressure back through the evaporator condenser, wherein the heat exchanger recovers sensible heat from outgoing condensed distilled water and contaminant concentrate recycled from the vacuum chamber.




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Hydrocarbon resource processing apparatus including a load resonance tracking circuit and related methods

A device for processing a hydrocarbon resource may include a hydrocarbon processing container configured to receive the hydrocarbon resource therein and having a pair of opposing ends with an enlarged width medial portion therebetween. The device may also a spirally wound electrical conductor surrounding the hydrocarbon processing container, and a radio frequency (RF) circuit coupled to the spirally wound electrical conductor and configured to supply RF power to the hydrocarbon resource while tracking a load resonance of the RF circuit. The RF circuit may be configured to generate magnetic fields within the hydrocarbon processing container parallel with an axis thereof.




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Process for the treatment of crude oil, process for the separation of a water-in-oil hydrocarbon emulsion and apparatus for implementing the same

The invention relates to a process for the purification of crude and apparatus for its implementation. This process comprises a separation into gas and degassed emulsion and separation of the degassed emulsion into water and oil. The invention also relates to a process of separating a hydrocarbon emulsion and apparatus for implementing this. This process comprises washing of the emulsion at an oil/water interface.




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Method of produced water treatment, method of water reuse, and systems for these methods

A method of produced water treatment in an in-situ recovery method of producing bitumen from oil sand, the method has the steps of: separating bitumen from bitumen-mixed fluid so as to leave produced water, the bitumen-mixed fluid having been recovered from the oil sand wells; and filtering the produced water via a microfiltration membrane made of polytetrafluoroethylene.




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Method and apparatus for excitation of resonances in molecules

A method is described to excite molecules at their natural resonance frequencies with sufficient energy to break or form chemical bonds using electromagnetic radiation in the radio frequency (RF) and microwave frequency range. Liquid, solid, or gaseous materials are prepared and injected into a resonant structure where they are bombarded with electromagnetic energy in the RF or microwave range at resonant frequencies of the molecules of the materials. Alternatively, electromagnetic energy tuned to dielectric particles prepared from the materials may also be supplied to further enhance the reaction.




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Apparatus for removing heavy polynuclear aromatic compounds from a hydroprocessed stream

An improved apparatus strips HPNA's from hydroprocessed streams in a fractionation column having a split shell configuration. Only one vapor stripping feed is required to the split shell of the fractionation column. The resulting reduction in steam requirement provides a superior fractionation in the column.




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Two-stage hydroprocessing apparatus with common fractionation

Two-stage hydroprocessing uses a common dividing wall fractionator. Hydroprocessed effluents from both stages of hydroprocessing are fed to opposite sides of the dividing wall.




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Filter device, method for its operation and use thereof

A filter device for filtering a suspension includes at least one filter for continuous creation of a filter cake including particles from the suspension, at least one dispensing device configured to apply at least one first wash liquid to the filter cakes, at least one steaming unit configured to steam the filter cake using steam; at least one removal device configured to remove a surface layer of the filter cake facing away from the at least one filter, wherein the filter device is configured to convey the filter cake to the at least one removal device, the at least one dispensing device and the at least one steaming device, and at least one transport device configured to transport the removed surface layer of the filter cake away from the filter device.




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Method and apparatus for converting coal to petroleum product

The present invention provides a method of converting coal to a petroleum product. The method includes the steps of mixing the coal and water to form a mixture, and heating the mixture to approximately 500 degrees Fahrenheit. The method further includes separating the mixture in a first separator into a liquid stream of a water bearing minerals and a solid stream of coal, and transferring the coal from the first separator to a coking reactor wherein the temperature is raised to approximately 1,000 degrees Fahrenheit to drive off lighter fractions of the coal as a gas. The method also includes transferring the gas to a fourth separator to separate water and liquid petroleum product from the gas.




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Method and apparatus for processing of spent lubricating oil

The present invention provides a method and an apparatus for recovery of spent lubricating oil. The evaporation of hydrocarbon fractions from spent lubricating oil is carried out in three steps. The first step is at approximately 150-1030 mbar and between 70-240° C. in which is greater than 99% water, greater than 99% of ethylene glycol and greater than 50% of hydrocarbon molecules with normal boiling point up to 310° C. are evaporated from spent oil. The second step is operated at 6-30 mbar and 200-2900 C in which predominantly gasoil and light vacuum gasoil fractions are evaporated. The third step is operated at 250-320° C. and 0.5-15 mbar in which mainly heavy vacuum gasoil (boiling range of 425 to 570° C. on ASTM D-1160 test) is evaporated from spent oil.




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Apparatus for upgrading whole crude oil to remove nitrogen and sulfur compounds

A crude oil feedstream is treated to remove or reduce the content of known undesired heteroatomic and polynuclear aromatic compounds containing nitrogen and sulfur by contacting the feedstream with one or more solid adsorbent materials selected from attapulgus clay, alumina, silica gel and activated carbon in a mixing vessel for a time that is sufficient to optimize the adsorption of the undesired compounds from the crude oil, subjecting the mixture to atmospheric flash distillation and then to vacuum flash distillation to recover presorbed boiling ranges of products having a lowered content of the undesired compounds, and preferably regenerating at least a portion of the solid adsorbent material for reuse in the process.




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Adjustable stitch holder

The adjustable stitch holder is a versatile and easy method for securely holding live stitches when knitting. The stitch holder allows for using smaller materials, a locking fastener and string, that are portable and take little storage room. Adjusting the locking fastener to a specific measurement allows an item to be tried on, to be measured properly, or to determine if the shape is correct. Because the string has little to no memory, the ends, regardless of length, will hang not pulling or distorting the knit material. In addition, the flexible string allows an item to be laid flat for measuring making the measurement more accurate. Further, stitches or knitted items have little chance of being damaged by the stitch holder and the stitch holder will conform to the knit item instead of being forced into a shape.




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Headband for use with medical sensor

Headbands configured to provide pressure against a medical sensor secured to a patient's forehead are provided. The headbands may include one or more low friction materials to enable an elastic band of a tensioning mechanism to evenly stretch. Additionally or alternatively, the headbands may include two or more bands adapted to secure the headband to various portions of a patient's head. Still further, the headbands may be configured to independently vary the pressure created between two or more sensors and the patient's head.




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Toe closing apparatus

An apparatus for closing a toe end of a tubular hosiery body includes a stitching device having a main body, a fixed reed, a movable reed pivoted to the fixed reed, and a main drive assembly for driving the movable reed to rotate relative to the fixed reed between juxtaposed and stacked positions. A rotary control unit includes a support frame supporting the main body, a rotary disc attached to the main body, a plurality of detent members disposed around the rotary disc, and a plurality of control drive members respectively driving the detent members. The control drive members consecutively operate to consecutively actuate the respective detent members such that the rotary disc together with the stitching device consecutively produces a limited amount of rotation in an intermittent manner.




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Method of knitting a gusseted tongue for a knitted component

A knitted component including a knit element and a gusseted tongue is incorporated into an upper of an article of footwear. The knit element defines a portion of an exterior surface of the upper and an opposite interior surface of the upper, with the interior surface defining a void for receiving a foot. The knit element and the gusseted tongue are formed together as a knitted component during a knitting process as a one-piece element. The gusseted tongue is formed of unitary knit construction with the knit element and is joined with the knit element in an instep area of the upper. The knitting process includes steps of forming portions of the knitted component, transferring portions of the knitted component to opposite needle beds, shifting needle beds along a lateral direction to cause portions to overlap, and joining the overlapped portions by knitting to form the gusseted tongue.




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Handgrip sleeve for use with a crochet hook

An apparatus for removably securing resilient cushioning and gripping support to a crochet hook to facilitate its manipulation. Handgrip sleeve for use with a crochet hook is a lightweight, resilient gripping sleeve having an interior cavity for the accommodation of a crochet hook. Complete with gripping members and an elastomeric composition, handgrip sleeve for use with a crochet hook provides increased comfort and decreased fatigue for a user during the completion of a handicraft project.




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Article of footwear including a monofilament knit element with a fusible strand

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures. A fusible strand may be knit with the monofilament knit element. Upon heating, the fusible strand can combine and surround the monofilament strand within the monofilament knit element.




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Method of knitting a gusseted tongue for a knitted component

A knitted component including a knit element and a gusseted tongue is incorporated into an upper of an article of footwear. The knit element defines a portion of an exterior surface of the upper and an opposite interior surface of the upper, with the interior surface defining a void for receiving a foot. The knit element and the gusseted tongue are formed together as a knitted component during a knitting process as a one-piece element. The gusseted tongue is formed of unitary knit construction with the knit element and is joined with the knit element in an instep area of the upper. The knitting process includes steps of forming portions of the knitted component, transferring portions of the knitted component to opposite needle beds, shifting needle beds along a lateral direction to cause portions to overlap, and joining the overlapped portions by knitting to form the gusseted tongue.




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Air belt and air belt apparatus

An air belt having mesh webbing sufficiently strong and sufficiently expandable in the circumferential direction of a bag-shaped belt and an air belt apparatus including the air belt are provided. An air belt includes a folded member being a bag-shaped belt folded in a band shape and mesh webbing covering the folded member of the bag-shaped belt. The mesh webbing hardly expands in the longitudinal direction of the air belt, and is flexibly expandable in the circumferential direction of the bag-shaped belt. The mesh webbing is made of a raschel-knitted material. The knitted material is arranged such that the extending direction of knot portions of yarn threads and corresponds to the longitudinal direction of the air belt.




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Apparatus for separating melon flesh from rind

An apparatus for preparing a melon juice concentrate, such as watermelon juice concentrate, includes a finisher with brushes for separating melon flesh from melon rind including leaving at least 1/16 inch flesh on the rind and screens for separating juice from flesh. The apparatus also includes a steamer to reduce bacteria count on whole melon, a chopper for chopping melons into pieces less than about 16 inches square, an extractor for extracting juice from the flesh, and an evaporator for concentrating melon juice to form melon juice concentrate. The steamer includes a cylinder frame, steam jets directing steam through apertures in the cylinder frame at whole melon therein, and a motivator to move the whole melon along the cylinder frame. The apparatus can also process cantaloupe, honeydew melon, and other melon.




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Packed bed scrubber using a fusel oil solvent

A two stage scrubber process for ethanol fermentation has a first stage using fusel oil to remove the hazardous air pollutants and recover the majority of the ethanol. A second stage uses water as the scrubbing solvent to recover any residual ethanol that is stripped from the first stage.




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Method and an apparatus for determining the residual time until a cooking process of a foodstuff has been finished

The invention relates to a method for determining the residual time until a cooking process of a foodstuff (12) has been finished. At first a set temperature value for a core (14) of the foodstuff (12) is defined. Next the actual temperatures in the core (14) of the foodstuff (12) at predetermined times are measured and the time dependence of the measured temperature in the core (14) of the foodstuff (12) is determined. At last the time dependence of the measured temperature is compared with the set temperature value and “the residual time of the cooking process is estimated. The invention relates further to a corresponding apparatus for determining the residual time until a cooking process of a foodstuff (12) has been finished.




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Vacuum frying device and method for using the same

A method of converting a conventional atmospheric frying device to a vacuum frying device is provided. The method includes positioning a hood on top of a conventional frying device to provide an enclosure for drawing a vacuum within the modified devices. In addition, the method can include strengthening the existing vat so that it is capable of withstanding the forces associated with vacuum frying.




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Apparatus and method for preparing ingredients for a baby bottle

An apparatus for preparing infant formula to be supplied to a bottle, and methods and circuits for operating the same, are disclosed. The apparatus includes a housing having a shape for integrating together components of the apparatus. A fluid reservoir for holding fluid and configured to be coupling to the housing is provided. Further provided is a formula disc disposed at a first location of the housing. The first location defined above a dispense location of the bottle, and the formula disc having a top end and a dispense end, the formula disc further includes a plurality of slots for holding the infant formula in a powder state. The apparatus has an end plate that is coupled to the dispense end of the formula disc, and the end plate has a dispense hole, such that the end plate is rotatable relative to the formula disc.




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Method and apparatus for beverage formation with reservoir access control

A method and apparatus for forming a beverage. Movement of a brew chamber may automatically enable the provision of beverage precursor liquid into a reservoir in a brewer, which is then used (heated or not) to form a beverage. For example, closing of the brew chamber may cause a lid for a water reservoir to be fully opened or otherwise permit movement of the lid to allow access to the reservoir, allowing a user to provide water into the reservoir. The reservoir lid may open with an abrupt action, causing attention to be drawn to the reservoir lid. In another arrangement, closure of the brew chamber may cause actuation of a baffle, pump, valve or other device to provide a suitable amount of water to a reservoir for beverage formation. In another arrangement, opening of the brew chamber may cause the reservoir lid to be automatically and simultaneously opened with the brew chamber.




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System and method for preparing a beverage suitable for consumption, and a use of such a system, a receiving chamber and a holder

A system for preparing a beverage suitable for consumption, for instance coffee and/or tea, is disclosed. The system comprises an apparatus for dispensing beverage under pressure to a nozzle of the system, and at least one receiving chamber which is placeable or is placed downstream of this nozzle. During use, the nozzle spouts a jet of the beverage with relatively high velocity to and/or into the receiving chamber. The receiving chamber is provided with at least one outflow opening for dispensing beverage received in this chamber. The system is at least configured to substantially counteract or prevent formation of foam of this beverage, in particular when the beverage is spouted to and/or into the receiving chamber. Further disclosed is an assembly at least provided with a holder, to a holder, a receiving body, the use of a said system and to a method for preparing a beverage suitable for consumption.




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Beverage brewing apparatus with pump dispensing system

A beverage machine for preparing and dispensing a hot beverage having a pump dispensing system. Hot water passes through a water distributor to infuse material in a filter basket. A coffee tank receives the brewed beverage and maintains it at an appropriate temperature. On demand, a pump dispensing system delivers the beverage through an outlet chamber and spout into a user's cup. The user manipulates a switch to vary the rate at which the pump dispensing system dispenses the beverage.




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BICYCLIC PYRAZOLONE COMPOUNDS AND METHODS OF USE

The present invention provides substituted bicyclic pyrazolone compounds, which are used to inhibit or modulate the activity of receptor tyrosine kinases, especially Axl, Mer, c-Met and Ron. The invention also provides pharmaceutical compositions comprising the compound disclosed herein, and a method of preventing, treating or lessening the severity of a proliferative disorder in a patient with the compounds or the pharmaceutical compositions disclosed herein.




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FACTOR H BINDING PROTEIN VARIANTS AND METHODS OF USE THEREOF

Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising such proteins, and methods of use of such proteins, are provided.




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METHODS AND COMPOSITIONS FOR SUPPRESSING RETROVIRUSES

The disclosure provides methods and compositions for suppressing retroviruses, including novel methods for treating a retroviral infection in a human in need of such treatment, comprising delivering a functional meiosis arrest female protein 1 (MARF1) to cells containing a retroviral provirus, together with novel expression constructs comprising a coding sequence encoding a functional MARF1 operatively linked to a promoter, vectors comprising such constructs, and packaging cell lines for use in making such vectors.




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MULTI-SPECIFIC ANTI-PSEUDOMONAS PSL AND PCRV BINDING MOLECULES AND USES THEREOF

This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV bispecific binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.