Students returning to schools in Virginia and New York this fall will be required to participate in mental-health education as part of their health and physical education courses.

Educators are changing instructional priorities, altering lessons, and working on ways to help teachers grow professionally, all in an effort to raise math achievement.

Rhode Island today became the first state in the nation adopt the Next Generation Science Standards.

Rhode Island may become the first state to adopt the Next Generation Science Standards. The state board will vote later today.

"The HIV resilience framework will be of relevance to a wide range of people involved at all levels of the HIV response. We hope it provides encouragement for government decision makers and policy developers to pursue consistent and enabling policy and legislative environments and work cooperatively between jurisdictions and across departments to achieve best practice. Our consultation suggests that consistent legislation with the goal of supporting strong health outcomes, making disclosure safe, and eliminating stigmatising laws is crucial to creating environments in which people with HIV feel safe to access testing, treatment, and care. The HIV resilience framework also contains valuable insights for those who have responsibility for HIV health program management and service delivery, providing guidance to help ensure that programs, services, interventions or strategies supporting people living with HIV are developed and delivered in a way that is mindful of the interlinked twin goals of building personal resilience and eliminating stigma and discrimination." --President's message (page 6).

Discoveries in geography.

Menarche.

Habiburahman, 1979-

UK : Institute of Ophthalmology, 1951.

UK : Institute of Ophthalmology, 1951.

While Kansas was the first state to to announce school closures for the remainder of the 2019-20 K-12 school year, there are signs it might not be the last.

Berlin : J. Springer, 1895.

London : Elliot Stock, 1886.

[Edinburgh] : [publisher not identified], 1870.

Bristol : Wright, 1905.

London : Longmans, Green, 1902.

Idaho became the first state in the country to prohibit transgender girls from participating in girls' school sports after Gov. Brad Little, a Republican, signed the "Fairness in Women's Sports Act" into law Tuesday.

In Tuesday night's Republican primary in West Virginia, Robert Karnes, a West Virginia Republican state senator who lashed out at teachers during their nine-day strike, lost to pro-labor candidate Bill Hamilton.

London : Longmans, Green, Reader and Dyer, 1870.

Nathel Burtley, 79, was a lifelong educator who led the Flint, Mich., school system, paving the way for other African-American educators to become the heads of districts. He died earlier this month from the coronavirus.

Rockville, Maryland : National Institute on Drug Abuse, 1978.

Nicola Kistler, Adrien Schertzer, Marius A. Schmidt.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 414--425.

Abstract:
The Poisson clumping heuristic has lead Aldous to conjecture the value of the oriented first passage percolation on the hypercube in the limit of large dimensions. Aldous’ conjecture has been rigorously confirmed by Fill and Pemantle ( Ann. Appl. Probab. 3 (1993) 593–629) by means of a variance reduction trick. We present here a streamlined and, we believe, more natural proof based on ideas emerged in the study of Derrida’s random energy models.

Daniel Ahlberg.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 2, 397--401.

Abstract:
We study the rate of convergence in the celebrated Shape Theorem in first-passage percolation, obtaining the precise asymptotic rate of decay for the probability of linear order deviations under a moment condition. Our results are presented from a temporal perspective and complement previous work by the same author, in which the rate of convergence was studied from the standard spatial perspective.

Marie Ernst, Gesine Reinert, Yvik Swan.

Source: Bernoulli, Volume 26, Number 3, 2051--2081.

Abstract:
We propose probabilistic representations for inverse Stein operators (i.e., solutions to Stein equations) under general conditions; in particular, we deduce new simple expressions for the Stein kernel. These representations allow to deduce uniform and nonuniform Stein factors (i.e., bounds on solutions to Stein equations) and lead to new covariance identities expressing the covariance between arbitrary functionals of an arbitrary univariate target in terms of a weighted covariance of the derivatives of the functionals. Our weights are explicit, easily computable in most cases and expressed in terms of objects familiar within the context of Stein’s method. Applications of the Cauchy–Schwarz inequality to these weighted covariance identities lead to sharp upper and lower covariance bounds and, in particular, weighted Poincaré inequalities. Many examples are given and, in particular, classical variance bounds due to Klaassen, Brascamp and Lieb or Otto and Menz are corollaries. Connections with more recent literature are also detailed.

Ilya Pavlyukevich, Georgiy Shevchenko.

Source: Bernoulli, Volume 26, Number 2, 1381--1409.

Abstract:
In this paper, we study the Stratonovich stochastic differential equation $mathrm{d}X=|X|^{alpha }circ mathrm{d}B$, $alpha in (-1,1)$, which has been introduced by Cherstvy et al. ( New J. Phys. 15 (2013) 083039) in the context of analysis of anomalous diffusions in heterogeneous media. We determine its weak and strong solutions, which are homogeneous strong Markov processes spending zero time at $0$: for $alpha in (0,1)$, these solutions have the form egin{equation*}X_{t}^{ heta }=((1-alpha)B_{t}^{ heta })^{1/(1-alpha )},end{equation*} where $B^{ heta }$ is the $ heta $-skew Brownian motion driven by $B$ and starting at $frac{1}{1-alpha }(X_{0})^{1-alpha }$, $ heta in [-1,1]$, and $(x)^{gamma }=|x|^{gamma }operatorname{sign}x$; for $alpha in (-1,0]$, only the case $ heta =0$ is possible. The central part of the paper consists in the proof of the existence of a quadratic covariation $[f(B^{ heta }),B]$ for a locally square integrable function $f$ and is based on the time-reversion technique for Markovian diffusions.

Kraus, Peter -- Biography.

Sherwell (Family)

London (33 Stillness Rd, SE23 1NG) : Cleanair, Campaign for a Smoke-free Environment, [198-?]

London (33 Stillness Road London SE23 1NG) : Cleanair Campaign for a Smoke-free Environment, [198-?]

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

Microglial cells are considered as sensors of brain pathology by detecting any sign of brain lesions, infections, or dysfunction and can influence the onset and progression of neurological diseases. They are capable of sensing their neuronal environment via many different signaling molecules, such as neurotransmitters, neurohormones and neuropeptides. The neuropeptide VGF has been associated with many metabolic and neurological disorders. TLQP21 is a VGF-derived peptide and has been shown to signal via C3aR1 and C1qBP receptors. The effect of TLQP21 on microglial functions in health or disease is not known. Studying microglial cells in acute brain slices, we found that TLQP21 impaired metabotropic purinergic signaling. Specifically, it attenuated the ATP-induced activation of a K⁺ conductance, the UDP-stimulated phagocytic activity, and the ATP-dependent laser lesion-induced process outgrowth. These impairments were reversed by blocking C1qBP, but not C3aR1 receptors. While microglia in brain slices from male mice lack C3aR1 receptors, both receptors are expressed in primary cultured microglia. In addition to the negative impact on purinergic signaling, we found stimulating effects of TLQP21 in cultured microglia, which were mediated by C3aR1 receptors: it directly evoked membrane currents, stimulated basal phagocytic activity, evoked intracellular Ca²⁺ transient elevations, and served as a chemotactic signal. We conclude that TLQP21 has differential effects on microglia depending on C3aR1 activation or C1qBP-dependent attenuation of purinergic signaling. Thus, TLQP21 can modulate the functional phenotype of microglia, which may have an impact on their function in health and disease.

SIGNIFICANCE STATEMENT The neuropeptide VGF and its peptides have been associated with many metabolic and neurological disorders. TLQP21 is a VGF-derived peptide that activates C1qBP receptors, which are expressed by microglia. We show here, for the first time, that TLQP21 impairs P2Y-mediated purinergic signaling and related functions. These include modulation of phagocytic activity and responses to injury. As purinergic signaling is central for microglial actions in the brain, this TLQP21-mediated mechanism might regulate microglial activity in health and disease. We furthermore show that, in addition to C1qBP, functional C3aR1 responses contribute to TLQP21 action on microglia. However, C3aR1 responses were only present in primary cultures but not in situ, suggesting that the expression of these receptors might vary between different microglial activation states.

Four years into the 2030 Agenda and there is a pressing need to understand where the world stands in eradicating hunger and food insecurity, as well as ensuring sustainable [...]

Harjo, a member of the Muskogee Creek Nation, says the appointment "honors the place of Native people in this country, the place of Native people’s poetry"

It's June 1945 and the USS Barb has just launched an unprecedented attack on the factories of the Japanese island of Shari

But the scientists still aren’t sure what the birds are saying

With no new infections reported in Hubei province in recent days, restrictions are easing up—but experts worry about possible 'second wave' of cases

Perhaps the cigar-shaped object is a shard from a shredded planetary body, a computer simulation suggests