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Aptamer aided plasmonic nano-urchin for reporter free surface-enhanced Raman spectroscopy analysis of cortisol

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00401A, Paper
Chengyu Li, Jing Hu, Nan Hu, Jianjun Zhao, Qianwen Li, Yanhui Han, Yanxiong Liu, Xufang Hu, Liyan Zheng, Qiu-E Cao
Cortisol is a vital glucocorticoid hormone reflecting stress levels and related disease processes. We present an aptamer functionalized plasmonic nano-urchin (α-FeOOH@Au-aptamer) aided cortisol capturing and Surface-enhanced Raman spectroscopy (SERS) analysis...
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Luminescent and time-resolved determination of gemifloxacin mesylate in pharmaceutical formulations and spiked blood plasma samples using a lanthanide complex as a probe

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00236A, Paper
Gasser M. Khairy, Rania M. Goda, Zeinab M. Anwar, Mohamed M. Aboelnga, Axel Duerkop
A new luminescent europium probe for the determination of the antibiotic gemifloxacin is presented. Time-resolved luminescence enables its quantitation in pharmaceutical formulations and blood samples.
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LAMP-based hydrogen ion selective electrochemical sensor for highly sensitive detection of Mycoplasma pneumoniae

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00341A, Paper
Huiqing Wang, Yang Li, Lin Tian, Xinyi Li, Qian Gao, Yaru Liu, Cuiping Ma, Qing Wang, Chao Shi
An urgent need for a concise and rapid detection method for Mycoplasma pneumoniae is required due to its severe impact on human’s health. To meet such a need, this study...
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A complementary method with PFBBr-derivatization based on a GC-EI-MS platform for the simultaneous quantitation of short-, medium- and long-chain fatty acids in murine plasma and feces samples

Anal. Methods, 2024, 16,2330-2339
DOI: 10.1039/D3AY02271D, Paper
Hong-Xu Zhou, Qing Jiang, Xin He, Xian Fu, Jun-Yan Liu
Fatty acids (FAs) are essential molecules in all organisms and are involved in various physiological and pathophysiological processes.
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Analysing micro- and nanoplastics with cutting-edge infrared spectroscopy techniques: a critical review

Anal. Methods, 2024, 16,2177-2197
DOI: 10.1039/D3AY01808C, Critical Review
Open Access
Junhao Xie, Aoife Gowen, Wei Xu, Junli Xu
In this review, we discussed and compared the applications of Fourier transform infrared spectroscopy, quantum cascade laser infrared spectroscopy, atomic force microscopy-based infrared spectroscopy, and optical photothermal infrared spectroscopy in MNP research from multiple perspectives.
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A better Twitter app for Android, at last




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​Last mile woes: On inflation data and the challenges

Inflation should not be allowed to undermine the economic momentum 




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Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer

RSC Med. Chem., 2024, 15,3433-3443
DOI: 10.1039/D4MD00468J, Research Article
Meijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing Li
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
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Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
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S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00619D, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott
25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.
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U.S. Presidential polls: Thulasendrapuram residents pray for Kamala Harris ‘victory




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Property owners block the entrance to Balasubramanya temple in Karur




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Govt. urged to extend last date to pay crop insurance premium by farmers




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Bikes for last mile connectivity

The Japanese are increasingly shunning cars to help the urban environment get greener.




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Superlative Class

The EQS SUV reinvigorates Mercedes-Benz’s game in the all-electric segment




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The last thing business founders need is a wasteful public spat

As entrepreneurship explodes in India, we need more iconic founders who not only build sustainable firms but also retain their humility




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The (E-) Class of 2024

A new E-Class is here and it promises to be better than before. How’s that even possible?




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Police rule out communal angle in clash near Jahangirpuri temple




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Delhi Transport Minister Kailash Gahlot announces two new bus routes for outer Delhi




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DMRC launches bike taxis for last-mile connectivity




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KAU, Asia’s largest cocoa germplasm repository, ready to release six more clones




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 Kuruvai coverage rose by 40% above normal in last five years

The normal coverage is about 3.24 lakh acres for the delta. However, going by the average for the last five years, the figure comes to 4.57 lakh acres — a nearly 40% rise.




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2024 turns out to be the worst-ever season for mango growers in Rayalaseema in five decades

With over 80% dip in yield following adverse weather conditions, the prospects of earning profits have faded; the situation has turned adverse, as competitors from Telangana and Tamil Nadu started supplying stocks to the pulp units predominantly located in Chittoor district




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Plastic is fantastic: Credit cards register highest growth in five years

Axis Bank leads charge, SBI narrows gap with ICICI, HDFC Bank on top; numbers inch up to 25m




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Investors can now file class action suits against errant cos




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Coimbatore car blast: NIA interrogates three accused of raising funds for operation

The NIA sleuths will interrogate them in custody till November 14, said a source privy to the investigation




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Stress amplification and relaxation imaging around cracks in nanocomposite gels using ultrasound elastography

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00909F, Paper
H. Le Blay, T. Deffieux, L. Laiarinandrasana, M. Tanter, A. Marcellan
Stress visualization around cracks in NC gels was performed using ultrasonic elastography. Temporal and spatial mapping are performed non-invasively. Over time, the stress gradient is erased by large-scale reorganization of the polymer network.
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Telephone cord blister formation in solvent swollen elastomer films

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM01035C, Paper
Open Access
James S. Sharp, Nathaniel M. Roberts, Sam Walker
Telephone cord blister formation is studied in PDMS films swollen in four different solvents. Buckling and fracture mechanics theories are developed to interpret blister morphology and growth rates. A simple surface patterning method is introduced.
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Modeling nematic phase main-chain liquid crystal elastomer synthesis, mechanics, and thermal actuation via coarse-grained molecular dynamics

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00528G, Paper
Nicolas Herard, Raja Annapooranan, Todd Henry, Martin Kroger, Shengqiang Cai, Nicholas Boechler, Yelena Sliozberg
This paper presents a coarse-grained molecular dynamics simulation study of the synthesis, mechanics, and thermal actuation of nematic phase main-chain liquid crystal elastomers (LCEs), a type of soft, temperature-responsive, polymeric...
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Enhanced chemotaxis efficiency of Escherichia coli in viscoelastic solutions

Soft Matter, 2024, 20,8675-8683
DOI: 10.1039/D4SM01094A, Paper
Shaoying Zhu, Rui He, Caijuan Yue, Rongjing Zhang, Junhua Yuan
E. coli shows enhanced chemotaxis in viscoelastic media, with faster migration and higher accumulation in attractant-rich areas compared to Newtonian conditions.
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Interfacial viscoelasticity in oscillating drops of cyclodextrin-surfactant aqueous solution: experiments and theory

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM01007H, Paper
José Roberto Romero-Arias, Alberto S. Luviano, Miguel Costas, Aurora Hernandez-Machado, Rafael A Barrio
We present experiments involving oscillating droplets in aqueous cyclodextrin-surfactant solutions. In these experiments, α-cyclodextrin (αCD) and anionic surfactants exhibit remarkable viscoelasticity at the liquid/air interface, with dilatational modulus varying across...
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A dynamical system approach to relaxation in glass-forming liquids

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00976B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jack F. Douglas, Qi-Lu Yuan, Jiarui Zhang, Hao Zhang, Wen-Sheng Xu
We adapt a dynamical system approach to the practical matter of estimating relaxation times in both cooled liquids and crystals at elevated temperatures, which we identify as weakly non-integrable dynamical systems.
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Eye Witness No. 74 / directed by: Jack Long, William Davidson ; produced by: Jack Olsen, Nicholas Balla ; production agency: National Film Board of Canada (Ottawa)

Montreal : National Film Board of Canada, 2024




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Thirteen leaders from Rayalaseema get nominated posts in A.P.

Somisetty Venkateshwarlu, Narasimha Yadav, Roopananda Reddy, Kappatralla Susheelamma, Mustaq Ahmed, Devendrappa, K.K. Choudhary, R. Sadashiva, C.R. Rajan, Neelayapalam Vijay Kumar, Poola Nagaraju, K. Hemalatha from TDP get nominated posts while T.C. Varun from JSP gets a post




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November 18 is the last date for filing of nominations for the East-West Godavari Teachers’ constituency MLC election




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GIS-based master plans being prepared for Class II towns, says A.P. Finance Minister

NDA govt. is taking steps for planned and sustainable urban development, says Finance Minister Payyavula Keshav after presenting the Budget for 2024-25




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Need to create awareness on Budget preparation among new MLAs, says Andhra Pradesh Assembly Speaker

‘It will equip them to express their opinion and they are also supposed to know the allocations made to 39 departments’




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Allocations to Rayalaseema: Andhra govt. aims to develop Tirupati and Kurnool




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Problems and theorems in classical set theory [electronic resource] / Peter Komjath, Vilmos Totik

New York ; Berlin : Springer, 2006




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Number theory revealed [electronic resource] : a masterclass / Andrew Granville.

Providence, Rhode Island : American Mathematical Society, [2019]




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Students stage protest demanding classrooms in the Nilgiris




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Vistara to make last flight today before Air India merger

Vistara, a joint venture between Tata Group and Singapore Airlines, will fully merge with Air India, also owned by Tata Group




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RBI announces rules to reclassify FPI investment as FDI once it crosses 10% holding in Indian firms

Investment made by foreign portfolio investor along with its investor group (hereinafter referred to as ‘FPI’) shall be less than 10% of the total paid-up equity capital on a fully diluted basis




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'Hannah Gadsby: Douglas' review: After 'Nanette', the extraordinary mind of Gadsby strikes again

The Australian’s charisma lies in her ability to be excruciatingly vulnerable to an audience with a swagger that’s both self-assured and relatable




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Real estate companies have raised over ₹1 lakh crore in last 20 months

92 per cent of it came through debt issuances




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32 STPs taken up by BRS govt. to cleanse Musi: MLAs

₹3.8k crore STP project was to protect Nalgonda ryots’ farm fields from sewage water




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Telangana State Cyber Security Bureau nabbed 165 cyber criminals involved in 795 cases in last six months

45% fraudsters are either graduates or post-graduates; indulge in crime due to peer pressure and for easy money, says data




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Focus on Delhi’s batting unit in clash against Chandigarh

A collective show of strength from the top six hasn’t yet been on view; Rawat and Badoni’s return bolsters the team’s batting options