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Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1H-pyrazole-5-carboxylate as an HIV-1 replication inhibitor

RSC Med. Chem., 2020, Advance Article
DOI: 10.1039/D0MD00025F, Research Article
Jeanne Fichez, Cathia Soulie, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier-Pelletier, Anne-Geneviève Marcelin, Vincent Calvez, Patricia Busca
Identified as an HIV-1 inhibitor in cellulo, this pyrazole does not belong to the three main classes of anti HIV-drugs, a feature of prime interest in the context of viral resistance.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Computer-aided discovery of phenylpyrazole based amides as potent S6K1 inhibitors

RSC Med. Chem., 2020, Advance Article
DOI: 10.1039/C9MD00537D, Research Article
Yan Yin, Yuxing Sun, Lianhua Zhao, Jinpeng Pan, Yangbo Feng
Ribosomal protein S6 kinase beta-1 (S6K1) is an attractive therapeutic target.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Surfactants for enhanced oil recovery applications Muhammad Sagir, Muhammad Mushtaq, M. Suleman Tahir, Muhammad Bilal Tahir, Abdul Ravoof Shaik

Online Resource




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Rare-earth metal recovery for green technologies: methods and applications / edited by Rajesh Kumar Jyothi

Online Resource




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Recovering history through fact and fiction : forgotten lives / edited by Dallas John Baker, Donna Lee Brien and Nike Sulway




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Ancient Jerusalem revealed : archaeological discoveries, 1998-2018 / editor : Hillel Geva




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[ASAP] Discovering New Lipidomic Features Using Cell Type Specific Fluorophore Expression to Provide Spatial and Biological Specificity in a Multimodal Workflow with MALDI Imaging Mass Spectrometry

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00446




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[ASAP] Mass Transfer Modulation and Gas Mapping Based on Covalent Organic Frameworks-Covered Theta Micropipette

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c01152




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Football: Some players are still recovering from coronavirus, says AC Milan president Scaroni

The Lombardy club returned to individual training this week and are expecting Swedish star Zlatan Ibrahimovic to return in the coming days.




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Detecting and modeling the changes of land use and land cover for land use planning in Da Nang City, Vietnam / Hoang Khanh Linh Nguyen

Rotch Library - HD890.5.Z9 D36 2018




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Ocean recovery: a sustainable future for global fisheries? / Ray Hilborn and Ulrike Hilborn

Dewey Library - SH329.S87 H55 2019




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Rediscovery of genetic and genomic resources for future food security Romesh Kumar Salgotra, Sajad Majeed Zargar, editors

Online Resource




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Mechanical robustness of monolayer nanoparticle-covered liquid marbles

Soft Matter, 2020, Advance Article
DOI: 10.1039/D0SM00496K, Paper
Junchao Huang, Ziheng Wang, Haixiao Shi, Xiaoguang Li
A particle shell as thin as ∼20 nm cannot protect internal liquid from wetting external solid.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Delhi ATM cash heist: Absconding cash van driver arrested, looted money recovered

Thirty-year old Satish and his cousin Shailender have been arrested from Etah in U.P.




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Nine live bombs recovered in Ranchi

Police also seized 19 gelatin sticks and two clocks fitted to the bombs.




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Pune ad professionals died in accident, bodies of 3 recovered from Nira river

While Chintan's body was recovered from the river water, the other three remained in the car.




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Recovering Australian threatened species : a book of hope / editors: Stephen Garnett, Peter Latch, David Lindenmayer and John Woinarski




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For the first time in 6 years, CPI(M) shows some signs of recovery in Bengal



  • DO NOT USE West Bengal
  • India

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Wills' mineral processing technology : an introduction to the practical aspects of ore treatment and mineral recovery / Barry A. Wills

Wills, B. A. (Barry Alan)




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The development of a resin-in-pulp process for the recovery of nickel and cobalt from laterite leach slurries / Zaimawati Zainol

Zainol, Zaimawati




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Pressure Hydrometallurgy 2004 : 34th Annual Hydrometallurgy Meeting of CIM, October 23 rd--27th, 2004, Banff, Alberta, Canada : proceedings of the International Conference on the Use of Pressure Vessels for Metal Extraction and Recovery / editors, M.J.Col

Hydrometallurgy Meeting (34th : 2004 : Banff, Alta.)




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Mineral processing technology : an introduction to the practical aspects of ore treatment and mineral recovery (in SI/metric units) / by B.A.Wills

Wills, B. A. (Barry Alan)




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Enhanced metal recovery from a modified caron leach of mixed nickel-cobalt hydroxide / Andrew Jones

Jones, Andrew N., author




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Wills' mineral processing technology : an introduction to the practical aspects of ore treatment and mineral recovery / Barry A. Wills, James A. Finch

Wills, B. A. (Barry Alan), author




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Forex reserve cover for imports increases to 11.4 months

The country’s foreign exchange reserves cover for imports increased to 11.4 months as of end December 2019 from the 10.4 months in September 2019, the




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JSJ 303: Test Coverage Tools with Ben Coe, Aaron Abramov, and Issac Schleuter

Panel: 

Charles Max Wood

Aimee Knight

Corey House

AJ O'Neal

Special Guests: Ben Coe, Aaron Abramov, and Issac Schleuter

In this episode, the JavaScript Jabber panelists talk with Ben Coe, Aaron Abramov, and Issac Schleuter about test coverage and testing tools. They talk about the different tools and libraries that they have contributed to the coding community, such as NYC, conf, and Jest. They also discuss what test coverage is actually about and when using test coverage tools is necessary.

In particular, we dive pretty deep on:

  • What have you contributed to the testing tools community?
  • npm
  • NYC tool and instanbul project
  • conf
  • Jest
  • These libraries were developed to be easy and have “batteries included”
  • False positives with test coverage
  • Encourage testing practices that don’t practice in a superficial way
  • Test coverage is about making sure you test every state a public API can get into
  • Think through the test you’re writing first
  • Barriers against testing
  • Don’t spike the code too quickly
  • Provides guardrails for newer developers to contribute to open source projects
  • Use tests to understand the system
  • How to spend your time better
  • When you need tests
  • Value is very short term
  • TDD
  • And much, much more!

Links:

Picks:

Charles

Aimee

AJ

Corey

Ben

Aaron

Issac




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Discovery of new polycyclic polyprenylated acylphloroglucinols with diverse architectures as potent cyclooxygenase-2 inhibitors

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00259C, Research Article
Shuangshuang Xie, Changxing Qi, Yulin Duan, Qianqian Xu, Yaping Liu, Yingying Huang, Xu Yin, Weiguang Sun, Yuan Zhou, Yonghui Zhang
Cyclooxygenase-2 (COX-2) is a significant therapeutic target of chronic inflammatory diseases.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display

Journal of the American Chemical Society
DOI: 10.1021/jacs.0c03152




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The meaning of Mary Magdalene : discovering the woman at the heart of Christianity / Cynthia Bourgeault

Bourgeault, Cynthia




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Biomarkers in Drug Discovery and Development: A Handbook of Practice, Application, and Strategy, 2nd Edition


 
This book continues the legacy of a well-established reference within the pharmaceutical industry – providing perspective, covering recent developments in technologies that have enabled the expanded use of biomarkers, and discussing biomarker characterization and validation and applications throughout drug discovery and development.

•    Explains where proper use of biomarkers can substantively impact drug development timelines and costs, enable selection

Read More...




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Flexible CSS cover images

I recently included the option to add a large cover image, like the one above, to my posts. The source image is cropped, and below specific maximum dimensions it’s displayed at a predetermined aspect ratio. This post describes the implementation.

Known support: Chrome, Firefox, Safari, Opera, IE 9+

Features

The way that the cover image scales, and changes aspect ratio, is illustrated in the following diagram.

The cover image component must:

  • render at a fixed aspect ratio, unless specific maximum dimensions are exceeded;
  • support different aspect ratios;
  • support max-height and max-width;
  • support different background images;
  • display the image to either fill, or be contained within the component;
  • center the image.

Aspect ratio

The aspect ratio of an empty, block-level element can be controlled by setting a percentage value for its padding-bottom or padding-top. Given a declaration of padding-bottom:50% (and no explicit height), the rendered height of the element will be 50% of its width.

.CoverImage {
  padding-bottom: 50%;
}

Changing that padding value will change the aspect ratio. For example, padding of 25% results in an aspect ratio of 4:1, padding of 33.333% results in an aspect ratio of 3:1, etc.

Maximum dimensions

The problem with using this aspect ratio hack is that if the element has a max-height declared, it will not be respected. To get around this, the hack can be applied to a pseudo-element instead.

.CoverImage:before {
  content: "";
  display: block;
  padding-bottom: 50%;
}

Now the main element can take a max-height. It should also clip the pseudo-element overflow.

.CoverImage {
  display: block;
  max-height: 300px;
  max-width: 1000px;
  overflow: hidden;
}

.CoverImage:before {
  content: "";
  display: block;
  padding-bottom: 50%;
}

This aspect ratio pattern is provided by the FlexEmbed component for SUITCSS. That component is primarily for responsive video embeds, but it’s flexible enough to be useful whenever you need an element rendered at a predetermined aspect ratio. It comes with modifiers for 2:1, 3:1, 16:9, and 4:3 aspect ratios. The cover image component can extend the FlexEmbed component.

<div class="CoverImage FlexEmbed FlexEmbed--2by1"></div>

Background image

The cover image is applied as a background image that is sized to cover the entire area of the element. This makes sure the image is clipped to fit the aspect ratio of the element.

.CoverImage {
  ...
  background-repeat: no-repeat;
  background-size: cover;
}

If you want different cover images for different instances of the component, they can be applied via the style attribute.

<div class="..." style="background-image: url(cover.jpg)"></div>

The image can be fully centered by using background positioning and block centering. This makes sure that the image is centered in the element, and that the element is centered within its parent (when it reaches the max-width value).

.CoverImage {
  ...
  background-position: 50%;
  background-repeat: no-repeat;
  background-size: cover;
  margin: 0 auto;
}

Final result

If you depend on the FlexEmbed module, the amount of additional code required is minimal. (See the demo for all the code, including the FlexEmbed dependency.)

/**
 * Requires: suitcss/flex-embed
 */

.CoverImage {
  background-position: 50%;
  background-repeat: no-repeat;
  background-size: cover;
  margin: 0 auto;
  max-height: 300px;
  max-width: 1000px;
}
<div class="CoverImage FlexEmbed FlexEmbed--3by1"
     style="background-image:url(cover.jpg)">
</div>

You can add further customizations, such as setting the accompanying background color, or providing a means to switch between the cover and contain keywords for background-size.




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JAMA Neurology : Effect of Dextroamphetamine on Poststroke Motor Recovery

Interview with Larry B. Goldstein, MD, author of Effect of Dextroamphetamine on Poststroke Motor Recovery: A Randomized Clinical Trial




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Covid-19 impact: No comfort in hotel stocks as recovery pushed to FY23

Expectations of a slow recovery, high fixed costs and debt worries are putting off investors




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RIL, Infosys, HUL account for 51% recovery in Sensex from 52-week low

In all, these three entities have added Rs 5.8 trillion to their m-cap during the period, against a Rs 11.3-trillion rise in the incremental m-cap of all 30 Sensex companies




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Indian-origin journalist Anita Rani discovers family’s fate during partition through TV show



  • DO NOT USE Indians Abroad
  • World

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Going for broke: insolvency tools to support cross-border asset recovery in corruption cases / Jean-Pierre Brun, Molly Silver

Online Resource




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Juve's Dybala recovers from coronavirus

In March, Dybala confirmed he and his girlfriend, Oriana Sabatini, tested positive for coronavirus.




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[ASAP] Discovery of Potent and Novel Quinazolinone Sulfide Inhibitors with Anti-ToCV Activity

Journal of Agricultural and Food Chemistry
DOI: 10.1021/acs.jafc.0c00686




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[ASAP] Comparison of the Flavonoid Profiles of Corn Silks to Select Efficient Varieties as Trap Plants for <italic toggle="yes">Helicoverpa zea</italic>

Journal of Agricultural and Food Chemistry
DOI: 10.1021/acs.jafc.0c01462




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Leaks of CFCs threaten ozone layer recovery and climate, researchers say

Aging equipment and plastic foam release chemicals




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A chemist enters a popular TV baking competition, and a cat food discovery




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Priestley Medal address 2020: The road less traveled&#8212;for love of detection, discovery, and all things radical in nature




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Emory-discovered antiviral is poised for COVID-19 clinical trials

The nucleoside inhibitor has advantages over Gilead's remdesivir but has yet to be tested in humans




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Meet Sheng Ding, who is tackling COVID-19 as director of China's Global Health Drug Discovery Institute

The chemist wants the Gates Foundation–backed institute to share its expertise during the coronavirus pandemic and advocate for public health




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Mansukh Wani, codiscoverer of Taxol, dies at age 95

Chemist's work focused on natural products as an important source of life-saving cancer drugs




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Rome Therapeutics launches to probe junk DNA for cancer drug discovery

Biotech veteran Rosana Kapeller co-founded the start-up, which raised $50 million to develop small-molecule drugs




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Rome Therapeutics launches to probe junk DNA for cancer drug discovery

Biotech veteran Rosana Kapeller cofounded the start-up, which raised $50 million to develop small-molecule drugs




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SRI and Exscientia partner on AI-assisted cancer drug discovery




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Aarogya Setu coming on feature phones; to cover the entire country

The Aarogya Setu app, developed by the government, will be expanded to all feature phone users, with the Centre planning to partner with telecom operators Bharti Airtel, Reliance Jio and Vodafone-Idea, who will enable calls to their subscribers, a top official told ET. There are around 550 million feature phone users in the country.




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Drug discovery and evaluation [electronic resource] : safety and pharmacokinetic assays / H. Gerhard Vogel (ed.) ; Franz Jakob Hock, Jochen Maas, Dieter Mayer (co-editors)

Berlin ; New York : Springer, [2006]