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3-parent gene therapy for mitochondrial diseases and a news roundup

Kimberly Dunham-Snary discusses the long-term health considerations of gene therapy for mitochondrial diseases and David Grimm talks about the smell of death, Mercury crashing, and animal IQ. Hosted by Susanne Bard. [Image credit: Ben Gracewood CC BY-NC 2.0, via flickr]




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Podcast: A recipe for clean and tasty drinking water, a gauge on rapidly rising seas, and fake flowers that can fool the most discerning insects

Online News Editor Catherine Matacic shares stories on what we can learn from 6million years of climate data, how to make lifelike orchids with 3D printing, and crowdsourced gender bias on eBay.   Fernando Rosario-Ortiz joins host Sarah Crespi to discuss how approaches to water purification differ between countries.   [Image: Eric Hunt/Wikipedia/CC BY-SA 3.0] 0]




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Podcast: Pollution hot spots in coastal waters, extreme bees, and diseased dinos

News stories on bees that live perilously close to the mouth of a volcano, diagnosing arthritis in dinosaur bones, and the evolution of the female orgasm, with David Grimm.  From the magazine Rivers deliver water to the ocean but water is also discharged along the coast in a much more diffuse way. This “submarine groundwater discharge” carries dissolved chemicals out to sea. But the underground nature of these outflows makes them difficult to quantify.  Audrey Sawyer talks with Sarah Crespi about the scale of this discharge and how it affects coastal waters surrounding the United States.  [Image: Hilary Erenler/Music: Jeffrey Cook]




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Podcast: An ethics conundrum from the Nazi era, baby dinosaur development, and a new test for mad cow disease

This week, we chat about how long dinosaur eggs take—or took—to hatch, a new survey that confirms the world’s hot spots for lightning, and replenishing endangered species with feral pets with Online News Editor Catherine Matacic. Plus, Science’s Alexa Billow talks to Megan Gannon about the dilemma presented by tissue samples collected during the Nazi era. And Sarah Crespi discusses a new test for mad cow disease with Kelly Servick.   Listen to previous podcasts.   [Image: NASA/flickr; Music: Jeffrey Cook]




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How the appendix could hold the keys to Parkinson’s disease, and materials scientists mimic nature

For a long time, Parkinson’s disease was thought to be merely a disorder of the nervous system. But in the past decade researchers have started to look elsewhere in the body for clues to this debilitating disease—particularly in the gut. Host Meagan Cantwell talks with Viviane Labrie of the Van Andel Institute in Grand Rapids, Michigan, about new research suggesting people without their appendixes have a reduced risk of Parkinson’s. Labrie also describes the possible mechanism behind this connection. And host Sarah Crespi talks with Peter Fratzl of the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, about what materials scientists can learn from nature. The natural world might not produce innovations like carbon nanotubes, but evolution has forged innumerable materials from very limited resources—mostly sugars, proteins, and minerals. Fratzl discusses how plants make time-release seedpods that are triggered by nothing but fire and rain, the amazing suckerin protein that comprises squid teeth, and how cicadas make their transparent, self-cleaning wings from simple building blocks. Fratzl’s review is part of a special section in Science on composite materials. Read the whole package, including a review on using renewables like coconut fiber for building cars and incorporating carbon nanotubes and graphene into composites. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Roger Smith/Flickr; Music: Jeffrey Cook]




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Race and disease risk and Berlin’s singing nightingales

Noncancerous tumors of the uterus—also known as fibroids—are extremely common in women. One risk factor, according to the scientific literature, is “black race.” But such simplistic categories may actually obscure the real drivers of the disparities in outcomes for women with fibroids, according to this week’s guest. Host Meagan Cantwell speaks with Jada Benn Torres, an associate professor of anthropology at Vanderbilt University in Nashville, about how using interdisciplinary approaches— incorporating both genetic and cultural perspectives—can paint a more complete picture of how race shapes our understanding of diseases and how they are treated. In our monthly books segment, book review editor Valerie Thompson talks with David Rothenberg, author of the book Nightingales in Berlin: Searching for the Perfect Sound, about spending time with birds, whales, and neuroscientists trying to understand the aesthetics of human and animal music. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Carlos Delgado/Wikipedia; Matthias Ripp/Flickr; Music: Jeffrey Cook]




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An app for eye disease, and planting memories in songbirds

Host Sarah Crespi talks with undergraduate student Micheal Munson from Baylor University in Waco, Texas, about a smartphone app that scans photos in the phone’s library for eye disease in kids.  And Sarah talks with Todd Roberts of the University of Texas Southwestern Medical Center in Dallas, Texas, about incepting memories into zebra finches to study how they learn their songs. Using a technique called optogenetics—in which specific neurons can be controlled by pulses of light—the researchers introduced false song memories by turning on neurons in different patterns, with longer or shorter note durations than typical zebra finch songs. This week’s episode was edited by Podigy. Ads on this week’s show: MOVA Globes; KiwiCo.com Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast  




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Researchers flouting clinical reporting rules, and linking gut microbes to heart disease and diabetes

Though a law requiring clinical trial results reporting has been on the books for decades, many researchers have been slow to comply. Now, 2 years after the law was sharpened with higher penalties for noncompliance, investigative correspondent Charles Piller took a look at the results. He talks with host Sarah Crespi about the investigation and a surprising lack of compliance and enforcement. Also this week, Sarah talks with Brett Finlay, a microbiologist at the University Of British Columbia, Vancouver, about an Insight in this week’s issue that aims to connect the dots between noncommunicable diseases like heart disease, diabetes, and cancer and the microbes that live in our guts. Could these diseases actually spread through our microbiomes? This week’s episode was edited by Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF). [Image: stu_spivack/Flickr; Music: Jeffrey Cook]




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Why some diseases come and go with the seasons, and how to develop smarter, safer chemicals

On this week’s show, host Joel Goldberg gets an update on the coronavirus pandemic from Senior Correspondent Jon Cohen. In addition, Cohen gives a rundown of his latest feature, which highlights the relationship between diseases and changing seasons—and how this relationship relates to a potential coronavirus vaccine. Also this week, from a recording made at this year’s AAAS annual meeting in Seattle, host Meagan Cantwell speaks with Alexandra Maertens, director of the Green Toxicology initiative at Johns Hopkins University, Baltimore, about the importance of incorporating nonanimal testing methods to study the adverse effects of chemicals. This week’s episode was produced with help from Podigy. Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Let Ideas Compete/Flickr; Music: Jeffrey Cook] 




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How COVID-19 disease models shape shutdowns, and detecting emotions in mice

On this week’s show, Contributing Correspondent Kai Kupferschmidt talks with host Sarah Crespi about modeling coronavirus spread and the role of forecasts in national lockdowns and other pandemic policies. They also talk about the launch of a global trial of promising treatments. See all of our News coverage of the pandemic here. See all of our Research and Editorials here. Also this week, Nadine Gogolla, research group leader at the Max Planck Institute of Neurobiology, talks with Sarah about linking the facial expressions of mice to their emotional states using machine learning. This week’s episode was produced with help from Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF)




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A deep learning approach to identify association of disease–gene using information of disease symptoms and protein sequences

Anal. Methods, 2020, 12,2016-2026
DOI: 10.1039/C9AY02333J, Paper
Xingyu Chen, Qixing Huang, Yang Wang, Jinlong Li, Haiyan Liu, Yun Xie, Zong Dai, Xiaoyong Zou, Zhanchao Li
Prediction of disease–gene association based on a deep convolutional neural network.
The content of this RSS Feed (c) The Royal Society of Chemistry




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ELISA as an effective tool to determine spatial and seasonal occurrence of emerging contaminants in the aquatic environment

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00426J, Paper
Carla Patrícia Silva, Tânia Carvalho, Rudolf J. Schneider, Valdemar I. Esteves, Diana L. D. Lima
Monitoring emerging contaminants is essential as they represent a risk to the aquatic environment. ELISA is a promising method for their quantification mostly because it allows controlling their concentration levels through large screening campaigns.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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'F1 season likely to hit glitch'

'If we want to go to Asia, or America, I think it's going to be when we get on planes and have to fly overseas where I think the risk will start to potentially get greater.'





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[ASAP] Bifunctional Au@Pt/Au core@shell Nanoparticles As Novel Electrocatalytic Tags in Immunosensing: Application for Alzheimer’s Disease Biomarker Detection

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00760




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[ASAP] 27-Plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer’s Disease

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00655




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Indian Football: AIFF suggests ISL, I-League follow AFC’s foreign player rule from 2021-’22 season

The members of the All India Football Federation Technical Committee, chaired by Shyam Thapa, discussed the idea through video-conferencing on Friday.




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Ighalo hopes his loan at Manchester United extends until coronavirus-hit Premier League season ends

The 30-year-old moved to Old Trafford from Chinese side Shanghai Shenhua in January and has a contract until May 31.




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No altruism: Watford chairman hits out at Premier League’s proposal to end season at neutral venues

Watford chairman Scott Duxbury said he was worried about the impact of a distorted nine-game mini-league.




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Positive Findings from Year 2 of the Centers for Medicare & Medicaid Services’ Million Hearts® Cardiovascular Disease Risk Reduction Model

Mathematica has released positive evaluation findings from Year 2 of the Million Hearts® model, just in time for American Heart Month this February.




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Powdery mildew disease of crucifers: biology, ecology and disease management / Govin Singh Saharan, Naresh K. Mehta, Prabhu Dayal Meena

Online Resource




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The Stockholm paradigm: climate change and emerging disease / Daniel R. Brooks, Eric P. Hoberg, and Walter A. Boeger

Dewey Library - QH543.B76 2019




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Sustainable management of phytoplasma diseases in crops grown in the tropical belt: biology and detection / Chrystel Y. Olivier, Tim J. Dumonceaux, Edel Pérez-López, editors

Online Resource




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Forest pest and disease management in Latin America: modern perspectives in natural forests and exotic plantations / Sergio A. Estay, editor

Online Resource




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Ocean outbreak: confronting the rising tide of marine disease / Drew Harvell

Hayden Library - QH541.5.S3 H37 2019




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Open season: legalized genocide of colored people / Ben Crump

Dewey Library - HV9950.C79 2019




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Centre tells states to tighten security during festival season

Home Ministry also asked five poll-bound states to beef up security in election rallies.




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In election season, Muslim factions unite, meet Sonia Gandhi

Majlis-e-Mushawarat, takes up Muzaffarnagar riots, anti-communal violence Bill with Sonia.




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Srinagar records first sub-zero temperature of season

Pahalgam was the coldest place in Kashmir valley with minimum temperature of minus 4 degree Celsius.




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Biosecurity : the socio-politics of invasive species and infectious diseases / edited by Andrew Dobson, Kezia Barker and Sarah L. Taylor




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Disease that kills kids reaches Bengal



  • DO NOT USE West Bengal
  • India

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Direct transfer of soil in the wet season as a method to establish resprouter species in rehabilitated bauxite mines / M.A. Norman, J.M. Koch

Norman, M. A




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Predicting Pulmonary to Systemic Flow Ratio Using Chest Radiograph in Congenital Heart Disease

This study develops and validates a quantitative method to predict the pulmonary to systemic flow ratio in patients with congenital heart disease from chest radiographs using deep learning.




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Blood Pressure Patterns in Young Adulthood and Cardiovascular Disease and Mortality in Middle Age

This cohort study assesses whether long-term variability and rate of change of blood pressure from young adulthood to midlife are associated with cardiovascular disease and all-cause mortality by middle age.




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Opportunities & Challenges for Polygenic Risk Scores in Prognostication & Prevention of Cardiovascular Disease

Lowering low-density lipoprotein cholesterol (LDL-C) levels remains a mainstay of cardiovascular disease prevention, but gaps in treatment remain, even in persons with hypercholesterolemia and greatly elevated LDL-C levels. Although well-described gene variants in the apolipoprotein B (APOB), low-density lipoprotein receptor (LDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes explain small but important fractions of monogenic hypercholesterolemia, recent attention has turned to prognostication of cardiovascular disease using polygenic risk scores (PRS) that incorporate common genetic variants derived from large-scale genome-wide association studies of lipid subfractions. Earlier PRS considered only variants with genome-wide significance, and newer studies have focused on methods that better capture the variance conferred by millions of variants, suggesting an ability to identify risk equivalent to monogenic mutations. There remains a gap in evidence from prospective observational studies or treatment trials regarding the appropriate placement of PRS in risk assessment and lipid treatment decisions relative to information on rare monogenic gene variants, particularly in multiethnic populations.




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Monogenic vs Polygenic Hypercholesterolemia and Atherosclerotic Cardiovascular Disease Risk

This cohort study uses the UK Biobank cohort data to compare the association of monogenic vs polygenic hypercholesterolemia with the risk of atherosclerotic cardiovascular disease among individuals with comparable levels of low-density lipoprotein cholesterol.




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[ASAP] Ultrasmall Rhodium Nanozyme with RONS Scavenging and Photothermal Activities for Anti-Inflammation and Antitumor Theranostics of Colon Diseases

Nano Letters
DOI: 10.1021/acs.nanolett.9b05035




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Seascape ecology / edited by Simon J. Pittman




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Nanostructured and advanced materials for applications in sensor, optoelectronic and photovaltaic technology / edited by A. Vaseashta, D. Dimova-Malinovska and J. M. Marshall

NATO Advanced Study Institute on Nanostructured and Advanced Materials for Applications in Sensors, Optoelectronic and Photovoltaic Technology (2004 : Sozopol, Bulgaria)




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A high-throughput and untargeted lipidomics approach reveals new mechanistic insight and the effects of salvianolic acid B on the metabolic profiles in coronary heart disease rats using ultra-performance liquid chromatography with mass spectrometry

RSC Adv., 2020, 10,17101-17113
DOI: 10.1039/D0RA00049C, Paper
Open Access
Ying-peng Li, Cong-ying Wang, Hong-tao Shang, Rui-rui Hu, Hui Fu, Xue-feng Xiao
High-throughput lipidomics provides the possibility for the development of new therapeutic drugs.
The content of this RSS Feed (c) The Royal Society of Chemistry









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JAMA Cardiology : Rivaroxaban and Thromboembolic Events in Patients With Heart Failure, Coronary Disease, and Sinus Rhythm

Interview with Barry H. Greenberg, author of Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary Disease, and Sinus Rhythm: A Post Hoc Analysis of the COMMANDER HF Trial, and Marvin A. Konstam, MD, author of Antithrombotic Therapy in Heart Failure—The Clot Thickens





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JAMA Cardiology : Longitudinal Associations Between Income Changes and Incident Cardiovascular Disease

Interview with Scott David Solomon, MD, and Stephen Yishu Wang, BS, authors of Longitudinal Associations Between Income Changes and Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities Study, and Edward P. Havranek, MD, author of The Influence of Social and Economic Factors on Heart Disease