hr Middle East Christians Suffer Still By www.atour.com Published On :: Sat, 13 Jul 2019 23:43:00 UT Middle East Christians Suffer Still Full Article International News
hr Kurdish Tribes Stealing Assyrian Christian Lands By www.atour.com Published On :: Sat, 11 Jan 2020 22:25:00 UT Kurdish Tribes Stealing Assyrian Christian Lands Full Article Bet-Nahren Assyria
hr Wing has made over 350,000 deliveries across three countries By postandparcel.info Published On :: Fri, 22 Mar 2024 17:06:51 +0000 DoorDash and Wing have announced the launch of their drone delivery partnership in the U.S., starting in Christiansburg, VA. Full Article E-Commerce Innovation Parcel Retail Sustainability
hr Grubhub: We’re thrilled to build on our successful collaboration with Amazon By postandparcel.info Published On :: Thu, 30 May 2024 04:00:43 +0000 Amazon and Grubhub today announced they are partnering to make restaurant delivery to customers’ doors more convenient and affordable. Full Article Retail
hr Boeing layoffs weren't just a strike threat By www.yahoo.com Published On :: 2024-11-12T18:22:00Z Full Article
hr Watch as Central California dust storm that caused 20-car pileup whips through Visalia By www.yahoo.com Published On :: 2024-11-12T19:21:29Z Full Article
hr CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients By scienceblogs.com Published On :: Thu, 06 Feb 2020 19:52:53 +0000 CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion. This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years. Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn. sb admin Thu, 02/06/2020 - 14:52 Categories Life Sciences Full Article
hr Are we on the cusp of historic medical breakthroughs? By www.washingtonexaminer.com Published On :: Sun, 31 Dec 2023 13:18:48 GMT During my lifetime, there have been numerous seminal breakthroughs in medicine that greatly changed our ability to prevent or treat disease. I have a good idea of what the next ones will be. Full Article
hr Gov. Josh Green threatens to bring down 'hammer' on landlords in fallout from Hawaii fire By www.washingtonexaminer.com Published On :: Sat, 16 Dec 2023 18:03:07 GMT Gov. Josh Green (D-HI) has threatened to use the "hammer" of emergency orders to convert 3,000 temporary vacation rentals into longer-term housing for survivors displaced by the wildfire that swept across the island of Maui in August. Full Article
hr Three former winners join Tseng at Kingsmill By www.washingtonexaminer.com Published On :: Fri, 05 Apr 2013 04:00:00 GMT Former winners at Kingsmill, Suzann Pettersen (2007), Karrie Webb (2006), and Se Ri Pak (2004), will join superstar Yani Tseng at the Kingsmill Championship, May 2-5. All four players will participate in the tournament for the first time since 2009. They skipped last year’s event, which ended a two-year hiatus for the LPGA Tour at Kingsmill. Full Article
hr Economists call arena relocation threats ‘extortion’ By www.washingtonexaminer.com Published On :: Mon, 07 Aug 2023 12:21:49 GMT (Center Square) — Monumental Sports and Entertainment have been in talks this summer of a future move to northern Virginia for some of Washington, D.C.’s professional sports teams if the city doesn’t chip in more for improvements to their sports arena, the Washington Post has reported. Full Article
hr Three times states went to war with the NCAA in 2023 By www.washingtonexaminer.com Published On :: Sun, 31 Dec 2023 11:00:05 GMT Several states have gone to war with the NCAA over various matters in 2023, marking a bumpy year for the governing body of college sports. Full Article
hr Glenn Youngkin’s popularity at record high, approval throughout Virginia By www.washingtonexaminer.com Published On :: Fri, 05 Jan 2024 18:03:32 GMT Virginia Gov. Glenn Youngkin’s popularity continues to soar, even after voters turned the commonwealth’s general assembly over to Democrats. Full Article
hr Officials confirm H5N1 bird flu outbreaks in three California dairy farms By www.latimes.com Published On :: Wed, 4 Sep 2024 10:00:19 GMT Testing has confirmed H5N1 bird flu outbreaks at three Central Valley dairy farms. Officials say the infections were likely the result of cattle transportation. Full Article
hr Three more California dairy herds infected with H5N1 bird flu By www.latimes.com Published On :: Wed, 11 Sep 2024 19:51:31 GMT Three more California dairy herds have been infected with H5N1 bird flu. A new case of human infection has also been reported in Missouri. Full Article
hr 'Grief into action.' Philanthropists give historic $150 million donation to City of Hope for pancreatic cancer research By www.latimes.com Published On :: Tue, 17 Sep 2024 09:30:06 GMT Entrepreneur Emmet Stephenson and his daughter are giving $150 million to City of Hope to fund an award for innovation research in pancreatic cancer. It's the largest single gift the center has received. Full Article
hr Are tiny black holes zipping through our solar system? Scientists hope to find out By www.latimes.com Published On :: Tue, 17 Sep 2024 10:00:27 GMT Scientists say microscopic black holes could explain the elusive "dark matter" that makes up a quarter of all matter in the universe. But can it be proven? Full Article
hr Jim Williams: Tennis legend Chris Evert believes Serena Williams will take home French Open trophy By www.washingtonexaminer.com Published On :: Mon, 27 May 2013 04:00:00 GMT In the long storied history of the French Open, few men or women has been more successful on the red clay of Roland Garros than Chris Evert. She holds a record nine French Open titles: seven singles championships and two in doubles. Evert's 94-15 record at the French Open is the best winning percentage in the history of the event. Full Article
hr Pelosi to throw out first pitch at Washington Nationals Night OUT game By www.washingtonexaminer.com Published On :: Tue, 06 Jun 2023 14:25:12 GMT Former House Speaker Nancy Pelosi (D-CA) is set to throw out the ceremonial first pitch Tuesday at the Washington Nationals' Night OUT game. Full Article
hr McConnell successor shrouded in uncertainty ahead of monumental Senate vote By www.washingtonexaminer.com Published On :: Wed, 13 Nov 2024 05:34:46 +0000 Republican senators emerged Tuesday night from a candidate forum largely tight-lipped on which of their colleagues they would support to replace Senate GOP Leader Mitch McConnell (R-KY) on the eve of a secret ballot vote and President-elect Donald Trump’s visit to Washington. Two hours of huddling behind closed doors with the trio of contenders fielding […] Full Article News Senate Congress John Cornyn John Thune Mitch McConnell Rick Scott
hr Raptors 96, Wizards 88: Three observations By www.washingtonexaminer.com Published On :: Wed, 20 Feb 2013 05:00:00 GMT That was some glorious return from the All-Star break for the Wizards, now wasn’t it? From the scoreboard that didn’t work, including the time and shot clock normally kept above the backboards, to Wale getting in a feud with the Toronto Raptors broadcasters, who called him a local rapper and said he was ‘no Drake,’ to the random “Jor-dan Craw-ford!” chant that sprang to life late as the Wizards failed to generate any consistent offensive flow and as Crawford himself remained reclined at the end of the bench throughout the game. Full Article
hr Wizards 105, Rockets 103: Three observations By www.washingtonexaminer.com Published On :: Sun, 24 Feb 2013 05:00:00 GMT *Whatever the trade deadline and All-Star break did to disrupt the flow of the resurgent Wizards, they’re back. The idea of home wins over legitimate Western Conference teams Denver and Houston on back-to-back nights appeared daunting after the Wizards looked lethargic in their loss to Toronto earlier in the week. Instead, they proved they can still dictate how they want to play defensively over the course of 48 minutes against two teams with different kinds of significant offensive punch. Full Article
hr Wizards 90, Raptors 84: Three observations By www.washingtonexaminer.com Published On :: Tue, 26 Feb 2013 05:00:00 GMT With their 90-84 win at Air Canada Centre on Monday, the Wizards sort of vindicated the notion that who they are now is a team that’s better on the road than their record (5-22) would indicate. I say “sort of” because that was the epitome of ugly. But it was also a game in which the Wizards never trailed by more than three points. As bad as they looked offensively at times (20 turnovers), they still had 23 assists on 34 field goals and made the Raptors, who shot 36.7 percent, look even worse. Full Article
hr Pistons 96, Wizards 95: Three observations By www.washingtonexaminer.com Published On :: Thu, 28 Feb 2013 05:00:00 GMT There’ll be no more teasing with the standings after the Wizards lost, 96-95, to the Detroit Pistons. I’ll get to that in a sec, but first: Full Article
hr Trump says he believes LIV-PGA merger will go through: 'Very good for golf' By www.washingtonexaminer.com Published On :: Sun, 02 Jul 2023 20:45:52 GMT Former President Donald Trump spoke favorably of the controversial merger between LIV Golf and PGA Tour. Full Article
hr In Silicon Valley, more support for Trump is trickling in. Is it a big threat to Biden? By www.latimes.com Published On :: Sat, 8 Jun 2024 00:47:57 GMT In the deeply Democratic Silicon Valley, there are some defectors. They're setting their sights — and their money — on Trump in the 2024 election. Full Article
hr Get paid or sue? How the news business is combating the threat of AI By www.latimes.com Published On :: Wed, 24 Jul 2024 10:00:42 GMT Many news outlets are already dealing with declining revenue from digital ads and subscriptions. Now, their business models are poised to be disrupted again by AI. Full Article
hr A new book chronicles the battle over AI, but fails to question whether AI is worth battling over By www.latimes.com Published On :: Fri, 6 Sep 2024 10:00:25 GMT Bloomberg's Parmy Olson delivers a buzzy, timely biography of AI's promoters, but what are they promoting? Full Article
hr Introducing iQue®'s 2nd Edition High-Throughput Cytometry Handbook: Fast. Simple. Discover the Future of Cell Analysis! By www.the-scientist.com Published On :: Tue, 29 Oct 2024 19:19:58 GMT This handbook is designed to empower both new and seasoned flow cytometry users who are curious about the unique capabilities of HTS cytometry. Full Article The Scientist The Marketplace
hr Genetic Signals Linked to X Chromosome Loss Later in Life By www.the-scientist.com Published On :: Tue, 12 Nov 2024 05:00:32 GMT Loss of the X chromosome increases with age and may have implications for health and disease risk. Full Article News News & Opinion
hr Microsoft Edge Has a New Trick to Get Data From Chrome Users on Windows By www.thurrott.com Published On :: Tue, 12 Nov 2024 17:19:38 +0000 Microsoft is once again trying to get Chrome users to share their browser data with its Edge browser on Windows. The post Microsoft Edge Has a New Trick to Get Data From Chrome Users on Windows appeared first on Thurrott.com. Full Article Cloud Microsoft Edge Google Chrome Microsoft Consumer Services Web browsers Windows Windows 11
hr Merry Christmas to All RSS Generator Users! By www.rssfeedsgenerator.com Published On :: Wed, 24 Dec 2014 20:00:02 +0000 Dear Friends, Our team would like to wish you a Merry Christmas and Happy New Year! We thank you for using our RSS tools and looking forward to meet you all next year full of energy and espiration! We would like to share our nearest development plans: RSS Reader New General RSS Feeds Generator […] Full Article Service News
hr Adopt A Child For Christmas By www.nativeamericanmusicfund.com Published On :: Wed, 15 Oct 2014 14:58:00 +0200 You can now "Adopt A Child" for Christmas. We will be hosting an adoption party. We hope many will donate funds to buy christmas instruments. Please help by adopting a child. Full Article Blog
hr Prevention of Deep Vein Thrombosis (DVT) By www.newlook.com.sg Published On :: Tue, 17 Aug 2004 18:42:49 +0800 This article shows a randomized, controlled prospective study to measure the effectiveness of calf compression in reducing the incidence of DVT. Full Article
hr TED Stockings: Proven DVT reduction through published peer reviewed clinical studies By www.newlook.com.sg Published On :: Thu, 19 Aug 2004 04:22:23 +0800 This article proves the point that only the T.E.D. Anti-Embolism Stocking has been clinically proven to prevent DVT in over 14,000 patients. Clinical proof is through published peer reviewed clinical studies. Full Article
hr 40 Years and Counting: Christian metal band Stryper continues to rock By www.tucsonweekly.com Published On :: Thu, 24 Oct 2024 04:00:00 -0700 Stryper is back with “When We Were Kings,” a solid album with big riffs and an even bigger message… Full Article Music/Music Feature
hr MeFi: Like a thriller, like a comedy, like a tragedy By www.metafilter.com Published On :: Sun, 14 Jul 2019 06:12:30 -0800 The Mueller Report From Business Insider, adapted by Mark Bowden, author of "Black Hawk Down", with illustrations by Chad Hurd, art director at "Archer." Full Article Favorite
hr MeFi: "One of the links you entered was found in 24 previous threads" By www.metafilter.com Published On :: Sun, 14 Jul 2024 08:48:23 -0800 Cat-Scan.com is one of the strangest sites I've seen in some time. I have no idea how these people got their cats wedged into their scanners, or why. Full Article Favorite
hr CounterSpin - Thr 6pm By www.kser.org Published On :: Wed, 16 Dec 2015 14:53:19 -0800 CounterSpin is FAIR’s weekly radio show, produced and hosted by Janine Jackson. The program provides a critical examination of the major stories every week, and exposes what corporate media might have missed in their own coverage. Full Article
hr Between the Lines - Thr 6:30pm By www.kser.org Published On :: Wed, 23 Dec 2015 13:21:05 -0800 Between The Lines is a weekly syndicated half-hour radio news magazine featuring progressive perspectives on national and international political, economic and social issues. Full Article
hr The Vault - Thr 10:30pm By www.kser.org Published On :: Tue, 15 Dec 2015 23:53:58 -0800 For those who remember KYYX, KJET and Skoochies, host Bill Davis creates a weekly mixtape of exploratory styles like new wave, industrial, goth, punk music and more! Full Article
hr Kamala Harris throws support behind federal cannabis legalization By www.inlander.com Published On :: Thu, 24 Oct 2024 01:30:00 -0700 Vice President Kamala Harris announced last week her intention, if elected president, to "legalize marijuana at the federal level."… Full Article Green Zone
hr Across the Inland Northwest, national and local talent comes together to deliver top-tier entertainment throughout the year By www.inlander.com Published On :: Mon, 23 Sep 2024 01:30:00 -0700 When you take stock of all the performing and fine arts offerings around the region, there's little doubt that entertainment lovers are spoiled for choice… Full Article Arts & Entertainment
hr New music we love: Fiona Apple's thrilling Fetch the Bolt Cutters is a rush of lacerating lyrics and swirling sonics By www.inlander.com Published On :: Fri, 24 Apr 2020 15:26:00 -0700 You don't have to wander around the internet long before bumping into a rave review of Fiona Apple's new record Fetch the Bolt Cutters: It has inspired breathless acclaim, has already been labeled a masterwork and is notably the first new album in nearly a decade that Pitchfork has assigned a perfect 10/10 rating… Full Article Music/Music News
hr Mark Rylance dazzles in a rare leading role in the suspense thriller The Outfit By www.inlander.com Published On :: Thu, 17 Mar 2022 01:30:00 -0700 For a few minutes there, I was about to make a huge mistake in contemplating Mark Rylance's performance in The Outfit: I was about to compare him to another actor… Full Article Screen/Movie Reviews
hr Elberton, Wash: This picturesque Palouse town thrived from agriculture and timber, but died out as nearby resources did By www.inlander.com Published On :: Thu, 31 Oct 2024 01:30:00 -0700 I don't realize it until I'm standing at the base of the steps of the United Brethren Church in Elberton, but I've made the hourlong drive from Spokane to the Whitman County ghost town on a Sunday… Full Article Arts & Culture
hr Three takeaways from Gonzaga’s dominant start to the season By www.inlander.com Published On :: Mon, 15 Nov 2021 14:43:27 -0800 The Gonzaga Bulldogs went 2-0 last week, with wins over Dixie State and Texas. One of those games may as well have been a scheduled win, while the other was a marquee match-up of two top-five teams… Full Article Culture/Sports
hr A Washington-wide nonprofit helps old places survive — and thrive By www.inlander.com Published On :: Thu, 13 Jan 2022 01:30:00 -0800 Since 1976, the nonprofit Washington Trust for Historic Preservation has been advocating to save old places from oblivion… Full Article Culture/Arts & Culture
hr Shrek, sharks and Kung Fu Panda: Spokane becomes the first U.S. destination for new Dreamworks Animation exhibit By www.inlander.com Published On :: Thu, 14 Apr 2022 01:30:00 -0700 Don't even try to deny it, you're a total sucker for an animated children's movie… Full Article Culture/Arts & Culture
hr Spokane artist Chris Bovey opens Vintage Print + Neon storefront, studio and workshop in the Garland District By www.inlander.com Published On :: Thu, 29 Sep 2022 01:00:00 -0700 Chris Bovey's new shop on Garland Avenue isn't technically open on Tuesday, but it's too enjoyably warm and sunny on a late September afternoon to keep the roll-up door along the sidewalk closed… Full Article Culture/Arts & Culture