Brussels is searching for bright ideas on how to fix the Common European Asylum System. While recent EU-level legal reforms have stalled, this report examines the many innovative, operations-focused approaches Member States have used since the 2015-16 migration crisis to improve registration and reception systems, asylum case processing, and options for returning failed asylum seekers.

In Staphylococcus aureus–caused endocarditis, the pathogen secretes staphylocoagulase (SC), thereby activating human prothrombin (ProT) and evading immune clearance. A previous structural comparison of the SC(1–325) fragment bound to thrombin and its inactive precursor prethrombin 2 has indicated that SC activates ProT by inserting its N-terminal dipeptide Ile1-Val2 into the ProT Ile16 pocket, forming a salt bridge with ProT's Asp194, thereby stabilizing the active conformation. We hypothesized that these N-terminal SC residues modulate ProT binding and activation. Here, we generated labeled SC(1–246) as a probe for competitively defining the affinities of N-terminal SC(1–246) variants preselected by modeling. Using ProT(R155Q,R271Q,R284Q) (ProTQQQ), a variant refractory to prothrombinase- or thrombin-mediated cleavage, we observed variant affinities between ∼1 and 650 nm and activation potencies ranging from 1.8-fold that of WT SC(1–246) to complete loss of function. Substrate binding to ProTQQQ caused allosteric tightening of the affinity of most SC(1–246) variants, consistent with zymogen activation through occupation of the specificity pocket. Conservative changes at positions 1 and 2 were well-tolerated, with Val1-Val2, Ile1-Ala2, and Leu1-Val2 variants exhibiting ProTQQQ affinity and activation potency comparable with WT SC(1–246). Weaker binding variants typically had reduced activation rates, although at near-saturating ProTQQQ levels, several variants exhibited limiting rates similar to or higher than that of WT SC(1–246). The Ile16 pocket in ProTQQQ appears to favor nonpolar, nonaromatic residues at SC positions 1 and 2. Our results suggest that SC variants other than WT Ile1-Val2-Thr3 might emerge with similar ProT-activating efficiency.

A modern flavour twist on an old favourite. Enjoy!

Monique Bowley, shared this recipe on Foodie Tuesday, a weekly segment on ABC Radio Melbourne's Drive program at 3.30pm.

OBJECTIVE

Data regarding the effects of sodium–glucose cotransporter 2 inhibitors in the elderly (age ≥65 years) and very elderly (age ≥75 years) are limited.

Watch a discussion between three educators who ran for their state legislatures about their experiences on the campaign trail.

In Arkansas, Ohio, and Wisconsin, educators and advocates will be on this year's ballot for governor, a position that will inevitably have an outsized role in shaping education policy.

Police in northeast Ohio have placed a school resource officer on unpaid leave for activating a Taser to wake up a sleeping student.

Watch a discussion between three educators who ran for their state legislatures about their experiences on the campaign trail.

High school teacher Jenefer Pasqua is running for Wyoming's state legislature to fight against education funding cuts.

Wayne Sanstead, who has been North Dakota's state schools superintendent for nearly three decades, has decided not to run for an eighth term this fall.

President Donald Trump has tapped Mark Schultz, a deputy commissioner of education in Nebraska, to serve as commissioner of the rehabilitation services administration at the Education Department.

In Arkansas, Ohio, and Wisconsin, educators and advocates will be on this year's ballot for governor, a position that will inevitably have an outsized role in shaping education policy.

Bethany Hill, the principal at Central Elementary School in Cabot, Ark., shuns a formal office in favor of roving around classrooms, hallways, the playground, and the cafeteria, where she can be as close as possible to teachers and students all day.

Atlanta's top school official has resigned and is fighting to keep a report investigating his background secret.

The Difficulties Of South American Football

This publication outlines the Commonwealth Child Safe Framework requirements and guidance for its implementation.The primary audience for this publication is Commonwealth entities. This publication has been developed to assist entities to understand and implement the requirements of the Commonwealth Child Safe Framework.

Exploring and Affirming My Life is designed to v help the reader undertake a personal exploration of his or her own life. Often important life issues get overlooked in the bustle of modern living and a guided encouragement to find issues that need to be celebrated or need to be reconciled helps as we grow older. Reminiscence can be a natural process of life but on its own it doesn't always bring out those things we need to focus upon. This book encourages the reader to look at spiritual issues particularly, and to find the joy and the forgiveness which comes when our lives are in tune with the wonderful God who loves us so deeply.

The Regional Recycling Transport Assistance Package provides funding to support resource recovery and recycling in regional Queensland, helping fund the costs of transporting recyclable material from regional Queensland to facilities where it can be recovered or processed and turned into new products. Details regarding eligible applicants, projects and costs are provided in these guidelines.

Aboriginal Australians -- Land tenure.

Human trafficking.

Leipzig : F.C.W. Vogel, 1889.

Berlin : Hirschwald, 1905.

London : Cassell, 1901.

London : Cassell, 1894.

Paris : G. Steinheil, 1888.