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The Bayesian Update: Variational Formulations and Gradient Flows

Nicolas Garcia Trillos, Daniel Sanz-Alonso.

Source: Bayesian Analysis, Volume 15, Number 1, 29--56.

Abstract:
The Bayesian update can be viewed as a variational problem by characterizing the posterior as the minimizer of a functional. The variational viewpoint is far from new and is at the heart of popular methods for posterior approximation. However, some of its consequences seem largely unexplored. We focus on the following one: defining the posterior as the minimizer of a functional gives a natural path towards the posterior by moving in the direction of steepest descent of the functional. This idea is made precise through the theory of gradient flows, allowing to bring new tools to the study of Bayesian models and algorithms. Since the posterior may be characterized as the minimizer of different functionals, several variational formulations may be considered. We study three of them and their three associated gradient flows. We show that, in all cases, the rate of convergence of the flows to the posterior can be bounded by the geodesic convexity of the functional to be minimized. Each gradient flow naturally suggests a nonlinear diffusion with the posterior as invariant distribution. These diffusions may be discretized to build proposals for Markov chain Monte Carlo (MCMC) algorithms. By construction, the diffusions are guaranteed to satisfy a certain optimality condition, and rates of convergence are given by the convexity of the functionals. We use this observation to propose a criterion for the choice of metric in Riemannian MCMC methods.




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A Bayesian Conjugate Gradient Method (with Discussion)

Jon Cockayne, Chris J. Oates, Ilse C.F. Ipsen, Mark Girolami.

Source: Bayesian Analysis, Volume 14, Number 3, 937--1012.

Abstract:
A fundamental task in numerical computation is the solution of large linear systems. The conjugate gradient method is an iterative method which offers rapid convergence to the solution, particularly when an effective preconditioner is employed. However, for more challenging systems a substantial error can be present even after many iterations have been performed. The estimates obtained in this case are of little value unless further information can be provided about, for example, the magnitude of the error. In this paper we propose a novel statistical model for this error, set in a Bayesian framework. Our approach is a strict generalisation of the conjugate gradient method, which is recovered as the posterior mean for a particular choice of prior. The estimates obtained are analysed with Krylov subspace methods and a contraction result for the posterior is presented. The method is then analysed in a simulation study as well as being applied to a challenging problem in medical imaging.




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High-Dimensional Confounding Adjustment Using Continuous Spike and Slab Priors

Joseph Antonelli, Giovanni Parmigiani, Francesca Dominici.

Source: Bayesian Analysis, Volume 14, Number 3, 825--848.

Abstract:
In observational studies, estimation of a causal effect of a treatment on an outcome relies on proper adjustment for confounding. If the number of the potential confounders ( $p$ ) is larger than the number of observations ( $n$ ), then direct control for all potential confounders is infeasible. Existing approaches for dimension reduction and penalization are generally aimed at predicting the outcome, and are less suited for estimation of causal effects. Under standard penalization approaches (e.g. Lasso), if a variable $X_{j}$ is strongly associated with the treatment $T$ but weakly with the outcome $Y$ , the coefficient $eta_{j}$ will be shrunk towards zero thus leading to confounding bias. Under the assumption of a linear model for the outcome and sparsity, we propose continuous spike and slab priors on the regression coefficients $eta_{j}$ corresponding to the potential confounders $X_{j}$ . Specifically, we introduce a prior distribution that does not heavily shrink to zero the coefficients ( $eta_{j}$ s) of the $X_{j}$ s that are strongly associated with $T$ but weakly associated with $Y$ . We compare our proposed approach to several state of the art methods proposed in the literature. Our proposed approach has the following features: 1) it reduces confounding bias in high dimensional settings; 2) it shrinks towards zero coefficients of instrumental variables; and 3) it achieves good coverages even in small sample sizes. We apply our approach to the National Health and Nutrition Examination Survey (NHANES) data to estimate the causal effects of persistent pesticide exposure on triglyceride levels.




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Larry Brown’s Work on Admissibility

Iain M. Johnstone.

Source: Statistical Science, Volume 34, Number 4, 657--668.

Abstract:
Many papers in the early part of Brown’s career focused on the admissibility or otherwise of estimators of a vector parameter. He established that inadmissibility of invariant estimators in three and higher dimensions is a general phenomenon, and found deep and beautiful connections between admissibility and other areas of mathematics. This review touches on several of his major contributions, with a focus on his celebrated 1971 paper connecting admissibility, recurrence and elliptic partial differential equations.




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Rejoinder: Response to Discussions and a Look Ahead

Vincent Dorie, Jennifer Hill, Uri Shalit, Marc Scott, Dan Cervone.

Source: Statistical Science, Volume 34, Number 1, 94--99.

Abstract:
Response to discussion of Dorie (2017), in which the authors of that piece express their gratitude to the discussants, rebut some specific criticisms, and argue that the limitations of the 2016 Atlantic Causal Inference Competition represent an exciting opportunity for future competitions in a similar mold.




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Tapadh leibh airson nach do smoc sibh / design : Biman Mullick.

London (33 Stillness Rd, SE23 1NG) : Cleanair, Campaign for a Smoke-free Environment, [198-?]




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Ha gubin wadnahaaga! = Heart burn. / design : Biman Mullick.

London : Cleanair (33 Stillness Rd, London, SE23 1NG), [198-?]




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Tapadh leibh airson nach do smoc sibh / design: Biman Mullick.

London (33 Stillness Road London SE23 1NG) : Cleanair Campaign for a Smoke-free Environment, [198-?]




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Smoking is bad for your image / design : Biman Mullick.

[London?], [199-?]




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Taylor Swift, Hailey Bieber, and Tons of Other Celebs’ Favorite Leggings Are on Sale Ahead of Black Friday

Here’s where you can snag their Alo Yoga Moto leggings for less.




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Forget Black Booties, Amal Clooney and J.Lo Are Wearing This Weather-Resistant Boot Trend Instead

And it’s on sale at Nordstrom.




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Gut Microbes and the Brain: Paradigm Shift in Neuroscience

Emeran A. Mayer
Nov 12, 2014; 34:15490-15496
Symposium




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Readiness Potential and Neuronal Determinism: New Insights on Libet Experiment

Karim Fifel
Jan 24, 2018; 38:784-786
Journal Club




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Advances in Enteric Neurobiology: The "Brain" in the Gut in Health and Disease

Subhash Kulkarni
Oct 31, 2018; 38:9346-9354
Symposium and Mini-Symposium




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Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

Irune Diaz-Aparicio
Feb 12, 2020; 40:1453-1482
Development Plasticity Repair




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Synaptic Specificity and Application of Anterograde Transsynaptic AAV for Probing Neural Circuitry

Brian Zingg
Apr 15, 2020; 40:3250-3267
Systems/Circuits




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The Representation of Semantic Information Across Human Cerebral Cortex During Listening Versus Reading Is Invariant to Stimulus Modality

Fatma Deniz
Sep 25, 2019; 39:7722-7736
BehavioralSystemsCognitive




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Daily Marijuana Use Is Not Associated with Brain Morphometric Measures in Adolescents or Adults

Barbara J. Weiland
Jan 28, 2015; 35:1505-1512
Neurobiology of Disease




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Grey Matter Volume Differences Associated with Extremely Low Levels of Cannabis Use in Adolescence

Catherine Orr
Mar 6, 2019; 39:1817-1827
BehavioralSystemsCognitive




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Endothelial Adora2a Activation Promotes Blood-Brain Barrier Breakdown and Cognitive Impairment in Mice with Diet-Induced Insulin Resistance

Masaki Yamamoto
May 22, 2019; 39:4179-4192
Neurobiology of Disease




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Increased Neural Activity in Mesostriatal Regions after Prefrontal Transcranial Direct Current Stimulation and L-DOPA Administration

Benjamin Meyer
Jul 3, 2019; 39:5326-5335
Systems/Circuits




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Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation [published erratum appears in J Neurosci 1992 Aug;1

KM Harris
Jul 1, 1992; 12:2685-2705
Articles




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Head-direction cells recorded from the postsubiculum in freely moving rats. I. Description and quantitative analysis

JS Taube
Feb 1, 1990; 10:420-435
Articles




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Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain

Fiona Doetsch
Jul 1, 1997; 17:5046-5061
Articles




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Broadband Shifts in Local Field Potential Power Spectra Are Correlated with Single-Neuron Spiking in Humans

Jeremy R. Manning
Oct 28, 2009; 29:13613-13620
BehavioralSystemsCognitive




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Adaptive representation of dynamics during learning of a motor task

R Shadmehr
May 1, 1994; 14:3208-3224
Articles




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Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex

Chris Englund
Jan 5, 2005; 25:247-251
BRIEF COMMUNICATION




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Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

HG Kuhn
Mar 15, 1996; 16:2027-2033
Articles




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BIRTHDAY PARTY PACKAGE/ DROP-IN LEADERS




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Rassegna trimestrale BRI dicembre 2017: Un paradossale inasprimento ci riporta all'enigma del mercato obbligazionario

Italian translation of the BIS press release about the BIS Quarterly Review, December 2017




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A fronte della diffusione delle criptovalute, le autorità devono essere pronte ad agire - Agustín Carstens

Italian translation of Press Release about BIS General Manager Agustín Carstens giving a speech on "Money in the digital age: what role for central banks?" (6 February 2018)




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Informe Trimestral del BPI, marzo de 2018: La volatilidad vuelve a cobrar protagonismo tras un episodio de inestabilidad en los mercados bursátiles

Spanish translation of the BIS press release about the BIS Quarterly Review, March 2018




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Las monedas digitales de bancos centrales podrían afectar a los pagos, la política monetaria y la estabilidad financiera

Spanish version of Press release about CPMI and the Markets Committee issuing a report on "Central bank digital currencies" (12 March 2018)




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Nuevos miembros del Comité de Pagos e Infraestructuras del Mercado

Spanish version of Press release about new members joining the Committee on Payments and Market Infrastructures (19 March 2018)




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Preguntas frecuentes sobre requerimientos de capital por riesgo de mercado

Spanish translation of "Frequently asked questions on market risk capital requirements" by the Basel Committee, March 2018.




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Las divergencias se amplían en los mercados: Informe Trimestral del BPI

Spanish translation of the BIS press release about the BIS Quarterly Review, September 2018




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Requisitos de divulgación para el Tercer Pilar - Macro actualizado

Spanish translation of "Pillar 3 disclosure requirements - updated framework", December 2018




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El Informe Trimestral del BPI analiza la caída y posterior rebote de los mercados

Spanish translation of the BIS press release about the BIS Quarterly Review, March 2019




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Pablo Hernández de Cos, nombrado Presidente del Comité de Supervisión Bancaria de Basilea

Spanish version of Press release about Pablo Hernández de Cos appointed as Chairman of Basel Committee on Banking Supervision, 7 March 2019. Pablo Hernández de Cos, nombrado Presidente del Comité de Supervisión Bancaria de Basilea.




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Oportunidades y riesgos de la entrada de las big tech en el sector financiero

Spanish version of BIS Press Release - Big tech in finance: opportunities and risks, 23 June 2019




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Ha llegado la hora de poner en marcha todos los motores

Spanish translation of the speech by Mr Agustín Carstens, General Manager of the BIS, on the occasion of the Bank's Annual General Meeting, Basel, 30 June 2019.




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Ha llegado la hora de poner en marcha todos los motores, afirma el BPI en su Informe Económico Anual

Spanish translation of the BIS press release on the presentation of the Annual Economic Report 2019, 30 June 2019.




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Aprendizajes derivados de veinticinco años de autonomía del Banco de México

Discurso del Dr. Agustín Carstens, Director General del Banco de Pagos Internacionales, en la Celebración del 25 Aniversario de la Autonomía del Banco de México, Ciudad de México, 22 de noviembre de 2019.




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you stupid bobblehead




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poetry reading i just quit my job today




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ASÍ QUE LO LOGRASTE QUIÉN IBA A DECIRLO. FELICIDADES Y ¡BIENVENIDO! S V




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Academy funds three leading engineers to tackle major industry challenges




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Academy welcomes budget announcements on infrastructure and research




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Academy responds to novel coronavirus and calls for ideas




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Academy President comments on postponement of COP26