el

Facile one-pot synthesis of novel imidates as multifunctional organic fluorescent materials

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01628A, Research Article
Feng-Ting Liu, Shuo Wang, Yong-Shun Chen, Jun-Ying Miao, Bao-Xiang Zhao, Zhao-Min Lin
A novel one-pot synthesis of multifunctional organic fluorescent imidates from quinolinium salt derivatives, nitrosoarenes and alcohols was presented. This method had a wide substrate scope and excellent isolated yields.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

General ppm-level Pd-catalysed asymmetric diarylalkyne hydrosilylation to access structurally diverse Si-stereogenic vinylsilanes

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01698J, Research Article
Heng Xu, Han-Xiao Yu, An-Jiu Wen, Fang-Ying Ling, Fei Ye, Li Li, Fuk Yee Kwong, Li-Wen Xu
The first example of enantioselective Pd-catalyzed hydrosilylation of symmetric and asymmetric diarylalkynes to access novel Si-stereogenic vinylsilanes with excellent ee and a high TON is realized under mild reaction conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Stereoselective access to furan-fused [5.5.0] bicyclic heterocycles enabled by gold-catalyzed asymmetric [8 + 4] cycloaddition

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01841A, Research Article
Xunhua Wang, Jianhua Wang, Xiaoxun Li
A gold-catalyzed asymmetric [8 + 4] cycloaddition was developed to afford highly functionalized furan/pyrrole-fused [5.5.0] polycyclic heterocycles with good diastereo- and enantioselectivity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Visible-light mediated selective phosphonylation modification of tryptophan residues in oligopeptides

Org. Chem. Front., 2024, 11,6287-6292
DOI: 10.1039/D4QO01028K, Research Article
Wenfang Xiong, Junye He, Jinyao Liu, Peiru Chen, Shiqi Xu, Yipeng Liu, Shiting Chen, Yuanyuan You, Zhenyu Chen, Jinwu Zhao
A direct C2-H phosphonylation strategy driven by visible light for specific modification of tryptophan-containing peptides has been reported, providing a plethora of phosphorylated tryptophan-containing peptides
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Towards the total synthesis of mandelalide B: construction of the tetrahydrofuran/α-hydroxyl lactone fragment

Org. Chem. Front., 2024, 11,6353-6357
DOI: 10.1039/D4QO01433B, Research Article
Jia-Lei Yan, Jie Yu, Yingying Cheng, Mingze Yang, Zhengshuang Xu, Tao Ye
A stereocontrolled synthesis of the tetrahydrofuran/α-hydroxy lactone fragment of mandelalide B has been accomplished. The synthesis features a Horner-Wadsworth-Emmons fragment assembly strategy and a highly stereospecific iodine-induced cyclization.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

18F-labelling of nitrogen-containing aryl boronates – anti-cancer drug melflufen as a case study

Org. Chem. Front., 2024, 11,6411-6417
DOI: 10.1039/D4QO01594K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kevin Bajerke, Fredrik Lehmann, Gunnar Antoni, Kálmán J. Szabó
This study addresses the 18F-labelling of nitrogen-containing arenes via copper-mediated radiofluorination (CMRF). In this case study, derivatives/fragments of the anti-cancer drug melflufen were targeted.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Chiral synthetic unprecedented spiro[indoline-2,3'-thiophen]-3-ones via an organocatalytic asymmetric sulfa-Michael/aldol cascade reaction

Org. Chem. Front., 2024, 11,6426-6436
DOI: 10.1039/D4QO01551G, Research Article
Mao Zhang, Xing-Hai Fei, Gui-Ping Yang, Cheng Lin, Wen-Jie Li, Ming-Liang Rao, Meng Zhou, Chong Zhao, Bin He, Yong-Long Zhao
A cinchona-derived squaramide-catalyzed asymmetric sulfa-Michael/aldol cascade reaction of 2-ylideneoxindoles with 1,4-dithiane-2,5-diol was developed to realize the chiral synthesis of spiro[indoline-2,3'-thiophen]-3-ones.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Well-defined chiral dinuclear copper-catalyzed tandem asymmetric propargylic amination–carboxylative cyclization sequence toward chiral 2-oxazolidinone derivatives

Org. Chem. Front., 2024, 11,6319-6326
DOI: 10.1039/D4QO01368A, Research Article
Yu Lan, Peng Liu, Zekai Fang, Lili Shao, Qilong Cai, Xiaoming Wang
A variety of chiral 2-oxazolidinones was obtained via a dinuclear copper-catalyzed asymmetric propargylic amination–carboxylative cyclization sequence of propargylic esters with alkyl amine hydrochlorides and CO2.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Theoretical insights into Pd-catalyzed dual γ-1,1-C(sp3)–H activation of aliphatic carboxylic acids: mechanistic pathways, substituent influence on product selectivity, diastereoselectivity, and additive effects

Org. Chem. Front., 2024, 11,6393-6410
DOI: 10.1039/D4QO01451K, Research Article
Jiaoyang Liu, Li-juan Huang, Zeang Sun, Juan Li
DFT calculations were employed to explore the detailed reaction mechanism and the origins of the experimentally observed product, regio-, and diastereoselectivities in the Pd-catalyzed dual-γ-1,1-C(sp3)–H activation of aliphatic carboxylic acids.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

A general method for E-selective olefination of acylsilanes with isocyanides via silver catalysis

Org. Chem. Front., 2024, 11,6450-6458
DOI: 10.1039/D4QO01528B, Research Article
Xiu-Xia Liang, Dan-Ni Yang, Xiao-Hui Yan, Peng Wang, Man-Yi Han
A silver-catalyzed olefination reaction between acylsilanes and isocyanides is developed, resulting in E-vinylsilanes with good yields and high stereoselectivities.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Nickel-catalysed enantioselective cross-electrophile coupling reaction with the retention of the β-fluorine atom

Org. Chem. Front., 2024, 11,6459-6469
DOI: 10.1039/D4QO01555J, Research Article
Xin-Yi Shi, Xueyuan Yan, Xiaodong Tang, Shi-Jing Zhai, Genping Huang, Jun-An Ma, Fa-Guang Zhang
A nickel-catalysed enantioselective reductive cross-coupling reaction of a new monofluoromethyl building block with acid chlorides is developed to give chiral α-monofluoromethyl acyloin derivatives.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Electrochemical approach for upgrading the pollutant CS2: three-component N–H thiocarbamylation of sulfoximines

Org. Chem. Front., 2024, 11,6477-6482
DOI: 10.1039/D4QO01310G, Research Article
Peng Qian, Wenjing Xiong, Qian Meng, Jinxiu Liu, Xiyuan Li, Liangquan Sheng
We report an electrochemical approach for upgrading the pollutant CS2via the thiocarbamylation of sulfoximines, in which CS2 and amines are incorporated as a readily available source of dithiocarbamate.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Carbonate-assisted selectively deoxygenative cross-coupling reaction between aryl and aliphatic aldehydes: a straightforward route to access α-alkylated aryl ketones

Org. Chem. Front., 2024, 11,6510-6517
DOI: 10.1039/D4QO01517G, Research Article
Yu Sun, Yi Wang, Zhijun Zuo
A novel reductive cross-coupling reaction of two different aldehydes for rapidly assembling α-alkylated aryl ketones has been developed. The inexpensive carbonate served not only as a base but also as an efficient electron donor.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Cobalt-catalyzed enantioselective reductive addition of ketimine with cyclopropyl chloride to construct chiral amino esters bearing cyclopropyl fragments

Org. Chem. Front., 2024, 11,6311-6318
DOI: 10.1039/D4QO01474J, Research Article
Jiangtao Hu, Tingting Xia, Xianqing Wu, Hongrui Feng, Jingping Qu, Yifeng Chen
Co-catalyzed asymmetric reductive addition of ketimine with cyclopropyl chloride has been realized to access diverse chiral amino esters bearing cyclopropyl fragments with broad functional group tolerance and excellent enantioselectivities.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Recent developments in the ring-opening transformations of gem-difluorocyclopropanes

Org. Chem. Front., 2024, 11,6518-6533
DOI: 10.1039/D4QO01583E, Review Article
Leiyang Lv, Junqi Su, Zhiping Li
This review summarizes the advances of gem-F2CPs as fluoroallylic synthons in transition metal-catalysed ring-opening/cross-coupling reactions via single, double or no C-F bond cleavage on the last two years.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Dendron-mediated control over self-assembly of chlorophyll rosettes into columnar vs. discrete aggregates

Org. Chem. Front., 2024, 11,6304-6310
DOI: 10.1039/D4QO01629G, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ryo Kudo, Hiroki Hanayama, Balaraman Vedhanarayanan, Hitoshi Tamiaki, Nobuyuki Hara, Sarah E. Rogers, Martin J. Hollamby, Biplab Manna, Koji Harano, Shiki Yagai
By controlling the π-π stacking of chlorophyll supramolecular rosettes through steric hindrance of alkyl dendrons, it become possible to create chlorophyll tubes and discrete rings that resemble to natural chlorophyll assemblies.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Enantioselective Addition of 3-hydroxyquinolin-2(1H)-one to Isatin and Pyrazole-4,5-dione Derived Ketimines

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01895H, Research Article
Yue Wei, Guishun Bai, Jiamin Wu, Yi Hua, Tao Zhang, Congyong Yue, Hong Wang, Xiaoze Bao
The enantioselective reactivity of 3-hydroxyquinolin-2(1H)-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural products scaffolds in high yield with excellent enantioselectivities....
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Regio- and stereoselective azidation of activated N-allenamides: an entry to α, β, γ and δ-amido-azides

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01802H, Research Article
Dorian Schutz, Maxime Hourtoule, Laurence Miesch
A totally controlled regiodivergent azidation of activated N-allenamides is described, offering a broad range of diverse functionalized amido-azide derivatives.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Catalyst-free C–H methylation of heteroarenes enabled by electron donor–acceptor complex photoactivation

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01309C, Research Article
Jiayang Wang, Baoer Shao, Haixia Ge, Huiyu Xue, Xiangyuan Ding, Yuqi Li, Peiyao Sheng
A visible-light-induced direct C–H methylation of heterocycles (including quinoxalinones, pyrazinones, quinolinones and coumarins) with methylamines via EDA complex photoactivation was developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Recent advances in carbon atom addition for ring-expanding single-atom skeletal editing

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01806K, Review Article
Ting Yuan, Lei Shi
This review focuses on recent advances in carbon atom addition for ring-expanding single-atom skeletal editing.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

A Stereoselective Organocatalyzed C-Glycosylation of Indole: Implications of Acceptor-Catalyst-Donor Interaction

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01873G, Research Article
Lihuang Xie, Wenchao Liu, Zhenbo Guo, Qinbo Jiao, Xiaomin Shen, Tianfei Liu, Chunfa Xu
A stereoselective pyridinium hexafluorophosphate-catalyzed C-glycosylation of indole is presented, featuring the plausible formation of a catalyst-acceptor complex and a crucial H-bond between the indole N-H and the oxygen at C6...
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Nickel-catalyzed reductive 1,2-alkylarylation of alkenes via a 1,5-hydrogen atom transfer (HAT) cascade

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01875C, Research Article
Xi Chen, Qiang Wang, Xiao-Ping Gong, Rui-Qiang Jiao, Xue-Yuan Liu, Yong-Min Liang
A nickel-catalyzed 1,2-alkylarylation of alkenes has been developed, leveraging amidyl radical-triggered 1,5-HAT with electrophiles as functionalizing reagents.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Iridium-catalyzed asymmetric cascade allylation/lactonization of methyl salicylates: enantioselective construction of chiral benzodioxepinones

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01771D, Research Article
Bendu Pan, Yunru Wu, Yaqi Zhang, Xiaobo He, Long Jiang, Liqin Qiu
An efficient asymmetric cascade allylation/lactonization of methyl salicylates is achieved. The utilization of chiral-bridged biphenyl phosphoramidite ligand resulted in good results for the construction of a wide range of chiral benzodioxepinones.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Stereocontrolled synthesis of heterocycles from unactivated alkynes by photoredox/nickel dual-catalyzed cyclization

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01627K, Research Article
Bo-Rong Leng, Feng Yang, Jin-Lian Bai, Yu-Wen Huang, Qing-Quan Liu, Ping Wei, De-Cai Wang, Yi-Long Zhu
We report a nickel/photoredox dual catalysis method for synthesizing heterocyclics from unactivated alkynes and aryl iodides, offering a direct, selective, and green alternative to traditional synthesis with potential in medicinal chemistry.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Integrating electrocatalysis with biocatalysis for asymmetric synthesis

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01899K, Highlight
Yuqi Lin, Jiage Yu, Ke-Yin Ye
This highlight presents recent advances in asymmetric synthesis that integrate electrocatalysis with biocatalysis and discusses future development directions in this field.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Probing Intersystem Crossing in Multi-brominated Eumelanin through Transient Absorption and Surface Hopping Dynamics

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01832J, Research Article
Open Access
Kavya Vinod, Lukhmanul Hakeem K., Diana Thomas, Pallavi Panthakkal Das, Mahesh Hariharan
Achieving intersystem crossing (ISC) through structural tuning in biological systems is an evolving area for therapeutic and materials research. Eumelanin, a natural pigment, offers huge potential for bio-inspired material design,...
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Magic effect of diphenylprolinol silyl ether for the enantioselective allenation of 2-alkynals

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00984C, Research Article
Guolin Wu, Zhen Liu, Shiwen Fan, Wenyao Li, Xue Zhang, Hui Qian, Shengming Ma
Chiral diphenylprolinol silyl ethers have been successfully identified for the enantioselective allenation reaction of terminal alkynes and 2-alkynals, delivering a diverse set of chiral allenynes with high efficiency.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Visible-light responsive defluorination-acyl fluoride exchange for photoclick labeling based on phenoxazine chromophores

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01870B, Research Article
Lijun Deng, Sitong Li, Cefei Zhang, Yuqiao Zhou, Zhishan Su, Changwei Hu, Xiaohu Zhao, Zhipeng Yu
We developed a new generation of photo-DAFEx reagents to realize photoaffinity labeling for drug discovery under 405 nm light control.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Mechanism and origins of regioselectivity of selenium-catalyzed allylic amination reactions

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01794C, Research Article
Xiaoxiao Hu, Dengmengfei Xiao, Yu Chen, Yi Lu, Zhihan Zhang, Peiyuan Yu
The mechanism of selenium-catalyzed allylic amination reactions with different ligands has been explored using density functional theory calculations.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Transition-metal-free skeletal editing of benzoisothiazol-3-ones to 2,3-dihydrobenzothiazin-4-ones via single-carbon insertion

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01714E, Research Article
Ke Yang, Qin Li, Yanqi Luo, Dan Yuan, Chunjian Qi, Zhengyi Li, Bijin Li, Xiaoqiang Sun
Transition-metal-free ring expansion of benzoisothiazol-3-ones has been established to construct various 2,3-dihydrobenzothiazin-4-ones via single-carbon insertion.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Rh-Catalysed Hydroacyloxylation of Cyclopropenes: Regio- and Diastereoselective Synthesis of Acyloxycyclopropanes

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01810A, Research Article
Ángel Manu Martínez, Gema Domínguez, Ines Alonso, Marta Palaín, Javier Perez-Castells
Cyclopropyl carboxylates are essential building blocks in biological and medicinal chemistry. However, their accessibility is severely limited by the need to pre-synthesise highly reactive cyclopropane derivatives. Herein, we report an...
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Influence of hydrogen bonds and π-π stacking on the self-assembly of aryldipyrrolidones

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01577K, Research Article
Open Access
Pedro Ximenis, Llorenç Rubert, Heike Ehmann, Bartolome Soberats
We report on the self-assembly behaviour in solution and solid-state of two newly designed bisdendronized aryldipyrrolidones (BDP and NDP) dyes with two free N-H at the lactam positions. Interestingly, while...
The content of this RSS Feed (c) The Royal Society of Chemistry




el

π-extended regioisomeric dithienoacenes fused pyrenes: structures, properties, and application in field-effect transistors

Org. Chem. Front., 2025, Accepted Manuscript
DOI: 10.1039/D4QO01592D, Research Article
Bin Lu, Shiqian Zhang, Dong Liu, Wendong Jin, Dalin Li, Zhiqiang Liu, Tao He
The development of π-conjugated semiconducting molecules with fused rings has been a focus of research in organic electronics. In this study, optoelectronic and field-effect transistors (FET) properties of two novel...
The content of this RSS Feed (c) The Royal Society of Chemistry




el

Telangana Cyber Security Bureau conducts digital awareness campaign for senior citizens




el

Telangana CID arrests two involved in pan-India job fraud racket




el

Telangana pharmaceutical industries logged 97 major fire accidents in past decade: Fire Services Director-General Y. Nagi Reddy

The new government would like to decentralise and set up pharma villages, in 10 clusters, Special Chief Secretary Jayesh Ranjan said




el

HYDRAA created fear among encroachers and big builders and not common people: Telangana CM




el

75th anniversary of Bharat Scouts and Guides celebrated




el

When hope meets hurdles: stark reality of Telangana’s job market

The State’s job crisis has come back to haunt the Congress party, which rode to power last year on promises of employment. While local youth wait, worry, and exchange dreams about securing government jobs, short-term opportunities are drawing people from other States. This dynamic has transformed Telangana into a job magnet for outsiders but a desert for its own aspirants, reports Serish Nanisetti




el

Telangana set to unveil new industrial sectoral policies 

Electric Mobility and Storage, Electronics, Life Sciences, Defence and Aerospace sectors to get new growth guiding documents as some existing policies have become outdated and those in other States are superior, senior official 




el

Congress shedding ‘çrocodile tears’ over BCs welfare: BJP leader Laxman




el

Key agent in Cambodia job racket arrested in Delhi




el

No more parties without permission: Telangana Excise Dept. to farmhouse owners




el

Telangana Deputy CM seeks proposals for retaining wall to prevent monsoon flooding in Madhira




el

Eleven transgenders arrested for public nuisance in Cyberabad




el

Kishan Reddy slams Revanth government for failing farmers, challenges Rahul Gandhi to tour villages in Telangana




el

Telangana govt. urged to release caste survey forms in English and Urdu




el

Three held for running brothel

Following a tip-off, police raided Hotel Akshaya and arrested three persons




el

Telangana delegation to embark on 3-day study tour in Karnataka for fisheries development




el

Guru Nanak’s 555th birth anniversary celebrations to begin in Hyderabad on November 11