Although treatment programs for childhood obesity can demonstrate success, long-term outcomes have seldom been evaluated. The benefit of intervention when overweight is identified in a screening assessment and parental recognition of the problem is minimal is understudied.

A low-dose (sessions every 1–3 months), but long-term (2 years), family-based intervention was effective at reducing BMI compared with usual care in children recruited via a weight screening initiative in which many parents had been unaware their child was overweight. (Read the full article)

Rudeness is routinely experienced by hospital-based medical teams. Individuals exposed to mildly rude behavior perform poorly on cognitive tasks, exhibit reduced creativity and flexibility, and are less helpful and prosocial.

Rudeness had adverse consequences on diagnostic and procedural performance of members of the NICU medical teams. Information-sharing mediated the adverse effect of rudeness on diagnostic performance, and help-seeking mediated the effect of rudeness on procedural performance. (Read the full article)

Intervention strategies are needed to reduce underage drinking. Meta-analyses of youth alcohol brief interventions (BIs) conclude that therapist-delivered BIs are efficacious; however, to maximize public health impact, recommendations include using technology to streamline intervention delivery, for which evidence is lacking.

A single-session BI, delivered by a computer or therapist in the emergency department, shows promise for underage drinkers. Findings for the stand-alone computer BI are particularly appealing given the ease of future implementation. (Read the full article)

The vitamin D concentration in breast milk of women taking 400 IU vitamin D per day is relatively low, leading to vitamin D deficiency in breastfeeding infants. As a result, the American Academy of Pediatrics recommends breastfeeding infant vitamin D supplementation within days after birth.

Maternal vitamin D supplementation alone with 6400 IU/day safely supplies breast milk with adequate vitamin D to satisfy the requirement of her nursing infant and offers an alternate strategy to direct infant supplementation. (Read the full article)

Urethral catheterization is a painful, yet common procedure to obtain a sterile urine sample in young children. There are conflicting results regarding the effectiveness of lidocaine to reduce pain, and it is unclear if it should be routinely used.

In young children, combined topical and intraurethral lidocaine does not reduce pain during urethral catheterization and is associated with more pain than nonanesthetic lubricant during instillation. Clinicians should use noninvasive methods of analgesia during this painful procedure. (Read the full article)

Deferral of consent avoids delaying emergency interventions while ensuring consent to ongoing participation and use of data. Deferred consent is particularly important for enabling trials in pediatric settings, where many medicines and devices are unlicensed and untested for use.

Approaches for seeking deferred consent should balance the potential burden of obtaining consent against risk of bias due to outcome-related attrition. Ethics committees could consider approving data use when best efforts to obtain deferred consent are met with no response. (Read the full article)

Endotracheal intubation is a mandatory skill for neonatal trainees. It is a difficult skill to acquire, and success rates of junior doctors are low and falling.

Videolaryngoscopy allows the supervisor to share the intubator’s view of the airway and provide more informed guidance. Teaching intubation using a videolaryngoscope with the screen visible to the instructor results in significantly higher success rates for inexperienced doctors. (Read the full article)

Previous studies have evaluated separately the effects of brief education and reminder/recall intervention strategies to increase human papillomavirus vaccine coverage. None have examined if intervention effects varied by race/ethnicity.

When compared with a general adolescent vaccine brochure, human papillomavirus vaccine-specific educational materials increased 1-dose coverage among Hispanic but not black individuals. Recalls for doses 2 and 3 were effective in increasing 3-dose coverage for both racial/ethnic groups. (Read the full article)

Continuous conventional EEG video is currently gold standard for identifying neonatal seizures and a substantial proportion of neonatal seizures are electrographic. Currently there is no direct evidence that EEG monitoring, seizure identification, or treatment impacts long-term outcomes.

In neonates with hypoxic ischemic encephalopathy, EEG monitoring and treatment of electrographic seizures results in significant reduction in seizure burden. Increasing seizure burden is associated with more severe brain injury and significantly lower performance scores on Bayley Scales of Infant Development III. (Read the full article)

The impact of neonatal abstinence syndrome is of concern because the number of newborns showing symptoms of withdrawal after intrauterine drug exposure is increasing worldwide. Newborns developing neonatal abstinence syndrome require prolonged medical treatment and longer hospital admission after birth.

This first randomized controlled trial presents data on newborns with neonatal abstinence syndrome treated with laser acupuncture. The findings suggest that adjuvant laser acupuncture has the potential to reduce duration of morphine therapy and length of hospital stay. (Read the full article)

On Thursday, the company sent an email to third-party dealers, saying they would need approval to sell used Nintendo Games. Turns out the email was actually sent out in error, Amazon claims.

The N64 game library feels historically slim compared to other Nintendo consoles, but these are the greatest Nintendo games of the 64-bit era

The new analysis significantly increases the annual estimate of undocumented high school students earning diplomas that has long been used in debates about immigration and special protections for immigrant youth who were illegally brought to the U.S. as children.

Indonesia was rattled by more than 11 500 earthquakes last year, almost double the annual average of the past decade, according to the nation’s meteorological agency.

Contezolid (MRX-I), a new oxazolidinone, is an antibiotic in development for treating complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. This was a thorough QT study conducted in 52 healthy subjects who were administered oral contezolid at a therapeutic (800 mg) dose, a supratherapeutic (1600 mg) dose, placebo, and oral moxifloxacin 400 mg in 4 separate treatment periods. The pharmacokinetic profile of contezolid was also evaluated. Time-point analysis indicated that the upper bounds of the two-sided 90% confidence interval (CI) for placebo-corrected change-from-baseline QTc (QTc) were <10 ms for the contezolid therapeutic dose at each time point. The upper bound of the 90% CI for QTc were slightly more than 10 ms with the contezolid supratherapeutic dose at 3 and 4 hours postdose, and the prolongation effect on the QT/QTc interval was less than that of the positive control, moxifloxacin 400 mg. At 3 and 4 h after the moxifloxacin dose, the moxifloxacin group met the assay sensitivity criteria outlined in ICH Guidance E14 with having a lower confidence bound ≥5 ms. The results of a linear exposure-response model which were similar to that of a time point analysis demonstrated a slightly positive relationship between contezolid plasma levels and QTcF interval with a slope of 0.227 ms per mg/L (90% CI: 0.188 to 0.266). In summary, contezolid did not prolong the QT interval at a therapeutic dose and may have a slight effect on QT interval prolongation at a supratherapeutic dose.

Background: MRSA pose significant therapeutic challenges, related to their: frequency in clinical infections; innate virulence properties; and propensity for multi-antibiotic resistance. MRSA are among the most common causes of endovascular infections, including infective endocarditis (IE).

Objective: To employ transthoracic echocardiography (TTE) to evaluate the effect of exebacase, a novel direct lytic agent, in experimental aortic valve MRSA IE.

Study Design: TTE was utilized to evaluate the in vivo effect of exebacase on MRSA-infected vegetation progression when combined with daptomycin (vs daptomycin alone). Primary intravegetation outcomes were: maximum size; weights at sacrifice; and MRSA counts at infection baseline vs after 4 days of daptomycin treatment (alone or in addition to exebacase administered once on treatment Day 1).

Results: A single dose of exebacase in addition to daptomycin cleared significantly more intravegetation MRSA than daptomycin alone. This was associated with a statistical trend toward reduced maximum vegetation size in the exebacase + daptomycin vs the daptomycin-alone therapy groups (p = 0.07). Also, mean vegetation weights in the exebacase-treated group were significantly lower vs daptomycin-alone (p < 0.0001). Maximum vegetation size by TTE correlated with vegetation weight (p = 0.005). In addition, intravegetation MRSA counts in the combination group were significantly lower vs untreated controls (p<0.0001) and the daptomycin-alone group (p<0.0001).

Conclusion: This study suggests that exebacase has a salutary impact on MRSA-infected vegetation progression when combined with daptomycin, especially in terms of vegetation MRSA burden, size and weight. Moreover, TTE appears to be an efficient non-invasive tool to assess therapeutic efficacies in experimental MRSA IE.

Security researchers are demonstrating how you can use the Windows 10 flaw, CVE-2020-0601, to spoof the trusted digital certificates for official website domains on Google's Chrome browser. These same certificates can warn you about hacking attempts.

BACKGROUND:

Approximately 25% of children with concussion have persistent postconcussive symptoms (PPCS) with resultant significant impacts on quality of life. Melatonin has significant neuroprotective properties, and promising preclinical data suggest its potential to improve outcomes after traumatic brain injury. We hypothesized that treatment with melatonin would result in a greater decrease in PPCS symptoms when compared with a placebo.

Today you can save $120 on the Lenovo Flex 14 2-in-1 laptop. Also, the 24-inch Dell S2419HGF 1080p monitor dropped is now just $149.99. Finally, the new Nintendo Switch, featuring improved battery life, is now available.

It's only a matter of time before your Windows 10 PC begins to run slowly. You can kick the operating system back into high gear with these useful tips. And they won't cost you a penny.

Loading and running Windows 10 from a USB drive is a handy option when you're using a computer saddled with an older version of Windows.

The Windows 10 search feature seems pretty simple, but it can be even more effective. Here are some ways to control your searches and find things faster.

Don’t like to wait for programs to boot up when you’re looking for a specific document? With the right tools, you can preview a variety of files in Windows 10 without opening their applications.

Some are bare-bones kits. Others are ready to go out of the box, complete with an OS, RAM, and memory installed. Whatever the form, these top Windows micro desktops all deliver surprising features, value, and pep for their size.

Save on the second-generation Apple AirPods with the wireless charging case, Logitech gaming gear, Dell laptops, the Nintendo Switch, and more today.

A family of four was caught flouting lockdown restrictions after attempting to travel to Motherwell for a mini-break.

T. Michael O'Shea
Jul 1, 1999; 104:15-21
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The STOP-ROP Multicenter Study Group
Feb 1, 2000; 105:295-310
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You can network your Windows 10 PCs and tablets to share files and printers. Windows 7 and 8.1 users can still use homegroups.

Now we're typing with scan lines!

When was the last time you opened these Windows apps?

Team reporter Joe Walker has watched Portugal throughout UEFA EURO 2016 and explains how the coach masterminded his side's first triumph at a major tournament.

"We have a key word from day one: 'winning'. We are going to keep fighting hard to keep doing that," said Fernando Santos as he prepared for four more years as Portugal coach.

Amazon is offering up to 34 percent off Samsung monitors and tablets today. Plus, you can save on the Dell XPS 15 and pre-order Nintendo Switch Animal Crossing: New Horizons Edition.

A Windows tablet with a detachable keyboard can be a more portable and versatile alternative to a laptop. We've tested all the major models, and these top performers should be on your short list. Check them out, along with our deep-dive reviews.

Microsoft will probably deliver critical patches after it ends Windows 7 support in January 2020. But it's not guaranteed, so users and organizations should upgrade to Windows 10 now.

The leading desktop operating system continues to improve, adding refinements, tool updates, new visuals, and more control over updates.

The internal Windows 10 builds that leaked last week ended up revealing a brand new edition of the OS Microsoft is planning for power users.

Mark Alpert made a generous gift $200,000 in memory of his late wife, Claire, to establish the Mark E. and Claire L. Alpert Graduate Fellowship in the Department of Civil and Environmental Engineering at Penn State.

This phase IIb randomized controlled trial demonstrates greater efficacy of phenobarbital than levetiracetam in the treatment of neonatal seizures; more adverse events occurred with phenobarbital.

Following huge interest from across the world, the window for UEFA EURO 2020 ticket applications has closed.

Two members of the Shoot To Kill (STK) gang, who were responsible for multiple armed robberies and three separate shootings—including the broad daylight murder of 15-year-old Brandon Wingo—have been sentenced by a Superior Court Judge. Diamonte Taylor, 22, of Wilmington, was sentenced life in prison plus 11 years after a Superior Court jury convicted him […]

Sept. 2, 2017 event moved from outdoors on the Dover Green to indoors at The Old State House.

THE DELAWARE DIVISION OF THE ARTS TO HOST A FREE ACCESSIBILITY PRESENTATION LED BY THE NATIONAL ENDOWMENT FOR THE ARTS Dr. Beth Bienvenu, accessibility director, will review how to make the arts accessible to all Wilmington, Del. (November 30, 2017) – Building off of this year’s Arts Summit theme: “Arts for All” and an earlier […]

THE NATIONAL ENDOWMENT FOR THE ARTS ANNOUNCES FY 2018 GRANTS TO SUPPORT THE ARTS Two Delaware organizations will receive $20,000 in federal grants Wilmington, Del. (February 7, 2018) – Each year, more than 4,500 communities large and small throughout the United States benefit from National Endowment for the Arts (NEA) grants to nonprofits. For the […]

Three Delaware organizations will receive $729,100 in federal grants Wilmington, Del. (May 15, 2018) – As the only funder in the country to support arts activities in all 50 states and five U.S. jurisdictions, the National Endowment for the Arts (NEA) announced that three Delaware organizations, including the Division of the Arts, will receive $729,100 in […]

Three Delaware organizations will receive $54,000 in federal grants Wilmington, Del. (February 15, 2019) — As the only funder in the country to support arts activities in all 50 states and five U.S. jurisdictions, the National Endowment for the Arts (NEA) announced that three Delaware organizations will receive $54,000 in federal grants. This is the […]

Two Delaware organizations will receive $55,000 in federal grants Wilmington, Del. (January 28, 2020) – As the only funder in the country to support arts activities in all 50 states and five U.S. jurisdictions, the National Endowment for the Arts announced that two Delaware organizations, will receive $55,000 in federal grants. This is the first […]

Success in today’s digital-first world depends on a marketing organisation’s ability to create and activate hyper-relevant, data-driven and omnichannel customer experiences, says Nikki Mendonca.

The first Air India flight from the UK, scheduled as part of the Vande Bharat Mission to repatriate Indians stranded overseas due to the coronavirus lockdown, took off from London's Heathrow Airport...