Title: Home Monitoring Program Improves Outcomes for Heart Patients
Category: Health News
Created: 5/2/2008 2:00:00 AM
Last Editorial Review: 5/2/2008 12:00:00 AM

Title: Health Tip: Installing a Playground at Home
Category: Health News
Created: 4/30/2012 8:05:00 AM
Last Editorial Review: 4/30/2012 12:00:00 AM

Title: Pediatrician Group Issues Home Birth Policy Statement
Category: Health News
Created: 4/29/2013 10:35:00 AM
Last Editorial Review: 4/29/2013 12:00:00 AM

Title: Health Tip: Manage Visitors After Bringing Home Baby
Category: Health News
Created: 4/29/2013 8:35:00 AM
Last Editorial Review: 4/29/2013 12:00:00 AM

Title: At-Home Drug Errors Common for Kids With Cancer, Research Shows
Category: Health News
Created: 5/3/2013 10:35:00 AM
Last Editorial Review: 5/3/2013 12:00:00 AM

Title: Home Visits May Help Heart Bypass Patients Fare Better
Category: Health News
Created: 5/1/2014 9:35:00 AM
Last Editorial Review: 5/1/2014 12:00:00 AM

Title: Traumatic Brain Injury Common Among Homeless Men
Category: Health News
Created: 4/30/2014 12:35:00 PM
Last Editorial Review: 5/1/2014 12:00:00 AM

Title: Cooking at Home Means Eating Better, Spending Less
Category: Health News
Created: 4/30/2017 12:00:00 AM
Last Editorial Review: 5/1/2017 12:00:00 AM

Title: Home Gym: The Benefits of a Cross-Country Ski Machine
Category: Health News
Created: 5/3/2018 12:00:00 AM
Last Editorial Review: 5/3/2018 12:00:00 AM

Ginsburg had gone to the hospital for outpatient tests that revealed an infection caused by a gall stone.

Title: Ear Infection Home Treatment
Category: Diseases and Conditions
Created: 1/25/2018 12:00:00 AM
Last Editorial Review: 3/21/2020 12:00:00 AM

Cellular membranes are not homogenous mixtures of proteins; rather, they are segregated into microdomains on the basis of preferential association between specific lipids and proteins. These microdomains, called lipid rafts, are well known for their role in receptor signaling on the plasma membrane (PM) and are essential to such cellular functions as signal transduction and spatial organization of the PM. A number of disease states, including atherosclerosis and other cardiovascular disorders, may be caused by dysfunctional maintenance of lipid rafts. Lipid rafts do not occur only in the PM but also have been found in intracellular membranes and extracellular vesicles (EVs). Here, we focus on discussing newly discovered functions of lipid rafts and microdomains in intracellular membranes, including lipid and protein trafficking from the ER, Golgi bodies, and endosomes to the PM, and we examine lipid raft involvement in the production and composition of EVs. Because lipid rafts are small and transient, visualization remains challenging. Future work with advanced techniques will continue to expand our knowledge about the roles of lipid rafts in cellular functioning.

Plants have evolved complex physiological and biochemical mechanisms to adapt to a heterogeneous soil phosphorus environment. PHOSPHATE2 (PHO2) is a phosphate (Pi) starvation-signaling regulator involved in maintaining Pi homeostasis in plants. Arabidopsis (Arabidopsis thaliana) PHO2 targets PHOSPHATE TRANSPORTER1 (PHT1) and PHO1 for degradation, whereas rice (Oryza sativa) PHO2 is thought to mediate PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 degradation. However, it is unclear whether and how PHO2 is post-translationally regulated. Here, we show that in rice, the CASEIN KINASE2 (OsCK2) catalytic subunit OsCK2α3 interacts with OsPHO2 in vitro and in vivo in vascular tissues cells, and phosphorylates OsPHO2 at Ser-841. Phosphorylated OsPHO2 is degraded more rapidly than native OsPHO2 in cell-free degradation assays. OsPHO2 interacts with OsPHO1 and targets it for degradation through a multivesicular body-mediated pathway. PHO1 mutation partially rescued the pho2 mutant phenotype. Further genetic analysis showed that a nonphosphorylatable version of OsPHO2 rescued the Ospho2 phenotype of high Pi accumulation in leaves better than native OsPHO2. In addition to the previously established role of OsCK2 in negatively regulating endoplasmic reticulum exit of PHT1 phosphate transporters, this work uncovers a role for OsCK2α3 in modulating Pi homeostasis through regulating the phosphorylation status and abundance of OsPHO2 in rice.

Calcineurin B-like protein (CBL) and CBL-interacting protein kinase (CIPK)-mediated calcium signaling has been widely reported to function in plant development and various stress responses, particularly in ion homeostasis. Sugars are the most important primary metabolites, and thus sugar homeostasis requires precise regulation. Here, we describe a CBL2-CIPK6-Tonoplast-Localized Sugar Transporter2 (TST2) molecular module in cotton (Gossypium hirsutum) that regulates plant sugar homeostasis, in particular Glc homeostasis. GhCIPK6 is recruited to the tonoplast by GhCBL2 and interacts with the tonoplast-localized sugar transporter GhTST2. Overexpression of either GhCBL2, GhCIPK6, or GhTST2 was sufficient to promote sugar accumulation in transgenic cotton, whereas RNAi-mediated knockdown of GhCIPK6 expression or CRISPR-Cas9-mediated knockout of GhTST2 resulted in significantly decreased Glc content. Moreover, mutation of GhCBL2 or GhTST2 in GhCIPK6-overexpressing cotton reinstated sugar contents comparable to wild-type plants. Heterologous expression of GhCIPK6 in Arabidopsis (Arabidopsis thaliana) also promoted Glc accumulation, whereas mutation of AtTST1/2 in GhCIPK6-overexpressing Arabidopsis similarly reinstated wild-type sugar contents, thus indicating conservation of CBL2-CIPK6-TST2-mediated sugar homeostasis among different plant species. Our characterization of the molecular players behind plant sugar homeostasis may be exploited to improve sugar contents and abiotic stress resistance in plants.

The American Academy of Pediatrics (AAP) believes that current data show that hospitals and accredited birth centers are the safest settings for birth in the United States. The AAP does not recommend planned home birth, which has been reported to be associated with a twofold to threefold increase in infant mortality in the United States. The AAP recognizes that women may choose to plan a home birth. This statement is intended to help pediatricians provide constructive, informed counsel to women considering home birth while retaining their role as child advocates and to summarize appropriate care for newborn infants born at home that is consistent with care provided for infants born in a medical care facility. Regardless of the circumstances of his or her birth, including location, every newborn infant deserves health care consistent with that highlighted in this statement, which is more completely described in other publications from the AAP, including Guidelines for Perinatal Care and the Textbook of Neonatal Resuscitation. All health care clinicians and institutions should promote communications and understanding on the basis of professional interaction and mutual respect.

Key Points

Daniel P. Small, Piero Calosi, Samuel P. S. Rastrick, Lucy M. Turner, Stephen Widdicombe, and John I. Spicer

Regulation of extracellular acid–base balance, while maintaining energy metabolism, is recognised as an important aspect when defining an organism's sensitivity to environmental changes. This study investigated the haemolymph buffering capacity and energy metabolism (oxygen consumption, haemolymph [l-lactate] and [protein]) in early benthic juveniles (carapace length <40 mm) of the European lobster, Homarus gammarus, exposed to elevated temperature and P_CO2. At 13°C, H. gammarus juveniles were able to fully compensate for acid–base disturbances caused by the exposure to elevated seawater P_CO2 at levels associated with ocean acidification and carbon dioxide capture and storage (CCS) leakage scenarios, via haemolymph [HCO₃^–] regulation. However, metabolic rate remained constant and food consumption decreased under elevated P_CO2, indicating reduced energy availability. Juveniles at 17°C showed no ability to actively compensate haemolymph pH, resulting in decreased haemolymph pH particularly under CCS conditions. Early benthic juvenile lobsters at 17°C were not able to increase energy intake to offset increased energy demand and therefore appear to be unable to respond to acid–base disturbances due to increased P_CO2 at elevated temperature. Analysis of haemolymph metabolites suggests that, even under control conditions, juveniles were energetically limited. They exhibited high haemolymph [l-lactate], indicating recourse to anaerobic metabolism. Low haemolymph [protein] was linked to minimal non-bicarbonate buffering and reduced oxygen transport capacity. We discuss these results in the context of potential impacts of ongoing ocean change and CCS leakage scenarios on the development of juvenile H. gammarus and future lobster populations and stocks.

Flemming Dahlke, Magnus Lucassen, Ulf Bickmeyer, Sylke Wohlrab, Velmurugu Puvanendran, Atle Mortensen, Melissa Chierici, Hans-Otto Pörtner, and Daniela Storch

The vulnerability of fish embryos and larvae to environmental factors is often attributed to a lack of adult-like organ systems (gills) and thus insufficient homeostatic capacity. However, experimental data supporting this hypothesis are scarce. Here, by using Atlantic cod (Gadus morhua) as a model, the relationship between embryo vulnerability (to projected ocean acidification and warming) and homeostatic capacity was explored through parallel analyses of stage-specific mortality and in vitro activity and expression of major ion pumps (ATP-Synthase, Na⁺/K⁺-ATPase, H⁺-ATPase) and co-transporters (NBC1, NKCC1). Immunolocalization of these transporters was used to study ionocyte morphology in newly-hatched larvae. Treatment-related embryo mortality until hatch (+20% due to acidification and warming) occurred primarily during an early period (gastrulation) characterized by extremely low ion transport capacities. Thereafter, embryo mortality decreased in parallel with an exponential increase in activity and expression of all investigated ion transporters. Significant changes in transporter activity and expression in response to acidification (+15% activity) and warming (-30% expression) indicate some potential for short-term acclimatization, although likely associated with energetic trade-offs. Interestingly, whole-larvae enzyme capacities (supported by abundant epidermal ionocytes) reached levels similar to those previously measured in gill tissue of adult cod, suggesting that early-life stages without functional gills are better equipped in terms of ion homeostasis than previously thought. This study implies that the gastrulation period represents a critical transition from inherited (maternal) defenses to active homeostatic regulation, which facilitates enhanced resilience of later stages to environmental factors.

Background

Fluid overload in patients undergoing hemodialysis contributes to cardiovascular morbidity and mortality. There is a global trend to lower dialysate sodium with the goal of reducing fluid overload.

Recent studies have strived to find an association between rapid antidepressant effects and a specific subset of pharmacological targets and molecular pathways. Here, we propose a broader hypothesis of encoding, consolidation, and renormalization in depression (ENCORE-D), which suggests that, fundamentally, rapid and sustained antidepressant effects rely on intrinsic homeostatic mechanisms evoked as a response to the acute pharmacological or physiologic effects triggered by the treatment. We review evidence that supports the notion that various treatments with a rapid onset of action, such as ketamine, electroconvulsive therapy, and sleep deprivation, share the ability to acutely excite cortical networks, which increases synaptic potentiation, alters patterns of functional connectivity, and ameliorates depressive symptoms. We proceed to examine how the initial effects are short-lived and, as such, require both consolidation during wake and maintenance throughout sleep to remain sustained. Here, we incorporate elements from the synaptic homeostasis hypothesis and theorize that the fundamental mechanisms of synaptic plasticity and sleep, particularly the homeostatic emergence of slow-wave electroencephalogram activity and the renormalization of synaptic strength, are at the center of sustained antidepressant effects. We conclude by discussing the various implications of the ENCORE-D hypothesis and offer several considerations for future experimental and clinical research.

ABSTRACTBackground:A home-based record (HBR) is a health document kept by the patient or their caregivers, rather than by the health care facility. HBRs are used in 163 countries, but they have not been implemented universally or consistently. Effective implementation maximizes both health impacts and cost-effectiveness. We sought to examine this research-to-practice gap and delineate the facilitators and barriers to the effective implementation and use of maternal and child health HBRs especially in low- and middle-income countries (LMICs).Methods:Using a framework analysis approach, we created a framework of implementation categories in advance using subject expert inputs. We collected information through 2 streams. First, we screened 69 gray literature documents, of which 18 were included for analysis. Second, we conducted semi-structured interviews with 12 key informants, each of whom had extensive experience with HBR implementation. We abstracted the relevant data from the documents and interviews into an analytic matrix. The matrix was based on the initial framework and adjusted according to emergent categories from the data.Results:We identified 8 contributors to successful HBR implementation. These include establishing high-level support from the government and ensuring clear communication between all ministries and nongovernmental organizations involved. Choice of appropriate contents within the record was noted as important for alignment with the health system and for end user acceptance, as were the design, its physical durability, and timely redesigns. Logistical considerations, such as covering costs sustainably and arranging printing and distribution, could be potential bottlenecks. Finally, end users' engagement with HBRs depended on how the record was initially introduced to them and how its importance was reinforced over time by those in leadership positions.Conclusions:This framework analysis is the first study to take a more comprehensive and broad approach to the HBR implementation process in LMICs. The findings provide guidance for policy makers, donors, and health care practitioners regarding best implementation practice and effective HBR use, as well as where further research is required.

Genes of the Notch signaling pathway are expressed in different cell types and organs at different time points during embryonic development and adulthood. The Notch ligand Delta-like 1 (DLL1) controls the decision between endocrine and exocrine fates of multipotent progenitors in the developing pancreas, and loss of Dll1 leads to premature endocrine differentiation. However, the role of Delta-Notch signaling in adult tissue homeostasis is not well understood. Here, we describe the spatial expression pattern of Notch pathway components in adult murine pancreatic islets and show that DLL1 and DLL4 are specifically expressed in β-cells, whereas JAGGED1 is expressed in α-cells. We show that mice lacking both DLL1 and DLL4 in adult β-cells display improved glucose tolerance, increased glucose-stimulated insulin secretion, and hyperglucagonemia. In contrast, overexpression of the intracellular domain of DLL1 in adult murine pancreatic β-cells results in impaired glucose tolerance and reduced insulin secretion, both in vitro and in vivo. These results suggest that Notch ligands play specific roles in the adult pancreas and highlight a novel function of the Delta/Notch pathway in β-cell insulin secretion.

Adolescents with type 1 diabetes face self-management challenges that make it difficult for them to achieve good glycemic control. In our population of adolescents with poorly controlled type 1 diabetes, the use of continuous glucose monitoring (CGM) improved patients’ glycemic time in range (TIR) and identified hypoglycemia more frequently than with intermittent self-monitoring of blood glucose throughout a 4-week interval. However, the adolescents were unable to synthesize this information to problem-solve or reduce the frequency of hypoglycemic events. Setting SMART (specific, measurable, achievable, relevant, and time-bound) diabetes management goals and providing intensive diabetes education and support could increase adolescents’ TIR and prevent hypoglycemia.

Công ty Cổ phần Đầu tư Địa ốc BigHomes  là đại lý phân phối chính thức các dự án bất động sản của tập đoàn VinGroup như: Vinhomes Smart City Hà Nội, Vinhomes Ocean Park, Vinhome Riverside, Vinpearl Phú Quốc...

BigHomes luôn tự hào là một trong những đại lý có thành tích xuất sắc về doanh số bán hàng ở các dự án từ Vinhome đến Vinpearl.

Luôn đặt lợi ích của quý khách hàng và quý đối tác lên hàng đầu, BigHomes cam kết trung thực, tận tâm, chuyên nghiệp trong mọi dịch vụ mà chúng tôi cung cấp.

Với đội ngũ nhân viên chuyên nghiệp, nguồn thông tin đầy đủ, chính xác, cập nhật nhanh nhất thị trường, quý khách hàng sẽ được tư vấn giải pháp tối ưu để sở hữu những BĐS tốt nhất với giá hợp lý nhất, có khả năng sinh lời cao.

Chất lượng dịch vụ uy tín từ Tâm!

Liên hệ: 

Mrs. Thương - Giám đốc kinh doanh

Email: Luuthuongvinpearl@gmail.com

Hotline: 0915 221 443 – 0971 436 167

Ban lãnh đạo cùng toàn thể nhân viên Công ty Bất động sản Home 4U luôn nỗ lực đáp ứng tối đa nhu cầu của đối tác và khách hàng nhằm đem lại cuộc sống tối ưu cho khách hàng và thỏa mãn nhu cầu của các bên đóng góp tích cực cho cộng đồng. Khách hàng luôn tin tưởng tuyệt đối khi giao dịch với công ty.

Trên hành trình phát triển của mình, chúng tôi nhận thức rằng, để thành công và phát triển bền vững, bên cạnh định hướng chiến lược đúng đắn, thì việc trân trọng giá trị đạo đức kinh doanh, mang giá trị thực, đảm bảo lợi ích tốt nhất cho Khách hàng, Đối tác và xã hội là triết lý kinh doanh đầy tính nhân văn mà công ty chúng tôi luôn hướng đến.

Tầm nhìn:

Bằng khát vọng tỏa sáng, cùng chiến lược đầu tư phát triển bền vững, Bất động sản Home 4U Land luôn phấn đấu trở thành tập đoàn bất động sản hàng đầu Việt Nam.

Sứ mệnh:

Chúng tôi phát triển dự án, tư vấn bất động sản góp phần kiến tạo cộng đồng nhân văn tiên tiến.
Đối với nhân viên: Xây dựng môi trường làm việc chuyên nghiệp, năng động, sáng tạo và nhân văn; tạo điều kiện thu nhập cao và cơ hội phát triển công bằng cho tất cả nhân viên.
Đối với xã hội: Hài hòa lợi ích doanh nghiệp với lợi ích xã hội; đóng góp tích cực vào các hoạt động hướng về cộng đồng, thể hiện tinh thần trách nhiệm công dân và niềm tự hào dân tộc.

Lĩnh vực hoạt động:

• Đầu tư kinh doanh bất động sản
• Môi giới các sản phẩm nhà đất
• Đầu tư dự án
• Xây dựng dân dụng, công nghiệp

Loại BĐS môi giới chủ yếu: bán nhà riêng quận Hoàng Mai, Hai Bà Trưng, Đống Đa, Cầu Giấy, Long Biên 

Liên hệ:

Địa chỉ: chung cư K35- Tân Mai - Hoàng Mai - Hà Nội.
Văn phòng giao dịch: chung cư K35 - Tân Ma i- Hoàng Mai - Hà Nội.
Hotline: 0942645234 - 0963266388
Email: canhmt.tmq@gmail.com
 

Nhà vườn, homestay từng nở rộ cách đây chục năm trước và bắt đầu thoái trào trong khoảng 2-3 năm trở lại đây. Tuy nhiên, trong mùa dịch Covid-19, nhiều người lại nhen nhóm ý định lùng mua đất làm nhà vườn để có chốn “nương náu”. Vậy phải làm sao để không hối tiếc khi mua đất làm nhà vườn?