The present invention provides a method and apparatus of reducing current requirements by increasing resistance of the blade structure by reducing the cross sectional area of at least one section of the blade so that the electrical current requirements for heating of the blade to cutting temperature are reduced wherein the power supply and substantially entire unit may be mounted within a hand held unit. Methods of shaping blades to perform various heat distributions for specialty blades for custom cutting are disclosed. Further, an improved blade mounting structure is provided which includes structure for maintaining the legs of the blade parallel to the direction of cut and provides for easy insertion of new blades by maintaining a slotted blade cradle stable and in alignment with the blades and a clamp member away from the blade when the clamp mounting structure is loosened.

An apparatus is configured to receive a tire having at least two bead portions, including a first bead portion and a second bead portion. The apparatus includes a plurality of members configured to engage the first bead portion of the tire, at least one expander configured to move the plurality of members outward, and a rotating device configured to rotate the plurality of members about an axis of the tire.

A mounting device for mounting or dismounting a vehicle tire on a wheel rim, the wheel rim or the wheel being supported on a mounting table and a pressing-down device being provided for sliding the vehicle tire on the wheel rim. A movement of the pressing-down device is essentially parallel to the wheel axis for sliding the vehicle tire on the wheel rim or pulling off the vehicle tire from the wheel rim.

A working tool orienting device in a tire demounting machine includes a base which supports a rotary apparatus, rotating about an axis of rotation and designed to bear and lock wheel rims thereon; a column rising from the base and having an end secured to the base and an end opposite thereto facing upward; a moving arm, which is moved between positions close to and away from the rotary apparatus; a support arrangement for supporting working tools, which is coupled with the upward facing end, and joint means interposed between the support arrangement and the upward facing end, which are configured to make the support arrangement movable relative to the arm.

A device for automatic demounting of a tire from a rim having: a support arm (4); a demounting tool (10) articulated to the support arm (4); an attachment member (12) having one end articulated to the demounting tool (10) by a first articulation pin (13) and the other end thereof pivoted to the support arm (4) around a second articulation pin (14) extending substantially parallel to the first articulation pin (13); at least one extension appendage of the support arm (4) or a section (17) of the support arm (4), which extends beyond the second articulation pin (14); and at least one tie rod member (18) that is articulated on one side to the tool, and on the other side to the extension appendage or section (17) of the support arm (4).

An apparatus (1) for mounting and removing a tire (2) on and from a respective rim (3) comprises: a movement element (9) for moving a bead (2a) of the tire (2) in order to insert/remove the bead (2a) into/from a respective groove in the rim (3); means (4) for supporting and moving the rim (3), designed to rotationally drive the rim about its longitudinal axis; characterized in that the means (4) for supporting and moving the rim (3) comprise a sensor (252) for measuring the mechanical strain applied to the supporting and movement means (4) as a result of the mechanical stress on the bead (2a) of the tire (2) during mounting/removal of the latter on/from the rim (3).

A bead breaking unit for tire changing machines includes an arm having a bead breaking tool and associated rotatable with a supporting structure between an away position, wherein the tool is spaced out from the supporting structure, and a work position, wherein the tool is near the supporting structure, an actuator apparatus having a mobile element associated sliding with the arm, a dragging device for dragging the arm, associated with the mobile element and suitable for operating during movement of the mobile element from an extracted position to a retracted position to bring the arm to the work position, a coupling device between the mobile element and the arm, suitable for operating during movement of the mobile element from the retracted to the extracted position to bring the arm from the work position to the away position, and a selection device associated with, and suitable for operating/disconnecting the coupling device.

The present invention relates to a demounting device comprising a support member translatable along a movement axis (y-y), drive means for the support member, a tool-holder arm (3) borne by the support member (2), an abutment element (4) and a hook-like extraction member (5) both supported by the tool-holder arm (3), the abutment element (4) having a substantially flat work surface (4a), whereas the hook-like extraction member (5) is suitable for being moved in a substantially transverse direction with respect to the rotation axis (x-x) of a rim (W).

The present invention relates to a device for demounting a tire (T) from a rim (W) including at least one support element;an articulation pin element borne by the at least one support element;a spring shackle element having a first end and a second end articulated on the articulation pin;a demounting lever;an actuator borne by the at least one support element and set to act on the demounting lever in order to make the demounting lever angularly move during use; andfriction or elastic loading means designed to slow the angular movement of the spring shackle element around the articulation pin with respect to its angular movement around the first axis (x-x).

The invention relates to a method for controlling a current fed to an electric motor during an operation to mount a tire on a rim of a wheel including the tire and the rim, or to demount the tire from the rim. The wheel is rotated by an electric motor about an axis, and the motor current fed to the electric motor is controlled dependent on the rotational speed and torque required for the mounting and/or demounting operation. The motor current is automatically changed to cause the electric motor to apply a high torque peak to rotate the wheel, when the motor current is measured to be greater than a preset limit at a low rotational speed during a preset time. Furthermore, the invention relates to an apparatus for mounting a tire on a rim or demounting the tire from the rim.

A tire changer machine and tire demounting methodology includes a demount tool assembly having a demount tool selectively positionable relative to a support and configured to extract a bead of the tire from the wheel rim. A guide element is mounted to the support, and the guide element is operable to provide a limited degree of freedom of the distal end from a predetermined path of motion in a tire demount procedure, thereby allowing the distal end to reliably grip the tire bead while the support arm is maintained in a stationary position relative to the wheel rim.

Apparatus and method are provided for making the longitudinal temperature distribution of the bulbous end of a longitudinally oriented workpiece, such as a rail's head, generally uniform when the head has a non-uniform longitudinal temperature distribution. A combination of crown and skirt electric inductors is used to achieve the generally uniform temperature distribution by modulating the magnetic field intensity produced by current flow through one or more of the combination of crown and skirt inductors as required for the non-uniformly heated regions of the rail's head.

A multipurpose organizer that can be quickly and easily converted into multiple articles such as but not limited to a carrying tote, a purse, a seat organizer and a head rest is provided. The method of making the multifunctional organizer and the methods of using the multifunctional organizer are also provided. In one embodiment the main body of consists of a single piece of material providing for low cost construction.

A head cover for a golf club includes a first surface having a removable cleaning pad thereon, and a second surface on which at least one golf accessory constructed of a ferrous metal is removably attached thereto. The second surface is part of a tri-layer construction with magnets forming the second middle layer so as to so retain the golf accessory thereon. The cleaning pad is removed by the golfer from the first surface and includes a scrubbing area to remove grit and/or debris from one of a golf ball and a golf club face.

A covering system includes a tarp made of an elastic membrane and a plurality of tarp fastening hooks. The fastening hooks allow the elastic membrane to be stretched over valuables and affixed to environmental anchors so that creases and puddle-enabling pockets in the membrane are eliminated. The fastening hooks clamp onto the elastic membrane and hook onto the environmental anchors to cause tension in the membrane. The clamping forces of the tarp fasteners are inherently increased in proportion to the tension in the clamped membrane.

Liquid consumption counter devices are described herein. One liquid consumption counter device can comprise a body having a number of indicator points, and a counter coupled to the body, wherein the counter rotates around the body to each of the number of indicator points and wherein rotation of the counter to each of the consecutive indicator points indicates consumption of a volume of liquid.

A display assembly includes a flexible sheet. The flexible sheet is formed of a flexible material supporting a first display panel and a second display panel. A mechanism is operatively connected to the flexible sheet. The mechanism moves the flexible sheet from a first position in which said first display panel may be viewed to a second position in which said second display panel may be viewed.

A picture frame assembly includes a backing plate having a front surface, a rear surface, and a plurality of parallel grooves in one of the surfaces. The material and thickness of the backing plate are chosen so that the backing plate can be plastically deformed about a bending axis parallel to the grooves. At least one frame element, which can be formed integrally with the backing plate, is for provided for retaining a planar picture element against the front surface of the backing plate. A fastener extends from the rear surface for mounting the assembly to any of various objects, such as a tree, flower stem, a candle, a vase, a basket, a gift wrapping device, a container, a column, and furniture.

A substrate processing apparatus that includes a process tank having a pair of opposed sidewalls for storing a chemical liquid, and processing a plurality of substrates by the chemical liquid; a substrate holding mechanism including a holding part for holding the plurality of substrates, and a back part connected to the holding part and interposed between the substrates held by the holding part and one sidewall of the pair of opposed sidewalls when the substrate holding mechanism is loaded into the process tank. A heating device is disposed on the process tank for heating the stored chemical liquid. The heating device includes at least a first heater disposed on the one sidewall, and a second heater disposed on the other sidewall of the pair of opposed sidewalls. Energy outputs of the first heater and the second heater are independently controlled.

An improved portable cleaning system for use in cleaning heat exchanger tube bundles, fin-fans, towers and other elongated components. The cleaning system comprises a cleaning unit having a cleaning enclosure that receives and cleans the component and a control unit that controls the operation of the system. The cleaning unit has a cleaning enclosure defining a chamber sized and configured to receive the component through a sealable lid. A roller assembly rotates the component while a spray assembly sprays cleaning fluid over and into the rotating component. The cleaning fluid is heated in the chamber using surface heating elements attached to heat transfer plates along sections of the chamber walls. A vapor recovery system captures and treats toxic vapors. In use, the cleaning system is transported to a facility to clean the components on-site using cleaning fluid supplied by the facility and discharging waste to the facility.

A method of cleaning an internal component (14) of a process vessel (10) includes opening a guide (42) extending at least from a vessel access port or entry nozzle (38) to the internal component (14), guiding a cleaning agent/device by means of the guide (42) to the internal component (14), cleaning the internal component (14) with the cleaning agent/device, and closing the guide (42). The process vessel (10) is then operated with the guide (42) remaining in the process vessel (10).

The embodiments described herein relate to methods and apparatus for counter-gravity formation of BMG-containing hollow parts. In one embodiment, the BMG-containing hollow parts may be formed by first feeding a molten metal alloy in a counter-gravity direction into a mold cavity to deposit the molten metal alloy on a surface of the mold cavity and then solidifying the deposited molten metal alloy.

A method of producing a trailing arm of a torsion beam axle in which an integrated drive unit of a wheel-adjacent electric drive has an electric machine and a transmission. By using the method, the trailing arm is produced in the form of a casting with a box profile. The contours for producing the area that accommodates the transmission, the connection point to the vehicle body, the bore that receives the cross-member which connects the two trailing arms to one another, the U-profile of the trailing arm, the box profile and the area that accommodates the electric machine, are modeled by cores such that the contours for producing the connection point of the trailing arm to the vehicle body, the bore that receives the cross-member and the U-profile of the trailing arm are modeled by one core.

A foundry mixture for making molds used for molding cast metal parts includes foundry sand, a non-aqueous binder, and a cleaning agent that includes calcium oxide. Residual foundry mixture remaining on the cast part after removal from the mold is removed by electrolytic cleaning of the cast part.

A tailings solvent recovery vessel substantially without conventional internals utilizes nozzles for forming very fine solvent-containing hydrocarbon droplets from a solvent-containing tailings feedstream. The hydrocarbon droplets are discrete from water droplets. The hydrocarbon droplets are small enough to result in a large surface area and a desired fall residence time but sufficiently large that they are not entrained with the rising vapor in the vessel. The feedstream is introduced to the vessel with a pressure drop to result in an initial flashing of the solvent from the solvent-containing droplets. Heat from the vessel atmosphere or from steam flowing countercurrent to the falling hydrocarbon droplets is transferred to the falling hydrocarbon droplets resulting in vaporization of any residual solvent therefrom. A substantially solvent-depleted pool is collected in the bottom of the vessel and retained only so long as is required to pump the underflow stream from the vessel.

Embodiments of extraction unit and an analysis method are provided. In one embodiment, the analysis method includes the steps of providing a feed stream and a species-selective solvent to the distillation column, drawing a vapor sample from the distillation column, condensing the vapor sample, and analyzing at least a portion of the condensed vapor sample.

A device for processing a hydrocarbon resource may include a hydrocarbon processing container configured to receive the hydrocarbon resource therein and having a pair of opposing ends with an enlarged width medial portion therebetween. The device may also include a radio frequency (RF) source, and a first spirally wound electrical conductor surrounding the hydrocarbon processing container and coupled to the RF source. The device may further include a second spirally wound electrical conductor carried within the hydrocarbon processing container. The first spirally wound electrical conductor may be configured to generate magnetic fields with the hydrocarbon processing container that are parallel with an axis thereof.

An improved apparatus strips HPNA's from hydroprocessed streams in a fractionation column having a split shell configuration. Only one vapor stripping feed is required to the split shell of the fractionation column. The resulting reduction in steam requirement provides a superior fractionation in the column.

A device for processing a hydrocarbon resource may include a hydrocarbon processing container configured to receive the hydrocarbon resource therein and having a pair of opposing ends with an enlarged width medial portion therebetween. The device may also include a radio frequency (RF) source, and a spirally wound electrical conductor surrounding the hydrocarbon processing container and coupled to the RF source. The spirally wound electrical conductor may be configured to generate magnetic fields within the hydrocarbon processing container that are parallel with an axis thereof.

A crude oil feedstream is treated to remove or reduce the content of known undesired heteroatomic and polynuclear aromatic compounds containing nitrogen and sulfur by contacting the feedstream with one or more solid adsorbent materials selected from attapulgus clay, alumina, silica gel and activated carbon in a mixing vessel for a time that is sufficient to optimize the adsorption of the undesired compounds from the crude oil, subjecting the mixture to atmospheric flash distillation and then to vacuum flash distillation to recover presorbed boiling ranges of products having a lowered content of the undesired compounds, and preferably regenerating at least a portion of the solid adsorbent material for reuse in the process.

A knit fabric having a modified knit structure, having a front layer of knit fabric and a back layer of knit fabric, wherein the front layer and back layer are joined together by rows of tuck stitches formed from a yarn having no more than 3% elongation and wherein the knit fabric is puncture resistant, and optionally cut and/or abrasion resistant, and a protective garment made therefrom.

Sinker cam segments in a circular knitting machine are located with respect to the generally radial direction by a generally radially inwardly facing location surface disposed radially outward of the segments. Each segment's radially outer end defines a contact region that abuts the locating surface. The contact region can be complementary surface contour to that of the locating surface, or a pair of discrete, spaced contact points protruding out from the radially outer end of the segment. The contact region is a reference for positioning the sinker cam segment with respect to the generally radial direction.

The invention relates to a method for determining the residual time until a cooking process of a foodstuff (12) has been finished. At first a set temperature value for a core (14) of the foodstuff (12) is defined. Next the actual temperatures in the core (14) of the foodstuff (12) at predetermined times are measured and the time dependence of the measured temperature in the core (14) of the foodstuff (12) is determined. At last the time dependence of the measured temperature is compared with the set temperature value and “the residual time of the cooking process is estimated. The invention relates further to a corresponding apparatus for determining the residual time until a cooking process of a foodstuff (12) has been finished.

A multi-functional electric cooker includes a heating boiler body (1) and a cover (2). The cooker also includes a rice soup collecting container (3) which is mounted between the heating boiler body (1) and the cover (2), a sealing ring (7) which is set between the rice soup collecting container (3) and the heating boiler body (1), and a rice soup sucker (6). An opening of one end of the sucker is located at the bottom of the rice soup collecting container (3) and the height of the opening is adjusted along with the amount of the rice in the heating boiler body. An opening of the other end of the sucker is located in the rice soup collecting container (3).

The present invention provides substituted bicyclic pyrazolone compounds, which are used to inhibit or modulate the activity of receptor tyrosine kinases, especially Axl, Mer, c-Met and Ron. The invention also provides pharmaceutical compositions comprising the compound disclosed herein, and a method of preventing, treating or lessening the severity of a proliferative disorder in a patient with the compounds or the pharmaceutical compositions disclosed herein.

Provided is a method of potentiating immunity or preventing or treating an immune-related disease comprising administering an anti-Ang2 antibody or an antigen-binding fragment thereof to a subject in need thereof.

The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose Alzheimer's Disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject.

The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≦7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≦1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.

Various aspects and embodiments of the invention are directed to high-throughput phage-engineering methods and recombinant bacteriophages with tunable host ranges for controlling phage specificity.

Described herein are methods and compositions for treatment of immune-related diseases or disorders by modulating DD1α activity, alone or in combination with modulation of PD-1 activity. In some embodiments, the methods and compositions described herein are directed to treatment of cancer and/or infections (e.g., bacterial infection, and/or fungal infection). In some embodiments, the methods and compositions described herein are directed to treatment of autoimmune diseases and/or inflammation. In some embodiments, the methods and compositions described herein are directed to treatment of asthma, and allergy. Methods for identifying patients who are more likely to be responsive to and benefit from an immunotherapy that targets DD1α and/or PD-1 activity or expression are also described herein.

A cold rolling mill is described wherein the unstressed shape of metal sheet is continuously sensed during rolling by a plurality of negligible displacement force sensors perpendicularly disposed relative to the pass line at a mill location producing a tensile stress above 4,000 p.s.i. in the metal sheet being rolled. The output signals from those sensors underlying opposite edges of the metal sheet are compared to equalize reduction at the sheet edges while the difference between the force measured by a centrally situated sensor and the average force measured by the sensors underlying opposite edges of the sheet provide a signal indicative of the roll bending force required to produce flat sheet.

A method for fabrication of a relatively low cost display or communicative novelty button in which a consumable restrictor sheet is placed over a vacuum draw type female mold cavity. The restrictor sheet may be of cardboard and be apertured with a diameter smaller than the mold cavity diameter. A thermoplastic sheet material is then placed over the restrictor sheet, heated to reach a formable state and vacuum drawn through the restricted aperture and down so that the sheet comes into contact with and generally conforms to the desired shape defined by the mold cavity. The plastic sheet material may then be trimmed near the edge of the restrictor sheet to leave a button shell mounted on a restrictor sheet which may then be used for purposes of display. The restrictor sheet also enables fabrication with an inwardly facing peripheral groove that may be used to secure a pin fastener. An alternate form of fastener in which a portion of the remaining plastic sheet is used is also disclosed.

A punch button (32) has a central disc (36) integral with and separable from an outer peripheral annular ring (38). The disc and ring are joined by a breakaway portion (40) of reduced thickness. A pair of peel points or pilot cuts (50 and 52) may be provided on distally opposite sides of the disc, and if so, the disc is initially separable from the ring at the peel points and then rotatable about a rotation axis perpendicular to an axis through the distally opposite pilot cuts. The punch button is formed by providing a strip of material of a first thickness, placing the strip in a die, performing an inner cut with the die and partially cutting through the strip to yield first and second subpieces joined to each other by material of a second reduced thickness, and performing an outer cut with the die and cutting all the way through the strip to yield a piece composed of the first and second subpieces providing the disc and ring. The pilot cuts are performed by the die during performance of the inner cut and to a deeper depth than the inner cut. All of the cuts are performed in a singular die step operation wherein an outer punch (58) is moved toward an inner punch (66) in one axial direction to perform the inner cut, the pilot cuts, and a portion of the outer cut, and continuing movement of the outer punch in the one direction and simultaneously moving the inner punch in the same direction in unison with the outer punch to complete the outer cut.

A universal assembly machine manufactures conventional buttons with formed backs. The machine comprises a rotatably indexable die table to which are mounted pickup and crimp dies. The die table indexes about a center column of the machine frame. A ram die is advancable and retractable in a pickup stroke and a crimp stroke by means of a handle. The ram die includes a ram outer ring that is rotatable by means of a shifter post joined to the die table. Indexing the die table causes the shifter post to rotate the ram outer ring into a pickup mode or a crimp mode to suit the ram pickup and crimp strokes, respectively. The universal assembly machine also manufactures buttons with flat backs by using a different crimp die pedestal than is used with the formed backs. An adapter on the crimp die pedestal used with formed backs allows that crimp die pedestal to also be used for manufacturing buttons with flat backs. The invention also embraces button medallions. A flat back button is loaded into the pickup die, and the die table is indexed. The ram die is advanced in a third press stroke to bend the shell frusto-conical wall of the flat back button inwardly to be flat and parallel to the flat back.

Disclosed is a wireless surround sound speaker system wherein a transmitter broadcasts a variety of FM signals that correspond to the individual speaker channels commonly found in a surround sound system. Receivers, individually equipped with signal receiving, conditioning and amplification components, are configured to receive any one of the broadcast signals in a remote location and are used to drive a conventional loudspeaker in that location. Powered by wall socket or via DC battery packs, the receivers, used in conjunction with the transmitter, provide surround sound capabilities without the need for complex and difficult wiring.

A button making device capable of simply exchanging a first pressed mold, a second pressed mold, and a pressing mold so as to produce buttons of different sizes; a polygonal button whose front surface plate is dome-wise curved and has its shape fixed; and such a button making device, are provided. The button making device has a sliding platform, two pressed molds, a fixed member, a pressing shaft, a pressing mold, and an operation mechanism. The pressed molds are provided on an attachment member which is removably attached to the sliding platform. The pressing mold is removably attached to a lower end of the pressing shaft using magnetic force. The present invention can be used for a button making device which can easily form a metal button by press processing which can be used as an accessory adhered to clothes or the like by a pin or the like.

A mounting device, for mounting a plurality of buttons on a product, includes a supporting member, a punching member, and a driving member The supporting member includes a supporting panel, a plurality of holding portions fixed on the supporting panel for supporting the product, a molding board having a plurality of molding holes a platform, and a base fixed on the platform for supporting the molding board. The punching member includes a retaining member positioned above the supporting member, and a plurality of cutters fixed to the retaining member The cutters cut the buttons off a button assembly, and couple to a vacuum generator for creating suction to hold the buttons. The driving member drives the punching member to mount the buttons on the product.

The present invention is directed to novel organoleptic compounds, a process of augmenting, enhancing or imparting taste to a material selected from the group consisting of a foodstuff, a chewing gum, a dental product, an oral hygiene product and a medicinal product comprising the step of incorporating an olfactory acceptable amount of such novel organoleptic compounds, and a process of improving, enhancing or modifying a fragrance composition through the addition of an olfactory acceptable amount of such novel organoleptic compounds.