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Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00264D, Paper
Mariya Antony John Felix, Santhiyagu Sahayaraj Rex Shanlee, Shen-Ming Chen, Sundaresan Ruspika, Ramachandran Balaji, Narendhar Chandrasekar, Periyanayagam Arockia Doss
Fabrication of potent electrocatalyst, La-based perovskites coupled with functionalized carbon nanofibers (LMO/f-CNF) for ultrasensitive electrochemical detection of roxarsone in edible and water samples.
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Novel advanced materials and magnetic solid phase extraction as approaches in sample preparation to enhance the analysis of ochratoxin A in peanuts

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00246F, Paper
Bingchen Wang, Yifan Wang, Xiuyuan Zhang, Kuo He
In order to improve the detection efficiency of ochratoxin, a superparamagnetic nano-material was synthesized for solid phase extraction of ochratoxin.
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A highly selective probe engineered to detect polarity and distinguish normal cells and tumor cells in tissue sections

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00438H, Paper
Sai Zhu, Lixuan Dai, Xiaoli Zhong, Weiying Lin
We have designed a polarity fluorescent probe (DCI-Cou-polar) with high selectivity for diagnosing cancer.
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Are These the Most Interesting Front-end Developer Tools for 2021?

When I come to the end of any given year, it’s always interesting to look back through the click-through stats for my weekly newsletter Web Tools Weekly to see which tools got the most attention.

This year wasn’t all that different from previous years. I’ve learned that clicks happen for basically one of two reasons:

The post Are These the Most Interesting Front-end Developer Tools for 2021? appeared first on Impressive Webs.



  • Roundups and Resources

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A Review of ipwhois.io for Reliable Geolocation Data

[Sponsored] If you’re building an app that requires delivering a dynamic experience based on the user’s location or other location-related data, a fast and easy-to-use Geolocation API will certainly come in handy. One such option is ipwhois.io. The service, which is free for small non-commercial projects that need fewer than 10,000 requests per month, is easy to integrate with your tech stack.

As usual, it’s always best to look at a few examples so you can see it in action. Their documentation is short and easy to follow, so I’ll demonstrate using the following example request:

The post A Review of ipwhois.io for Reliable Geolocation Data appeared first on Impressive Webs.




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Filestack: A File Uploader and Powerful APIs to Deliver and Transform App Content

[Sponsored] If you’re building an app that requires a lot of user-generated content and media that needs to be processed, tagged, filtered, or otherwise manipulated in real-time, you definitely want a solution that’s fast and seamless and doesn’t get in the way of your app’s primary functionality. Filestack is a service you’ll want to consider. Here’s what Filestack offers:

The post Filestack: A File Uploader and Powerful APIs to Deliver and Transform App Content appeared first on Impressive Webs.




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Meet capella star Alaa Wardi




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How mobile data can help rationalise bus routes




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Down to the wire: On the run-up to the U.S. presidential election

The U.S. presidential race is poised on a knife’s edge




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Wrong notion: On simultaneous elections

The idea of simultaneous elections is inherently anti-federal




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Sri Lanka’s verdict: On the Island nation’s ninth Presidential election

The spirit of the mandate of the presidential poll was clear — for change




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​Rogue state: On Israel’s conflict with Hezbollah  

Israel is choosing war over peace, escalation over compromise 




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​Kashmir conflict: On the J&K elections

The political divide between national parties and regional parties is clear 




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​Delay and bail: On former Tamil Nadu Minister V. Senthilbalaji’s case

Senthilbalaji’s release on bail was overdue, but he should not be made a Minister




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​Heartland murmurs: On the Haryana Assembly elections

Haryana may throw up surprises after the realignments




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​Healthy sign: On the voting in the 2024 J&K Assembly elections

Turnout numbers in the Assembly elections show distinct patterns in south Kashmir




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​Regulation role: On the 2024 Medicine Nobel

The discovery of microRNA changed the understanding of gene regulation




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Deep roots: On the 2024 Physics Nobel Prize 

Physics Nobel Prize acknowledges the diverse foundations of AI




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​Flipping scripts: On the Haryana and J&K election results  

BJP and INDIA bloc emerge clear winners in Haryana and Jammu & Kashmir




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​Against the odds: On the 2024 Haryana Assembly elections

The Congress could not counter the caste polarisation in Haryana 




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​Respect the mandate: On the 2024 Jammu and Kashmir elections

With elections done and dusted, J&K now must return to statehood




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Biology transformed: On the Nobel Prize in chemistry

Nobel for determining protein structure recognises a big advance




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A Korean win: On the 2024 Nobel Prize in Literature

A Nobel raises Korean prose to success levels of its drama and music 




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​Sufferers, awarded: On the 2024 Nobel Peace Prize

The Nobel Peace for the selfless Nihon Hidankyo should help stir debates on nuclear disarmament




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Battle of wits: On the Maharashtra and Jharkhand elections 

The Maharashtra and Jharkhand polls will witness intense political battles




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Fate of nations: On the 2024 Economics Nobel

The 2024 Nobel recognises the need for ‘inclusive’ institutions




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Israel versus the UN: On Tel Aviv’s move and India’s response

India’s stand must keep in mind the UN’s importance in the global order




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​Allow for deliberation: On the legitimate demands of Ladakh

The lack of a legislature and regional autonomy in Ladakh has led to the current protests




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​Celebration and vigil: On India, kala-azar and trachoma

India must not let its guard down on kala-azar




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Neck and neck: On the U.S. presidential election

Trump and Harris offer U.S. voters vastly different choices 




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​Escalation ladder: On conflict between Israel and Iran

Iran should show strategic restraint; and the world should rein in Israel




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​Tough task: On the battle lines in the Jharkhand Assembly election

Coalitional incoherence could stymie the INDIA bloc’s effort to retain power in Jharkhand




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Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells

RSC Med. Chem., 2024, 15,3418-3432
DOI: 10.1039/D4MD00170B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van Tran
Madecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer

RSC Med. Chem., 2024, 15,3433-3443
DOI: 10.1039/D4MD00468J, Research Article
Meijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing Li
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
The content of this RSS Feed (c) The Royal Society of Chemistry




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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate

RSC Med. Chem., 2024, 15,3485-3494
DOI: 10.1039/D4MD00246F, Research Article
Shouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng Xu
A novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024)

RSC Med. Chem., 2024, 15,3371-3394
DOI: 10.1039/D4MD00384E, Review Article
Debasis Das, Lingzhi Xie, Jian Hong
Prospects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists

RSC Med. Chem., 2024, 15,3616-3624
DOI: 10.1039/D4MD00306C, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. Sheldrake
Cyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00517A, Research Article
Open Access
Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00471J, Research Article
Poorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar Shrivastava
Screening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.
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Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00297K, Research Article
Branislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea Nikolić
In this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
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The content of this RSS Feed (c) The Royal Society of Chemistry