el Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00264D, PaperMariya Antony John Felix, Santhiyagu Sahayaraj Rex Shanlee, Shen-Ming Chen, Sundaresan Ruspika, Ramachandran Balaji, Narendhar Chandrasekar, Periyanayagam Arockia DossFabrication of potent electrocatalyst, La-based perovskites coupled with functionalized carbon nanofibers (LMO/f-CNF) for ultrasensitive electrochemical detection of roxarsone in edible and water samples.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Novel advanced materials and magnetic solid phase extraction as approaches in sample preparation to enhance the analysis of ochratoxin A in peanuts By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00246F, PaperBingchen Wang, Yifan Wang, Xiuyuan Zhang, Kuo HeIn order to improve the detection efficiency of ochratoxin, a superparamagnetic nano-material was synthesized for solid phase extraction of ochratoxin.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el A highly selective probe engineered to detect polarity and distinguish normal cells and tumor cells in tissue sections By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00438H, PaperSai Zhu, Lixuan Dai, Xiaoli Zhong, Weiying LinWe have designed a polarity fluorescent probe (DCI-Cou-polar) with high selectivity for diagnosing cancer.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Are These the Most Interesting Front-end Developer Tools for 2021? By www.impressivewebs.com Published On :: Tue, 05 Jan 2021 09:47:31 +0000 When I come to the end of any given year, it’s always interesting to look back through the click-through stats for my weekly newsletter Web Tools Weekly to see which tools got the most attention. This year wasn’t all that different from previous years. I’ve learned that clicks happen for basically one of two reasons: The post Are These the Most Interesting Front-end Developer Tools for 2021? appeared first on Impressive Webs. Full Article Roundups and Resources
el A Review of ipwhois.io for Reliable Geolocation Data By www.impressivewebs.com Published On :: Mon, 07 Feb 2022 11:00:00 +0000 [Sponsored] If you’re building an app that requires delivering a dynamic experience based on the user’s location or other location-related data, a fast and easy-to-use Geolocation API will certainly come in handy. One such option is ipwhois.io. The service, which is free for small non-commercial projects that need fewer than 10,000 requests per month, is easy to integrate with your tech stack. As usual, it’s always best to look at a few examples so you can see it in action. Their documentation is short and easy to follow, so I’ll demonstrate using the following example request: The post A Review of ipwhois.io for Reliable Geolocation Data appeared first on Impressive Webs. Full Article Sponsored
el Filestack: A File Uploader and Powerful APIs to Deliver and Transform App Content By www.impressivewebs.com Published On :: Wed, 11 May 2022 10:00:00 +0000 [Sponsored] If you’re building an app that requires a lot of user-generated content and media that needs to be processed, tagged, filtered, or otherwise manipulated in real-time, you definitely want a solution that’s fast and seamless and doesn’t get in the way of your app’s primary functionality. Filestack is a service you’ll want to consider. Here’s what Filestack offers: The post Filestack: A File Uploader and Powerful APIs to Deliver and Transform App Content appeared first on Impressive Webs. Full Article Sponsored Web Design Articles
el Meet capella star Alaa Wardi By www.thehindubusinessline.com Published On :: Mon, 22 Apr 2013 12:31:39 +0530 Full Article R Dinakaran
el How mobile data can help rationalise bus routes By www.thehindubusinessline.com Published On :: Wed, 01 May 2013 16:35:55 +0530 Full Article R Dinakaran
el Down to the wire: On the run-up to the U.S. presidential election By www.thehindu.com Published On :: Tue, 17 Sep 2024 00:30:00 +0530 The U.S. presidential race is poised on a knife’s edge Full Article Editorial
el Wrong notion: On simultaneous elections By www.thehindu.com Published On :: Fri, 20 Sep 2024 00:10:00 +0530 The idea of simultaneous elections is inherently anti-federal Full Article Editorial
el Sri Lanka’s verdict: On the Island nation’s ninth Presidential election By www.thehindu.com Published On :: Mon, 23 Sep 2024 00:10:00 +0530 The spirit of the mandate of the presidential poll was clear — for change Full Article Editorial
el Rogue state: On Israel’s conflict with Hezbollah By www.thehindu.com Published On :: Thu, 26 Sep 2024 00:10:00 +0530 Israel is choosing war over peace, escalation over compromise Full Article Editorial
el Kashmir conflict: On the J&K elections By www.thehindu.com Published On :: Thu, 26 Sep 2024 00:20:00 +0530 The political divide between national parties and regional parties is clear Full Article Editorial
el Delay and bail: On former Tamil Nadu Minister V. Senthilbalaji’s case By www.thehindu.com Published On :: Sat, 28 Sep 2024 00:20:00 +0530 Senthilbalaji’s release on bail was overdue, but he should not be made a Minister Full Article Editorial
el Heartland murmurs: On the Haryana Assembly elections By www.thehindu.com Published On :: Wed, 02 Oct 2024 00:20:00 +0530 Haryana may throw up surprises after the realignments Full Article Editorial
el Healthy sign: On the voting in the 2024 J&K Assembly elections By www.thehindu.com Published On :: Thu, 03 Oct 2024 00:10:00 +0530 Turnout numbers in the Assembly elections show distinct patterns in south Kashmir Full Article Editorial
el Regulation role: On the 2024 Medicine Nobel By www.thehindu.com Published On :: Tue, 08 Oct 2024 00:36:00 +0530 The discovery of microRNA changed the understanding of gene regulation Full Article Editorial
el Deep roots: On the 2024 Physics Nobel Prize By www.thehindu.com Published On :: Wed, 09 Oct 2024 00:10:00 +0530 Physics Nobel Prize acknowledges the diverse foundations of AI Full Article Editorial
el Flipping scripts: On the Haryana and J&K election results By www.thehindu.com Published On :: Wed, 09 Oct 2024 00:20:00 +0530 BJP and INDIA bloc emerge clear winners in Haryana and Jammu & Kashmir Full Article Editorial
el Against the odds: On the 2024 Haryana Assembly elections By www.thehindu.com Published On :: Thu, 10 Oct 2024 00:20:00 +0530 The Congress could not counter the caste polarisation in Haryana Full Article Editorial
el Respect the mandate: On the 2024 Jammu and Kashmir elections By www.thehindu.com Published On :: Fri, 11 Oct 2024 00:20:00 +0530 With elections done and dusted, J&K now must return to statehood Full Article Editorial
el Biology transformed: On the Nobel Prize in chemistry By www.thehindu.com Published On :: Mon, 14 Oct 2024 00:28:00 +0530 Nobel for determining protein structure recognises a big advance Full Article Editorial
el A Korean win: On the 2024 Nobel Prize in Literature By www.thehindu.com Published On :: Tue, 15 Oct 2024 00:20:00 +0530 A Nobel raises Korean prose to success levels of its drama and music Full Article Editorial
el Sufferers, awarded: On the 2024 Nobel Peace Prize By www.thehindu.com Published On :: Wed, 16 Oct 2024 00:20:00 +0530 The Nobel Peace for the selfless Nihon Hidankyo should help stir debates on nuclear disarmament Full Article Editorial
el Battle of wits: On the Maharashtra and Jharkhand elections By www.thehindu.com Published On :: Fri, 18 Oct 2024 00:20:00 +0530 The Maharashtra and Jharkhand polls will witness intense political battles Full Article Editorial
el Fate of nations: On the 2024 Economics Nobel By www.thehindu.com Published On :: Sat, 19 Oct 2024 00:10:00 +0530 The 2024 Nobel recognises the need for ‘inclusive’ institutions Full Article Editorial
el Israel versus the UN: On Tel Aviv’s move and India’s response By www.thehindu.com Published On :: Sat, 19 Oct 2024 00:20:00 +0530 India’s stand must keep in mind the UN’s importance in the global order Full Article Editorial
el Allow for deliberation: On the legitimate demands of Ladakh By www.thehindu.com Published On :: Tue, 22 Oct 2024 00:15:00 +0530 The lack of a legislature and regional autonomy in Ladakh has led to the current protests Full Article Editorial
el Celebration and vigil: On India, kala-azar and trachoma By www.thehindu.com Published On :: Thu, 24 Oct 2024 00:10:00 +0530 India must not let its guard down on kala-azar Full Article Editorial
el Neck and neck: On the U.S. presidential election By www.thehindu.com Published On :: Sat, 26 Oct 2024 00:10:00 +0530 Trump and Harris offer U.S. voters vastly different choices Full Article Editorial
el Escalation ladder: On conflict between Israel and Iran By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:15:00 +0530 Iran should show strategic restraint; and the world should rein in Israel Full Article Editorial
el Tough task: On the battle lines in the Jharkhand Assembly election By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:20:00 +0530 Coalitional incoherence could stymie the INDIA bloc’s effort to retain power in Jharkhand Full Article Editorial
el Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3395-3417DOI: 10.1039/D4MD00334A, Research ArticleVu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh ThanhD-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3495-3506DOI: 10.1039/D4MD00275J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. RussellThe optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3418-3432DOI: 10.1039/D4MD00170B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van TranMadecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3444-3459DOI: 10.1039/D4MD00318G, Research ArticleAnuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar MaitiNiloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3433-3443DOI: 10.1039/D4MD00468J, Research ArticleMeijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing LiA synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3460-3468DOI: 10.1039/D4MD00405A, Research ArticleXiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli BiSchematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3485-3494DOI: 10.1039/D4MD00246F, Research ArticleShouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng XuA novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024) By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3371-3394DOI: 10.1039/D4MD00384E, Review ArticleDebasis Das, Lingzhi Xie, Jian HongProspects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3609-3615DOI: 10.1039/D4MD00501E, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. VealeRationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam. By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3558-3575DOI: 10.1039/D4MD00391H, Research ArticlePothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar MaitiMalabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3616-3624DOI: 10.1039/D4MD00306C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. SheldrakeCyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00257A, Research Article Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob AlamIn light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00517A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca ReA novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00537F, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry LombergetA series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00471J, Research ArticlePoorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar ShrivastavaScreening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00297K, Research ArticleBranislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea NikolićIn this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00594E, Research ArticleNagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza ElrayessOne benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
el Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00645C, Research ArticleGeetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra BorahVirtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article